Details for: CNGA4

Gene ID: 1262

Symbol: CNGA4

Ensembl ID: ENSG00000132259

Description: cyclic nucleotide gated channel subunit alpha 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1653
    Cell Significance Index: 1.9700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.1575
    Cell Significance Index: 45.3200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.1291
    Cell Significance Index: 3.2200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1142
    Cell Significance Index: 3.2900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0946
    Cell Significance Index: 18.9700
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 0.0217
    Cell Significance Index: 0.1000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0091
    Cell Significance Index: 1.6400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0044
    Cell Significance Index: 3.0600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0032
    Cell Significance Index: 1.1500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0014
    Cell Significance Index: 2.5300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0006
    Cell Significance Index: 1.1200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0010
    Cell Significance Index: -0.0600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0032
    Cell Significance Index: -4.3800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0034
    Cell Significance Index: -5.1700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0053
    Cell Significance Index: -0.2300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0070
    Cell Significance Index: -4.4500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0076
    Cell Significance Index: -4.1400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0078
    Cell Significance Index: -5.7900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0111
    Cell Significance Index: -6.2900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0136
    Cell Significance Index: -6.1900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0161
    Cell Significance Index: -0.2300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0174
    Cell Significance Index: -3.4500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0185
    Cell Significance Index: -2.6900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0209
    Cell Significance Index: -2.5700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0305
    Cell Significance Index: -5.2100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0311
    Cell Significance Index: -6.5600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0420
    Cell Significance Index: -5.7700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0429
    Cell Significance Index: -4.9100
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0468
    Cell Significance Index: -0.6700
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.0479
    Cell Significance Index: -0.5400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0489
    Cell Significance Index: -1.7200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0508
    Cell Significance Index: -1.3600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0516
    Cell Significance Index: -1.4400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0570
    Cell Significance Index: -5.9300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0602
    Cell Significance Index: -4.0500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0608
    Cell Significance Index: -3.7400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0698
    Cell Significance Index: -8.2300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0750
    Cell Significance Index: -5.7600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0815
    Cell Significance Index: -1.5900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0833
    Cell Significance Index: -2.1400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0841
    Cell Significance Index: -3.7200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0845
    Cell Significance Index: -4.7400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0932
    Cell Significance Index: -3.5300
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0952
    Cell Significance Index: -3.0100
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1065
    Cell Significance Index: -1.0100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1116
    Cell Significance Index: -5.0600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1156
    Cell Significance Index: -5.4400
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.1156
    Cell Significance Index: -1.0000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1207
    Cell Significance Index: -4.2300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1212
    Cell Significance Index: -6.1300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1250
    Cell Significance Index: -3.9800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1319
    Cell Significance Index: -4.3200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1367
    Cell Significance Index: -3.6500
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1394
    Cell Significance Index: -2.4100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1517
    Cell Significance Index: -2.6000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1527
    Cell Significance Index: -6.2500
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.1562
    Cell Significance Index: -1.6200
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.1568
    Cell Significance Index: -2.2300
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.1580
    Cell Significance Index: -1.9700
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.1611
    Cell Significance Index: -2.1100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1640
    Cell Significance Index: -3.4800
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.1656
    Cell Significance Index: -2.0900
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -0.1661
    Cell Significance Index: -1.5900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1702
    Cell Significance Index: -5.4500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1710
    Cell Significance Index: -4.8800
  • Cell Name: immature NK T cell (CL0000914)
    Fold Change: -0.1719
    Cell Significance Index: -2.2000
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.1812
    Cell Significance Index: -2.4900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1908
    Cell Significance Index: -4.7600
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.2044
    Cell Significance Index: -4.1600
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: -0.2049
    Cell Significance Index: -2.1200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2055
    Cell Significance Index: -4.4400
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: -0.2068
    Cell Significance Index: -1.6200
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2076
    Cell Significance Index: -5.2900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2090
    Cell Significance Index: -5.9900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2142
    Cell Significance Index: -4.6900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2147
    Cell Significance Index: -4.3100
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.2168
    Cell Significance Index: -3.1600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.2190
    Cell Significance Index: -4.5700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2256
    Cell Significance Index: -5.4100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2264
    Cell Significance Index: -6.0600
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: -0.2282
    Cell Significance Index: -2.0600
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.2290
    Cell Significance Index: -2.0700
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.2305
    Cell Significance Index: -3.9400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2321
    Cell Significance Index: -4.5900
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.2428
    Cell Significance Index: -1.6500
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: -0.2428
    Cell Significance Index: -2.2900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.2464
    Cell Significance Index: -4.1500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2472
    Cell Significance Index: -6.1800
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.2477
    Cell Significance Index: -2.8400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2491
    Cell Significance Index: -6.5500
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.2593
    Cell Significance Index: -2.6800
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.2599
    Cell Significance Index: -3.7000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.2615
    Cell Significance Index: -3.8600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2644
    Cell Significance Index: -6.4100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.2721
    Cell Significance Index: -6.6400
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2725
    Cell Significance Index: -6.8100
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.2743
    Cell Significance Index: -4.4100
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.2759
    Cell Significance Index: -4.6400
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.2768
    Cell Significance Index: -3.6900
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.2825
    Cell Significance Index: -3.6600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **CNG channel subunit**: CNGA4 is a subunit of the CNG channel, which is a heterotrimeric channel composed of three subunits: α, β, and γ. 2. **Sensory neuron-specific expression**: CNGA4 is highly expressed in sensory neurons, particularly in the retina, where it plays a crucial role in detecting odorant molecules. 3. **Ion channel activity**: CNGA4 is an ion channel that responds to cyclic nucleotides, such as cAMP and cGMP, and allows the flow of cations into the cell. 4. **Regulation of sensory perception**: CNGA4 is involved in the detection of odorant molecules and plays a critical role in the regulation of sensory perception, particularly in the olfactory system. **Pathways and Functions:** 1. **Olfactory signaling pathway**: CNGA4 is involved in the detection of odorant molecules and plays a critical role in the olfactory signaling pathway. 2. **Ciliary membrane assembly**: CNGA4 is involved in the assembly of the ciliary membrane, which is essential for the proper functioning of the cilium. 3. **Cargo trafficking**: CNGA4 is involved in the trafficking of cargo to the periciliary membrane, which is essential for the proper functioning of the cilium. 4. **Cell signaling**: CNGA4 is involved in cell signaling pathways, including the regulation of ion channels and the detection of odorant molecules. **Clinical Significance:** 1. **Retinal degeneration**: Abnormalities in CNGA4 have been implicated in several retinal degeneration disorders, including retinitis pigmentosa and age-related macular degeneration. 2. **Olfactory dysfunction**: Abnormalities in CNGA4 have been implicated in several olfactory dysfunction disorders, including anosmia and hyposmia. 3. **Neurodegenerative diseases**: Abnormalities in CNGA4 have been implicated in several neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. 4. **Therapeutic potential**: CNGA4 has been identified as a potential therapeutic target for the treatment of retinal degeneration and olfactory dysfunction disorders. In conclusion, CNGA4 is a critical gene involved in various cellular processes, including sensory perception, cell signaling, and organogenesis. Abnormalities in CNGA4 have been implicated in several neurological disorders, including retinal degeneration and olfactory dysfunction. Further research is needed to fully understand the role of CNGA4 in these disorders and to identify potential therapeutic targets.

Genular Protein ID: 791025640

Symbol: CNGA4_HUMAN

Name: Cyclic nucleotide-gated channel alpha-4

UniProtKB Accession Codes:

Q8IV77

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 13 DMDM 1 DNASU 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 16 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 1 Rhea 8 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11764791

Title: Nomenclature for ion channel subunits.

PubMed ID: 11764791

DOI: 10.1126/science.294.5549.2095

PubMed ID: 15195096

Title: Calmodulin permanently associates with rat olfactory CNG channels under native conditions.

PubMed ID: 15195096

DOI: 10.1038/nn1266

PubMed ID: 17032767

Title: Interplay between PIP3 and calmodulin regulation of olfactory cyclic nucleotide-gated channels.

PubMed ID: 17032767

DOI: 10.1073/pnas.0603344103

Sequence Information:

  • Length: 575
  • Mass: 65999
  • Checksum: 4249188A8563A461
  • Sequence:
    • MSQDTKVKTT ESSPPAPSKA RKLLPVLDPS GDYYYWWLNT MVFPVMYNLI ILVCRACFPD 
LQHGYLVAWL VLDYTSDLLY LLDMVVRFHT GFLEQGILVV DKGRISSRYV RTWSFFLDLA 
SLMPTDVVYV RLGPHTPTLR LNRFLRAPRL FEAFDRTETR TAYPNAFRIA KLMLYIFVVI 
HWNSCLYFAL SRYLGFGRDA WVYPDPAQPG FERLRRQYLY SFYFSTLILT TVGDTPPPAR 
EEEYLFMVGD FLLAVMGFAT IMGSMSSVIY NMNTADAAFY PDHALVKKYM KLQHVNRKLE 
RRVIDWYQHL QINKKMTNEV AILQHLPERL RAEVAVSVHL STLSRVQIFQ NCEASLLEEL 
VLKLQPQTYS PGEYVCRKGD IGQEMYIIRE GQLAVVADDG ITQYAVLGAG LYFGEISIIN 
IKGNMSGNRR TANIKSLGYS DLFCLSKEDL REVLSEYPQA QTIMEEKGRE ILLKMNKLDV 
NAEAAEIALQ EATESRLRGL DQQLDDLQTK FARLLAELES SALKIAYRIE RLEWQTREWP 
MPEDLAEADD EGEPEEGTSK DEEGRASQEG PPGPE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.