Details for: CNGA2

Gene ID: 1260

Symbol: CNGA2

Ensembl ID: ENSG00000183862

Description: cyclic nucleotide gated channel subunit alpha 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.3893
    Cell Significance Index: 4.6600
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.3149
    Cell Significance Index: 1.8700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.2983
    Cell Significance Index: 7.6000
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.2591
    Cell Significance Index: 1.6100
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.1957
    Cell Significance Index: 3.1700
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.1793
    Cell Significance Index: 2.3600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.1420
    Cell Significance Index: 1.4700
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.0831
    Cell Significance Index: 1.4200
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.0637
    Cell Significance Index: 0.7700
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.0622
    Cell Significance Index: 0.6200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0493
    Cell Significance Index: 0.7100
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.0118
    Cell Significance Index: 0.1200
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.0105
    Cell Significance Index: 0.1400
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.0032
    Cell Significance Index: 0.0400
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0018
    Cell Significance Index: -0.0200
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0030
    Cell Significance Index: -0.0400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0046
    Cell Significance Index: -0.9200
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0051
    Cell Significance Index: -0.0700
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0075
    Cell Significance Index: -0.1500
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0092
    Cell Significance Index: -0.1200
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0096
    Cell Significance Index: -0.1100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0108
    Cell Significance Index: -0.2900
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: -0.0117
    Cell Significance Index: -0.1100
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0124
    Cell Significance Index: -0.1600
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.0126
    Cell Significance Index: -0.1400
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0131
    Cell Significance Index: -0.1600
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: -0.0133
    Cell Significance Index: -0.1400
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0145
    Cell Significance Index: -0.1600
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0159
    Cell Significance Index: -0.2000
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.0167
    Cell Significance Index: -0.1500
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0170
    Cell Significance Index: -0.2000
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0181
    Cell Significance Index: -0.1900
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0211
    Cell Significance Index: -0.2500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0220
    Cell Significance Index: -0.3300
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.0230
    Cell Significance Index: -0.1600
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.0235
    Cell Significance Index: -0.2600
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0246
    Cell Significance Index: -0.3300
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0247
    Cell Significance Index: -0.3000
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0274
    Cell Significance Index: -0.2900
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0311
    Cell Significance Index: -0.4000
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0311
    Cell Significance Index: -0.2900
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0313
    Cell Significance Index: -0.3700
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0316
    Cell Significance Index: -0.6200
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: -0.0318
    Cell Significance Index: -0.2300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0349
    Cell Significance Index: -0.8400
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0376
    Cell Significance Index: -0.4000
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0408
    Cell Significance Index: -0.4300
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.0408
    Cell Significance Index: -0.2600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0449
    Cell Significance Index: -1.4700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0458
    Cell Significance Index: -0.9200
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0467
    Cell Significance Index: -0.3400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0475
    Cell Significance Index: -1.0300
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0504
    Cell Significance Index: -0.6200
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0510
    Cell Significance Index: -0.5700
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.0515
    Cell Significance Index: -0.3400
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0523
    Cell Significance Index: -0.7600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0550
    Cell Significance Index: -0.9200
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0569
    Cell Significance Index: -0.6600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0577
    Cell Significance Index: -1.4400
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0579
    Cell Significance Index: -0.6200
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: -0.0594
    Cell Significance Index: -0.4600
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0616
    Cell Significance Index: -0.7100
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.0635
    Cell Significance Index: -0.8900
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0660
    Cell Significance Index: -1.1100
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0669
    Cell Significance Index: -0.6700
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0678
    Cell Significance Index: -0.8900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0678
    Cell Significance Index: -1.4400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0688
    Cell Significance Index: -0.7500
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: -0.0700
    Cell Significance Index: -0.6100
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0743
    Cell Significance Index: -0.8500
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0766
    Cell Significance Index: -0.6500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0772
    Cell Significance Index: -1.6900
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0778
    Cell Significance Index: -0.7300
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0787
    Cell Significance Index: -0.9400
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0876
    Cell Significance Index: -0.8300
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.0892
    Cell Significance Index: -1.1300
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0932
    Cell Significance Index: -1.2000
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0967
    Cell Significance Index: -0.8800
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.1145
    Cell Significance Index: -1.1700
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.1195
    Cell Significance Index: -0.6400
  • Cell Name: cerebellar neuron (CL1001611)
    Fold Change: -0.1326
    Cell Significance Index: -0.9200
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: -0.1347
    Cell Significance Index: -1.5600
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: -0.1367
    Cell Significance Index: -1.1300
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: -0.1468
    Cell Significance Index: -1.6300
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.1479
    Cell Significance Index: -1.6800
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.1493
    Cell Significance Index: -1.7000
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.1670
    Cell Significance Index: -1.7300
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: -0.1676
    Cell Significance Index: -1.2300
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.1795
    Cell Significance Index: -1.1700
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.1979
    Cell Significance Index: -1.7300
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: -0.2443
    Cell Significance Index: -1.1200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CNGA2 is a transmembrane protein that belongs to the CNG channel family, which is characterized by the presence of cyclic nucleotide-binding domains. The CNGA2 subunit is highly conserved across species and is found in various cell types, including sensory neurons, immune cells, and epithelial cells. CNGA2 is known to interact with other subunits and proteins to form functional CNG channels. **Pathways and Functions:** CNGA2 plays a crucial role in the detection of odorants and other chemical cues through the activation of CNG channels. The activation of CNG channels by cyclic nucleotides (cAMP and cGMP) leads to the influx of cations, which depolarizes the sensory neuron and triggers the perception of the odorant. CNGA2 is also involved in other cellular processes, including: 1. **Cargo trafficking to the periciliary membrane**: CNGA2 is required for the targeting of olfactory receptors to the periciliary membrane, where they can interact with odorants. 2. **Ciliary membrane and cilium assembly**: CNGA2 is involved in the assembly and maintenance of cilia, which are essential for the detection of chemical cues. 3. **Intracellular camp-activated cation channel activity**: CNGA2 is activated by cAMP and cGMP, leading to the influx of cations and the depolarization of sensory neurons. 4. **Monoatomic cation transmembrane transport**: CNGA2 is involved in the transport of monoatomic cations across the cell membrane. **Clinical Significance:** Dysregulation of CNGA2 has been implicated in various diseases, including: 1. **Mucopolysaccharidosis type IVA (MPS IVA)**: A genetic disorder caused by mutations in the CNGA2 gene, leading to the accumulation of glycosaminoglycans and the development of various systemic and skeletal abnormalities. 2. **Congenital insensitivity to pain with anhidrosis (CIPA)**: A rare disorder caused by mutations in the CNGA2 gene, leading to impaired pain perception and anhidrosis (absence of sweat). 3. **Olfactory dysfunction**: Mutations in the CNGA2 gene have been associated with impaired olfactory function and the development of anosmia (loss of smell). In conclusion, CNGA2 is a critical subunit of CNG channels, which play a pivotal role in sensory perception and other cellular processes. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding the function and significance of this gene in human health and disease.

Genular Protein ID: 3654805154

Symbol: CNGA2_HUMAN

Name: Cyclic nucleotide-gated channel alpha-2

UniProtKB Accession Codes:

Q16280 A0AVD0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 13 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EMBL 3 Ensembl 1 GO 17 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 Rhea 7 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7532814

Title: Expression of cyclic nucleotide-gated cation channels in non-sensory tissues and cells.

PubMed ID: 7532814

DOI: 10.1016/0028-3908(94)90027-2

PubMed ID: 11764791

Title: Nomenclature for ion channel subunits.

PubMed ID: 11764791

DOI: 10.1126/science.294.5549.2095

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 664
  • Mass: 76048
  • Checksum: E8FB934468429CE5
  • Sequence:
    • MTEKTNGVKS SPANNHNHHA PPAIKANGKD DHRTSSRPHS AADDDTSSEL QRLADVDAPQ 
QGRSGFRRIV RLVGIIREWA NKNFREEEPR PDSFLERFRG PELQTVTTQE GDGKGDKDGE 
DKGTKKKFEL FVLDPAGDWY YCWLFVIAMP VLYNWCLLVA RACFSDLQKG YYLVWLVLDY 
VSDVVYIADL FIRLRTGFLE QGLLVKDTKK LRDNYIHTLQ FKLDVASIIP TDLIYFAVDI 
HSPEVRFNRL LHFARMFEFF DRTETRTNYP NIFRISNLVL YILVIIHWNA CIYYAISKSI 
GFGVDTWVYP NITDPEYGYL AREYIYCLYW STLTLTTIGE TPPPVKDEEY LFVIFDFLIG 
VLIFATIVGN VGSMISNMNA TRAEFQAKID AVKHYMQFRK VSKGMEAKVI RWFDYLWTNK 
KTVDEREILK NLPAKLRAEI AINVHLSTLK KVRIFHDCEA GLLVELVLKL RPQVFSPGDY 
ICRKGDIGKE MYIIKEGKLA VVADDGVTQY ALLSAGSCFG EISILNIKGS KMGNRRTANI 
RSLGYSDLFC LSKDDLMEAV TEYPDAKKVL EERGREILMK EGLLDENEVA TSMEVDVQEK 
LGQLETNMET LYTRFGRLLA EYTGAQQKLK QRITVLETKM KQNNEDDYLS DGMNSPELAA 
ADEP

Genular Protein ID: 1354887110

Symbol: B3KXY3_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KXY3

Database IDs:

ARBA 22 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 6 DNASU 1 DisGeNET 1 EMBL 2 GO 3 Gene3D 4 InterPro 7 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 4 PeptideAtlas 1 Pfam 3 PharmGKB 1 RefSeq 1 Rhea 6 SAM 2 SMART 1 SUPFAM 2

Sequence Information:

  • Length: 664
  • Mass: 76064
  • Checksum: EE77BCFDFE6D23FF
  • Sequence:
    • MTEKTNGVKS SPANNHNHHA PPAIKANGKD DHRTSSRPHS AADDDTSSEL QRLADVDAPQ 
QGRSGFRRIV RLVGIIREWS NKNFREEEPR PDSFLERFRG PELQTVTTQE GDGKGDKDGE 
DKGTKKKFEL FVLDPAGDWY YCWLFVIAMP VLYNWCLLVA RACFSDLQKG YYLVWLVLDY 
VSDVVYIADL FIRLRTGFLE QGLLVKDTKK LRDNYIHTLQ FKLDVASIIP TDLIYFAVDI 
HSPEVRFNRL LHFARMFEFF DRTETRTNYP NIFRISNLVL YILVIIHWNA CIYYAISKSI 
GFGVDTWVYP NITDPEYGYL AREYIYCLYW STLTLTTIGE TPPPVKDEEY LFVIFDFLIG 
VLIFATIVGN VGSMISNMNA TRAEFQAKID AVKHYMQFRK VSKGMEAKVI RWFDYLWTNK 
KTVDEREILK NLPAKLRAEI AINVHLSTLK KVRIFHDCEA GLLVELVLKL RPQVFSPGDY 
ICRKGDIGKE MYIIKEGKLA VVADDGVTQY ALLSAGSCFG EISILNIKGS KMGNRRTANI 
RSLGYSDLFC LSKDDLMEAV TEYPDAKKVL EERGREILMK EGLLDENEVA TSMEVDVQEK 
LGQLETNMET LYTRFGRLLA EYTGAQQKLK QRITVLETKM KQNNEDDYLS DGMNSPELAA 
ADEP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.