Details for: CNN1

Gene ID: 1264

Symbol: CNN1

Ensembl ID: ENSG00000130176

Description: calponin 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 5.44
    Marker Score: 7084
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 3.07
    Marker Score: 1161
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.38
    Marker Score: 5610
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.38
    Marker Score: 4467.5
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 2.12
    Marker Score: 601
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 1.85
    Marker Score: 542
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.85
    Marker Score: 7958
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 1.67
    Marker Score: 1102
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.66
    Marker Score: 3636
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.63
    Marker Score: 1389
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 1.59
    Marker Score: 523
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 169317
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.36
    Marker Score: 865
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.36
    Marker Score: 6656
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.22
    Marker Score: 1161
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 1.13
    Marker Score: 805
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 1.1
    Marker Score: 289
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.05
    Marker Score: 332.5
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251800
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 791
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71818
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48043
  • Cell Name: fibrocyte (CL0000135)
    Fold Change: 0.99
    Marker Score: 307
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.98
    Marker Score: 250
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5348
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2737
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.9
    Marker Score: 260
  • Cell Name: smooth muscle cell of small intestine (CL1000275)
    Fold Change: 0.89
    Marker Score: 234
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.89
    Marker Score: 370
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5284
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.83
    Marker Score: 13008
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.81
    Marker Score: 9070
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.78
    Marker Score: 271
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1256
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 705
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 394
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.75
    Marker Score: 924
  • Cell Name: bronchial smooth muscle cell (CL0002598)
    Fold Change: 0.72
    Marker Score: 204
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.72
    Marker Score: 329
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.69
    Marker Score: 402
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.67
    Marker Score: 646
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.65
    Marker Score: 187
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.63
    Marker Score: 343
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.61
    Marker Score: 2545
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.6
    Marker Score: 277
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.6
    Marker Score: 20377
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.59
    Marker Score: 147
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.56
    Marker Score: 1974.5
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.55
    Marker Score: 756
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.54
    Marker Score: 260
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.53
    Marker Score: 1068
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.52
    Marker Score: 267
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.51
    Marker Score: 6729
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: 0.48
    Marker Score: 133
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.46
    Marker Score: 6156
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.46
    Marker Score: 876
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 275
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.45
    Marker Score: 111
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.44
    Marker Score: 111
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.43
    Marker Score: 9526
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.41
    Marker Score: 702
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.4
    Marker Score: 699
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.38
    Marker Score: 445
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.38
    Marker Score: 771
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 369
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.33
    Marker Score: 82
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.33
    Marker Score: 1226
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.32
    Marker Score: 142
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 0.29
    Marker Score: 120
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.29
    Marker Score: 217
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.28
    Marker Score: 1685.5
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.28
    Marker Score: 541
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.26
    Marker Score: 175
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.26
    Marker Score: 1696
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.26
    Marker Score: 275
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.25
    Marker Score: 135
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.25
    Marker Score: 170
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.24
    Marker Score: 63
  • Cell Name: regular cardiac myocyte (CL0002098)
    Fold Change: 0.22
    Marker Score: 78
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.21
    Marker Score: 69
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.21
    Marker Score: 85
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.21
    Marker Score: 118
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.21
    Marker Score: 259
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.2
    Marker Score: 328
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.2
    Marker Score: 631
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.2
    Marker Score: 119
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.2
    Marker Score: 517
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.2
    Marker Score: 70
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.2
    Marker Score: 48
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.19
    Marker Score: 101
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.19
    Marker Score: 1237
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.19
    Marker Score: 83
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.18
    Marker Score: 89
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.18
    Marker Score: 58
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.18
    Marker Score: 196

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Other Information

**Key characteristics:** - CNN1 is a transmembrane protein that is expressed in a variety of cell types. - It is a cytoskeletal protein that is involved in the regulation of smooth muscle contraction. - It is a key regulator of vascular smooth muscle cell proliferation. - It is also involved in the regulation of smooth muscle contraction. **Pathways and functions:** - CNN1 is involved in the regulation of smooth muscle contraction through a variety of pathways. These pathways include the actin cytoskeleton, the actin filament binding, the actin filament organization, the calmodulin binding, the cytoskeleton, the focal adhesion, and the negative regulation of vascular associated smooth muscle cell proliferation. - CNN1 also plays a role in the regulation of vascular smooth muscle cell proliferation. - It is involved in the regulation of smooth muscle contraction through the modulation of the actin cytoskeleton. - It also regulates the migration and proliferation of smooth muscle cells. **Clinical significance:** - Mutations in the CNN1 gene have been linked to a number of human diseases, including pulmonary arterial hypertension, esophageal atresia, and benign prostatic hyperplasia. - CNN1 is a promising target for the treatment of these diseases.

Genular Protein ID: 2631768016

Symbol: CNN1_HUMAN

Name: Calponin-1

UniProtKB Accession Codes:

P51911 B2R868 B4DUX6 O00638 Q15416 Q8IY93 Q99438

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 11 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 2 PRINTS 2 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8526917

Title: Molecular cloning and gene mapping of human basic and acidic calponins.

PubMed ID: 8526917

DOI: 10.1006/bbrc.1995.2769

PubMed ID: 9332369

Title: Expression, genomic structure and high resolution mapping to 19p13.2 of the human smooth muscle cell calponin gene.

PubMed ID: 9332369

DOI: 10.1016/s0378-1119(97)00265-5

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 297
  • Mass: 33170
  • Checksum: A949573543BC246C
  • Sequence:
    • MSSAHFNRGP AYGLSAEVKN KLAQKYDHQR EQELREWIEG VTGRRIGNNF MDGLKDGIIL 
CEFINKLQPG SVKKINESTQ NWHQLENIGN FIKAITKYGV KPHDIFEAND LFENTNHTQV 
QSTLLALASM AKTKGNKVNV GVKYAEKQER KFEPGKLREG RNIIGLQMGT NKFASQQGMT 
AYGTRRHLYD PKLGTDQPLD QATISLQMGT NKGASQAGMT APGTKRQIFE PGLGMEHCDT 
LNVSLQMGSN KGASQRGMTV YGLPRQVYDP KYCLTPEYPE LGEPAHNHHA HNYYNSA

Genular Protein ID: 3696711579

Symbol: B7Z7E1_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z7E1

Database IDs:

ARBA 5 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 5 EPD 1 Ensembl 3 GO 3 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 5 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 4 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 3 RuleBase 1 SMART 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

Sequence Information:

  • Length: 247
  • Mass: 27398
  • Checksum: 9914FBC92590A02A
  • Sequence:
    • MDGLKDGIIL CEFINKLQPG SVKKINESTQ NWHQLENIGN FIKAITKYGV KPHDIFEAND 
LFENTNHTQV QSTLLALASM AKTKGNKVNV GVKYAEKQER KFEPGKLREG RNIIGLQMGT 
NKFASQQGMT AYGTRRHLYD PKLGTDQPLD QATISLQMGT NKGASQAGMT APGTKRQIFE 
PGLGMEHCDT LNVSLQMGSN KGASQRGMTV YGLPRQVYDP KYCLTPEYPE LGEPAHNHHA 
HNYYNSA

Genular Protein ID: 2527992515

Symbol: Q53FP8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q53FP8

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 3 Gene3D 1 GenomeRNAi 1 InterPro 5 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 4 PeptideAtlas 1 Pfam 2 RefSeq 1 RuleBase 1 SMART 1 SUPFAM 1

Citations:

PubMed ID: 8125298

Title: Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.

PubMed ID: 8125298

DOI: 10.1016/0378-1119(94)90802-8

PubMed ID: 9373149

Title: Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.

PubMed ID: 9373149

DOI: 10.1016/S0378-1119(97)00411-3

Sequence Information:

  • Length: 297
  • Mass: 33185
  • Checksum: B9B7A7298EA0F5A1
  • Sequence:
    • MSSAHFNRGP AYGLSAEVKN KLAQKYDHQR EQELREWIEG VTGRRIGNNF MDGLKDGIIL 
CEFINKLQPG SVKKINESTQ NWHQLENIGN FIKAITKYGV KPHDIFEAND LFENTNHTQV 
QSTLLALASM AKTKGNKVNV GVKYAEKQER KFEPGKLREG RNIIGLQMGT NKFASQQGMT 
AYGTRRHLYD PKLGTDQPLD QATISQQMGT NKGASQAGMT APGTKRQIFE PGLGMEHCDT 
LNVSLQMGSN KGASQRGMTV YGLPRQVYDP KYCLTPEYPE LGEPAHNHHA HNYYNSA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.