Genular: Defining Cellular Identity and Function

Details for: Cdyl

Gene ID: 12593

Symbol: Cdyl

Ensembl ID: ENSMUSG00000059288

Description: chromodomain protein, Y chromosome-like

Associated with

Acyltransferase activity
(GO:0016746)
Cell differentiation
(GO:0030154)
Chromatin binding
(GO:0003682)
Chromosome
(GO:0005694)
Crotonyl-coa hydratase activity
(GO:0120092)
Cytoplasm
(GO:0005737)
Histone acetyltransferase activity
(GO:0004402)
Identical protein binding
(GO:0042802)
Lyase activity
(GO:0016829)
Methylated histone binding
(GO:0035064)
Negative regulation of peptidyl-lysine crotonylation
(GO:0120094)
Nuclear speck
(GO:0016607)
Nucleus
(GO:0005634)
Protein-macromolecule adaptor activity
(GO:0030674)
Protein binding
(GO:0005515)
Random inactivation of x chromosome
(GO:0060816)
Spermatid development
(GO:0007286)
Spermatogenesis
(GO:0007283)
Transcription corepressor activity
(GO:0003714)
Transferase activity
(GO:0016740)

Other Information

Proteins

CDYL_MOUSE

Genular Protein ID: 2921301637

Symbol: CDYL_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q9WTK2 Q3U0W2 Q6P6N3

Database IDs:

Citations:

PubMed ID: 10192397

Title: Retroposition of autosomal mRNA yielded testis-specific gene family on human Y chromosome.

PubMed ID: 10192397

DOI: 10.1038/7771

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12072557

Title: Previously uncharacterized histone acetyltransferases implicated in mammalian spermatogenesis.

PubMed ID: 12072557

DOI: 10.1073/pnas.082248899

PubMed ID: 12947414

Title: Cdyl: a new transcriptional co-repressor.

PubMed ID: 12947414

DOI: 10.1038/sj.embor.embor917

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 24144980

Title: Cdyl, a new partner of the inactive X chromosome and potential reader of H3K27me3 and H3K9me2.

PubMed ID: 24144980

DOI: 10.1128/mcb.00866-13

PubMed ID: 28076783

Title: CDYL deficiency disrupts neuronal migration and increases susceptibility to epilepsy.

PubMed ID: 28076783

DOI: 10.1016/j.celrep.2016.12.043

PubMed ID: 27932493

Title: PRDM9 interactions with other proteins provide a link between recombination hotspots and the chromosomal axis in meiosis.

PubMed ID: 27932493

DOI: 10.1091/mbc.e16-09-0686

PubMed ID: 28803779

Title: Chromodomain protein CDYL acts as a crotonyl-CoA hydratase to regulate histone crotonylation and spermatogenesis.

PubMed ID: 28803779

DOI: 10.1016/j.molcel.2017.07.011

PubMed ID: 28842554

Title: CDYL suppresses epileptogenesis in mice through repression of axonal Nav1.6 sodium channel expression.

PubMed ID: 28842554

DOI: 10.1038/s41467-017-00368-z

PubMed ID: 29177481

Title: CDYL1 fosters double-strand break-induced transcription silencing and promotes homology-directed repair.

PubMed ID: 29177481

DOI: 10.1093/jmcb/mjx050

PubMed ID: 30665597

Title: Chromodomain Y-like Protein-Mediated Histone Crotonylation Regulates Stress-Induced Depressive Behaviors.

PubMed ID: 30665597

DOI: 10.1016/j.biopsych.2018.11.025

Sequence Information:

Length: 593
Mass: 65211
Checksum: 470D5B97D7E52CCA
Sequence:

MGIGNSQPNS QEAQLCTLPE KAEQPTDDNT CQQNNVVPAT VSEPDQASPA IQDAETQVES 
IVDKRKNKKG KTEYLVRWKG YDSEDDTWEP EQHLVNCEEY IHDFNRRHNE RQKEGSLARA 
SRASPSNARK QISRSTHSTL SKTNSKALVV GKDHESKSSQ LLAASQKFRK NPAPSLANRK 
NMDLAKSGIK ILVPKSPVKG RTSVDGFQGE SPEKLDPVDQ GAEDTVAPEV TAEKPTGALL 
GPGAERARMG SRPRIHPLVP QVSGPVTAAM ATGLAVNGKG TSPFMDALAA NGTVTIQTSV 
TGVTAGKRKF IDDRRDQPFD KRLRFSVRQT ESAYRYRDIV VRKQDGFTHI LLSTKSSENN 
SLNPEVMKEV QSALSTAAAD DSKLVLLSAV GSVFCCGLDF IYFIRRLTDD RKRESTKMAD 
AIRNFVNTFI QFKKPIIVAV NGPAIGLGAS ILPLCDVVWA NEKAWFQTPY TTFGQSPDGC 
STVMFPKIMG GASANEMLFS GRKLTAQEAC GKGLVSQVFW PGTFTQEVMV RIKELASCNP 
VVLEESKALV RCNMKMELEQ ANERECEVLK KIWGSAQGMD SMLKYLQRKI DEF

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Cdyl

Associated with

Other Information

Retroposition of autosomal mRNA yielded testis-specific gene family on human Y chromosome. PubMed ID: 10192397

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Previously uncharacterized histone acetyltransferases implicated in mammalian spermatogenesis. PubMed ID: 12072557

Cdyl: a new transcriptional co-repressor. PubMed ID: 12947414

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Cdyl, a new partner of the inactive X chromosome and potential reader of H3K27me3 and H3K9me2. PubMed ID: 24144980

CDYL deficiency disrupts neuronal migration and increases susceptibility to epilepsy. PubMed ID: 28076783

PRDM9 interactions with other proteins provide a link between recombination hotspots and the chromosomal axis in meiosis. PubMed ID: 27932493

Chromodomain protein CDYL acts as a crotonyl-CoA hydratase to regulate histone crotonylation and spermatogenesis. PubMed ID: 28803779

CDYL suppresses epileptogenesis in mice through repression of axonal Nav1.6 sodium channel expression. PubMed ID: 28842554

CDYL1 fosters double-strand break-induced transcription silencing and promotes homology-directed repair. PubMed ID: 29177481

Chromodomain Y-like Protein-Mediated Histone Crotonylation Regulates Stress-Induced Depressive Behaviors. PubMed ID: 30665597