Genular: Defining Cellular Identity and Function

Details for: Cflar

Gene ID: 12633

Symbol: Cflar

Ensembl ID: ENSMUSG00000026031

Description: CASP8 and FADD-like apoptosis regulator

Associated with

Apoptosis
(R-MMU-109581)
Casp8 activity is inhibited
(R-MMU-5218900)
Caspase activation via death receptors in the presence of ligand
(R-MMU-140534)
Caspase activation via extrinsic apoptotic signalling pathway
(R-MMU-5357769)
Death receptor signaling
(R-MMU-73887)
Dimerization of procaspase-8
(R-MMU-69416)
Programmed cell death
(R-MMU-5357801)
Regulated necrosis
(R-MMU-5218859)
Regulation by c-flip
(R-MMU-3371378)
Regulation of necroptotic cell death
(R-MMU-5675482)
Regulation of tnfr1 signaling
(R-MMU-5357905)
Ripk1-mediated regulated necrosis
(R-MMU-5213460)
Signal transduction
(R-MMU-162582)
Tnf signaling
(R-MMU-75893)
Trail signaling
(R-MMU-75158)
Apoptotic process
(GO:0006915)
Cd95 death-inducing signaling complex
(GO:0031265)
Cellular response to nitric oxide
(GO:0071732)
Cysteine-type endopeptidase activity
(GO:0004197)
Cysteine-type endopeptidase activity involved in apoptotic signaling pathway
(GO:0097199)
Cysteine-type endopeptidase activity involved in execution phase of apoptosis
(GO:0097200)
Cysteine-type peptidase activity
(GO:0008234)
Cytoplasm
(GO:0005737)
Death-inducing signaling complex
(GO:0031264)
Death receptor binding
(GO:0005123)
Enzyme activator activity
(GO:0008047)
Erythrocyte differentiation
(GO:0030218)
Execution phase of apoptosis
(GO:0097194)
Keratinocyte differentiation
(GO:0030216)
Necroptotic process
(GO:0070266)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of cardiac muscle cell apoptotic process
(GO:0010667)
Negative regulation of cellular response to transforming growth factor beta stimulus
(GO:1903845)
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
(GO:0043154)
Negative regulation of epithelial cell apoptotic process
(GO:1904036)
Negative regulation of extrinsic apoptotic signaling pathway
(GO:2001237)
Negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
(GO:1902042)
Negative regulation of hepatocyte apoptotic process
(GO:1903944)
Negative regulation of myoblast fusion
(GO:1901740)
Negative regulation of necroptotic process
(GO:0060546)
Negative regulation of reactive oxygen species biosynthetic process
(GO:1903427)
Neuron differentiation
(GO:0030182)
Peptidase activator activity
(GO:0016504)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of extracellular matrix organization
(GO:1903055)
Positive regulation of glomerular mesangial cell proliferation
(GO:0072126)
Positive regulation of hepatocyte proliferation
(GO:2000347)
Positive regulation of neuron apoptotic process
(GO:0043525)
Positive regulation of neuron projection development
(GO:0010976)
Positive regulation of nf-kappab transcription factor activity
(GO:0051092)
Protease binding
(GO:0002020)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Proteolysis
(GO:0006508)
Regulation of apoptotic process
(GO:0042981)
Regulation of necroptotic process
(GO:0060544)
Regulation of skeletal muscle satellite cell proliferation
(GO:0014842)
Response to bacterium
(GO:0009617)
Response to testosterone
(GO:0033574)
Ripoptosome
(GO:0097342)
Skeletal muscle atrophy
(GO:0014732)
Skeletal muscle tissue development
(GO:0007519)
Skeletal muscle tissue regeneration
(GO:0043403)
Skeletal myofibril assembly
(GO:0014866)
Wound healing
(GO:0042060)

Other Information

Proteins

CASP8 and FADD-like apoptosis regulator
Q5U4G3_MOUSE

Genular Protein ID: 1257245136

Symbol: CFLAR_MOUSE

Name: CASP8 and FADD-like apoptosis regulator

UniProtKB Accession Codes:

O35732 D3Z0W6 O35707 O35733

Database IDs:

Citations:

PubMed ID: 9289491

Title: CASH, a novel caspase homologue with death effector domains.

PubMed ID: 9289491

DOI: 10.1074/jbc.272.32.19641

PubMed ID: 9217161

Title: Inhibition of death receptor signals by cellular FLIP.

PubMed ID: 9217161

DOI: 10.1038/40657

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 10894163

Title: Requirement for Casper (c-FLIP) in regulation of death receptor-induced apoptosis and embryonic development.

PubMed ID: 10894163

DOI: 10.1016/s1074-7613(00)80214-9

PubMed ID: 10602037

Title: Inhibition of Fas-mediated apoptosis by the B cell antigen receptor through c-FLIP.

PubMed ID: 10602037

DOI: 10.1002/1521-4141(200001)30:1<155::aid-immu155>3.0.co;2-x

PubMed ID: 31519887

Title: K63-linked ubiquitination regulates RIPK1 kinase activity to prevent cell death during embryogenesis and inflammation.

PubMed ID: 31519887

DOI: 10.1038/s41467-019-12033-8

PubMed ID: 31511692

Title: Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis.

PubMed ID: 31511692

DOI: 10.1016/j.immuni.2013.06.018

Sequence Information:

Length: 481
Mass: 54875
Checksum: 433E07E2E5FA5A05
Sequence:

MAQSPVSAEV IHQVEECLDE DEKEMMLFLC RDVTENLAAP NVRDLLDSLS ERGQLSFATL 
AELLYRVRRF DLLKRILKTD KATVEDHLRR NPHLVSDYRV LLMEIGESLD QNDVSSLVFL 
TRDYTGRGKI AKDKSFLDLV IELEKLNLIA SDQLNLLEKC LKNIHRIDLN TKIQKYTQSS 
QGARSNMNTL QASLPKLSIK YNSRLQNGRS KEPRFVEYRD SQRTLVKTSI QESGAFLPPH 
IREETYRMQS KPLGICLIID CIGNDTKYLQ ETFTSLGYHI QLFLFPKSHD ITQIVRRYAS 
MAQHQDYDSF ACVLVSLGGS QSMMGRDQVH SGFSLDHVKN MFTGDTCPSL RGKPKLFFIQ 
NYESLGSQLE DSSLEVDGPS IKNVDSKPLQ PRHCTTHPEA DIFWSLCTAD VSHLEKPSSS 
SSVYLQKLSQ QLKQGRRRPL VDLHVELMDK VYAWNSGVSS KEKYSLSLQH TLRKKLILAP 
T

Genular Protein ID: 1351685090

Symbol: Q5U4G3_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q5U4G3

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

Length: 215
Mass: 24534
Checksum: 3E13F936D5F21580
Sequence:

MAQSPVSAEV IHQVEECLDE DEKEMMLFLC RDVTENLAAP NVRDLLDSLS ERGQLSFATL 
AELLYRVRRF DLLKRILKTD KATVEDHLRR NPHLVSDYRV LLMEIGESLD QNDVSSLVFL 
TRDYTGRGKI AKDKSFLDLV IELEKLNLIA SDQLNLLEKC LKNIHRIDLN TKIQKYTQSS 
QGARSNMNTL QASLPKLSIK YNSRVSLEPV YGVPA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Cflar

Associated with

Other Information

CASH, a novel caspase homologue with death effector domains. PubMed ID: 9289491

Inhibition of death receptor signals by cellular FLIP. PubMed ID: 9217161

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

Requirement for Casper (c-FLIP) in regulation of death receptor-induced apoptosis and embryonic development. PubMed ID: 10894163

Inhibition of Fas-mediated apoptosis by the B cell antigen receptor through c-FLIP. PubMed ID: 10602037

K63-linked ubiquitination regulates RIPK1 kinase activity to prevent cell death during embryogenesis and inflammation. PubMed ID: 31519887

Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis. PubMed ID: 31511692

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073