Genular: Defining Cellular Identity and Function

Details for: Cdkn2b

Gene ID: 12579

Symbol: Cdkn2b

Ensembl ID: ENSMUSG00000073802

Description: cyclin dependent kinase inhibitor 2B

Associated with

Cell cycle, mitotic
(R-MMU-69278)
Cellular responses to stimuli
(R-MMU-8953897)
Cellular responses to stress
(R-MMU-2262752)
Cyclin d associated events in g1
(R-MMU-69231)
G1 phase
(R-MMU-69236)
Mitotic g1 phase and g1/s transition
(R-MMU-453279)
Oncogene induced senescence
(R-MMU-2559585)
Oxidative stress induced senescence
(R-MMU-2559580)
Senescence-associated secretory phenotype (sasp)
(R-MMU-2559582)
Cell cycle
(GO:0007049)
Cellular response to extracellular stimulus
(GO:0031668)
Cellular response to nutrient
(GO:0031670)
Cellular senescence
(GO:0090398)
Cyclin-dependent protein serine/threonine kinase inhibitor activity
(GO:0004861)
Cytoplasm
(GO:0005737)
Negative regulation of cell cycle g1/s phase transition
(GO:1902807)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of epithelial cell proliferation
(GO:0050680)
Negative regulation of g1/s transition of mitotic cell cycle
(GO:2000134)
Negative regulation of glial cell proliferation
(GO:0060253)
Negative regulation of phosphorylation
(GO:0042326)
Nucleus
(GO:0005634)
Positive regulation of transforming growth factor beta receptor signaling pathway
(GO:0030511)
Protein kinase binding
(GO:0019901)
Regulation of cyclin-dependent protein serine/threonine kinase activity
(GO:0000079)
Regulation of g0 to g1 transition
(GO:0070316)
Regulation of g1/s transition of mitotic cell cycle
(GO:2000045)
Spleen development
(GO:0048536)

Other Information

Proteins

Cyclin-dependent kinase 4 inhibitor B

Genular Protein ID: 3533727271

Symbol: CDN2B_MOUSE

Name: Cyclin-dependent kinase 4 inhibitor B

UniProtKB Accession Codes:

P55271

Database IDs:

Citations:

PubMed ID: 7651726

Title: Cloning and characterization of murine p16INK4a and p15INK4b genes.

PubMed ID: 7651726

PubMed ID: 9178896

Title: Inactivation of the cyclin-dependent kinase inhibitor p15INK4b by deletion and de novo methylation with independence of p16INK4a alterations in murine primary T-cell lymphomas.

PubMed ID: 9178896

DOI: 10.1038/sj.onc.1200969

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15345747

Title: Phosphoproteomic analysis of the developing mouse brain.

PubMed ID: 15345747

DOI: 10.1074/mcp.m400085-mcp200

PubMed ID: 10556039

Title: Tumor suppressor INK4: comparisons of conformational properties between p16(INK4A) and p18(INK4C).

PubMed ID: 10556039

DOI: 10.1006/jmbi.1999.3231

Sequence Information:

Length: 130
Mass: 13789
Checksum: 7AAD60FF552BCFF9
Sequence:

MLGGSSDAGL ATAAARGQVE TVRQLLEAGA DPNALNRFGR RPIQVMMMGS AQVAELLLLH 
GAEPNCADPA TLTRPVHDAA REGFLDTLVV LHRAGARLDV CDAWGRLPVD LAEEQGHRDI 
ARYLHAATGD

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Cdkn2b

Associated with

Other Information

Cloning and characterization of murine p16INK4a and p15INK4b genes. PubMed ID: 7651726

Inactivation of the cyclin-dependent kinase inhibitor p15INK4b by deletion and de novo methylation with independence of p16INK4a alterations in murine primary T-cell lymphomas. PubMed ID: 9178896

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334