Details for: PLK3

Gene ID: 1263

Symbol: PLK3

Ensembl ID: ENSG00000173846

Description: polo like kinase 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 152.8816
    Cell Significance Index: -23.7800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 89.6929
    Cell Significance Index: -22.7500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 57.8714
    Cell Significance Index: -23.8400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 53.0206
    Cell Significance Index: -21.5400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 45.8800
    Cell Significance Index: -23.6000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 34.4102
    Cell Significance Index: -23.0900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 22.6867
    Cell Significance Index: -21.6600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 19.3843
    Cell Significance Index: -23.9000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.4883
    Cell Significance Index: -20.0600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.2674
    Cell Significance Index: -19.2500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.0770
    Cell Significance Index: -23.9800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.6873
    Cell Significance Index: -8.0700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.4611
    Cell Significance Index: 43.4900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.8821
    Cell Significance Index: 51.2300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.7932
    Cell Significance Index: 38.8500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.4638
    Cell Significance Index: 41.9600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.4591
    Cell Significance Index: 170.0400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.4522
    Cell Significance Index: 26.8400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.4071
    Cell Significance Index: 66.1300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.2421
    Cell Significance Index: 92.5700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.2006
    Cell Significance Index: 17.9900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.1929
    Cell Significance Index: 54.0700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.1866
    Cell Significance Index: 16.1900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.1362
    Cell Significance Index: 59.0200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.1228
    Cell Significance Index: 32.3500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.0205
    Cell Significance Index: 131.8500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5062
    Cell Significance Index: 457.0700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4399
    Cell Significance Index: 194.4900
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.3689
    Cell Significance Index: 2.2700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3347
    Cell Significance Index: 21.6000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3216
    Cell Significance Index: 52.3100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2808
    Cell Significance Index: 30.5500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2268
    Cell Significance Index: 7.9700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2185
    Cell Significance Index: 119.3200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2131
    Cell Significance Index: 27.3200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2114
    Cell Significance Index: 26.0000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1984
    Cell Significance Index: 27.2400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1866
    Cell Significance Index: 18.4600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1796
    Cell Significance Index: 34.1800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1604
    Cell Significance Index: 7.4800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1057
    Cell Significance Index: 19.0600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0881
    Cell Significance Index: 6.0900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0508
    Cell Significance Index: 10.2000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0477
    Cell Significance Index: 0.9900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0128
    Cell Significance Index: 2.5400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0008
    Cell Significance Index: -0.5500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0080
    Cell Significance Index: -0.8200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0083
    Cell Significance Index: -15.6500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0094
    Cell Significance Index: -14.4400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0119
    Cell Significance Index: -8.9800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0120
    Cell Significance Index: -0.3200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0125
    Cell Significance Index: -4.4800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0138
    Cell Significance Index: -25.4500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0168
    Cell Significance Index: -0.4500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0194
    Cell Significance Index: -26.3900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0289
    Cell Significance Index: -21.2000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0290
    Cell Significance Index: -18.4100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0331
    Cell Significance Index: -24.4900
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0382
    Cell Significance Index: -0.5800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0422
    Cell Significance Index: -26.3300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0425
    Cell Significance Index: -23.9400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0501
    Cell Significance Index: -22.7400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0633
    Cell Significance Index: -18.2100
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0724
    Cell Significance Index: -0.5900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0855
    Cell Significance Index: -14.6000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0915
    Cell Significance Index: -1.0400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0971
    Cell Significance Index: -11.4500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1027
    Cell Significance Index: -2.8700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1063
    Cell Significance Index: -7.5200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1122
    Cell Significance Index: -16.3100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1202
    Cell Significance Index: -2.5600
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1250
    Cell Significance Index: -1.7800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1260
    Cell Significance Index: -26.5500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1417
    Cell Significance Index: -7.3800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1551
    Cell Significance Index: -17.7700
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.1814
    Cell Significance Index: -2.9900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1816
    Cell Significance Index: -3.0400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2267
    Cell Significance Index: -7.2600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2324
    Cell Significance Index: -24.2000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2438
    Cell Significance Index: -7.1600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2890
    Cell Significance Index: -22.8900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2977
    Cell Significance Index: -18.2500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2978
    Cell Significance Index: -22.8600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3065
    Cell Significance Index: -16.0900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3142
    Cell Significance Index: -19.8100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3251
    Cell Significance Index: -7.5100
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.3308
    Cell Significance Index: -4.2600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3419
    Cell Significance Index: -22.9900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3480
    Cell Significance Index: -19.5300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3563
    Cell Significance Index: -12.3800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.3651
    Cell Significance Index: -3.7800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3773
    Cell Significance Index: -23.1900
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.4287
    Cell Significance Index: -2.8000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4762
    Cell Significance Index: -17.4800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4768
    Cell Significance Index: -9.9800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4771
    Cell Significance Index: -21.1100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.4965
    Cell Significance Index: -12.4100
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.5319
    Cell Significance Index: -9.1700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.5374
    Cell Significance Index: -14.1300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5610
    Cell Significance Index: -21.2500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cell cycle regulation:** PLK3 is involved in the regulation of the cell cycle, particularly in the transition from G1 to S phase and from G2 to M phase. 2. **Apoptosis regulation:** PLK3 has anti-apoptotic properties, and its dysregulation can lead to increased apoptosis and cell death. 3. **Stress response:** PLK3 is activated in response to osmotic stress, radiation, and reactive oxygen species, and plays a role in regulating the cellular response to these stresses. 4. **Protein phosphorylation:** PLK3 phosphorylates various proteins, including p53, which is a key regulator of the cell cycle and apoptosis. 5. **Cell type-specific expression:** PLK3 is expressed in various cell types, including glandular epithelial cells, fibroblasts, and immune cells. **Pathways and Functions:** 1. **Apoptotic process:** PLK3 regulates the apoptotic process by phosphorylating and activating anti-apoptotic proteins, such as Bcl-2. 2. **DNA damage response:** PLK3 is involved in the response to DNA damage, and its dysregulation can lead to genomic instability and increased cancer risk. 3. **Cell cycle regulation:** PLK3 regulates the cell cycle by phosphorylating and activating cyclin-dependent kinases (CDKs) and other proteins involved in the cell cycle. 4. **Mitotic spindle organization:** PLK3 plays a role in organizing the mitotic spindle and regulating cytokinesis. 5. **Transcriptional regulation:** PLK3 regulates transcription by phosphorylating and activating transcription factors, such as p53. **Clinical Significance:** Dysregulation of PLK3 has been implicated in various diseases, including: 1. **Cancer:** PLK3 overexpression has been observed in several types of cancer, including breast, lung, and colon cancer. 2. **Immune disorders:** PLK3 dysregulation has been implicated in autoimmune diseases, such as rheumatoid arthritis and lupus. 3. **Neurological disorders:** PLK3 has been implicated in neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. 4. **Infectious diseases:** PLK3 has been involved in the response to infections, such as malaria and tuberculosis. In conclusion, Polo-like Kinase 3 (PLK3) is a multifunctional kinase that plays a crucial role in regulating cell cycle, apoptosis, and stress response in humans. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding the mechanisms of PLK3 in normal and diseased states.

Genular Protein ID: 496121503

Symbol: PLK3_HUMAN

Name: Serine/threonine-protein kinase PLK3

UniProtKB Accession Codes:

Q9H4B4 Q15767 Q5JR99 Q96CV1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CTD 1 ChEBI 12 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EC 3 EMBL 6 Ensembl 1 EvolutionaryTrace 1 GO 37 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 Rhea 6 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11039900

Title: Adhesion induced expression of the serine/threonine kinase Fnk in human macrophages.

PubMed ID: 11039900

DOI: 10.1038/sj.onc.1203845

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8702627

Title: Prk, a cytokine-inducible human protein serine/threonine kinase whose expression appears to be down-regulated in lung carcinomas.

PubMed ID: 8702627

DOI: 10.1074/jbc.271.32.19402

PubMed ID: 11746980

Title: Intron/exon organization and polymorphisms of the PLK3/PRK gene in human lung carcinoma cell lines.

PubMed ID: 11746980

DOI: 10.1002/gcc.1204

PubMed ID: 12242661

Title: Mammalian Polo-like kinase 3 (Plk3) is a multifunctional protein involved in stress response pathways.

PubMed ID: 12242661

DOI: 10.1038/sj.onc.1205850

PubMed ID: 9353331

Title: Human Prk is a conserved protein serine/threonine kinase involved in regulating M phase functions.

PubMed ID: 9353331

DOI: 10.1074/jbc.272.45.28646

PubMed ID: 10557092

Title: The physical association and phosphorylation of Cdc25C protein phosphatase by Prk.

PubMed ID: 10557092

DOI: 10.1038/sj.onc.1202983

PubMed ID: 11156373

Title: Incomplete cytokinesis and induction of apoptosis by overexpression of the mammalian polo-like kinase, Plk3.

PubMed ID: 11156373

PubMed ID: 11447225

Title: Reactive oxygen species-induced phosphorylation of p53 on serine 20 is mediated in part by polo-like kinase-3.

PubMed ID: 11447225

DOI: 10.1074/jbc.m104157200

PubMed ID: 11551930

Title: Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway.

PubMed ID: 11551930

DOI: 10.1074/jbc.m106050200

PubMed ID: 11971976

Title: Cell cycle arrest and apoptosis induced by human Polo-like kinase 3 is mediated through perturbation of microtubule integrity.

PubMed ID: 11971976

DOI: 10.1128/mcb.22.10.3450-3459.2002

PubMed ID: 14980500

Title: Polo-like kinase 3 is Golgi localized and involved in regulating Golgi fragmentation during the cell cycle.

PubMed ID: 14980500

DOI: 10.1016/j.yexcr.2003.10.022

PubMed ID: 14968113

Title: Cdc25C phosphorylation on serine 191 by Plk3 promotes its nuclear translocation.

PubMed ID: 14968113

DOI: 10.1038/sj.onc.1207425

PubMed ID: 15021912

Title: MEK1-induced Golgi dynamics during cell cycle progression is partly mediated by Polo-like kinase-3.

PubMed ID: 15021912

DOI: 10.1038/sj.onc.1207479

PubMed ID: 16478733

Title: Polo box domain of Plk3 functions as a centrosome localization signal, overexpression of which causes mitotic arrest, cytokinesis defects, and apoptosis.

PubMed ID: 16478733

DOI: 10.1074/jbc.m513156200

PubMed ID: 16481012

Title: Priming phosphorylation of Chk2 by polo-like kinase 3 (Plk3) mediates its full activation by ATM and a downstream checkpoint in response to DNA damage.

PubMed ID: 16481012

DOI: 10.1016/j.mrfmmm.2005.12.002

PubMed ID: 17804415

Title: Stress-induced c-Jun activation mediated by Polo-like kinase 3 in corneal epithelial cells.

PubMed ID: 17804415

DOI: 10.1074/jbc.m702791200

PubMed ID: 17264206

Title: Polo-like kinase 3 is required for entry into S phase.

PubMed ID: 17264206

DOI: 10.1073/pnas.0610856104

PubMed ID: 18062778

Title: Plk3 phosphorylates topoisomerase IIalpha at Thr(1342), a site that is not recognized by Plk1.

PubMed ID: 18062778

DOI: 10.1042/bj20071394

PubMed ID: 18650425

Title: Activation of Polo-like kinase 3 by hypoxic stresses.

PubMed ID: 18650425

DOI: 10.1074/jbc.m801326200

PubMed ID: 19490146

Title: Plk3 inhibits pro-apoptotic activity of p73 through physical interaction and phosphorylation.

PubMed ID: 19490146

DOI: 10.1111/j.1365-2443.2009.01309.x

PubMed ID: 19103756

Title: Plk3 interacts with and specifically phosphorylates VRK1 in Ser342, a downstream target in a pathway that induces Golgi fragmentation.

PubMed ID: 19103756

DOI: 10.1128/mcb.01341-08

PubMed ID: 20889502

Title: Plk3 functions as an essential component of the hypoxia regulatory pathway by direct phosphorylation of HIF-1alpha.

PubMed ID: 20889502

DOI: 10.1074/jbc.m110.160325

PubMed ID: 20940307

Title: Regulation of PTEN stability and activity by Plk3.

PubMed ID: 20940307

DOI: 10.1074/jbc.m110.166462

PubMed ID: 20951827

Title: Calcium- and integrin-binding protein 1 regulates microtubule organization and centrosome segregation through polo like kinase 3 during cell cycle progression.

PubMed ID: 20951827

DOI: 10.1016/j.biocel.2010.10.003

PubMed ID: 20473878

Title: Calcium-dependent inhibition of polo-like kinase 3 activity by CIB1 in breast cancer cells.

PubMed ID: 20473878

DOI: 10.1002/ijc.25388

PubMed ID: 21098032

Title: Hyperosmotic stress-induced ATF-2 activation through Polo-like kinase 3 in human corneal epithelial cells.

PubMed ID: 21098032

DOI: 10.1074/jbc.m110.166009

PubMed ID: 21840391

Title: Bcl-xL phosphorylation at Ser49 by polo kinase 3 during cell cycle progression and checkpoints.

PubMed ID: 21840391

DOI: 10.1016/j.cellsig.2011.07.017

PubMed ID: 21376736

Title: Absence of polo-like kinase 3 in mice stabilizes Cdc25A after DNA damage but is not sufficient to produce tumors.

PubMed ID: 21376736

DOI: 10.1016/j.mrfmmm.2011.02.006

PubMed ID: 21264284

Title: Calcium- and integrin-binding protein 1 regulates endomitosis and its interaction with Polo-like kinase 3 is enhanced in endomitotic Dami cells.

PubMed ID: 21264284

DOI: 10.1371/journal.pone.0014513

PubMed ID: 20671765

Title: Multifaceted polo-like kinases: drug targets and antitargets for cancer therapy.

PubMed ID: 20671765

DOI: 10.1038/nrd3184

Sequence Information:

  • Length: 646
  • Mass: 71629
  • Checksum: 324CA3E9DE482514
  • Sequence:
    • MEPAAGFLSP RPFQRAAAAP APPAGPGPPP SALRGPELEM LAGLPTSDPG RLITDPRSGR 
TYLKGRLLGK GGFARCYEAT DTETGSAYAV KVIPQSRVAK PHQREKILNE IELHRDLQHR 
HIVRFSHHFE DADNIYIFLE LCSRKSLAHI WKARHTLLEP EVRYYLRQIL SGLKYLHQRG 
ILHRDLKLGN FFITENMELK VGDFGLAARL EPPEQRKKTI CGTPNYVAPE VLLRQGHGPE 
ADVWSLGCVM YTLLCGSPPF ETADLKETYR CIKQVHYTLP ASLSLPARQL LAAILRASPR 
DRPSIDQILR HDFFTKGYTP DRLPISSCVT VPDLTPPNPA RSLFAKVTKS LFGRKKKSKN 
HAQERDEVSG LVSGLMRTSV GHQDARPEAP AASGPAPVSL VETAPEDSSP RGTLASSGDG 
FEEGLTVATV VESALCALRN CIAFMPPAEQ NPAPLAQPEP LVWVSKWVDY SNKFGFGYQL 
SSRRVAVLFN DGTHMALSAN RKTVHYNPTS TKHFSFSVGA VPRALQPQLG ILRYFASYME 
QHLMKGGDLP SVEEVEVPAP PLLLQWVKTD QALLMLFSDG TVQVNFYGDH TKLILSGWEP 
LLVTFVARNR SACTYLASHL RQLGCSPDLR QRLRYALRLL RDRSPA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.