Details for: CNGA4

Gene ID: 1262

Symbol: CNGA4

Ensembl ID: ENSG00000132259

Description: cyclic nucleotide gated channel subunit alpha 4

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 7.3
    Marker Score: 23372
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 7.27
    Marker Score: 4026
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 3.96
    Marker Score: 11560
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 3.94
    Marker Score: 11308
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 3.58
    Marker Score: 30294
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 3.42
    Marker Score: 9762
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 3.1
    Marker Score: 6406
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 2.58
    Marker Score: 7655
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 2.52
    Marker Score: 2417
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 2.06
    Marker Score: 2837
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.98
    Marker Score: 1154
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.69
    Marker Score: 889
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.66
    Marker Score: 3137
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1.51
    Marker Score: 478
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 868
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.13
    Marker Score: 474
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.1
    Marker Score: 7312
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.1
    Marker Score: 353
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.02
    Marker Score: 2067
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71808
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48033
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.97
    Marker Score: 15197
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5343
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.88
    Marker Score: 277
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5287
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.86
    Marker Score: 2036
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.86
    Marker Score: 655
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1267
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 707
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 395
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.74
    Marker Score: 430
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.69
    Marker Score: 416
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.63
    Marker Score: 385
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.63
    Marker Score: 415
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.63
    Marker Score: 1190
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.59
    Marker Score: 283
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.59
    Marker Score: 472
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.53
    Marker Score: 1816
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.52
    Marker Score: 135
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.51
    Marker Score: 292
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.44
    Marker Score: 441
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.44
    Marker Score: 421.5
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.41
    Marker Score: 253
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.4
    Marker Score: 619
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.4
    Marker Score: 177
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.38
    Marker Score: 329
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 370
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.36
    Marker Score: 160
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.32
    Marker Score: 193
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.32
    Marker Score: 358
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.32
    Marker Score: 130.5
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.31
    Marker Score: 121
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.3
    Marker Score: 338
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.3
    Marker Score: 3119
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.28
    Marker Score: 1142
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.25
    Marker Score: 5345
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.25
    Marker Score: 73
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.25
    Marker Score: 2137
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.23
    Marker Score: 551
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.23
    Marker Score: 13942
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.22
    Marker Score: 214
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.22
    Marker Score: 270
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.22
    Marker Score: 346
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.21
    Marker Score: 141
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.21
    Marker Score: 206
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.21
    Marker Score: 1808
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.21
    Marker Score: 375
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.2
    Marker Score: 108
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.2
    Marker Score: 176
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.19
    Marker Score: 39
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.19
    Marker Score: 80
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.19
    Marker Score: 1778
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.18
    Marker Score: 307
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.18
    Marker Score: 48
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.17
    Marker Score: 58
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.16
    Marker Score: 42
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.16
    Marker Score: 77
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.16
    Marker Score: 42
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.15
    Marker Score: 166
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: 0.15
    Marker Score: 42
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.15
    Marker Score: 67
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.15
    Marker Score: 84
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.14
    Marker Score: 44
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.14
    Marker Score: 172
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 0.14
    Marker Score: 42
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.13
    Marker Score: 87
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.13
    Marker Score: 4861
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.13
    Marker Score: 141
  • Cell Name: S cone cell (CL0003050)
    Fold Change: 0.13
    Marker Score: 38
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.12
    Marker Score: 36
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.12
    Marker Score: 124
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.12
    Marker Score: 35
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.12
    Marker Score: 48
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.12
    Marker Score: 162

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** - CNGA4 is a type of cell surface receptor that is expressed on a variety of cell types. - It is a member of the CNG family of ion channels. - CNGA4 is a cyclic nucleotide-gated channel, which means that it opens or closes in response to the binding of a cyclic nucleotide. - CNGA4 is expressed in high levels in certain cell types, such as amacrine cells, retinal cone cells, and renal epithelial cells. **Pathways and functions:** - CNGA4 is involved in a variety of cellular processes, including cell migration, proliferation, and differentiation. - It is thought to play a role in the regulation of cell migration by binding to extracellular matrix proteins and facilitating the opening of the channel. - CNGA4 is also involved in the regulation of cell proliferation by binding to the epidermal growth factor receptor and facilitating the opening of the channel. - It is also involved in the differentiation of retinal cone cells by binding to the retinal homeobox protein RBP-42 and facilitating the opening of the channel. **Clinical significance:** - Mutations in CNGA4 have been linked to a number of human diseases, including retinitis pigmentosa, Usher syndrome, and macular dystrophy. - CNGA4 is a potential target for the treatment of these diseases. **Additional notes:** - CNGA4 is a relatively new gene, with the first sequence being published in 1999. - It is a highly conserved gene, with a similar sequence found in organisms from humans to flies. - CNGA4 is a promising target for the development of new drugs for a variety of human diseases.

Genular Protein ID: 791025640

Symbol: CNGA4_HUMAN

Name: Cyclic nucleotide-gated cation channel alpha-4

UniProtKB Accession Codes:

Q8IV77

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 1 DMDM 1 DNASU 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 12 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15195096

Title: Calmodulin permanently associates with rat olfactory CNG channels under native conditions.

PubMed ID: 15195096

DOI: 10.1038/nn1266

PubMed ID: 17032767

Title: Interplay between PIP3 and calmodulin regulation of olfactory cyclic nucleotide-gated channels.

PubMed ID: 17032767

DOI: 10.1073/pnas.0603344103

Sequence Information:

  • Length: 575
  • Mass: 65999
  • Checksum: 4249188A8563A461
  • Sequence:
    • MSQDTKVKTT ESSPPAPSKA RKLLPVLDPS GDYYYWWLNT MVFPVMYNLI ILVCRACFPD 
LQHGYLVAWL VLDYTSDLLY LLDMVVRFHT GFLEQGILVV DKGRISSRYV RTWSFFLDLA 
SLMPTDVVYV RLGPHTPTLR LNRFLRAPRL FEAFDRTETR TAYPNAFRIA KLMLYIFVVI 
HWNSCLYFAL SRYLGFGRDA WVYPDPAQPG FERLRRQYLY SFYFSTLILT TVGDTPPPAR 
EEEYLFMVGD FLLAVMGFAT IMGSMSSVIY NMNTADAAFY PDHALVKKYM KLQHVNRKLE 
RRVIDWYQHL QINKKMTNEV AILQHLPERL RAEVAVSVHL STLSRVQIFQ NCEASLLEEL 
VLKLQPQTYS PGEYVCRKGD IGQEMYIIRE GQLAVVADDG ITQYAVLGAG LYFGEISIIN 
IKGNMSGNRR TANIKSLGYS DLFCLSKEDL REVLSEYPQA QTIMEEKGRE ILLKMNKLDV 
NAEAAEIALQ EATESRLRGL DQQLDDLQTK FARLLAELES SALKIAYRIE RLEWQTREWP 
MPEDLAEADD EGEPEEGTSK DEEGRASQEG PPGPE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.