Details for: PLK3

Gene ID: 1263

Symbol: PLK3

Ensembl ID: ENSG00000173846

Description: polo like kinase 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 2.28
    Marker Score: 5600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.49
    Marker Score: 50719
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167842
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.43
    Marker Score: 354
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.42
    Marker Score: 2088
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 1.35
    Marker Score: 1952
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.35
    Marker Score: 5191.5
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.28
    Marker Score: 71393
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.24
    Marker Score: 2096
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 1.21
    Marker Score: 1134
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 1.12
    Marker Score: 1209
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.12
    Marker Score: 952
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.06
    Marker Score: 896
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 1.06
    Marker Score: 802
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.05
    Marker Score: 2047
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.05
    Marker Score: 10352
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.04
    Marker Score: 1093
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.03
    Marker Score: 8038
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.02
    Marker Score: 54173
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.02
    Marker Score: 2863
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.02
    Marker Score: 26057
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 1.02
    Marker Score: 2583
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1
    Marker Score: 997
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71688.5
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47911
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.99
    Marker Score: 2580
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.99
    Marker Score: 4249
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.98
    Marker Score: 409
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30390
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.96
    Marker Score: 431
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.96
    Marker Score: 1158
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.96
    Marker Score: 411
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.95
    Marker Score: 1937
  • Cell Name: basophil (CL0000767)
    Fold Change: 0.95
    Marker Score: 450
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2391
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 481
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 0.93
    Marker Score: 378.5
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 437
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.92
    Marker Score: 532
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.92
    Marker Score: 769
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.92
    Marker Score: 980
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.92
    Marker Score: 278
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2722
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.9
    Marker Score: 982
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.88
    Marker Score: 2013
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.88
    Marker Score: 975
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.87
    Marker Score: 250
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.87
    Marker Score: 883
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.87
    Marker Score: 990
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.86
    Marker Score: 1727
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.86
    Marker Score: 431
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.86
    Marker Score: 306
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.86
    Marker Score: 5219
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.86
    Marker Score: 13460
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 308
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.86
    Marker Score: 736
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.85
    Marker Score: 4151
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.84
    Marker Score: 665
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.84
    Marker Score: 394
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.84
    Marker Score: 2177
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.82
    Marker Score: 816
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.82
    Marker Score: 539
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.82
    Marker Score: 3520.5
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.82
    Marker Score: 1981
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.82
    Marker Score: 4664
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 0.82
    Marker Score: 419
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 0.81
    Marker Score: 215
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.81
    Marker Score: 261
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.81
    Marker Score: 9124
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.81
    Marker Score: 4913
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.81
    Marker Score: 253
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.8
    Marker Score: 248
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.8
    Marker Score: 1800
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.8
    Marker Score: 462
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.79
    Marker Score: 604
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.78
    Marker Score: 447
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1263
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.77
    Marker Score: 486
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.77
    Marker Score: 308
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.75
    Marker Score: 674
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.75
    Marker Score: 1829
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.74
    Marker Score: 1184
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.74
    Marker Score: 540
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.74
    Marker Score: 472
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.73
    Marker Score: 522
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.73
    Marker Score: 362
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.73
    Marker Score: 1197
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.73
    Marker Score: 335
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.73
    Marker Score: 251
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 375
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.72
    Marker Score: 527
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.72
    Marker Score: 1307
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.71
    Marker Score: 4559
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.71
    Marker Score: 450
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.71
    Marker Score: 426
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.71
    Marker Score: 912
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.7
    Marker Score: 485
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.69
    Marker Score: 173
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.69
    Marker Score: 396
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.69
    Marker Score: 173

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Other Information

**Key characteristics:** * PLK3 is a serine/threonine kinase that is highly conserved across different species. * It is a key regulator of the p53 tumor suppressor pathway. * It is involved in the regulation of cell cycle progression, apoptosis, and inflammation. * It is a target for various cancer drugs. **Pathways and functions:** * PLK3 is involved in the apoptotic process by regulating the expression of pro-apoptotic genes. * It is also involved in the regulation of cell cycle progression by phosphorylating and inhibiting the TP53 tumor suppressor protein. * In the G1/S transition of the mitotic cell cycle, PLK3 is phosphorylated by MAPK and inhibited, leading to cell cycle arrest. * In the G2/M transition of the mitotic cell cycle, PLK3 is phosphorylated by cyclin-dependent kinase 1 (CDK1) and activated, leading to cell cycle progression. * It also regulates the expression of cell cycle genes through the p53 tumor suppressor pathway. * PLK3 is a key regulator of inflammation by promoting the production of inflammatory cytokines. **Clinical significance:** * PLK3 is a promising target for cancer therapy. * Inhibition of PLK3 has been shown to inhibit cancer cell growth and metastasis. * PLK3 inhibitors are currently being evaluated in clinical trials for the treatment of various cancers, including breast cancer, lung cancer, and colon cancer. **Additional notes:** * PLK3 is a highly regulated gene, and its expression can be influenced by a variety of factors, including growth factors, cytokines, and genetic variants. * Mutations in PLK3 have been linked to a number of human cancers. * PLK3 is a promising target for cancer therapy due to its important role in cell cycle regulation and inflammation.

Genular Protein ID: 496121503

Symbol: PLK3_HUMAN

Name: Serine/threonine-protein kinase PLK3

UniProtKB Accession Codes:

Q9H4B4 Q15767 Q5JR99 Q96CV1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CTD 1 ChEBI 12 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EC 3 EMBL 6 Ensembl 1 GO 37 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PRO 1 PROSITE 4 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 Rhea 6 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11039900

Title: Adhesion induced expression of the serine/threonine kinase Fnk in human macrophages.

PubMed ID: 11039900

DOI: 10.1038/sj.onc.1203845

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8702627

Title: Prk, a cytokine-inducible human protein serine/threonine kinase whose expression appears to be down-regulated in lung carcinomas.

PubMed ID: 8702627

DOI: 10.1074/jbc.271.32.19402

PubMed ID: 11746980

Title: Intron/exon organization and polymorphisms of the PLK3/PRK gene in human lung carcinoma cell lines.

PubMed ID: 11746980

DOI: 10.1002/gcc.1204

PubMed ID: 12242661

Title: Mammalian Polo-like kinase 3 (Plk3) is a multifunctional protein involved in stress response pathways.

PubMed ID: 12242661

DOI: 10.1038/sj.onc.1205850

PubMed ID: 9353331

Title: Human Prk is a conserved protein serine/threonine kinase involved in regulating M phase functions.

PubMed ID: 9353331

DOI: 10.1074/jbc.272.45.28646

PubMed ID: 10557092

Title: The physical association and phosphorylation of Cdc25C protein phosphatase by Prk.

PubMed ID: 10557092

DOI: 10.1038/sj.onc.1202983

PubMed ID: 11156373

Title: Incomplete cytokinesis and induction of apoptosis by overexpression of the mammalian polo-like kinase, Plk3.

PubMed ID: 11156373

PubMed ID: 11447225

Title: Reactive oxygen species-induced phosphorylation of p53 on serine 20 is mediated in part by polo-like kinase-3.

PubMed ID: 11447225

DOI: 10.1074/jbc.m104157200

PubMed ID: 11551930

Title: Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway.

PubMed ID: 11551930

DOI: 10.1074/jbc.m106050200

PubMed ID: 11971976

Title: Cell cycle arrest and apoptosis induced by human Polo-like kinase 3 is mediated through perturbation of microtubule integrity.

PubMed ID: 11971976

DOI: 10.1128/mcb.22.10.3450-3459.2002

PubMed ID: 14980500

Title: Polo-like kinase 3 is Golgi localized and involved in regulating Golgi fragmentation during the cell cycle.

PubMed ID: 14980500

DOI: 10.1016/j.yexcr.2003.10.022

PubMed ID: 14968113

Title: Cdc25C phosphorylation on serine 191 by Plk3 promotes its nuclear translocation.

PubMed ID: 14968113

DOI: 10.1038/sj.onc.1207425

PubMed ID: 15021912

Title: MEK1-induced Golgi dynamics during cell cycle progression is partly mediated by Polo-like kinase-3.

PubMed ID: 15021912

DOI: 10.1038/sj.onc.1207479

PubMed ID: 16478733

Title: Polo box domain of Plk3 functions as a centrosome localization signal, overexpression of which causes mitotic arrest, cytokinesis defects, and apoptosis.

PubMed ID: 16478733

DOI: 10.1074/jbc.m513156200

PubMed ID: 16481012

Title: Priming phosphorylation of Chk2 by polo-like kinase 3 (Plk3) mediates its full activation by ATM and a downstream checkpoint in response to DNA damage.

PubMed ID: 16481012

DOI: 10.1016/j.mrfmmm.2005.12.002

PubMed ID: 17804415

Title: Stress-induced c-Jun activation mediated by Polo-like kinase 3 in corneal epithelial cells.

PubMed ID: 17804415

DOI: 10.1074/jbc.m702791200

PubMed ID: 17264206

Title: Polo-like kinase 3 is required for entry into S phase.

PubMed ID: 17264206

DOI: 10.1073/pnas.0610856104

PubMed ID: 18062778

Title: Plk3 phosphorylates topoisomerase IIalpha at Thr(1342), a site that is not recognized by Plk1.

PubMed ID: 18062778

DOI: 10.1042/bj20071394

PubMed ID: 18650425

Title: Activation of Polo-like kinase 3 by hypoxic stresses.

PubMed ID: 18650425

DOI: 10.1074/jbc.m801326200

PubMed ID: 19490146

Title: Plk3 inhibits pro-apoptotic activity of p73 through physical interaction and phosphorylation.

PubMed ID: 19490146

DOI: 10.1111/j.1365-2443.2009.01309.x

PubMed ID: 19103756

Title: Plk3 interacts with and specifically phosphorylates VRK1 in Ser342, a downstream target in a pathway that induces Golgi fragmentation.

PubMed ID: 19103756

DOI: 10.1128/mcb.01341-08

PubMed ID: 20889502

Title: Plk3 functions as an essential component of the hypoxia regulatory pathway by direct phosphorylation of HIF-1alpha.

PubMed ID: 20889502

DOI: 10.1074/jbc.m110.160325

PubMed ID: 20940307

Title: Regulation of PTEN stability and activity by Plk3.

PubMed ID: 20940307

DOI: 10.1074/jbc.m110.166462

PubMed ID: 20951827

Title: Calcium- and integrin-binding protein 1 regulates microtubule organization and centrosome segregation through polo like kinase 3 during cell cycle progression.

PubMed ID: 20951827

DOI: 10.1016/j.biocel.2010.10.003

PubMed ID: 20473878

Title: Calcium-dependent inhibition of polo-like kinase 3 activity by CIB1 in breast cancer cells.

PubMed ID: 20473878

DOI: 10.1002/ijc.25388

PubMed ID: 21098032

Title: Hyperosmotic stress-induced ATF-2 activation through Polo-like kinase 3 in human corneal epithelial cells.

PubMed ID: 21098032

DOI: 10.1074/jbc.m110.166009

PubMed ID: 21840391

Title: Bcl-xL phosphorylation at Ser49 by polo kinase 3 during cell cycle progression and checkpoints.

PubMed ID: 21840391

DOI: 10.1016/j.cellsig.2011.07.017

PubMed ID: 21376736

Title: Absence of polo-like kinase 3 in mice stabilizes Cdc25A after DNA damage but is not sufficient to produce tumors.

PubMed ID: 21376736

DOI: 10.1016/j.mrfmmm.2011.02.006

PubMed ID: 21264284

Title: Calcium- and integrin-binding protein 1 regulates endomitosis and its interaction with Polo-like kinase 3 is enhanced in endomitotic Dami cells.

PubMed ID: 21264284

DOI: 10.1371/journal.pone.0014513

PubMed ID: 20671765

Title: Multifaceted polo-like kinases: drug targets and antitargets for cancer therapy.

PubMed ID: 20671765

DOI: 10.1038/nrd3184

Sequence Information:

  • Length: 646
  • Mass: 71629
  • Checksum: 324CA3E9DE482514
  • Sequence:
    • MEPAAGFLSP RPFQRAAAAP APPAGPGPPP SALRGPELEM LAGLPTSDPG RLITDPRSGR 
TYLKGRLLGK GGFARCYEAT DTETGSAYAV KVIPQSRVAK PHQREKILNE IELHRDLQHR 
HIVRFSHHFE DADNIYIFLE LCSRKSLAHI WKARHTLLEP EVRYYLRQIL SGLKYLHQRG 
ILHRDLKLGN FFITENMELK VGDFGLAARL EPPEQRKKTI CGTPNYVAPE VLLRQGHGPE 
ADVWSLGCVM YTLLCGSPPF ETADLKETYR CIKQVHYTLP ASLSLPARQL LAAILRASPR 
DRPSIDQILR HDFFTKGYTP DRLPISSCVT VPDLTPPNPA RSLFAKVTKS LFGRKKKSKN 
HAQERDEVSG LVSGLMRTSV GHQDARPEAP AASGPAPVSL VETAPEDSSP RGTLASSGDG 
FEEGLTVATV VESALCALRN CIAFMPPAEQ NPAPLAQPEP LVWVSKWVDY SNKFGFGYQL 
SSRRVAVLFN DGTHMALSAN RKTVHYNPTS TKHFSFSVGA VPRALQPQLG ILRYFASYME 
QHLMKGGDLP SVEEVEVPAP PLLLQWVKTD QALLMLFSDG TVQVNFYGDH TKLILSGWEP 
LLVTFVARNR SACTYLASHL RQLGCSPDLR QRLRYALRLL RDRSPA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.