Details for: ADH1C

Gene ID: 126

Symbol: ADH1C

Ensembl ID: ENSG00000248144

Description: alcohol dehydrogenase 1C (class I), gamma polypeptide

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 71.9994
    Cell Significance Index: -29.6600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 7.4102
    Cell Significance Index: 76.7100
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 6.6559
    Cell Significance Index: 45.1000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 2.8783
    Cell Significance Index: 43.3800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.8361
    Cell Significance Index: 128.5500
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 2.3963
    Cell Significance Index: 27.8600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 2.1005
    Cell Significance Index: 60.5200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.8572
    Cell Significance Index: 1676.9000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.6404
    Cell Significance Index: 191.1700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.4880
    Cell Significance Index: 102.9000
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.2292
    Cell Significance Index: 8.6500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.1139
    Cell Significance Index: 181.1700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.0538
    Cell Significance Index: 15.7900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.9725
    Cell Significance Index: 24.3100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.9638
    Cell Significance Index: 30.8700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.9466
    Cell Significance Index: 20.1600
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.7134
    Cell Significance Index: 6.5400
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.6166
    Cell Significance Index: 6.3600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.4336
    Cell Significance Index: 6.4000
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.3350
    Cell Significance Index: 4.7600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.2067
    Cell Significance Index: 43.5300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1616
    Cell Significance Index: 20.7200
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.1234
    Cell Significance Index: 1.9800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1206
    Cell Significance Index: 22.9500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0904
    Cell Significance Index: 8.9400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0542
    Cell Significance Index: 1.5100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0518
    Cell Significance Index: 32.3300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0294
    Cell Significance Index: 21.7900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0159
    Cell Significance Index: 0.5600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0124
    Cell Significance Index: 2.1100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0042
    Cell Significance Index: 0.1800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0027
    Cell Significance Index: -1.5500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0249
    Cell Significance Index: -0.5400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0291
    Cell Significance Index: -1.4700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0331
    Cell Significance Index: -3.7900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0352
    Cell Significance Index: -26.6200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0374
    Cell Significance Index: -27.4300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0382
    Cell Significance Index: -20.8800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0413
    Cell Significance Index: -7.4400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0447
    Cell Significance Index: -28.3800
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: -0.0525
    Cell Significance Index: -0.5300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0754
    Cell Significance Index: -3.0900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0877
    Cell Significance Index: -10.0100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0930
    Cell Significance Index: -42.1900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1268
    Cell Significance Index: -25.4400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1353
    Cell Significance Index: -16.6400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1435
    Cell Significance Index: -28.4700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1501
    Cell Significance Index: -15.3300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1617
    Cell Significance Index: -22.2100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1959
    Cell Significance Index: -28.4700
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: -0.2262
    Cell Significance Index: -1.8700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2393
    Cell Significance Index: -30.9200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3291
    Cell Significance Index: -4.4900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3610
    Cell Significance Index: -28.6000
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: -0.3983
    Cell Significance Index: -3.1200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.4055
    Cell Significance Index: -6.8300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4151
    Cell Significance Index: -30.9400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4377
    Cell Significance Index: -33.5900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4560
    Cell Significance Index: -27.9600
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: -0.4855
    Cell Significance Index: -2.8500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5046
    Cell Significance Index: -12.9700
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.5261
    Cell Significance Index: -3.4300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.5553
    Cell Significance Index: -25.8900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.5622
    Cell Significance Index: -26.4300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.6112
    Cell Significance Index: -31.7500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.6117
    Cell Significance Index: -21.4300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.6234
    Cell Significance Index: -34.9800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.6334
    Cell Significance Index: -38.9300
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.7194
    Cell Significance Index: -9.5900
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.7400
    Cell Significance Index: -9.3500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.7789
    Cell Significance Index: -25.5000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.7917
    Cell Significance Index: -21.5500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.8371
    Cell Significance Index: -30.7300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.8437
    Cell Significance Index: -26.8700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.8480
    Cell Significance Index: -16.5500
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.8527
    Cell Significance Index: -5.2900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.8642
    Cell Significance Index: -30.0300
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.9058
    Cell Significance Index: -14.3700
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -0.9090
    Cell Significance Index: -2.0500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.9508
    Cell Significance Index: -27.2600
  • Cell Name: PP cell (CL0000696)
    Fold Change: -0.9778
    Cell Significance Index: -9.9400
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: -0.9793
    Cell Significance Index: -8.4300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.9805
    Cell Significance Index: -20.3400
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.9906
    Cell Significance Index: -7.2000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.9968
    Cell Significance Index: -29.3600
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: -0.9992
    Cell Significance Index: -4.7600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.0293
    Cell Significance Index: -27.5800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -1.0363
    Cell Significance Index: -25.8500
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -1.0555
    Cell Significance Index: -9.4300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -1.0636
    Cell Significance Index: -28.4000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -1.0804
    Cell Significance Index: -28.4100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -1.1036
    Cell Significance Index: -27.5200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -1.1103
    Cell Significance Index: -23.2400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -1.1378
    Cell Significance Index: -28.9900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -1.1809
    Cell Significance Index: -18.2700
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -1.1923
    Cell Significance Index: -24.2600
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -1.2106
    Cell Significance Index: -12.8600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -1.2132
    Cell Significance Index: -26.2100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -1.2258
    Cell Significance Index: -26.8400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -1.2362
    Cell Significance Index: -25.8000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** ADH1C is a gamma polypeptide variant of the ADH1 gene, which is encoded by the ADH1 gene locus. The gamma polypeptide is the smallest subunit of the ADH enzyme, consisting of 87 amino acids. ADH1C is primarily expressed in cells involved in the respiratory and gastrointestinal tracts, including tracheal goblet cells, nasal mucosa goblet cells, and colon epithelial cells. Its expression is also detected in microglial cells, blood vessel endothelial cells, and skeletal muscle fibroblasts. **Pathways and Functions** ADH1C is involved in various cellular pathways, including: 1. **Alcohol Metabolism**: ADH1C facilitates the oxidation of ethanol into acetaldehyde, a key intermediate in the metabolic pathway. 2. **Biological Oxidations**: ADH1C participates in the oxidation of other alcohols, including retinol and retinaldehyde. 3. **Zinc-dependent Enzymes**: ADH1C is a zinc-dependent enzyme, requiring zinc ions for its catalytic activity. 4. **Signaling by Nuclear Receptors**: ADH1C has been implicated in the regulation of signaling by nuclear receptors, including retinoic acid receptors. 5. **Retinoic Acid Metabolism**: ADH1C is involved in the metabolism of retinoic acid and its derivatives. **Clinical Significance** The ADH1C gene has been studied in the context of various diseases and disorders, including: 1. **Alcohol Dependence**: Variations in the ADH1C gene have been associated with an increased risk of alcohol dependence and excessive drinking. 2. **Cancer**: ADH1C has been implicated in the regulation of retinoic acid metabolism, which is critical in the development and progression of various cancers, including lung, breast, and colon cancers. 3. **Neurological Disorders**: ADH1C has been studied in the context of neurological disorders, including Alzheimer's disease and Parkinson's disease, where its role in the regulation of retinoic acid metabolism has been explored. In conclusion, ADH1C is a gamma polypeptide variant of the ADH enzyme family, with a complex role in the metabolism of ethanol and other alcohols, as well as in various cellular processes, including signaling by nuclear receptors and the regulation of retinoic acid metabolism. Further studies are necessary to fully elucidate the clinical significance of ADH1C and its role in human disease.

Genular Protein ID: 3737739884

Symbol: ADH1G_HUMAN

Name: Alcohol dehydrogenase 1C

UniProtKB Accession Codes:

P00326 Q4PJ18 Q5WRV0 Q6LBW4 Q6NWV0 Q6NZA7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 25 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 22 DrugCentral 1 EC 2 EMBL 15 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 9 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 Rhea 3 SABIO-RK 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TopDownProteomics 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3758060

Title: The gamma 1 and gamma 2 subunits of human liver alcohol dehydrogenase. cDNA structures, two amino acid replacements, and compatibility with changes in the enzymatic properties.

PubMed ID: 3758060

DOI: 10.1111/j.1432-1033.1986.tb09855.x

PubMed ID: 2935875

Title: Three human alcohol dehydrogenase subunits: cDNA structure and molecular and evolutionary divergence.

PubMed ID: 2935875

DOI: 10.1073/pnas.83.3.634

PubMed ID: 1524834

Title: Molecular structure of the human alcohol dehydrogenase 3 gene.

PubMed ID: 1524834

DOI: 10.1266/jjg.67.167

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 6391921

Title: Human liver alcohol dehydrogenase. 2. The primary structure of the gamma 1 protein chain.

PubMed ID: 6391921

DOI: 10.1111/j.1432-1033.1984.tb08575.x

PubMed ID: 6391957

Title: Differential susceptibility of human alcohol dehydrogenase isoenzymes to anions.

PubMed ID: 6391957

DOI: 10.1016/0014-5793(84)80610-9

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 11274460

Title: Three-dimensional structures of the three human class I alcohol dehydrogenases.

PubMed ID: 11274460

DOI: 10.1110/ps.45001

PubMed ID: 15449945

Title: Structure of three class I human alcohol dehydrogenases complexed with isoenzyme specific formamide inhibitors.

PubMed ID: 15449945

DOI: 10.1021/bi0489107

Sequence Information:

  • Length: 375
  • Mass: 39868
  • Checksum: 414D73CC4C104C84
  • Sequence:
    • MSTAGKVIKC KAAVLWELKK PFSIEEVEVA PPKAHEVRIK MVAAGICRSD EHVVSGNLVT 
PLPVILGHEA AGIVESVGEG VTTVKPGDKV IPLFTPQCGK CRICKNPESN YCLKNDLGNP 
RGTLQDGTRR FTCSGKPIHH FVGVSTFSQY TVVDENAVAK IDAASPLEKV CLIGCGFSTG 
YGSAVKVAKV TPGSTCAVFG LGGVGLSVVM GCKAAGAARI IAVDINKDKF AKAKELGATE 
CINPQDYKKP IQEVLKEMTD GGVDFSFEVI GRLDTMMASL LCCHEACGTS VIVGVPPDSQ 
NLSINPMLLL TGRTWKGAIF GGFKSKESVP KLVADFMAKK FSLDALITNI LPFEKINEGF 
DLLRSGKSIR TVLTF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.