CNGB1 | ENSG00000070729 | NCBI 1258

Details for: CNGB1

Gene ID: 1258

Symbol: CNGB1

Ensembl ID: ENSG00000070729

Description: cyclic nucleotide gated channel subunit beta 1

Associated with

Activation of the phototransduction cascade
(R-HSA-2485179)
Cargo trafficking to the periciliary membrane
(R-HSA-5620920)
Cilium assembly
(R-HSA-5617833)
Inactivation, recovery and regulation of the phototransduction cascade
(R-HSA-2514859)
Olfactory signaling pathway
(R-HSA-381753)
Organelle biogenesis and maintenance
(R-HSA-1852241)
Sensory perception
(R-HSA-9709957)
The phototransduction cascade
(R-HSA-2514856)
Visual phototransduction
(R-HSA-2187338)
Vxpx cargo-targeting to cilium
(R-HSA-5620916)
Camp binding
(GO:0030552)
Cgmp binding
(GO:0030553)
Ciliary membrane
(GO:0060170)
Detection of chemical stimulus involved in sensory perception of smell
(GO:0050911)
Detection of light stimulus involved in visual perception
(GO:0050908)
Golgi-associated vesicle membrane
(GO:0030660)
Intracellular camp-activated cation channel activity
(GO:0005222)
Intracellular cgmp-activated cation channel activity
(GO:0005223)
Intracellular cyclic nucleotide activated cation channel complex
(GO:0017071)
Ion channel modulating, g protein-coupled receptor signaling pathway
(GO:0099105)
Ligand-gated monoatomic ion channel activity
(GO:0015276)
Membrane depolarization
(GO:0051899)
Monoatomic cation transmembrane transport
(GO:0098655)
Monoatomic cation transport
(GO:0006812)
Olfactory nerve maturation
(GO:0021630)
Photoreceptor cell maintenance
(GO:0045494)
Photoreceptor cell outer segment organization
(GO:0035845)
Photoreceptor outer segment
(GO:0001750)
Phototransduction
(GO:0007602)
Plasma membrane
(GO:0005886)
Positive regulation of gene expression
(GO:0010628)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein localization to organelle
(GO:0033365)
Regulation of cytosolic calcium ion concentration
(GO:0051480)
Response to odorant
(GO:1990834)
Retina homeostasis
(GO:0001895)
Terminal bouton
(GO:0043195)
Transmembrane transporter complex
(GO:1902495)
Visual perception
(GO:0007601)

Other Information

Proteins

Cyclic nucleotide-gated cation channel beta-1

Genular Protein ID: 1215173794

Symbol: CNGB1_HUMAN

Name: Cyclic nucleotide-gated cation channel beta-1

UniProtKB Accession Codes:

Q14028 H3BN09 O43636 Q13059 Q14029 Q9UMG2

Database IDs:

Citations:

PubMed ID: 7682292

Title: A new subunit of the cyclic nucleotide-gated cation channel in retinal rods.

PubMed ID: 7682292

DOI: 10.1038/362764a0

PubMed ID: 7590744

Title: cDNA, gene structure, and chromosomal localization of human GAR1 (CNCG3L), a homolog of the third subunit of bovine photoreceptor cGMP-gated channel.

PubMed ID: 7590744

DOI: 10.1006/geno.1995.1102

PubMed ID: 8766832

Title: The beta subunit of human rod photoreceptor cGMP-gated cation channel is generated from a complex transcription unit.

PubMed ID: 8766832

DOI: 10.1016/0014-5793(96)00588-1

PubMed ID: 9535905

Title: Identification of a domain on the beta-subunit of the rod cGMP-gated cation channel that mediates inhibition by calcium-calmodulin.

PubMed ID: 9535905

DOI: 10.1074/jbc.273.15.9148

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 10717482

Title: Genomic organization of the human rod photoreceptor cGMP-gated cation channel beta-subunit gene.

PubMed ID: 10717482

DOI: 10.1016/s0378-1119(00)00023-8

PubMed ID: 15195096

Title: Calmodulin permanently associates with rat olfactory CNG channels under native conditions.

PubMed ID: 15195096

DOI: 10.1038/nn1266

PubMed ID: 16407240

Title: The glutamic acid-rich protein-2 (GARP2) is a high affinity rod photoreceptor phosphodiesterase (PDE6)-binding protein that modulates its catalytic properties.

PubMed ID: 16407240

DOI: 10.1074/jbc.m507488200

PubMed ID: 16280326

Title: Glutamic acid-rich proteins of rod photoreceptors are natively unfolded.

PubMed ID: 16280326

DOI: 10.1074/jbc.m505012200

PubMed ID: 11379879

Title: Segregation of a mutation in CNGB1 encoding the beta-subunit of the rod cGMP-gated channel in a family with autosomal recessive retinitis pigmentosa.

PubMed ID: 11379879

DOI: 10.1007/s004390100496

Sequence Information:

Length: 1251
Mass: 139678
Checksum: 7A45CB399EB2B20C
Sequence:

MLGWVQRVLP QPPGTPRKTK MQEEEEVEPE PEMEAEVEPE PNPEEAETES ESMPPEESFK 
EEEVAVADPS PQETKEAALT STISLRAQGA EISEMNSPSR RVLTWLMKGV EKVIPQPVHS 
ITEDPAQILG HGSTGDTGCT DEPNEALEAQ DTRPGLRLLL WLEQNLERVL PQPPKSSEVW 
RDEPAVATGA ASDPAPPGRP QEMGPKLQAR ETPSLPTPIP LQPKEEPKEA PAPEPQPGSQ 
AQTSSLPPTR DPARLVAWVL HRLEMALPQP VLHGKIGEQE PDSPGICDVQ TISILPGGQV 
EPDLVLEEVE PPWEDAHQDV STSPQGTEVV PAYEEENKAV EKMPRELSRI EEEKEDEEEE 
EEEEEEEEEE EVTEVLLDSC VVSQVGVGQS EEDGTRPQST SDQKLWEEVG EEAKKEAEEK 
AKEEAEEVAE EEAEKEPQDW AETKEEPEAE AEAASSGVPA TKQHPEVQVE DTDADSCPLM 
AEENPPSTVL PPPSPAKSDT LIVPSSASGT HRKKLPSEDD EAEELKALSP AESPVVAWSD 
PTTPKDTDGQ DRAASTASTN SAIINDRLQE LVKLFKERTE KVKEKLIDPD VTSDEESPKP 
SPAKKAPEPA PDTKPAEAEP VEEEHYCDML CCKFKHRPWK KYQFPQSIDP LTNLMYVLWL 
FFVVMAWNWN CWLIPVRWAF PYQTPDNIHH WLLMDYLCDL IYFLDITVFQ TRLQFVRGGD 
IITDKKDMRN NYLKSRRFKM DLLSLLPLDF LYLKVGVNPL LRLPRCLKYM AFFEFNSRLE 
SILSKAYVYR VIRTTAYLLY SLHLNSCLYY WASAYQGLGS THWVYDGVGN SYIRCYYFAV 
KTLITIGGLP DPKTLFEIVF QLLNYFTGVF AFSVMIGQMR DVVGAATAGQ TYYRSCMDST 
VKYMNFYKIP KSVQNRVKTW YEYTWHSQGM LDESELMVQL PDKMRLDLAI DVNYNIVSKV 
ALFQGCDRQM IFDMLKRLRS VVYLPNDYVC KKGEIGREMY IIQAGQVQVL GGPDGKSVLV 
TLKAGSVFGE ISLLAVGGGN RRTANVVAHG FTNLFILDKK DLNEILVHYP ESQKLLRKKA 
RRMLRSNNKP KEEKSVLILP PRAGTPKLFN AALAMTGKMG GKGAKGGKLA HLRARLKELA 
ALEAAAKQQE LVEQAKSSQD VKGEEGSAAP DQHTHPKEAA TDPPAPRTPP EPPGSPPSSP 
PPASLGRPEG EEEGPAEPEE HSVRICMSPG PEPGEQILSV KMPEEREEKA E

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CNGB1

Associated with

Other Information

A new subunit of the cyclic nucleotide-gated cation channel in retinal rods. PubMed ID: 7682292

cDNA, gene structure, and chromosomal localization of human GAR1 (CNCG3L), a homolog of the third subunit of bovine photoreceptor cGMP-gated channel. PubMed ID: 7590744

The beta subunit of human rod photoreceptor cGMP-gated cation channel is generated from a complex transcription unit. PubMed ID: 8766832

Identification of a domain on the beta-subunit of the rod cGMP-gated cation channel that mediates inhibition by calcium-calmodulin. PubMed ID: 9535905

The sequence and analysis of duplication-rich human chromosome 16. PubMed ID: 15616553

Genomic organization of the human rod photoreceptor cGMP-gated cation channel beta-subunit gene. PubMed ID: 10717482

Calmodulin permanently associates with rat olfactory CNG channels under native conditions. PubMed ID: 15195096

The glutamic acid-rich protein-2 (GARP2) is a high affinity rod photoreceptor phosphodiesterase (PDE6)-binding protein that modulates its catalytic properties. PubMed ID: 16407240

Glutamic acid-rich proteins of rod photoreceptors are natively unfolded. PubMed ID: 16280326

Segregation of a mutation in CNGB1 encoding the beta-subunit of the rod cGMP-gated channel in a family with autosomal recessive retinitis pigmentosa. PubMed ID: 11379879