Details for: CNGB1

Gene ID: 1258

Symbol: CNGB1

Ensembl ID: ENSG00000070729

Description: cyclic nucleotide gated channel subunit beta 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 3.9
    Marker Score: 11123
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 2.9
    Marker Score: 865
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.76
    Marker Score: 5022
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.59
    Marker Score: 3290
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.54
    Marker Score: 2917
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.38
    Marker Score: 2799
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.29
    Marker Score: 609
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 1.22
    Marker Score: 722
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.2
    Marker Score: 18834
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.12
    Marker Score: 7421
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.09
    Marker Score: 11262
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71822
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48047
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.96
    Marker Score: 2440
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5350
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.89
    Marker Score: 401
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.89
    Marker Score: 464
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5286
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.87
    Marker Score: 293
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.8
    Marker Score: 254
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1260
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 708
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 396
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.73
    Marker Score: 438
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.71
    Marker Score: 2906
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.7
    Marker Score: 224
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.62
    Marker Score: 872
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.54
    Marker Score: 170
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.51
    Marker Score: 215
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.51
    Marker Score: 569
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.5
    Marker Score: 388
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.5
    Marker Score: 1439
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.49
    Marker Score: 236
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.49
    Marker Score: 369
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 0.48
    Marker Score: 158
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.46
    Marker Score: 710
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.39
    Marker Score: 123
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.38
    Marker Score: 643
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.38
    Marker Score: 888
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.37
    Marker Score: 252
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.36
    Marker Score: 98
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.35
    Marker Score: 153
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.31
    Marker Score: 397
  • Cell Name: S cone cell (CL0003050)
    Fold Change: 0.29
    Marker Score: 86
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.28
    Marker Score: 81
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.27
    Marker Score: 99
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.27
    Marker Score: 70
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.26
    Marker Score: 92
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.26
    Marker Score: 287
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.26
    Marker Score: 168
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.25
    Marker Score: 151
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.25
    Marker Score: 308
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.25
    Marker Score: 2315
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.24
    Marker Score: 947
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.24
    Marker Score: 137
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.23
    Marker Score: 124
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.22
    Marker Score: 301.5
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.21
    Marker Score: 2841
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.2
    Marker Score: 221
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.19
    Marker Score: 167
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.19
    Marker Score: 69
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.18
    Marker Score: 84
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.17
    Marker Score: 55
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.17
    Marker Score: 80
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.16
    Marker Score: 78
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.16
    Marker Score: 91
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.16
    Marker Score: 148
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.15
    Marker Score: 59
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.15
    Marker Score: 1309
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.15
    Marker Score: 133
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.14
    Marker Score: 37
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.14
    Marker Score: 96
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.14
    Marker Score: 56
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.14
    Marker Score: 94
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.14
    Marker Score: 170
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.13
    Marker Score: 78
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.13
    Marker Score: 1142
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.13
    Marker Score: 181
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.12
    Marker Score: 60
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.12
    Marker Score: 74
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.11
    Marker Score: 25
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.11
    Marker Score: 29
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.11
    Marker Score: 112
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.11
    Marker Score: 260
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 0.11
    Marker Score: 360
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.11
    Marker Score: 117.5
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.1
    Marker Score: 99
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.1
    Marker Score: 114
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.1
    Marker Score: 354
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.1
    Marker Score: 5633
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.1
    Marker Score: 97
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.1
    Marker Score: 36
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.1
    Marker Score: 45
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.1
    Marker Score: 409
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.1
    Marker Score: 24
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.1
    Marker Score: 23
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.1
    Marker Score: 279

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Other Information

**Key characteristics:** * CNGB1 is a transmembrane protein with a molecular weight of approximately 140 kDa. * It is a member of the cyclic nucleotide-gated channel family of ion channels. * CNGB1 is expressed in high levels in the retina and other tissues that are involved in visual function. * It is a key regulator of the phototransduction cascade, and its expression is modulated by a variety of factors, including light, hormones, and neurotransmitters. **Pathways and functions:** * CNGB1 is a key component of the phototransduction cascade, which is a signaling pathway that is involved in the transduction of light information from the retina to the brain. * The phototransduction cascade is responsible for converting light energy into neural signals that are sent to the brain. * CNGB1 is one of the seven subunits of the cyclic nucleotide-gated channel complex, which is responsible for the opening and closing of the channel in response to changes in the concentration of cyclic GMP-AMP. * CNGB1 is also a ligand-gated ion channel, which means that it is opened by specific ligands. * It is expressed in a variety of cell types in the eye, including retinal rod cells, photoreceptor cells, and retinal ganglion cells. **Clinical significance:** * Mutations in the CNGB1 gene have been linked to a number of eye diseases, including retinal degenerative diseases such as age-related macular degeneration (AMD) and retinal vascular disease. * CNGB1 is a potential target for therapeutic intervention in eye diseases that are caused by mutations in the gene. * Studies of CNGB1 have also shown that it is involved in a variety of other cellular processes, such as cell migration, neurite outgrowth, and differentiation. **Additional information:** * CNGB1 is a highly conserved gene, with a similar gene found in other vertebrates. * It is expressed in a pattern that is consistent with its known function in the phototransduction cascade. * CNGB1 is a promising target for therapeutic intervention in eye diseases.

Genular Protein ID: 1215173794

Symbol: CNGB1_HUMAN

Name: Cyclic nucleotide-gated cation channel beta-1

UniProtKB Accession Codes:

Q14028 H3BN09 O43636 Q13059 Q14029 Q9UMG2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChEBI 3 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EMDB 7 EPD 1 Ensembl 3 ExpressionAtlas 1 GO 29 Gene3D 3 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 13 PDBsum 9 PIR 3 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 RNAct 1 Reactome 4 RefSeq 3 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7682292

Title: A new subunit of the cyclic nucleotide-gated cation channel in retinal rods.

PubMed ID: 7682292

DOI: 10.1038/362764a0

PubMed ID: 7590744

Title: cDNA, gene structure, and chromosomal localization of human GAR1 (CNCG3L), a homolog of the third subunit of bovine photoreceptor cGMP-gated channel.

PubMed ID: 7590744

DOI: 10.1006/geno.1995.1102

PubMed ID: 8766832

Title: The beta subunit of human rod photoreceptor cGMP-gated cation channel is generated from a complex transcription unit.

PubMed ID: 8766832

DOI: 10.1016/0014-5793(96)00588-1

PubMed ID: 9535905

Title: Identification of a domain on the beta-subunit of the rod cGMP-gated cation channel that mediates inhibition by calcium-calmodulin.

PubMed ID: 9535905

DOI: 10.1074/jbc.273.15.9148

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 10717482

Title: Genomic organization of the human rod photoreceptor cGMP-gated cation channel beta-subunit gene.

PubMed ID: 10717482

DOI: 10.1016/s0378-1119(00)00023-8

PubMed ID: 15195096

Title: Calmodulin permanently associates with rat olfactory CNG channels under native conditions.

PubMed ID: 15195096

DOI: 10.1038/nn1266

PubMed ID: 16407240

Title: The glutamic acid-rich protein-2 (GARP2) is a high affinity rod photoreceptor phosphodiesterase (PDE6)-binding protein that modulates its catalytic properties.

PubMed ID: 16407240

DOI: 10.1074/jbc.m507488200

PubMed ID: 16280326

Title: Glutamic acid-rich proteins of rod photoreceptors are natively unfolded.

PubMed ID: 16280326

DOI: 10.1074/jbc.m505012200

PubMed ID: 11379879

Title: Segregation of a mutation in CNGB1 encoding the beta-subunit of the rod cGMP-gated channel in a family with autosomal recessive retinitis pigmentosa.

PubMed ID: 11379879

DOI: 10.1007/s004390100496

Sequence Information:

  • Length: 1251
  • Mass: 139678
  • Checksum: 7A45CB399EB2B20C
  • Sequence:
    • MLGWVQRVLP QPPGTPRKTK MQEEEEVEPE PEMEAEVEPE PNPEEAETES ESMPPEESFK 
EEEVAVADPS PQETKEAALT STISLRAQGA EISEMNSPSR RVLTWLMKGV EKVIPQPVHS 
ITEDPAQILG HGSTGDTGCT DEPNEALEAQ DTRPGLRLLL WLEQNLERVL PQPPKSSEVW 
RDEPAVATGA ASDPAPPGRP QEMGPKLQAR ETPSLPTPIP LQPKEEPKEA PAPEPQPGSQ 
AQTSSLPPTR DPARLVAWVL HRLEMALPQP VLHGKIGEQE PDSPGICDVQ TISILPGGQV 
EPDLVLEEVE PPWEDAHQDV STSPQGTEVV PAYEEENKAV EKMPRELSRI EEEKEDEEEE 
EEEEEEEEEE EVTEVLLDSC VVSQVGVGQS EEDGTRPQST SDQKLWEEVG EEAKKEAEEK 
AKEEAEEVAE EEAEKEPQDW AETKEEPEAE AEAASSGVPA TKQHPEVQVE DTDADSCPLM 
AEENPPSTVL PPPSPAKSDT LIVPSSASGT HRKKLPSEDD EAEELKALSP AESPVVAWSD 
PTTPKDTDGQ DRAASTASTN SAIINDRLQE LVKLFKERTE KVKEKLIDPD VTSDEESPKP 
SPAKKAPEPA PDTKPAEAEP VEEEHYCDML CCKFKHRPWK KYQFPQSIDP LTNLMYVLWL 
FFVVMAWNWN CWLIPVRWAF PYQTPDNIHH WLLMDYLCDL IYFLDITVFQ TRLQFVRGGD 
IITDKKDMRN NYLKSRRFKM DLLSLLPLDF LYLKVGVNPL LRLPRCLKYM AFFEFNSRLE 
SILSKAYVYR VIRTTAYLLY SLHLNSCLYY WASAYQGLGS THWVYDGVGN SYIRCYYFAV 
KTLITIGGLP DPKTLFEIVF QLLNYFTGVF AFSVMIGQMR DVVGAATAGQ TYYRSCMDST 
VKYMNFYKIP KSVQNRVKTW YEYTWHSQGM LDESELMVQL PDKMRLDLAI DVNYNIVSKV 
ALFQGCDRQM IFDMLKRLRS VVYLPNDYVC KKGEIGREMY IIQAGQVQVL GGPDGKSVLV 
TLKAGSVFGE ISLLAVGGGN RRTANVVAHG FTNLFILDKK DLNEILVHYP ESQKLLRKKA 
RRMLRSNNKP KEEKSVLILP PRAGTPKLFN AALAMTGKMG GKGAKGGKLA HLRARLKELA 
ALEAAAKQQE LVEQAKSSQD VKGEEGSAAP DQHTHPKEAA TDPPAPRTPP EPPGSPPSSP 
PPASLGRPEG EEEGPAEPEE HSVRICMSPG PEPGEQILSV KMPEEREEKA E

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.