Genular: Defining Cellular Identity and Function

Details for: Ch25h

Gene ID: 12642

Symbol: Ch25h

Ensembl ID: ENSMUSG00000050370

Description: cholesterol 25-hydroxylase

Associated with

Bile acid and bile salt metabolism
(R-MMU-194068)
Metabolism
(R-MMU-1430728)
Metabolism of lipids
(R-MMU-556833)
Metabolism of steroids
(R-MMU-8957322)
Synthesis of bile acids and bile salts
(R-MMU-192105)
B cell chemotaxis
(GO:0035754)
C-4 methylsterol oxidase activity
(GO:0000254)
Cholesterol 25-hydroxylase activity
(GO:0001567)
Cholesterol metabolic process
(GO:0008203)
Endoplasmic reticulum
(GO:0005783)
Endoplasmic reticulum membrane
(GO:0005789)
Iron ion binding
(GO:0005506)
Lipid biosynthetic process
(GO:0008610)
Lipid metabolic process
(GO:0006629)
Membrane
(GO:0016020)
Metal ion binding
(GO:0046872)
Monooxygenase activity
(GO:0004497)
Negative regulation of cholesterol metabolic process
(GO:0090206)
Negative regulation of fusion of virus membrane with host plasma membrane
(GO:1903914)
Oxidoreductase activity
(GO:0016491)
Response to type i interferon
(GO:0034340)
Steroid biosynthetic process
(GO:0006694)
Steroid hydroxylase activity
(GO:0008395)
Steroid metabolic process
(GO:0008202)
Sterol biosynthetic process
(GO:0016126)

Other Information

Proteins

Cholesterol 25-monooxygenase

Genular Protein ID: 1991643186

Symbol: CH25H_MOUSE

Name: Cholesterol 25-monooxygenase

UniProtKB Accession Codes:

Q9Z0F5 Q3TUM6 Q8CHQ2

Database IDs:

Citations:

PubMed ID: 9852097

Title: cDNA cloning of mouse and human cholesterol 25-hydroxylases, polytopic membrane proteins that synthesize a potent oxysterol regulator of lipid metabolism.

PubMed ID: 9852097

DOI: 10.1074/jbc.273.51.34316

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12543708

Title: The enzymes, regulation, and genetics of bile acid synthesis.

PubMed ID: 12543708

DOI: 10.1146/annurev.biochem.72.121801.161712

PubMed ID: 22999953

Title: Oxysterol gradient generation by lymphoid stromal cells guides activated B cell movement during humoral responses.

PubMed ID: 22999953

DOI: 10.1016/j.immuni.2012.06.015

PubMed ID: 29033131

Title: Oxysterol restraint of cholesterol synthesis prevents AIM2 inflammasome activation.

PubMed ID: 29033131

DOI: 10.1016/j.cell.2017.09.029

Sequence Information:

Length: 298
Mass: 34672
Checksum: BBCE4A97A20284C6
Sequence:

MGCYNGSELQ DLGCSSQLLL QPLWDTIRTR EAFTRSPIFP VTFSIITYVG FCLPFVVLDV 
LYPWVPILRR YKIHPDFSPS VKQLLPCLGL TLYQHLVFVF PVTLLHWVRS PALLPQEAPE 
LVQLLSHVLI CLLLFDTEIF AWHLLHHKVP WLYRTFHKVH HQNSSSFALA TQYMSFWELL 
SLTFFDVLNV AVLRCHPLTI FTFHVINIWL SVEDHSGYDF PWSTHRLVPF GWYGGVAHHD 
MHHSQFNCNF APYFTHWDKM LGTLRSAPLP ESLCACGERC VNSRERCAVH LIQKKKQT

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ch25h

Associated with

Other Information

cDNA cloning of mouse and human cholesterol 25-hydroxylases, polytopic membrane proteins that synthesize a potent oxysterol regulator of lipid metabolism. PubMed ID: 9852097

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The enzymes, regulation, and genetics of bile acid synthesis. PubMed ID: 12543708

Oxysterol gradient generation by lymphoid stromal cells guides activated B cell movement during humoral responses. PubMed ID: 22999953