Details for: Cftr
Associated with
Other Information
Genular Protein ID: 1432123864
Symbol: CFTR_MOUSE
Name: Cystic fibrosis transmembrane conductance regulator
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 1712752
Title: Cloning the mouse homolog of the human cystic fibrosis transmembrane conductance regulator gene.
PubMed ID: 1712752
PubMed ID: 1716243
Title: Molecular cloning and sequence analysis of the murine cDNA for the cystic fibrosis transmembrane conductance regulator.
PubMed ID: 1716243
PubMed ID: 10655503
Title: Comparative genomic sequence analysis of the human and mouse cystic fibrosis transmembrane conductance regulator genes.
PubMed ID: 10655503
PubMed ID: 7526924
Title: Analysis of the mouse and rat CFTR promoter regions.
PubMed ID: 7526924
DOI: 10.1093/hmg/3.7.1089
PubMed ID: 7691356
Title: Cystic fibrosis transmembrane conductance regulator splice variants are not conserved and fail to produce chloride channels.
PubMed ID: 7691356
DOI: 10.1038/ng0893-426
PubMed ID: 7685652
Title: Production of a severe cystic fibrosis mutation in mice by gene targeting.
PubMed ID: 7685652
DOI: 10.1038/ng0593-35
PubMed ID: 19033647
Title: IRBIT coordinates epithelial fluid and HCO3- secretion by stimulating the transporters pNBC1 and CFTR in the murine pancreatic duct.
PubMed ID: 19033647
DOI: 10.1172/jci36983
PubMed ID: 21183079
Title: A tissue-specific atlas of mouse protein phosphorylation and expression.
PubMed ID: 21183079
PubMed ID: 20231442
Title: Mouse cystic fibrosis transmembrane conductance regulator forms cAMP-PKA-regulated apical chloride channels in cortical collecting duct.
PubMed ID: 20231442
PubMed ID: 21976599
Title: Participation of the Cl-/HCO(3)- exchangers SLC26A3 and SLC26A6, the Cl- channel CFTR, and the regulatory factor SLC9A3R1 in mouse sperm capacitation.
PubMed ID: 21976599
PubMed ID: 23542070
Title: Irbit mediates synergy between ca(2+) and cAMP signaling pathways during epithelial transport in mice.
PubMed ID: 23542070
PubMed ID: 26823428
Title: Airway acidification initiates host defense abnormalities in cystic fibrosis mice.
PubMed ID: 26823428
PubMed ID: 21884936
Title: Rescue of DeltaF508-CFTR trafficking via a GRASP-dependent unconventional secretion pathway.
PubMed ID: 21884936
PubMed ID: 30659401
Title: Mapping the sites of localization of epithelial sodium channel (ENaC) and CFTR in segments of the mammalian epididymis.
PubMed ID: 30659401
PubMed ID: 14685259
Title: Structure of nucleotide-binding domain 1 of the cystic fibrosis transmembrane conductance regulator.
PubMed ID: 14685259
PubMed ID: 15619636
Title: Side chain and backbone contributions of Phe508 to CFTR folding.
PubMed ID: 15619636
DOI: 10.1038/nsmb881
PubMed ID: 22265409
Title: Requirements for efficient correction of F508 CFTR revealed by analyses of evolved sequences.
PubMed ID: 22265409
Sequence Information:
- Length: 1476
- Mass: 167870
- Checksum: 3D1B0BBDD80C1DA8
- Sequence:
MQKSPLEKAS FISKLFFSWT TPILRKGYRH HLELSDIYQA PSADSADHLS EKLEREWDRE QASKKNPQLI HALRRCFFWR FLFYGILLYL GEVTKAVQPV LLGRIIASYD PENKVERSIA IYLGIGLCLL FIVRTLLLHP AIFGLHRIGM QMRTAMFSLI YKKTLKLSSR VLDKISIGQL VSLLSNNLNK FDEGLALAHF IWIAPLQVTL LMGLLWDLLQ FSAFCGLGLL IILVIFQAIL GKMMVKYRDQ RAAKINERLV ITSEIIDNIY SVKAYCWESA MEKMIENLRE VELKMTRKAA YMRFFTSSAF FFSGFFVVFL SVLPYTVING IVLRKIFTTI SFCIVLRMSV TRQFPTAVQI WYDSFGMIRK IQDFLQKQEY KVLEYNLMTT GIIMENVTAF WEEGFGELLE KVQQSNGDRK HSSDENNVSF SHLCLVGNPV LKNINLNIEK GEMLAITGST GSGKTSLLML ILGELEASEG IIKHSGRVSF CSQFSWIMPG TIKENIIFGV SYDEYRYKSV VKACQLQQDI TKFAEQDNTV LGEGGVTLSG GQRARISLAR AVYKDADLYL LDSPFGYLDV FTEEQVFESC VCKLMANKTR ILVTSKMEHL RKADKILILH QGSSYFYGTF SELQSLRPDF SSKLMGYDTF DQFTEERRSS ILTETLRRFS VDDSSAPWSK PKQSFRQTGE VGEKRKNSIL NSFSSVRKIS IVQKTPLCID GESDDLQEKR LSLVPDSEQG EAALPRSNMI ATGPTFPGRR RQSVLDLMTF TPNSGSSNLQ RTRTSIRKIS LVPQISLNEV DVYSRRLSQD STLNITEEIN EEDLKECFLD DVIKIPPVTT WNTYLRYFTL HKGLLLVLIW CVLVFLVEVA ASLFVLWLLK NNPVNSGNNG TKISNSSYVV IITSTSFYYI FYIYVGVADT LLALSLFRGL PLVHTLITAS KILHRKMLHS ILHAPMSTIS KLKAGGILNR FSKDIAILDD FLPLTIFDFI QLVFIVIGAI IVVSALQPYI FLATVPGLVV FILLRAYFLH TAQQLKQLES EGRSPIFTHL VTSLKGLWTL RAFRRQTYFE TLFHKALNLH TANWFMYLAT LRWFQMRIDM IFVLFFIVVT FISILTTGEG EGTAGIILTL AMNIMSTLQW AVNSSIDTDS LMRSVSRVFK FIDIQTEESM YTQIIKELPR EGSSDVLVIK NEHVKKSDIW PSGGEMVVKD LTVKYMDDGN AVLENISFSI SPGQRVGLLG RTGSGKSTLL SAFLRMLNIK GDIEIDGVSW NSVTLQEWRK AFGVITQKVF IFSGTFRQNL DPNGKWKDEE IWKVADEVGL KSVIEQFPGQ LNFTLVDGGY VLSHGHKQLM CLARSVLSKA KIILLDEPSA HLDPITYQVI RRVLKQAFAG CTVILCEHRI EAMLDCQRFL VIEESNVWQY DSLQALLSEK SIFQQAISSS EKMRFFQGRH SSKHKPRTQI TALKEETEEE VQETRL
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.