Details for: ADH1C

Gene ID: 126

Symbol: ADH1C

Ensembl ID: ENSG00000248144

Description: alcohol dehydrogenase 1C (class I), gamma polypeptide

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 11.17
    Marker Score: 31542.5
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 3.75
    Marker Score: 6831.5
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 2.9
    Marker Score: 1936
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2.79
    Marker Score: 6329
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 2.57
    Marker Score: 16422
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.54
    Marker Score: 18873
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.32
    Marker Score: 2338.5
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 2.16
    Marker Score: 6773
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.98
    Marker Score: 1303
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.96
    Marker Score: 736
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.81
    Marker Score: 4303.5
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.8
    Marker Score: 838.5
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.59
    Marker Score: 7636
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.53
    Marker Score: 443
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.53
    Marker Score: 300
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.34
    Marker Score: 662
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.33
    Marker Score: 1330.5
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.23
    Marker Score: 3090
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.2
    Marker Score: 1033
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.08
    Marker Score: 7191
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.08
    Marker Score: 9392
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251799
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71816.5
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48042.5
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 506
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 459
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5352
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2737
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.91
    Marker Score: 225
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 323
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5294
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.83
    Marker Score: 215
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.82
    Marker Score: 327
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1269
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.78
    Marker Score: 3263
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 699
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 394
  • Cell Name: epithelial fate stem cell (CL0000036)
    Fold Change: 0.74
    Marker Score: 213
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 468
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.66
    Marker Score: 631
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.64
    Marker Score: 1212
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 0.62
    Marker Score: 213
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.59
    Marker Score: 2013
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.58
    Marker Score: 366.5
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.58
    Marker Score: 167
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.57
    Marker Score: 1081
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.54
    Marker Score: 249
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 0.5
    Marker Score: 138
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.5
    Marker Score: 123
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.49
    Marker Score: 336
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.49
    Marker Score: 998
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 274.5
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.45
    Marker Score: 188
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.42
    Marker Score: 181
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.41
    Marker Score: 331
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.41
    Marker Score: 477
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.41
    Marker Score: 129
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.4
    Marker Score: 6291
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.4
    Marker Score: 447
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.4
    Marker Score: 244
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.4
    Marker Score: 631
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.39
    Marker Score: 605
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.39
    Marker Score: 284
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.39
    Marker Score: 117
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.39
    Marker Score: 233
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.38
    Marker Score: 161
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.38
    Marker Score: 685
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.37
    Marker Score: 394
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.36
    Marker Score: 464.5
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 0.36
    Marker Score: 202
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.35
    Marker Score: 301
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.35
    Marker Score: 358
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.35
    Marker Score: 1449.5
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.34
    Marker Score: 486
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.34
    Marker Score: 4585
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.34
    Marker Score: 352
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.34
    Marker Score: 174
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.33
    Marker Score: 75
  • Cell Name: tendon cell (CL0000388)
    Fold Change: 0.32
    Marker Score: 79
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.3
    Marker Score: 143
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.3
    Marker Score: 65
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.3
    Marker Score: 492
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.26
    Marker Score: 161
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.26
    Marker Score: 88
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.24
    Marker Score: 506.5
  • Cell Name: brush cell of trachebronchial tree (CL0002075)
    Fold Change: 0.24
    Marker Score: 74
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.23
    Marker Score: 226
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.23
    Marker Score: 988
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.21
    Marker Score: 251.5
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.21
    Marker Score: 343
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.2
    Marker Score: 53
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.2
    Marker Score: 197
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.2
    Marker Score: 51
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.2
    Marker Score: 178.5
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.2
    Marker Score: 116
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.2
    Marker Score: 1041

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Other Information

**Key characteristics:** - Gene name: ADH1C - Ensembl ID: ENSG00000248144 - Pathway/Ontology: Alcohol dehydrogenase (NAD+) activity, Alcohol dehydrogenase activity, Zinc-dependent, Biological oxidations, Cytosol, Ethanol oxidation, Metabolism, Nad-retinol dehydrogenase activity, Nucleoplasm, Phase i - functionalization of compounds, Plasma membrane, Ra biosynthesis pathway, Retinoic acid metabolic process, Retinol metabolic process, Signaling by nuclear receptors, Signaling by retinoic acid, Signal transduction **Pathways and functions:** - ADH1C is involved in the metabolism of alcohol in the liver. - It is expressed in various cell types, including tracheal goblet cell, microglial cell, nasal mucosa goblet cell, mucous neck cell, foveolar cell of stomach, basal cell of epithelium of trachea, blood vessel endothelial cell, colon epithelial cell, skeletal muscle fibroblast, and intestinal crypt stem cell. - ADH1C activity is regulated by various factors, including alcohol, insulin, and estrogen. - It plays a role in the detoxification of alcohol in the body. **Clinical significance:** - Mutations in the ADH1C gene have been linked to an increased risk of developing liver disease and certain types of cancer. - ADH1C inhibitors are being investigated as potential treatments for liver diseases and cancer.

Genular Protein ID: 3737739884

Symbol: ADH1G_HUMAN

Name: Alcohol dehydrogenase 1C

UniProtKB Accession Codes:

P00326 Q4PJ18 Q5WRV0 Q6LBW4 Q6NWV0 Q6NZA7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 25 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 22 DrugCentral 1 EC 2 EMBL 15 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 10 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 Rhea 3 SABIO-RK 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TopDownProteomics 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3758060

Title: The gamma 1 and gamma 2 subunits of human liver alcohol dehydrogenase. cDNA structures, two amino acid replacements, and compatibility with changes in the enzymatic properties.

PubMed ID: 3758060

DOI: 10.1111/j.1432-1033.1986.tb09855.x

PubMed ID: 2935875

Title: Three human alcohol dehydrogenase subunits: cDNA structure and molecular and evolutionary divergence.

PubMed ID: 2935875

DOI: 10.1073/pnas.83.3.634

PubMed ID: 1524834

Title: Molecular structure of the human alcohol dehydrogenase 3 gene.

PubMed ID: 1524834

DOI: 10.1266/jjg.67.167

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 6391921

Title: Human liver alcohol dehydrogenase. 2. The primary structure of the gamma 1 protein chain.

PubMed ID: 6391921

DOI: 10.1111/j.1432-1033.1984.tb08575.x

PubMed ID: 6391957

Title: Differential susceptibility of human alcohol dehydrogenase isoenzymes to anions.

PubMed ID: 6391957

DOI: 10.1016/0014-5793(84)80610-9

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 11274460

Title: Three-dimensional structures of the three human class I alcohol dehydrogenases.

PubMed ID: 11274460

DOI: 10.1110/ps.45001

PubMed ID: 15449945

Title: Structure of three class I human alcohol dehydrogenases complexed with isoenzyme specific formamide inhibitors.

PubMed ID: 15449945

DOI: 10.1021/bi0489107

Sequence Information:

  • Length: 375
  • Mass: 39868
  • Checksum: 414D73CC4C104C84
  • Sequence:
    • MSTAGKVIKC KAAVLWELKK PFSIEEVEVA PPKAHEVRIK MVAAGICRSD EHVVSGNLVT 
PLPVILGHEA AGIVESVGEG VTTVKPGDKV IPLFTPQCGK CRICKNPESN YCLKNDLGNP 
RGTLQDGTRR FTCSGKPIHH FVGVSTFSQY TVVDENAVAK IDAASPLEKV CLIGCGFSTG 
YGSAVKVAKV TPGSTCAVFG LGGVGLSVVM GCKAAGAARI IAVDINKDKF AKAKELGATE 
CINPQDYKKP IQEVLKEMTD GGVDFSFEVI GRLDTMMASL LCCHEACGTS VIVGVPPDSQ 
NLSINPMLLL TGRTWKGAIF GGFKSKESVP KLVADFMAKK FSLDALITNI LPFEKINEGF 
DLLRSGKSIR TVLTF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.