Cfl1 | ENSMUSG00000056201 | NCBI 12631

Details for: Cfl1

Gene ID: 12631

Symbol: Cfl1

Ensembl ID: ENSMUSG00000056201

Description: cofilin 1, non-muscle

Associated with

Actin binding
(GO:0003779)
Actin cytoskeleton
(GO:0015629)
Actin filament binding
(GO:0051015)
Actin filament depolymerization
(GO:0030042)
Actin filament fragmentation
(GO:0030043)
Actin filament organization
(GO:0007015)
Actin filament severing
(GO:0051014)
Cell-cell junction
(GO:0005911)
Cell leading edge
(GO:0031252)
Cell motility
(GO:0048870)
Cell projection
(GO:0042995)
Cell projection organization
(GO:0030030)
Cellular response to epidermal growth factor stimulus
(GO:0071364)
Cellular response to hydrogen peroxide
(GO:0070301)
Cellular response to insulin-like growth factor stimulus
(GO:1990314)
Cellular response to interleukin-1
(GO:0071347)
Cellular response to interleukin-6
(GO:0071354)
Cellular response to tumor necrosis factor
(GO:0071356)
Cofilin-actin rod
(GO:0090732)
Cortical actin cytoskeleton
(GO:0030864)
Cytoplasm
(GO:0005737)
Cytoskeleton
(GO:0005856)
Cytoskeleton organization
(GO:0007010)
Cytosol
(GO:0005829)
Dendritic spine
(GO:0043197)
Establishment of cell polarity
(GO:0030010)
Establishment of spindle localization
(GO:0051293)
Extracellular region
(GO:0005576)
Filopodium
(GO:0030175)
Focal adhesion
(GO:0005925)
Glutamatergic synapse
(GO:0098978)
Growth cone
(GO:0030426)
Lamellipodium
(GO:0030027)
Membrane
(GO:0016020)
Mitochondrial membrane
(GO:0031966)
Mitotic cytokinesis
(GO:0000281)
Modification of postsynaptic actin cytoskeleton
(GO:0098885)
Modulation of chemical synaptic transmission
(GO:0050804)
Negative regulation of actin filament bundle assembly
(GO:0032232)
Negative regulation of actin filament depolymerization
(GO:0030835)
Negative regulation of cell adhesion
(GO:0007162)
Negative regulation of cell motility
(GO:2000146)
Negative regulation of cell size
(GO:0045792)
Negative regulation of dendritic spine maintenance
(GO:1902951)
Negative regulation of lamellipodium assembly
(GO:0010593)
Negative regulation of postsynaptic density organization
(GO:1905875)
Negative regulation of unidimensional cell growth
(GO:0051511)
Neural crest cell migration
(GO:0001755)
Neural fold formation
(GO:0001842)
Neuronal cell body
(GO:0043025)
Nucleus
(GO:0005634)
Phosphatidylinositol bisphosphate binding
(GO:1902936)
Plasma membrane
(GO:0005886)
Positive regulation by host of viral process
(GO:0044794)
Positive regulation of actin filament depolymerization
(GO:0030836)
Positive regulation of barbed-end actin filament capping
(GO:2000814)
Positive regulation of cell growth
(GO:0030307)
Positive regulation of cell motility
(GO:2000147)
Positive regulation of dendritic spine development
(GO:0060999)
Positive regulation of embryonic development
(GO:0040019)
Positive regulation of establishment of cell polarity regulating cell shape
(GO:2000784)
Positive regulation of focal adhesion assembly
(GO:0051894)
Positive regulation of lamellipodium assembly
(GO:0010592)
Positive regulation of protein localization to cell leading edge
(GO:1905873)
Positive regulation of proteolysis
(GO:0045862)
Positive regulation of synaptic plasticity
(GO:0031915)
Protein binding
(GO:0005515)
Protein import into nucleus
(GO:0006606)
Protein phosphatase binding
(GO:0019903)
Protein phosphorylation
(GO:0006468)
Regulation of cell morphogenesis
(GO:0022604)
Regulation of dendritic spine morphogenesis
(GO:0061001)
Response to amino acid
(GO:0043200)
Signaling receptor binding
(GO:0005102)
Synaptic membrane
(GO:0097060)

Other Information

Proteins

Cofilin-1

Genular Protein ID: 167163117

Symbol: COF1_MOUSE

Name: Cofilin-1

UniProtKB Accession Codes:

P18760

Database IDs:

Citations:

PubMed ID: 2349104

Title: Nucleotide sequence of mouse cofilin cDNA.

PubMed ID: 2349104

DOI: 10.1093/nar/18.10.3053

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11809832

Title: The three mouse actin-depolymerizing factor/cofilins evolved to fulfill cell-type-specific requirements for actin dynamics.

PubMed ID: 11809832

DOI: 10.1091/mbc.01-07-0331

PubMed ID: 15649475

Title: The actin depolymerizing factor n-cofilin is essential for neural tube morphogenesis and neural crest cell migration.

PubMed ID: 15649475

DOI: 10.1016/j.ydbio.2004.11.010

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 16452087

Title: Comprehensive identification of phosphorylation sites in postsynaptic density preparations.

PubMed ID: 16452087

DOI: 10.1074/mcp.t500041-mcp200

PubMed ID: 17947660

Title: Quantitative time-resolved phosphoproteomic analysis of mast cell signaling.

PubMed ID: 17947660

DOI: 10.4049/jimmunol.179.9.5864

PubMed ID: 19131326

Title: Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry.

PubMed ID: 19131326

DOI: 10.1074/mcp.m800451-mcp200

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 25107909

Title: Adaptor protein LRAP25 mediates myotonic dystrophy kinase-related Cdc42-binding kinase (MRCK) regulation of LIMK1 protein in lamellipodial F-actin dynamics.

PubMed ID: 25107909

DOI: 10.1074/jbc.m114.588079

PubMed ID: 25208553

Title: The subcortical maternal complex controls symmetric division of mouse zygotes by regulating F-actin dynamics.

PubMed ID: 25208553

DOI: 10.1038/ncomms5887

PubMed ID: 27723745

Title: C9ORF72 interaction with cofilin modulates actin dynamics in motor neurons.

PubMed ID: 27723745

DOI: 10.1038/nn.4407

PubMed ID: 30550596

Title: A quantitative proteomic analysis of cofilin phosphorylation in myeloid cells and its modulation using the LIM kinase inhibitor Pyr1.

PubMed ID: 30550596

DOI: 10.1371/journal.pone.0208979

Sequence Information:

Length: 166
Mass: 18560
Checksum: 19834E8CA80747B2
Sequence:

MASGVAVSDG VIKVFNDMKV RKSSTPEEVK KRKKAVLFCL SEDKKNIILE EGKEILVGDV 
GQTVDDPYTT FVKMLPDKDC RYALYDATYE TKESKKEDLV FIFWAPENAP LKSKMIYASS 
KDAIKKKLTG IKHELQANCY EEVKDRCTLA EKLGGSAVIS LEGKPL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Cfl1

Associated with

Other Information

Nucleotide sequence of mouse cofilin cDNA. PubMed ID: 2349104

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The three mouse actin-depolymerizing factor/cofilins evolved to fulfill cell-type-specific requirements for actin dynamics. PubMed ID: 11809832

The actin depolymerizing factor n-cofilin is essential for neural tube morphogenesis and neural crest cell migration. PubMed ID: 15649475

Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. PubMed ID: 15592455

Comprehensive identification of phosphorylation sites in postsynaptic density preparations. PubMed ID: 16452087

Quantitative time-resolved phosphoproteomic analysis of mast cell signaling. PubMed ID: 17947660

Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry. PubMed ID: 19131326

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Adaptor protein LRAP25 mediates myotonic dystrophy kinase-related Cdc42-binding kinase (MRCK) regulation of LIMK1 protein in lamellipodial F-actin dynamics. PubMed ID: 25107909

The subcortical maternal complex controls symmetric division of mouse zygotes by regulating F-actin dynamics. PubMed ID: 25208553

C9ORF72 interaction with cofilin modulates actin dynamics in motor neurons. PubMed ID: 27723745

A quantitative proteomic analysis of cofilin phosphorylation in myeloid cells and its modulation using the LIM kinase inhibitor Pyr1. PubMed ID: 30550596