Details for: Cebpb

Gene ID: 12608

Symbol: Cebpb

Ensembl ID: ENSMUSG00000056501

Description: CCAAT/enhancer binding protein beta

Associated with

  • Cellular responses to stimuli
    (R-MMU-8953897)
  • Cellular responses to stress
    (R-MMU-2262752)
  • Cellular senescence
    (R-MMU-2559583)
  • Senescence-associated secretory phenotype (sasp)
    (R-MMU-2559582)
  • Brown fat cell differentiation
    (GO:0050873)
  • Cell differentiation
    (GO:0030154)
  • Cellular response to amino acid stimulus
    (GO:0071230)
  • Cellular response to interleukin-1
    (GO:0071347)
  • Cellular response to lipopolysaccharide
    (GO:0071222)
  • Chromatin
    (GO:0000785)
  • Chromatin binding
    (GO:0003682)
  • Chromatin dna binding
    (GO:0031490)
  • Condensed chromosome, centromeric region
    (GO:0000779)
  • Cytoplasm
    (GO:0005737)
  • Defense response to bacterium
    (GO:0042742)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription factor binding
    (GO:0140297)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Dna-templated transcription
    (GO:0006351)
  • Dna binding
    (GO:0003677)
  • Embryonic placenta development
    (GO:0001892)
  • Fat cell differentiation
    (GO:0045444)
  • Granuloma formation
    (GO:0002432)
  • Hepatocyte proliferation
    (GO:0072574)
  • Histone acetyltransferase binding
    (GO:0035035)
  • Histone deacetylase binding
    (GO:0042826)
  • Identical protein binding
    (GO:0042802)
  • Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
    (GO:0070059)
  • Kinase binding
    (GO:0019900)
  • Liver regeneration
    (GO:0097421)
  • Mammary gland epithelial cell differentiation
    (GO:0060644)
  • Mammary gland epithelial cell proliferation
    (GO:0033598)
  • Myeloid cell development
    (GO:0061515)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of neuron apoptotic process
    (GO:0043524)
  • Negative regulation of t cell proliferation
    (GO:0042130)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Neuron differentiation
    (GO:0030182)
  • Nuclear glucocorticoid receptor binding
    (GO:0035259)
  • Nuclear matrix
    (GO:0016363)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Ovarian follicle development
    (GO:0001541)
  • Positive regulation of biomineral tissue development
    (GO:0070169)
  • Positive regulation of cold-induced thermogenesis
    (GO:0120162)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of fat cell differentiation
    (GO:0045600)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of inflammatory response
    (GO:0050729)
  • Positive regulation of interleukin-4 production
    (GO:0032753)
  • Positive regulation of osteoblast differentiation
    (GO:0045669)
  • Positive regulation of sodium-dependent phosphate transport
    (GO:2000120)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Protein heterodimerization activity
    (GO:0046982)
  • Protein homodimerization activity
    (GO:0042803)
  • Regulation of cell differentiation
    (GO:0045595)
  • Regulation of dendritic cell differentiation
    (GO:2001198)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of interleukin-6 production
    (GO:0032675)
  • Regulation of odontoblast differentiation
    (GO:1901329)
  • Regulation of osteoclast differentiation
    (GO:0045670)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Response to endoplasmic reticulum stress
    (GO:0034976)
  • Response to lipopolysaccharide
    (GO:0032496)
  • Rna polymerase ii-specific dna-binding transcription factor binding
    (GO:0061629)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Rna polymerase ii core promoter sequence-specific dna binding
    (GO:0000979)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Sequence-specific dna binding
    (GO:0043565)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • T-helper 1 cell activation
    (GO:0035711)
  • Transcription by rna polymerase ii
    (GO:0006366)
  • Transcription cis-regulatory region binding
    (GO:0000976)
  • Ubiquitin-like protein ligase binding
    (GO:0044389)

Other Information

Genular Protein ID: 1053513972

Symbol: CEBPB_MOUSE

Name: AGP/EBP

UniProtKB Accession Codes:

P28033

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 ComplexPortal 3 DIP 1 DNASU 1 EMBL 3 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 73 Gene3D 1 GeneTree 1 Genevisible 1 GlyCosmos 1 GlyGen 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MGI 2 MINT 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PIRSF 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 1 RefSeq 3 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1

Citations:

PubMed ID: 1701020

Title: Molecular cloning of a transcription factor, AGP/EBP, that belongs to members of the C/EBP family.

PubMed ID: 1701020

DOI: 10.1128/mcb.10.12.6642-6653.1990

PubMed ID: 1840554

Title: Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells.

PubMed ID: 1840554

DOI: 10.1101/gad.5.9.1538

PubMed ID: 7598808

Title: Autoregulated induction of the acute-phase response transcription factor gene, agp/ebp.

PubMed ID: 7598808

DOI: 10.1089/dna.1995.14.529

PubMed ID: 1314426

Title: Calcium-regulated phosphorylation within the leucine zipper of C/EBP beta.

PubMed ID: 1314426

DOI: 10.1126/science.256.5055.370

PubMed ID: 9303532

Title: An essential role for C/EBPbeta in female reproduction.

PubMed ID: 9303532

DOI: 10.1101/gad.11.17.2153

PubMed ID: 9727068

Title: CCAAT enhancer- binding protein beta is required for normal hepatocyte proliferation in mice after partial hepatectomy.

PubMed ID: 9727068

DOI: 10.1172/jci3135

PubMed ID: 9742105

Title: Coactivator TIF1beta interacts with transcription factor C/EBPbeta and glucocorticoid receptor to induce alpha1-acid glycoprotein gene expression.

PubMed ID: 9742105

DOI: 10.1128/mcb.18.10.5880

PubMed ID: 10635333

Title: Phosphorylation of rat serine 105 or mouse threonine 217 in C/EBP beta is required for hepatocyte proliferation induced by TGF alpha.

PubMed ID: 10635333

DOI: 10.1016/s1097-2765(00)80237-3

PubMed ID: 11792321

Title: Mechanism of c-Myb-C/EBP beta cooperation from separated sites on a promoter.

PubMed ID: 11792321

DOI: 10.1016/s0092-8674(01)00636-5

PubMed ID: 15509779

Title: Essential requirement of CCAAT/enhancer binding proteins in embryogenesis.

PubMed ID: 15509779

DOI: 10.1128/mcb.24.22.9744-9751.2004

PubMed ID: 15644333

Title: Delta-interacting protein A, a new inhibitory partner of CCAAT/enhancer-binding protein beta, implicated in adipocyte differentiation.

PubMed ID: 15644333

DOI: 10.1074/jbc.m411741200

PubMed ID: 15879117

Title: IFN-gamma-stimulated transcriptional activation by IFN-gamma-activated transcriptional element-binding factor 1 occurs via an inducible interaction with CAAAT/enhancer-binding protein-beta.

PubMed ID: 15879117

DOI: 10.4049/jimmunol.174.10.6203

PubMed ID: 15985551

Title: Sequential phosphorylation of CCAAT enhancer-binding protein beta by MAPK and glycogen synthase kinase 3beta is required for adipogenesis.

PubMed ID: 15985551

DOI: 10.1073/pnas.0503891102

PubMed ID: 16585579

Title: SUMOylation interferes with CCAAT/enhancer-binding protein beta-mediated c-myc repression, but not IL-4 activation in T cells.

PubMed ID: 16585579

DOI: 10.4049/jimmunol.176.8.4843

PubMed ID: 17911624

Title: The C/EBP beta isoform 34-kDa LAP is responsible for NF-IL-6-mediated gene induction in activated macrophages, but is not essential for intracellular bacteria killing.

PubMed ID: 17911624

DOI: 10.4049/jimmunol.179.8.5378

PubMed ID: 17301242

Title: Glucocorticoid-stimulated preadipocyte differentiation is mediated through acetylation of C/EBPbeta by GCN5.

PubMed ID: 17301242

DOI: 10.1073/pnas.0607378104

PubMed ID: 17601773

Title: Role of cdk2 in the sequential phosphorylation/activation of C/EBPbeta during adipocyte differentiation.

PubMed ID: 17601773

DOI: 10.1073/pnas.0703771104

PubMed ID: 18647749

Title: G9a-mediated lysine methylation alters the function of CCAAT/enhancer-binding protein-beta.

PubMed ID: 18647749

DOI: 10.1074/jbc.m802132200

PubMed ID: 18486321

Title: Acetylation and deacetylation regulate CCAAT/enhancer binding protein beta at K39 in mediating gene transcription.

PubMed ID: 18486321

DOI: 10.1016/j.mce.2008.03.009

PubMed ID: 19015024

Title: THOC5 couples M-CSF receptor signaling to transcription factor expression.

PubMed ID: 19015024

DOI: 10.1016/j.cellsig.2008.10.018

PubMed ID: 19440205

Title: Transcription factor C/EBPbeta isoform ratio regulates osteoclastogenesis through MafB.

PubMed ID: 19440205

DOI: 10.1038/emboj.2009.127

PubMed ID: 19478079

Title: O-linked N-acetylglucosamine modification on CCAAT enhancer-binding protein beta: role during adipocyte differentiation.

PubMed ID: 19478079

DOI: 10.1074/jbc.m109.005678

PubMed ID: 19324970

Title: The orphan nuclear receptor RORalpha restrains adipocyte differentiation through a reduction of C/EBPbeta activity and perilipin gene expression.

PubMed ID: 19324970

DOI: 10.1210/me.2008-0277

PubMed ID: 19641492

Title: Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-beta transcriptional complex.

PubMed ID: 19641492

DOI: 10.1038/nature08262

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20111005

Title: Crosstalk between C/EBPbeta phosphorylation, arginine methylation, and SWI/SNF/Mediator implies an indexing transcription factor code.

PubMed ID: 20111005

DOI: 10.1038/emboj.2010.3

PubMed ID: 20194620

Title: Control of adipogenesis by the SUMO-specific protease SENP2.

PubMed ID: 20194620

DOI: 10.1128/mcb.00852-09

PubMed ID: 21602272

Title: Regulation of adipocyte differentiation by the zinc finger protein ZNF638.

PubMed ID: 21602272

DOI: 10.1074/jbc.m110.212506

PubMed ID: 22245780

Title: Cidea is an essential transcriptional coactivator regulating mammary gland secretion of milk lipids.

PubMed ID: 22245780

DOI: 10.1038/nm.2614

PubMed ID: 24061474

Title: Protein inhibitor of activated STAT 1 (PIAS1) is identified as the SUMO E3 ligase of CCAAT/enhancer-binding protein beta (C/EBPbeta) during adipogenesis.

PubMed ID: 24061474

DOI: 10.1128/mcb.00723-13

PubMed ID: 24216764

Title: p300-dependent acetylation of activating transcription factor 5 enhances C/EBPbeta transactivation of C/EBPalpha during 3T3-L1 differentiation.

PubMed ID: 24216764

DOI: 10.1128/mcb.00956-13

PubMed ID: 25451943

Title: Transcriptional Regulation of Adipocyte Differentiation: A Central Role for CCAAT/Enhancer-binding Protein (C/EBP) beta.

PubMed ID: 25451943

DOI: 10.1074/jbc.r114.619957

PubMed ID: 27923061

Title: Comparative Transcriptomic and Epigenomic Analyses Reveal New Regulators of Murine Brown Adipogenesis.

PubMed ID: 27923061

DOI: 10.1371/journal.pgen.1006474

PubMed ID: 11018027

Title: Crystal structure of the CCAAT box/enhancer-binding protein beta activating transcription factor-4 basic leucine zipper heterodimer in the absence of DNA.

PubMed ID: 11018027

DOI: 10.1074/jbc.m005594200

Sequence Information:

  • Length: 296
  • Mass: 31446
  • Checksum: 827AC4AFC209AE89
  • Sequence:
    • MHRLLAWDAA CLPPPPAAFR PMEVANFYYE PDCLAYGAKA ARAAPRAPAA EPAIGEHERA 
IDFSPYLEPL APAADFAAPA PAHHDFLSDL FADDYGAKPS KKPADYGYVS LGRAGAKAAP 
PACFPPPPPA ALKAEPGFEP ADCKRADDAP AMAAGFPFAL RAYLGYQATP SGSSGSLSTS 
SSSSPPGTPS PADAKAAPAA CFAGPPAAPA KAKAKKTVDK LSDEYKMRRE RNNIAVRKSR 
DKAKMRNLET QHKVLELTAE NERLQKKVEQ LSRELSTLRN LFKQLPEPLL ASAGHC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.