Genular: Defining Cellular Identity and Function

Details for: Cebpa

Gene ID: 12606

Symbol: Cebpa

Ensembl ID: ENSMUSG00000034957

Description: CCAAT/enhancer binding protein alpha

Associated with

Developmental biology
(R-MMU-1266738)
Transcriptional regulation of granulopoiesis
(R-MMU-9616222)
Brown fat cell differentiation
(GO:0050873)
Cell population proliferation
(GO:0008283)
Cellular response to lithium ion
(GO:0071285)
Cellular response to organic cyclic compound
(GO:0071407)
Cellular response to tumor necrosis factor
(GO:0071356)
Cholesterol metabolic process
(GO:0008203)
Chromatin binding
(GO:0003682)
Chromatin dna binding
(GO:0031490)
Cytokine-mediated signaling pathway
(GO:0019221)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna-binding transcription factor binding
(GO:0140297)
Dna-templated transcription
(GO:0006351)
Dna binding
(GO:0003677)
Embryonic placenta development
(GO:0001892)
Epithelial cell maturation
(GO:0002070)
Fat cell differentiation
(GO:0045444)
Glucose homeostasis
(GO:0042593)
Granulocyte differentiation
(GO:0030851)
Hematopoietic stem cell proliferation
(GO:0071425)
Histone deacetylase binding
(GO:0042826)
Hmg box domain binding
(GO:0071837)
Identical protein binding
(GO:0042802)
Inner ear development
(GO:0048839)
Interleukin-6-mediated signaling pathway
(GO:0070102)
Kinase binding
(GO:0019900)
Lipid homeostasis
(GO:0055088)
Liver development
(GO:0001889)
Lung development
(GO:0030324)
Macrophage differentiation
(GO:0030225)
Mitochondrion organization
(GO:0007005)
Multicellular organism development
(GO:0007275)
Myeloid cell differentiation
(GO:0030099)
Negative regulation of cell cycle
(GO:0045786)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of hematopoietic stem cell proliferation
(GO:1902034)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Notch signaling pathway
(GO:0007219)
Nucleus
(GO:0005634)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of dna-templated transcription initiation
(GO:2000144)
Positive regulation of fat cell differentiation
(GO:0045600)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of inflammatory response
(GO:0050729)
Positive regulation of macrophage activation
(GO:0043032)
Positive regulation of osteoblast differentiation
(GO:0045669)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein domain specific binding
(GO:0019904)
Protein heterodimerization activity
(GO:0046982)
Protein homodimerization activity
(GO:0042803)
Regulation of cell population proliferation
(GO:0042127)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase i transcription regulatory region sequence-specific dna binding
(GO:0001163)
Sequence-specific dna binding
(GO:0043565)
Stat family protein binding
(GO:0097677)
Transcription by rna polymerase i
(GO:0006360)
Transcription cis-regulatory region binding
(GO:0000976)
Transcription factor binding
(GO:0008134)
Urea cycle
(GO:0000050)
White fat cell differentiation
(GO:0050872)

Other Information

Proteins

CEBPA_MOUSE

Genular Protein ID: 1809887674

Symbol: CEBPA_MOUSE

Name: N/A

UniProtKB Accession Codes:

P53566 Q91XB6

Database IDs:

Citations:

PubMed ID: 2006196

Title: CCAAT/enhancer binding protein gene promoter: binding of nuclear factors during differentiation of 3T3-L1 preadipocytes.

PubMed ID: 2006196

DOI: 10.1073/pnas.88.6.2593

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1935900

Title: The CCAAT/enhancer binding protein and its role in adipocyte differentiation: evidence for direct involvement in terminal adipocyte development.

PubMed ID: 1935900

DOI: 10.1002/j.1460-2075.1991.tb04948.x

PubMed ID: 8415748

Title: A 30-kDa alternative translation product of the CCAAT/enhancer binding protein alpha message: transcriptional activator lacking antimitotic activity.

PubMed ID: 8415748

DOI: 10.1073/pnas.90.20.9606

PubMed ID: 8090719

Title: CCAAT/enhancer binding protein alpha is sufficient to initiate the 3T3-L1 adipocyte differentiation program.

PubMed ID: 8090719

DOI: 10.1073/pnas.91.19.8757

PubMed ID: 8798745

Title: Increased hepatic cell proliferation and lung abnormalities in mice deficient in CCAAT/enhancer binding protein alpha.

PubMed ID: 8798745

DOI: 10.1074/jbc.271.40.24753

PubMed ID: 11672531

Title: E2F repression by C/EBPalpha is required for adipogenesis and granulopoiesis in vivo.

PubMed ID: 11672531

DOI: 10.1016/s0092-8674(01)00516-5

PubMed ID: 15107404

Title: Liver tumors escape negative control of proliferation via PI3K/Akt-mediated block of C/EBP alpha growth inhibitory activity.

PubMed ID: 15107404

DOI: 10.1101/gad.1183304

PubMed ID: 15589173

Title: Enhancement of hematopoietic stem cell repopulating capacity and self-renewal in the absence of the transcription factor C/EBP alpha.

PubMed ID: 15589173

DOI: 10.1016/j.immuni.2004.11.006

PubMed ID: 14660596

Title: The CCAAT enhancer-binding protein alpha (C/EBPalpha) requires a SWI/SNF complex for proliferation arrest.

PubMed ID: 14660596

DOI: 10.1074/jbc.m312709200

PubMed ID: 15509779

Title: Essential requirement of CCAAT/enhancer binding proteins in embryogenesis.

PubMed ID: 15509779

DOI: 10.1128/mcb.24.22.9744-9751.2004

PubMed ID: 17090532

Title: SIRT1 regulates adiponectin gene expression through Foxo1-C/enhancer-binding protein alpha transcriptional complex.

PubMed ID: 17090532

DOI: 10.1074/jbc.m607215200

PubMed ID: 17290224

Title: Distinct C/EBPalpha motifs regulate lipogenic and gluconeogenic gene expression in vivo.

PubMed ID: 17290224

DOI: 10.1038/sj.emboj.7601563

PubMed ID: 17627282

Title: Foxo1 links insulin signaling to C/EBPalpha and regulates gluconeogenesis during liver development.

PubMed ID: 17627282

DOI: 10.1038/sj.emboj.7601784

PubMed ID: 19641492

Title: Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-beta transcriptional complex.

PubMed ID: 19641492

DOI: 10.1038/nature08262

PubMed ID: 20075868

Title: Nucleolar retention of a translational C/EBPalpha isoform stimulates rDNA transcription and cell size.

PubMed ID: 20075868

DOI: 10.1038/emboj.2009.404

PubMed ID: 21602272

Title: Regulation of adipocyte differentiation by the zinc finger protein ZNF638.

PubMed ID: 21602272

DOI: 10.1074/jbc.m110.212506

PubMed ID: 24367003

Title: Initiation of MLL-rearranged AML is dependent on C/EBPalpha.

PubMed ID: 24367003

DOI: 10.1084/jem.20130932

PubMed ID: 27923061

Title: Comparative Transcriptomic and Epigenomic Analyses Reveal New Regulators of Murine Brown Adipogenesis.

PubMed ID: 27923061

DOI: 10.1371/journal.pgen.1006474

PubMed ID: 36228616

Title: Obesity caused by an OVOL2 mutation reveals dual roles of OVOL2 in promoting thermogenesis and limiting white adipogenesis.

PubMed ID: 36228616

DOI: 10.1016/j.cmet.2022.09.018

Sequence Information:

Length: 359
Mass: 37430
Checksum: 1E6CC09A330BEFEF
Sequence:

MESADFYEVE PRPPMSSHLQ SPPHAPSNAA FGFPRGAGPA PPPAPPAAPE PLGGICEHET 
SIDISAYIDP AAFNDEFLAD LFQHSRQQEK AKAAAGPAGG GGDFDYPGAP AGPGGAVMSA 
GAHGPPPGYG CAAAGYLDGR LEPLYERVGA PALRPLVIKQ EPREEDEAKQ LALAGLFPYQ 
PPPPPPPPHP HASPAHLAAP HLQFQIAHCG QTTMHLQPGH PTPPPTPVPS PHAAPALGAA 
GLPGPGSALK GLAGAHPDLR TGGGGGGSGA GAGKAKKSVD KNSNEYRVRR ERNNIAVRKS 
RDKAKQRNVE TQQKVLELTS DNDRLRKRVE QLSRELDTLR GIFRQLPESS LVKAMGNCA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Cebpa

Associated with

Other Information

CCAAT/enhancer binding protein gene promoter: binding of nuclear factors during differentiation of 3T3-L1 preadipocytes. PubMed ID: 2006196

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The CCAAT/enhancer binding protein and its role in adipocyte differentiation: evidence for direct involvement in terminal adipocyte development. PubMed ID: 1935900

A 30-kDa alternative translation product of the CCAAT/enhancer binding protein alpha message: transcriptional activator lacking antimitotic activity. PubMed ID: 8415748

CCAAT/enhancer binding protein alpha is sufficient to initiate the 3T3-L1 adipocyte differentiation program. PubMed ID: 8090719

Increased hepatic cell proliferation and lung abnormalities in mice deficient in CCAAT/enhancer binding protein alpha. PubMed ID: 8798745

E2F repression by C/EBPalpha is required for adipogenesis and granulopoiesis in vivo. PubMed ID: 11672531

Liver tumors escape negative control of proliferation via PI3K/Akt-mediated block of C/EBP alpha growth inhibitory activity. PubMed ID: 15107404

Enhancement of hematopoietic stem cell repopulating capacity and self-renewal in the absence of the transcription factor C/EBP alpha. PubMed ID: 15589173

The CCAAT enhancer-binding protein alpha (C/EBPalpha) requires a SWI/SNF complex for proliferation arrest. PubMed ID: 14660596

Essential requirement of CCAAT/enhancer binding proteins in embryogenesis. PubMed ID: 15509779

SIRT1 regulates adiponectin gene expression through Foxo1-C/enhancer-binding protein alpha transcriptional complex. PubMed ID: 17090532

Distinct C/EBPalpha motifs regulate lipogenic and gluconeogenic gene expression in vivo. PubMed ID: 17290224

Foxo1 links insulin signaling to C/EBPalpha and regulates gluconeogenesis during liver development. PubMed ID: 17627282

Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-beta transcriptional complex. PubMed ID: 19641492

Nucleolar retention of a translational C/EBPalpha isoform stimulates rDNA transcription and cell size. PubMed ID: 20075868

Regulation of adipocyte differentiation by the zinc finger protein ZNF638. PubMed ID: 21602272

Initiation of MLL-rearranged AML is dependent on C/EBPalpha. PubMed ID: 24367003

Comparative Transcriptomic and Epigenomic Analyses Reveal New Regulators of Murine Brown Adipogenesis. PubMed ID: 27923061

Obesity caused by an OVOL2 mutation reveals dual roles of OVOL2 in promoting thermogenesis and limiting white adipogenesis. PubMed ID: 36228616