Genular: Defining Cellular Identity and Function

Details for: Cftr

Gene ID: 12638

Symbol: Cftr

Ensembl ID: ENSMUSG00000041301

Description: cystic fibrosis transmembrane conductance regulator

Associated with

Abc-family proteins mediated transport
(R-MMU-382556)
Aggrephagy
(R-MMU-9646399)
Autophagy
(R-MMU-9612973)
Cargo recognition for clathrin-mediated endocytosis
(R-MMU-8856825)
Clathrin-mediated endocytosis
(R-MMU-8856828)
Deubiquitination
(R-MMU-5688426)
Macroautophagy
(R-MMU-1632852)
Membrane trafficking
(R-MMU-199991)
Metabolism of proteins
(R-MMU-392499)
Post-translational protein modification
(R-MMU-597592)
Rho gtpase cycle
(R-MMU-9012999)
Rho gtpase effectors
(R-MMU-195258)
Rho gtpases regulate cftr trafficking
(R-MMU-5627083)
Rhoq gtpase cycle
(R-MMU-9013406)
Selective autophagy
(R-MMU-9663891)
Signaling by rho gtpases
(R-MMU-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-MMU-9716542)
Signal transduction
(R-MMU-162582)
Transport of small molecules
(R-MMU-382551)
Ub-specific processing proteases
(R-MMU-5689880)
Vesicle-mediated transport
(R-MMU-5653656)
Abc-type transporter activity
(GO:0140359)
Amelogenesis
(GO:0097186)
Apical plasma membrane
(GO:0016324)
Atpase-coupled transmembrane transporter activity
(GO:0042626)
Atp binding
(GO:0005524)
Atp hydrolysis activity
(GO:0016887)
Basolateral plasma membrane
(GO:0016323)
Bicarbonate transmembrane transporter activity
(GO:0015106)
Bicarbonate transport
(GO:0015701)
Cell surface
(GO:0009986)
Cellular response to camp
(GO:0071320)
Cellular response to forskolin
(GO:1904322)
Chloride channel activity
(GO:0005254)
Chloride channel inhibitor activity
(GO:0019869)
Chloride transmembrane transport
(GO:1902476)
Chloride transmembrane transporter activity
(GO:0015108)
Chloride transport
(GO:0006821)
Cholesterol biosynthetic process
(GO:0006695)
Cholesterol transport
(GO:0030301)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dendrite
(GO:0030425)
Early endosome
(GO:0005769)
Enamel mineralization
(GO:0070166)
Endoplasmic reticulum
(GO:0005783)
Endoplasmic reticulum membrane
(GO:0005789)
Endosome
(GO:0005768)
Enzyme binding
(GO:0019899)
Establishment of localization in cell
(GO:0051649)
Intracellularly atp-gated chloride channel activity
(GO:0005260)
Intracellular ph elevation
(GO:0051454)
Isomerase activity
(GO:0016853)
Lung development
(GO:0030324)
Membrane
(GO:0016020)
Membrane hyperpolarization
(GO:0060081)
Microvillus
(GO:0005902)
Monoatomic ion transmembrane transport
(GO:0034220)
Monoatomic ion transport
(GO:0006811)
Multicellular organismal-level water homeostasis
(GO:0050891)
Negative regulation of type b pancreatic cell development
(GO:2000077)
Negative regulation of vascular associated smooth muscle cell apoptotic process
(GO:1905460)
Nucleotide binding
(GO:0000166)
Nucleus
(GO:0005634)
Pdz domain binding
(GO:0030165)
Plasma membrane
(GO:0005886)
Positive regulation of cyclic nucleotide-gated ion channel activity
(GO:1902161)
Positive regulation of enamel mineralization
(GO:0070175)
Positive regulation of establishment of sertoli cell barrier
(GO:1904446)
Positive regulation of exocytosis
(GO:0045921)
Positive regulation of insulin secretion involved in cellular response to glucose stimulus
(GO:0035774)
Positive regulation of mast cell activation
(GO:0033005)
Positive regulation of voltage-gated chloride channel activity
(GO:1902943)
Protein-containing complex
(GO:0032991)
Protein-folding chaperone binding
(GO:0051087)
Protein binding
(GO:0005515)
Regulation of membrane depolarization
(GO:0003254)
Response to endoplasmic reticulum stress
(GO:0034976)
Response to xenobiotic stimulus
(GO:0009410)
Sec61 translocon complex binding
(GO:0106138)
Sodium ion transmembrane transport
(GO:0035725)
Sperm capacitation
(GO:0048240)
Transepithelial chloride transport
(GO:0030321)
Transepithelial water transport
(GO:0035377)
Transmembrane transport
(GO:0055085)
Vasodilation
(GO:0042311)
Vesicle docking involved in exocytosis
(GO:0006904)
Water transport
(GO:0006833)

Other Information

Proteins

Cystic fibrosis transmembrane conductance regulator

Genular Protein ID: 1432123864

Symbol: CFTR_MOUSE

Name: Cystic fibrosis transmembrane conductance regulator

UniProtKB Accession Codes:

P26361 Q63893 Q63894 Q9JKQ6

Database IDs:

Citations:

PubMed ID: 1712752

Title: Cloning the mouse homolog of the human cystic fibrosis transmembrane conductance regulator gene.

PubMed ID: 1712752

DOI: 10.1016/0888-7543(91)90312-3

PubMed ID: 1716243

Title: Molecular cloning and sequence analysis of the murine cDNA for the cystic fibrosis transmembrane conductance regulator.

PubMed ID: 1716243

DOI: 10.1016/0888-7543(91)90434-g

PubMed ID: 10655503

Title: Comparative genomic sequence analysis of the human and mouse cystic fibrosis transmembrane conductance regulator genes.

PubMed ID: 10655503

DOI: 10.1073/pnas.97.3.1172

PubMed ID: 7526924

Title: Analysis of the mouse and rat CFTR promoter regions.

PubMed ID: 7526924

DOI: 10.1093/hmg/3.7.1089

PubMed ID: 7691356

Title: Cystic fibrosis transmembrane conductance regulator splice variants are not conserved and fail to produce chloride channels.

PubMed ID: 7691356

DOI: 10.1038/ng0893-426

PubMed ID: 7685652

Title: Production of a severe cystic fibrosis mutation in mice by gene targeting.

PubMed ID: 7685652

DOI: 10.1038/ng0593-35

PubMed ID: 19033647

Title: IRBIT coordinates epithelial fluid and HCO3- secretion by stimulating the transporters pNBC1 and CFTR in the murine pancreatic duct.

PubMed ID: 19033647

DOI: 10.1172/jci36983

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20231442

Title: Mouse cystic fibrosis transmembrane conductance regulator forms cAMP-PKA-regulated apical chloride channels in cortical collecting duct.

PubMed ID: 20231442

DOI: 10.1073/pnas.0902661107

PubMed ID: 21976599

Title: Participation of the Cl-/HCO(3)- exchangers SLC26A3 and SLC26A6, the Cl- channel CFTR, and the regulatory factor SLC9A3R1 in mouse sperm capacitation.

PubMed ID: 21976599

DOI: 10.1095/biolreprod.111.094037

PubMed ID: 23542070

Title: Irbit mediates synergy between ca(2+) and cAMP signaling pathways during epithelial transport in mice.

PubMed ID: 23542070

DOI: 10.1053/j.gastro.2013.03.047

PubMed ID: 26823428

Title: Airway acidification initiates host defense abnormalities in cystic fibrosis mice.

PubMed ID: 26823428

DOI: 10.1126/science.aad5589

PubMed ID: 21884936

Title: Rescue of DeltaF508-CFTR trafficking via a GRASP-dependent unconventional secretion pathway.

PubMed ID: 21884936

DOI: 10.1016/j.cell.2011.07.021

PubMed ID: 30659401

Title: Mapping the sites of localization of epithelial sodium channel (ENaC) and CFTR in segments of the mammalian epididymis.

PubMed ID: 30659401

DOI: 10.1007/s10735-019-09813-3

PubMed ID: 14685259

Title: Structure of nucleotide-binding domain 1 of the cystic fibrosis transmembrane conductance regulator.

PubMed ID: 14685259

DOI: 10.1038/sj.emboj.7600040

PubMed ID: 15619636

Title: Side chain and backbone contributions of Phe508 to CFTR folding.

PubMed ID: 15619636

DOI: 10.1038/nsmb881

PubMed ID: 22265409

Title: Requirements for efficient correction of F508 CFTR revealed by analyses of evolved sequences.

PubMed ID: 22265409

DOI: 10.1016/j.cell.2011.11.023

Sequence Information:

Length: 1476
Mass: 167870
Checksum: 3D1B0BBDD80C1DA8
Sequence:

MQKSPLEKAS FISKLFFSWT TPILRKGYRH HLELSDIYQA PSADSADHLS EKLEREWDRE 
QASKKNPQLI HALRRCFFWR FLFYGILLYL GEVTKAVQPV LLGRIIASYD PENKVERSIA 
IYLGIGLCLL FIVRTLLLHP AIFGLHRIGM QMRTAMFSLI YKKTLKLSSR VLDKISIGQL 
VSLLSNNLNK FDEGLALAHF IWIAPLQVTL LMGLLWDLLQ FSAFCGLGLL IILVIFQAIL 
GKMMVKYRDQ RAAKINERLV ITSEIIDNIY SVKAYCWESA MEKMIENLRE VELKMTRKAA 
YMRFFTSSAF FFSGFFVVFL SVLPYTVING IVLRKIFTTI SFCIVLRMSV TRQFPTAVQI 
WYDSFGMIRK IQDFLQKQEY KVLEYNLMTT GIIMENVTAF WEEGFGELLE KVQQSNGDRK 
HSSDENNVSF SHLCLVGNPV LKNINLNIEK GEMLAITGST GSGKTSLLML ILGELEASEG 
IIKHSGRVSF CSQFSWIMPG TIKENIIFGV SYDEYRYKSV VKACQLQQDI TKFAEQDNTV 
LGEGGVTLSG GQRARISLAR AVYKDADLYL LDSPFGYLDV FTEEQVFESC VCKLMANKTR 
ILVTSKMEHL RKADKILILH QGSSYFYGTF SELQSLRPDF SSKLMGYDTF DQFTEERRSS 
ILTETLRRFS VDDSSAPWSK PKQSFRQTGE VGEKRKNSIL NSFSSVRKIS IVQKTPLCID 
GESDDLQEKR LSLVPDSEQG EAALPRSNMI ATGPTFPGRR RQSVLDLMTF TPNSGSSNLQ 
RTRTSIRKIS LVPQISLNEV DVYSRRLSQD STLNITEEIN EEDLKECFLD DVIKIPPVTT 
WNTYLRYFTL HKGLLLVLIW CVLVFLVEVA ASLFVLWLLK NNPVNSGNNG TKISNSSYVV 
IITSTSFYYI FYIYVGVADT LLALSLFRGL PLVHTLITAS KILHRKMLHS ILHAPMSTIS 
KLKAGGILNR FSKDIAILDD FLPLTIFDFI QLVFIVIGAI IVVSALQPYI FLATVPGLVV 
FILLRAYFLH TAQQLKQLES EGRSPIFTHL VTSLKGLWTL RAFRRQTYFE TLFHKALNLH 
TANWFMYLAT LRWFQMRIDM IFVLFFIVVT FISILTTGEG EGTAGIILTL AMNIMSTLQW 
AVNSSIDTDS LMRSVSRVFK FIDIQTEESM YTQIIKELPR EGSSDVLVIK NEHVKKSDIW 
PSGGEMVVKD LTVKYMDDGN AVLENISFSI SPGQRVGLLG RTGSGKSTLL SAFLRMLNIK 
GDIEIDGVSW NSVTLQEWRK AFGVITQKVF IFSGTFRQNL DPNGKWKDEE IWKVADEVGL 
KSVIEQFPGQ LNFTLVDGGY VLSHGHKQLM CLARSVLSKA KIILLDEPSA HLDPITYQVI 
RRVLKQAFAG CTVILCEHRI EAMLDCQRFL VIEESNVWQY DSLQALLSEK SIFQQAISSS 
EKMRFFQGRH SSKHKPRTQI TALKEETEEE VQETRL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Cftr

Associated with

Other Information

Cloning the mouse homolog of the human cystic fibrosis transmembrane conductance regulator gene. PubMed ID: 1712752

Molecular cloning and sequence analysis of the murine cDNA for the cystic fibrosis transmembrane conductance regulator. PubMed ID: 1716243

Comparative genomic sequence analysis of the human and mouse cystic fibrosis transmembrane conductance regulator genes. PubMed ID: 10655503

Analysis of the mouse and rat CFTR promoter regions. PubMed ID: 7526924

Cystic fibrosis transmembrane conductance regulator splice variants are not conserved and fail to produce chloride channels. PubMed ID: 7691356

Production of a severe cystic fibrosis mutation in mice by gene targeting. PubMed ID: 7685652

IRBIT coordinates epithelial fluid and HCO3- secretion by stimulating the transporters pNBC1 and CFTR in the murine pancreatic duct. PubMed ID: 19033647

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Mouse cystic fibrosis transmembrane conductance regulator forms cAMP-PKA-regulated apical chloride channels in cortical collecting duct. PubMed ID: 20231442

Participation of the Cl-/HCO(3)- exchangers SLC26A3 and SLC26A6, the Cl- channel CFTR, and the regulatory factor SLC9A3R1 in mouse sperm capacitation. PubMed ID: 21976599

Irbit mediates synergy between ca(2+) and cAMP signaling pathways during epithelial transport in mice. PubMed ID: 23542070

Airway acidification initiates host defense abnormalities in cystic fibrosis mice. PubMed ID: 26823428

Rescue of DeltaF508-CFTR trafficking via a GRASP-dependent unconventional secretion pathway. PubMed ID: 21884936

Mapping the sites of localization of epithelial sodium channel (ENaC) and CFTR in segments of the mammalian epididymis. PubMed ID: 30659401

Structure of nucleotide-binding domain 1 of the cystic fibrosis transmembrane conductance regulator. PubMed ID: 14685259

Side chain and backbone contributions of Phe508 to CFTR folding. PubMed ID: 15619636

Requirements for efficient correction of F508 CFTR revealed by analyses of evolved sequences. PubMed ID: 22265409