Details for: Cdx2

Gene ID: 12591

Symbol: Cdx2

Ensembl ID: ENSMUSG00000029646

Description: caudal type homeobox 2

Associated with

  • Animal organ morphogenesis
    (GO:0009887)
  • Anterior/posterior axis specification
    (GO:0009948)
  • Anterior/posterior pattern specification
    (GO:0009952)
  • Blastocyst development
    (GO:0001824)
  • Blood vessel development
    (GO:0001568)
  • Cell differentiation
    (GO:0030154)
  • Condensed nuclear chromosome
    (GO:0000794)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Dna binding
    (GO:0003677)
  • Double-stranded dna binding
    (GO:0003690)
  • Embryo development
    (GO:0009790)
  • Endosome to lysosome transport
    (GO:0008333)
  • Establishment or maintenance of epithelial cell apical/basal polarity
    (GO:0045197)
  • Intestinal epithelial cell differentiation
    (GO:0060575)
  • Labyrinthine layer development
    (GO:0060711)
  • Methyl-cpg binding
    (GO:0008327)
  • Multicellular organism development
    (GO:0007275)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Pattern specification process
    (GO:0007389)
  • Placenta development
    (GO:0001890)
  • Positive regulation of cell differentiation
    (GO:0045597)
  • Positive regulation of cell population proliferation
    (GO:0008284)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein-containing complex
    (GO:0032991)
  • Protein binding
    (GO:0005515)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of somitogenesis
    (GO:0014807)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Sequence-specific dna binding
    (GO:0043565)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Somatic stem cell population maintenance
    (GO:0035019)
  • Stem cell differentiation
    (GO:0048863)
  • Transcription repressor complex
    (GO:0017053)
  • Trophectodermal cell differentiation
    (GO:0001829)

Other Information

Genular Protein ID: 2970060542

Symbol: CDX2_MOUSE

Name: Homeobox protein CDX-2

UniProtKB Accession Codes:

P43241

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 Ensembl 1 ExpressionAtlas 1 GO 35 Gene3D 1 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MGI 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 7910823

Title: Structure of the murine homeobox gene cdx-2. Expression in embryonic and adult intestinal epithelium.

PubMed ID: 7910823

DOI: 10.1016/s0021-9258(17)36596-1

PubMed ID: 7935448

Title: A homeodomain protein related to caudal regulates intestine-specific gene transcription.

PubMed ID: 7935448

DOI: 10.1128/mcb.14.11.7340-7351.1994

PubMed ID: 1671571

Title: Homeobox gene expression in the intestinal epithelium of adult mice.

PubMed ID: 1671571

DOI: 10.1016/s0021-9258(18)49981-4

PubMed ID: 9512360

Title: Colon carbonic anhydrase 1: transactivation of gene expression by the homeodomain protein Cdx2.

PubMed ID: 9512360

DOI: 10.1016/s0014-5793(98)00103-3

PubMed ID: 9933478

Title: The caudal-related homeodomain protein Cdx-2 regulates vitamin D receptor gene expression in the small intestine.

PubMed ID: 9933478

DOI: 10.1359/jbmr.1999.14.2.240

PubMed ID: 11729123

Title: Phosphorylation of the serine 60 residue within the Cdx2 activation domain mediates its transactivation capacity.

PubMed ID: 11729123

DOI: 10.1053/gast.2001.29618

PubMed ID: 16027724

Title: Phosphorylation of the homeotic tumor suppressor Cdx2 mediates its ubiquitin-dependent proteasome degradation.

PubMed ID: 16027724

DOI: 10.1038/sj.onc.1208945

Sequence Information:

  • Length: 311
  • Mass: 33476
  • Checksum: 71FFC4C263462FF3
  • Sequence:
    • MYVSYLLDKD VSMYPSSVRH SGGLNLAPQN FVSPPQYPDY GGYHVAAAAA ATANLDSAQS 
PGPSWPTAYG APLREDWNGY APGGAAAANA VAHGLNGGSP AAAMGYSSPA EYHAHHHPHH 
HPHHPAASPS CASGLLQTLN LGPPGPAATA AAEQLSPSGQ RRNLCEWMRK PAQQSLGSQV 
KTRTKDKYRV VYTDHQRLEL EKEFHFSRYI TIRRKSELAA TLGLSERQVK IWFQNRRAKE 
RKIKKKQQQQ QQQQQQQPPQ PPPQPSQPQP GALRSVPEPL SPVTSLQGSV PGSVPGVLGP 
AGGVLNSTVT Q

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.