Details for: CNN1

Gene ID: 1264

Symbol: CNN1

Ensembl ID: ENSG00000130176

Description: calponin 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 28.4988
    Cell Significance Index: -11.7400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 24.1473
    Cell Significance Index: -9.8100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 22.4200
    Cell Significance Index: -10.5900
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 16.3625
    Cell Significance Index: 86.1000
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 2.9207
    Cell Significance Index: 8.3700
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 1.5723
    Cell Significance Index: 25.9100
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 1.4511
    Cell Significance Index: 6.7000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.2885
    Cell Significance Index: -2.8200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.8655
    Cell Significance Index: 15.3000
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.7556
    Cell Significance Index: 8.4500
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.5996
    Cell Significance Index: 6.9400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.5226
    Cell Significance Index: 14.9800
  • Cell Name: basal-myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.3795
    Cell Significance Index: 2.8100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2887
    Cell Significance Index: 22.1600
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.2107
    Cell Significance Index: 1.7700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1792
    Cell Significance Index: 24.6100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.1510
    Cell Significance Index: 2.2300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1147
    Cell Significance Index: 52.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0758
    Cell Significance Index: 142.7300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0280
    Cell Significance Index: 5.0500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0233
    Cell Significance Index: 10.3000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0120
    Cell Significance Index: 0.2000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0034
    Cell Significance Index: -0.3500
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0078
    Cell Significance Index: -0.1200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0091
    Cell Significance Index: -16.8400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0098
    Cell Significance Index: -1.2500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0110
    Cell Significance Index: -16.9100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0118
    Cell Significance Index: -7.5300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0130
    Cell Significance Index: -17.7000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0150
    Cell Significance Index: -10.9800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0153
    Cell Significance Index: -8.3800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0179
    Cell Significance Index: -13.5300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0190
    Cell Significance Index: -6.8200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0202
    Cell Significance Index: -14.9800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0268
    Cell Significance Index: -15.1200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0271
    Cell Significance Index: -5.4400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0311
    Cell Significance Index: -8.9500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0373
    Cell Significance Index: -0.7800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0486
    Cell Significance Index: -6.2800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0526
    Cell Significance Index: -10.4400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0614
    Cell Significance Index: -8.9200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0662
    Cell Significance Index: -8.1400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0692
    Cell Significance Index: -3.5000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0702
    Cell Significance Index: -14.7900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0771
    Cell Significance Index: -8.9800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0803
    Cell Significance Index: -13.7200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0879
    Cell Significance Index: -6.5500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0926
    Cell Significance Index: -10.6100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0961
    Cell Significance Index: -2.6900
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -0.0971
    Cell Significance Index: -0.9300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1030
    Cell Significance Index: -10.5200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1190
    Cell Significance Index: -3.0600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1229
    Cell Significance Index: -3.1400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1236
    Cell Significance Index: -5.8100
  • Cell Name: supporting cell (CL0000630)
    Fold Change: -0.1451
    Cell Significance Index: -0.6700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1499
    Cell Significance Index: -6.1400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1538
    Cell Significance Index: -18.1400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1737
    Cell Significance Index: -9.0500
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: -0.1743
    Cell Significance Index: -0.8300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1795
    Cell Significance Index: -12.0700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1810
    Cell Significance Index: -8.4400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1821
    Cell Significance Index: -9.4600
  • Cell Name: muscle cell (CL0000187)
    Fold Change: -0.2080
    Cell Significance Index: -1.9900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2125
    Cell Significance Index: -9.2400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2191
    Cell Significance Index: -13.4700
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.2464
    Cell Significance Index: -2.3900
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.2485
    Cell Significance Index: -3.5400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2748
    Cell Significance Index: -15.4200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2770
    Cell Significance Index: -3.1500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.2796
    Cell Significance Index: -3.0400
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.2879
    Cell Significance Index: -2.9000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3099
    Cell Significance Index: -10.8600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3122
    Cell Significance Index: -10.8500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3133
    Cell Significance Index: -16.4500
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.3233
    Cell Significance Index: -4.3600
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: -0.3261
    Cell Significance Index: -1.5600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3375
    Cell Significance Index: -11.0500
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -0.3388
    Cell Significance Index: -3.4400
  • Cell Name: myoblast (CL0000056)
    Fold Change: -0.3430
    Cell Significance Index: -3.3700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3457
    Cell Significance Index: -15.2900
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.3540
    Cell Significance Index: -5.0300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.3563
    Cell Significance Index: -8.6300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3599
    Cell Significance Index: -10.6000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3648
    Cell Significance Index: -11.6200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3763
    Cell Significance Index: -10.0700
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.3931
    Cell Significance Index: -3.0300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.3956
    Cell Significance Index: -9.8800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4003
    Cell Significance Index: -15.1600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.4022
    Cell Significance Index: -10.0300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.4027
    Cell Significance Index: -10.9600
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.4125
    Cell Significance Index: -5.2900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4131
    Cell Significance Index: -11.7900
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.4163
    Cell Significance Index: -2.5500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.4260
    Cell Significance Index: -11.3800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4340
    Cell Significance Index: -11.6300
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: -0.4361
    Cell Significance Index: -3.2700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4556
    Cell Significance Index: -16.7300
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -0.4583
    Cell Significance Index: -2.6900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.4606
    Cell Significance Index: -11.4900
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.4740
    Cell Significance Index: -6.0700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Gene Structure and Expression:** Calponin 1 is encoded by the CNN1 gene, which spans approximately 10 kilobases and consists of 10 exons. The gene is highly expressed in smooth muscle cells, with significant expression levels observed in uterine, large intestinal, and tracheobronchial smooth muscle cells. 2. **Protein Function:** Calponin 1 is a calcium-binding protein that regulates actin filament organization and dynamics, thereby modulating smooth muscle contraction and relaxation. It interacts with actin, tropomyosin, and calmodulin to control the actin-myosin interaction and regulate muscle contraction. 3. **Cellular Localization:** Calponin 1 is primarily localized to the actin cytoskeleton, where it regulates actin filament organization and dynamics. It is also present on the surface of smooth muscle cells, where it interacts with integrins and other adhesion molecules to regulate cell adhesion and motility. **Pathways and Functions:** 1. **Actin Cytoskeleton Organization:** Calponin 1 regulates actin filament organization and dynamics, which is essential for maintaining cellular shape, motility, and contractility. 2. **Smooth Muscle Contraction:** Calponin 1 modulates the actin-myosin interaction, regulating smooth muscle contraction and relaxation. 3. **Negative Regulation of Vascular-Associated Smooth Muscle Cell Proliferation:** Calponin 1 inhibits the proliferation of vascular-associated smooth muscle cells, which is critical for maintaining vascular homeostasis and preventing disease. 4. **Regulation of Smooth Muscle Contraction:** Calponin 1 regulates smooth muscle contraction by modulating the actin-myosin interaction, which is essential for maintaining tissue homeostasis and function. **Clinical Significance:** 1. **Smooth Muscle-Related Disorders:** Calponin 1 is a critical regulator of smooth muscle function, and dysregulation of this gene has been implicated in various smooth muscle-related disorders, including atherosclerosis, hypertension, and smooth muscle tumors. 2. **Vascular Disease:** Calponin 1 plays a critical role in regulating vascular-associated smooth muscle cell proliferation, which is essential for maintaining vascular homeostasis and preventing disease. 3. **Prostate Cancer:** Calponin 1 is overexpressed in prostate cancer cells, where it regulates cell adhesion, motility, and invasion. 4. **Diagnostic and Therapeutic Applications:** Calponin 1 is a valuable diagnostic and therapeutic target for the treatment of smooth muscle-related disorders, including atherosclerosis, hypertension, and smooth muscle tumors. In conclusion, the calponin 1 gene (CNN1) is a critical regulator of smooth muscle function and regulation, and its dysregulation has been implicated in various smooth muscle-related disorders. Further research is needed to fully understand the mechanisms by which CNN1 regulates smooth muscle function and to develop effective diagnostic and therapeutic strategies for the treatment of smooth muscle-related disorders.

Genular Protein ID: 2631768016

Symbol: CNN1_HUMAN

Name: Calponin-1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8526917

Title: Molecular cloning and gene mapping of human basic and acidic calponins.

PubMed ID: 8526917

DOI: 10.1006/bbrc.1995.2769

PubMed ID: 9332369

Title: Expression, genomic structure and high resolution mapping to 19p13.2 of the human smooth muscle cell calponin gene.

PubMed ID: 9332369

DOI: 10.1016/s0378-1119(97)00265-5

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 297
  • Mass: 33170
  • Checksum: A949573543BC246C
  • Sequence:
  • MSSAHFNRGP AYGLSAEVKN KLAQKYDHQR EQELREWIEG VTGRRIGNNF MDGLKDGIIL 
    CEFINKLQPG SVKKINESTQ NWHQLENIGN FIKAITKYGV KPHDIFEAND LFENTNHTQV 
    QSTLLALASM AKTKGNKVNV GVKYAEKQER KFEPGKLREG RNIIGLQMGT NKFASQQGMT 
    AYGTRRHLYD PKLGTDQPLD QATISLQMGT NKGASQAGMT APGTKRQIFE PGLGMEHCDT 
    LNVSLQMGSN KGASQRGMTV YGLPRQVYDP KYCLTPEYPE LGEPAHNHHA HNYYNSA

Genular Protein ID: 3696711579

Symbol: B7Z7E1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 247
  • Mass: 27398
  • Checksum: 9914FBC92590A02A
  • Sequence:
  • MDGLKDGIIL CEFINKLQPG SVKKINESTQ NWHQLENIGN FIKAITKYGV KPHDIFEAND 
    LFENTNHTQV QSTLLALASM AKTKGNKVNV GVKYAEKQER KFEPGKLREG RNIIGLQMGT 
    NKFASQQGMT AYGTRRHLYD PKLGTDQPLD QATISLQMGT NKGASQAGMT APGTKRQIFE 
    PGLGMEHCDT LNVSLQMGSN KGASQRGMTV YGLPRQVYDP KYCLTPEYPE LGEPAHNHHA 
    HNYYNSA

Genular Protein ID: 2527992515

Symbol: Q53FP8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8125298

Title: Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.

PubMed ID: 8125298

DOI: 10.1016/0378-1119(94)90802-8

PubMed ID: 9373149

Title: Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.

PubMed ID: 9373149

DOI: 10.1016/S0378-1119(97)00411-3

Sequence Information:

  • Length: 297
  • Mass: 33185
  • Checksum: B9B7A7298EA0F5A1
  • Sequence:
  • MSSAHFNRGP AYGLSAEVKN KLAQKYDHQR EQELREWIEG VTGRRIGNNF MDGLKDGIIL 
    CEFINKLQPG SVKKINESTQ NWHQLENIGN FIKAITKYGV KPHDIFEAND LFENTNHTQV 
    QSTLLALASM AKTKGNKVNV GVKYAEKQER KFEPGKLREG RNIIGLQMGT NKFASQQGMT 
    AYGTRRHLYD PKLGTDQPLD QATISQQMGT NKGASQAGMT APGTKRQIFE PGLGMEHCDT 
    LNVSLQMGSN KGASQRGMTV YGLPRQVYDP KYCLTPEYPE LGEPAHNHHA HNYYNSA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.