Genular: Defining Cellular Identity and Function

Details for: Chek1

Gene ID: 12649

Symbol: Chek1

Ensembl ID: ENSMUSG00000032113

Description: checkpoint kinase 1

Associated with

Activation of atr in response to replication stress
(R-MMU-176187)
Cell cycle checkpoints
(R-MMU-69620)
Dna double-strand break repair
(R-MMU-5693532)
G1/s dna damage checkpoints
(R-MMU-69615)
G2/m checkpoints
(R-MMU-69481)
G2/m dna damage checkpoint
(R-MMU-69473)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Hdr through homologous recombination (hrr)
(R-MMU-5685942)
Hdr through homologous recombination (hrr) or single strand annealing (ssa)
(R-MMU-5693567)
Homologous dna pairing and strand exchange
(R-MMU-5693579)
Homology directed repair
(R-MMU-5693538)
P53-independent dna damage response
(R-MMU-69610)
P53-independent g1/s dna damage checkpoint
(R-MMU-69613)
Presynaptic phase of homologous dna pairing and strand exchange
(R-MMU-5693616)
Processing of dna double-strand break ends
(R-MMU-5693607)
Regulation of tp53 activity
(R-MMU-5633007)
Regulation of tp53 activity through phosphorylation
(R-MMU-6804756)
Rna polymerase ii transcription
(R-MMU-73857)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signaling by scf-kit
(R-MMU-1433557)
Signal transduction
(R-MMU-162582)
Transcriptional regulation by e2f6
(R-MMU-8953750)
Transcriptional regulation by tp53
(R-MMU-3700989)
Ubiquitin mediated degradation of phosphorylated cdc25a
(R-MMU-69601)
Apoptotic process
(GO:0006915)
Apoptotic process involved in development
(GO:1902742)
Atp binding
(GO:0005524)
Cell cycle
(GO:0007049)
Centrosome
(GO:0005813)
Chromatin
(GO:0000785)
Chromatin remodeling
(GO:0006338)
Chromosome
(GO:0005694)
Chromosome, telomeric region
(GO:0000781)
Condensed nuclear chromosome
(GO:0000794)
Cytoplasm
(GO:0005737)
Cytoskeleton
(GO:0005856)
Dna damage checkpoint signaling
(GO:0000077)
Dna damage response
(GO:0006974)
Dna repair
(GO:0006281)
G2/m transition of mitotic cell cycle
(GO:0000086)
Histone h3t11 kinase activity
(GO:0035402)
Inner cell mass cell proliferation
(GO:0001833)
Intracellular membrane-bounded organelle
(GO:0043231)
Kinase activity
(GO:0016301)
Mitotic cell cycle checkpoint signaling
(GO:0007093)
Mitotic g2 dna damage checkpoint signaling
(GO:0007095)
Mitotic g2/m transition checkpoint
(GO:0044818)
Negative regulation of dna biosynthetic process
(GO:2000279)
Negative regulation of g2/m transition of mitotic cell cycle
(GO:0010972)
Negative regulation of gene expression, epigenetic
(GO:0045814)
Negative regulation of mitotic nuclear division
(GO:0045839)
Nucleoplasm
(GO:0005654)
Nucleotide binding
(GO:0000166)
Nucleus
(GO:0005634)
Nucleus organization
(GO:0006997)
Peptidyl-threonine phosphorylation
(GO:0018107)
Phosphorylation
(GO:0016310)
Positive regulation of cell cycle
(GO:0045787)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Protein domain specific binding
(GO:0019904)
Protein kinase activity
(GO:0004672)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Regulation of cell population proliferation
(GO:0042127)
Regulation of double-strand break repair via homologous recombination
(GO:0010569)
Regulation of gene expression
(GO:0010468)
Regulation of mitotic centrosome separation
(GO:0046602)
Replication fork
(GO:0005657)
Signal transduction in response to dna damage
(GO:0042770)
Transferase activity
(GO:0016740)

Other Information

Proteins

Serine/threonine-protein kinase Chk1

Genular Protein ID: 723075970

Symbol: CHK1_MOUSE

Name: Serine/threonine-protein kinase Chk1

UniProtKB Accession Codes:

O35280 O54925 Q8CI40 Q9D0N2

Database IDs:

Citations:

PubMed ID: 9278511

Title: Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25.

PubMed ID: 9278511

DOI: 10.1126/science.277.5331.1497

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9382850

Title: Atm-dependent interactions of a mammalian chk1 homolog with meiotic chromosomes.

PubMed ID: 9382850

DOI: 10.1016/s0960-9822(06)00417-9

PubMed ID: 10859163

Title: Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice.

PubMed ID: 10859163

PubMed ID: 10859164

Title: Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint.

PubMed ID: 10859164

PubMed ID: 15261141

Title: Chk1 is haploinsufficient for multiple functions critical to tumor suppression.

PubMed ID: 15261141

DOI: 10.1016/j.ccr.2004.06.015

PubMed ID: 15710331

Title: Lack of PTEN sequesters CHK1 and initiates genetic instability.

PubMed ID: 15710331

DOI: 10.1016/j.ccr.2005.01.009

PubMed ID: 17376776

Title: Mice lacking protein phosphatase 5 are defective in ataxia telangiectasia mutated (ATM)-mediated cell cycle arrest.

PubMed ID: 17376776

DOI: 10.1074/jbc.c700019200

PubMed ID: 18243098

Title: Chk1 is a histone H3 threonine 11 kinase that regulates DNA damage-induced transcriptional repression.

PubMed ID: 18243098

DOI: 10.1016/j.cell.2007.12.013

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 23418588

Title: Mammalian TIMELESS is involved in period determination and DNA damage-dependent phase advancing of the circadian clock.

PubMed ID: 23418588

DOI: 10.1371/journal.pone.0056623

Sequence Information:

Length: 476
Mass: 54381
Checksum: 0642D238EB3C5BE3
Sequence:

MAVPFVEDWD LVQTLGEGAY GEVQLAVNRI TEEAVAVKIV DMKRAIDCPE NIKKEICINK 
MLSHENVVKF YGHRREGHIQ YLFLEYCSGG ELFDRIEPDI GMPEQDAQRF FHQLMAGVVY 
LHGIGITHRD IKPENLLLDE RDNLKISDFG LATVFRHNNR ERLLNKMCGT LPYVAPELLK 
RKEFHAEPVD VWSCGIVLTA MLAGELPWDQ PSDSCQEYSD WKEKKTYLNP WKKIDSAPLA 
LLHKILVETP SARITIPDIK KDRWYNKPLN RGAKRPRATS GGMSESSSGF SKHIHSNLDF 
SPVNNGSSEE TVKFSSSQPE PRTGLSLWDT GPSNVDKLVQ GISFSQPTCP EHMLVNSQLL 
GTPGSSQNPW QRLVKRMTRF FTKLDADKSY QCLKETFEKL GYQWKKSCMN QVTVSTTDRR 
NNKLIFKINL VEMDEKILVD FRLSKGDGLE FKRHFLKIKG KLSDVVSSQK VWFPVT

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Chek1

Associated with

Other Information

Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25. PubMed ID: 9278511

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Atm-dependent interactions of a mammalian chk1 homolog with meiotic chromosomes. PubMed ID: 9382850

Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice. PubMed ID: 10859163

Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint. PubMed ID: 10859164

Chk1 is haploinsufficient for multiple functions critical to tumor suppression. PubMed ID: 15261141

Lack of PTEN sequesters CHK1 and initiates genetic instability. PubMed ID: 15710331

Mice lacking protein phosphatase 5 are defective in ataxia telangiectasia mutated (ATM)-mediated cell cycle arrest. PubMed ID: 17376776

Chk1 is a histone H3 threonine 11 kinase that regulates DNA damage-induced transcriptional repression. PubMed ID: 18243098

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Mammalian TIMELESS is involved in period determination and DNA damage-dependent phase advancing of the circadian clock. PubMed ID: 23418588