PLK3 | ENSG00000173846 | NCBI 1263

Details for: PLK3

Gene ID: 1263

Symbol: PLK3

Ensembl ID: ENSG00000173846

Description: polo like kinase 3

Associated with

Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Regulation of tp53 activity
(R-HSA-5633007)
Regulation of tp53 activity through phosphorylation
(R-HSA-6804756)
Rna polymerase ii transcription
(R-HSA-73857)
Tp53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
(R-HSA-6804115)
Tp53 regulates transcription of cell cycle genes
(R-HSA-6791312)
Transcriptional regulation by tp53
(R-HSA-3700989)
Apoptotic process
(GO:0006915)
Atp binding
(GO:0005524)
Centrosome
(GO:0005813)
Cytoplasm
(GO:0005737)
Cytoplasmic microtubule organization
(GO:0031122)
Dendrite
(GO:0030425)
Dna damage response
(GO:0006974)
Dna damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
(GO:0006977)
Endomitotic cell cycle
(GO:0007113)
G1/s transition of mitotic cell cycle
(GO:0000082)
G2/m transition of mitotic cell cycle
(GO:0000086)
Golgi disassembly
(GO:0090166)
Golgi stack
(GO:0005795)
Kinetochore
(GO:0000776)
Mitotic g1/s transition checkpoint signaling
(GO:0044819)
Mitotic spindle organization
(GO:0007052)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Neuronal cell body
(GO:0043025)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
P53 binding
(GO:0002039)
Phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0043491)
Positive regulation of chaperone-mediated autophagy
(GO:1904716)
Positive regulation of intracellular protein transport
(GO:0090316)
Positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia
(GO:2000777)
Protein binding
(GO:0005515)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Protein serine kinase activity
(GO:0106310)
Regulation of cell division
(GO:0051302)
Regulation of cytokinesis
(GO:0032465)
Regulation of signal transduction by p53 class mediator
(GO:1901796)
Response to osmotic stress
(GO:0006970)
Response to radiation
(GO:0009314)
Response to reactive oxygen species
(GO:0000302)
Spindle pole
(GO:0000922)

Other Information

Proteins

Serine/threonine-protein kinase PLK3

Genular Protein ID: 496121503

Symbol: PLK3_HUMAN

Name: Serine/threonine-protein kinase PLK3

UniProtKB Accession Codes:

Q9H4B4 Q15767 Q5JR99 Q96CV1

Database IDs:

Citations:

PubMed ID: 11039900

Title: Adhesion induced expression of the serine/threonine kinase Fnk in human macrophages.

PubMed ID: 11039900

DOI: 10.1038/sj.onc.1203845

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8702627

Title: Prk, a cytokine-inducible human protein serine/threonine kinase whose expression appears to be down-regulated in lung carcinomas.

PubMed ID: 8702627

DOI: 10.1074/jbc.271.32.19402

PubMed ID: 11746980

Title: Intron/exon organization and polymorphisms of the PLK3/PRK gene in human lung carcinoma cell lines.

PubMed ID: 11746980

DOI: 10.1002/gcc.1204

PubMed ID: 12242661

Title: Mammalian Polo-like kinase 3 (Plk3) is a multifunctional protein involved in stress response pathways.

PubMed ID: 12242661

DOI: 10.1038/sj.onc.1205850

PubMed ID: 9353331

Title: Human Prk is a conserved protein serine/threonine kinase involved in regulating M phase functions.

PubMed ID: 9353331

DOI: 10.1074/jbc.272.45.28646

PubMed ID: 10557092

Title: The physical association and phosphorylation of Cdc25C protein phosphatase by Prk.

PubMed ID: 10557092

DOI: 10.1038/sj.onc.1202983

PubMed ID: 11156373

Title: Incomplete cytokinesis and induction of apoptosis by overexpression of the mammalian polo-like kinase, Plk3.

PubMed ID: 11156373

PubMed ID: 11447225

Title: Reactive oxygen species-induced phosphorylation of p53 on serine 20 is mediated in part by polo-like kinase-3.

PubMed ID: 11447225

DOI: 10.1074/jbc.m104157200

PubMed ID: 11551930

Title: Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway.

PubMed ID: 11551930

DOI: 10.1074/jbc.m106050200

PubMed ID: 11971976

Title: Cell cycle arrest and apoptosis induced by human Polo-like kinase 3 is mediated through perturbation of microtubule integrity.

PubMed ID: 11971976

DOI: 10.1128/mcb.22.10.3450-3459.2002

PubMed ID: 14980500

Title: Polo-like kinase 3 is Golgi localized and involved in regulating Golgi fragmentation during the cell cycle.

PubMed ID: 14980500

DOI: 10.1016/j.yexcr.2003.10.022

PubMed ID: 14968113

Title: Cdc25C phosphorylation on serine 191 by Plk3 promotes its nuclear translocation.

PubMed ID: 14968113

DOI: 10.1038/sj.onc.1207425

PubMed ID: 15021912

Title: MEK1-induced Golgi dynamics during cell cycle progression is partly mediated by Polo-like kinase-3.

PubMed ID: 15021912

DOI: 10.1038/sj.onc.1207479

PubMed ID: 16478733

Title: Polo box domain of Plk3 functions as a centrosome localization signal, overexpression of which causes mitotic arrest, cytokinesis defects, and apoptosis.

PubMed ID: 16478733

DOI: 10.1074/jbc.m513156200

PubMed ID: 16481012

Title: Priming phosphorylation of Chk2 by polo-like kinase 3 (Plk3) mediates its full activation by ATM and a downstream checkpoint in response to DNA damage.

PubMed ID: 16481012

DOI: 10.1016/j.mrfmmm.2005.12.002

PubMed ID: 17804415

Title: Stress-induced c-Jun activation mediated by Polo-like kinase 3 in corneal epithelial cells.

PubMed ID: 17804415

DOI: 10.1074/jbc.m702791200

PubMed ID: 17264206

Title: Polo-like kinase 3 is required for entry into S phase.

PubMed ID: 17264206

DOI: 10.1073/pnas.0610856104

PubMed ID: 18062778

Title: Plk3 phosphorylates topoisomerase IIalpha at Thr(1342), a site that is not recognized by Plk1.

PubMed ID: 18062778

DOI: 10.1042/bj20071394

PubMed ID: 18650425

Title: Activation of Polo-like kinase 3 by hypoxic stresses.

PubMed ID: 18650425

DOI: 10.1074/jbc.m801326200

PubMed ID: 19490146

Title: Plk3 inhibits pro-apoptotic activity of p73 through physical interaction and phosphorylation.

PubMed ID: 19490146

DOI: 10.1111/j.1365-2443.2009.01309.x

PubMed ID: 19103756

Title: Plk3 interacts with and specifically phosphorylates VRK1 in Ser342, a downstream target in a pathway that induces Golgi fragmentation.

PubMed ID: 19103756

DOI: 10.1128/mcb.01341-08

PubMed ID: 20889502

Title: Plk3 functions as an essential component of the hypoxia regulatory pathway by direct phosphorylation of HIF-1alpha.

PubMed ID: 20889502

DOI: 10.1074/jbc.m110.160325

PubMed ID: 20940307

Title: Regulation of PTEN stability and activity by Plk3.

PubMed ID: 20940307

DOI: 10.1074/jbc.m110.166462

PubMed ID: 20951827

Title: Calcium- and integrin-binding protein 1 regulates microtubule organization and centrosome segregation through polo like kinase 3 during cell cycle progression.

PubMed ID: 20951827

DOI: 10.1016/j.biocel.2010.10.003

PubMed ID: 20473878

Title: Calcium-dependent inhibition of polo-like kinase 3 activity by CIB1 in breast cancer cells.

PubMed ID: 20473878

DOI: 10.1002/ijc.25388

PubMed ID: 21098032

Title: Hyperosmotic stress-induced ATF-2 activation through Polo-like kinase 3 in human corneal epithelial cells.

PubMed ID: 21098032

DOI: 10.1074/jbc.m110.166009

PubMed ID: 21840391

Title: Bcl-xL phosphorylation at Ser49 by polo kinase 3 during cell cycle progression and checkpoints.

PubMed ID: 21840391

DOI: 10.1016/j.cellsig.2011.07.017

PubMed ID: 21376736

Title: Absence of polo-like kinase 3 in mice stabilizes Cdc25A after DNA damage but is not sufficient to produce tumors.

PubMed ID: 21376736

DOI: 10.1016/j.mrfmmm.2011.02.006

PubMed ID: 21264284

Title: Calcium- and integrin-binding protein 1 regulates endomitosis and its interaction with Polo-like kinase 3 is enhanced in endomitotic Dami cells.

PubMed ID: 21264284

DOI: 10.1371/journal.pone.0014513

PubMed ID: 20671765

Title: Multifaceted polo-like kinases: drug targets and antitargets for cancer therapy.

PubMed ID: 20671765

DOI: 10.1038/nrd3184

Sequence Information:

Length: 646
Mass: 71629
Checksum: 324CA3E9DE482514
Sequence:

MEPAAGFLSP RPFQRAAAAP APPAGPGPPP SALRGPELEM LAGLPTSDPG RLITDPRSGR 
TYLKGRLLGK GGFARCYEAT DTETGSAYAV KVIPQSRVAK PHQREKILNE IELHRDLQHR 
HIVRFSHHFE DADNIYIFLE LCSRKSLAHI WKARHTLLEP EVRYYLRQIL SGLKYLHQRG 
ILHRDLKLGN FFITENMELK VGDFGLAARL EPPEQRKKTI CGTPNYVAPE VLLRQGHGPE 
ADVWSLGCVM YTLLCGSPPF ETADLKETYR CIKQVHYTLP ASLSLPARQL LAAILRASPR 
DRPSIDQILR HDFFTKGYTP DRLPISSCVT VPDLTPPNPA RSLFAKVTKS LFGRKKKSKN 
HAQERDEVSG LVSGLMRTSV GHQDARPEAP AASGPAPVSL VETAPEDSSP RGTLASSGDG 
FEEGLTVATV VESALCALRN CIAFMPPAEQ NPAPLAQPEP LVWVSKWVDY SNKFGFGYQL 
SSRRVAVLFN DGTHMALSAN RKTVHYNPTS TKHFSFSVGA VPRALQPQLG ILRYFASYME 
QHLMKGGDLP SVEEVEVPAP PLLLQWVKTD QALLMLFSDG TVQVNFYGDH TKLILSGWEP 
LLVTFVARNR SACTYLASHL RQLGCSPDLR QRLRYALRLL RDRSPA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PLK3

Associated with

Other Information

Adhesion induced expression of the serine/threonine kinase Fnk in human macrophages. PubMed ID: 11039900

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Prk, a cytokine-inducible human protein serine/threonine kinase whose expression appears to be down-regulated in lung carcinomas. PubMed ID: 8702627

Intron/exon organization and polymorphisms of the PLK3/PRK gene in human lung carcinoma cell lines. PubMed ID: 11746980

Mammalian Polo-like kinase 3 (Plk3) is a multifunctional protein involved in stress response pathways. PubMed ID: 12242661

Human Prk is a conserved protein serine/threonine kinase involved in regulating M phase functions. PubMed ID: 9353331

The physical association and phosphorylation of Cdc25C protein phosphatase by Prk. PubMed ID: 10557092

Incomplete cytokinesis and induction of apoptosis by overexpression of the mammalian polo-like kinase, Plk3. PubMed ID: 11156373

Reactive oxygen species-induced phosphorylation of p53 on serine 20 is mediated in part by polo-like kinase-3. PubMed ID: 11447225

Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway. PubMed ID: 11551930

Cell cycle arrest and apoptosis induced by human Polo-like kinase 3 is mediated through perturbation of microtubule integrity. PubMed ID: 11971976

Polo-like kinase 3 is Golgi localized and involved in regulating Golgi fragmentation during the cell cycle. PubMed ID: 14980500

Cdc25C phosphorylation on serine 191 by Plk3 promotes its nuclear translocation. PubMed ID: 14968113

MEK1-induced Golgi dynamics during cell cycle progression is partly mediated by Polo-like kinase-3. PubMed ID: 15021912

Polo box domain of Plk3 functions as a centrosome localization signal, overexpression of which causes mitotic arrest, cytokinesis defects, and apoptosis. PubMed ID: 16478733

Priming phosphorylation of Chk2 by polo-like kinase 3 (Plk3) mediates its full activation by ATM and a downstream checkpoint in response to DNA damage. PubMed ID: 16481012

Stress-induced c-Jun activation mediated by Polo-like kinase 3 in corneal epithelial cells. PubMed ID: 17804415

Polo-like kinase 3 is required for entry into S phase. PubMed ID: 17264206

Plk3 phosphorylates topoisomerase IIalpha at Thr(1342), a site that is not recognized by Plk1. PubMed ID: 18062778

Activation of Polo-like kinase 3 by hypoxic stresses. PubMed ID: 18650425

Plk3 inhibits pro-apoptotic activity of p73 through physical interaction and phosphorylation. PubMed ID: 19490146

Plk3 interacts with and specifically phosphorylates VRK1 in Ser342, a downstream target in a pathway that induces Golgi fragmentation. PubMed ID: 19103756

Plk3 functions as an essential component of the hypoxia regulatory pathway by direct phosphorylation of HIF-1alpha. PubMed ID: 20889502

Regulation of PTEN stability and activity by Plk3. PubMed ID: 20940307

Calcium- and integrin-binding protein 1 regulates microtubule organization and centrosome segregation through polo like kinase 3 during cell cycle progression. PubMed ID: 20951827

Calcium-dependent inhibition of polo-like kinase 3 activity by CIB1 in breast cancer cells. PubMed ID: 20473878

Hyperosmotic stress-induced ATF-2 activation through Polo-like kinase 3 in human corneal epithelial cells. PubMed ID: 21098032

Bcl-xL phosphorylation at Ser49 by polo kinase 3 during cell cycle progression and checkpoints. PubMed ID: 21840391

Absence of polo-like kinase 3 in mice stabilizes Cdc25A after DNA damage but is not sufficient to produce tumors. PubMed ID: 21376736

Calcium- and integrin-binding protein 1 regulates endomitosis and its interaction with Polo-like kinase 3 is enhanced in endomitotic Dami cells. PubMed ID: 21264284

Multifaceted polo-like kinases: drug targets and antitargets for cancer therapy. PubMed ID: 20671765