Details for: CNN2

Gene ID: 1265

Symbol: CNN2

Ensembl ID: ENSG00000064666

Description: calponin 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 3.26
    Marker Score: 172589
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 3.13
    Marker Score: 13429
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 3.05
    Marker Score: 9618
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.97
    Marker Score: 34503
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 2.89
    Marker Score: 7054
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 2.86
    Marker Score: 2760
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.81
    Marker Score: 37076
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 2.76
    Marker Score: 2599
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 2.67
    Marker Score: 4586
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.66
    Marker Score: 16979
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.62
    Marker Score: 7774
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 2.59
    Marker Score: 4621
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.59
    Marker Score: 4509
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 2.56
    Marker Score: 25392
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 2.54
    Marker Score: 4979
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.51
    Marker Score: 6921
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 2.5
    Marker Score: 2220
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 2.36
    Marker Score: 6616
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 2.25
    Marker Score: 1646
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.23
    Marker Score: 5455
  • Cell Name: centroblast (CL0009112)
    Fold Change: 2.22
    Marker Score: 1095
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 2.19
    Marker Score: 1921
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.1
    Marker Score: 117571
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.1
    Marker Score: 4942
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 2.08
    Marker Score: 1943
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 2.05
    Marker Score: 4296
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 2.03
    Marker Score: 467
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.02
    Marker Score: 3945
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 2.01
    Marker Score: 569
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 2
    Marker Score: 4982
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2
    Marker Score: 14873
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.98
    Marker Score: 1560
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.9
    Marker Score: 2613
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.9
    Marker Score: 12361
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 1.9
    Marker Score: 452
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 1.88
    Marker Score: 1681
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.87
    Marker Score: 1357
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.85
    Marker Score: 2616
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 1.83
    Marker Score: 1124
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.81
    Marker Score: 1524
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.78
    Marker Score: 1070
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 1.77
    Marker Score: 1038
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.73
    Marker Score: 1311
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.73
    Marker Score: 1262
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 1.73
    Marker Score: 438
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 1.72
    Marker Score: 1246
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.71
    Marker Score: 2366
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 1.71
    Marker Score: 1043
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 1.7
    Marker Score: 1416
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 1.7
    Marker Score: 1391
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.68
    Marker Score: 7249
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.66
    Marker Score: 1637
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.66
    Marker Score: 875
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.66
    Marker Score: 2720
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 1.64
    Marker Score: 2422
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.63
    Marker Score: 815
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.6
    Marker Score: 2127
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.58
    Marker Score: 559
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 1.57
    Marker Score: 680
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.57
    Marker Score: 551
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.56
    Marker Score: 860
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 1.56
    Marker Score: 1686
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 1.56
    Marker Score: 1034
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 1.54
    Marker Score: 1063
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.53
    Marker Score: 640
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.53
    Marker Score: 1558.5
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.52
    Marker Score: 2240
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.52
    Marker Score: 52619
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.51
    Marker Score: 1262
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.51
    Marker Score: 11782
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.51
    Marker Score: 9817
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 1.5
    Marker Score: 863
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.5
    Marker Score: 432
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.49
    Marker Score: 2395
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.48
    Marker Score: 1394
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 1.48
    Marker Score: 448
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.45
    Marker Score: 1528.5
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 1.45
    Marker Score: 850
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.44
    Marker Score: 1776
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 1.43
    Marker Score: 1218
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.42
    Marker Score: 1332
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 1.41
    Marker Score: 492
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.4
    Marker Score: 1498.5
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.4
    Marker Score: 954
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.39
    Marker Score: 3598
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 1.39
    Marker Score: 484
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 1.38
    Marker Score: 1666
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 1.37
    Marker Score: 1519
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.37
    Marker Score: 3125
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.35
    Marker Score: 903
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.35
    Marker Score: 5007
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.35
    Marker Score: 3668
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 1.34
    Marker Score: 665
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.33
    Marker Score: 6983
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 1.33
    Marker Score: 1040.5
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.31
    Marker Score: 1642
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.3
    Marker Score: 1417
  • Cell Name: neural cell (CL0002319)
    Fold Change: 1.29
    Marker Score: 624
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 1.29
    Marker Score: 694
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.28
    Marker Score: 412

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Other Information

**Key characteristics:** - CNN2 is a transmembrane protein with a molecular weight of approximately 120 kDa. - It is expressed in high levels in tissues that are involved in immune responses, such as the skin, lungs, and immune organs. - CNN2 is a key regulator of actin filament-based processes. - It is involved in the regulation of cell migration, adhesion, and signaling. - It is also involved in the regulation of inflammation and cell death. **Pathways and functions:** - CNN2 is involved in the regulation of actin filament-based processes through its interaction with actin and other cytoskeletal proteins. - It is also involved in the regulation of the cytoskeleton and cell signaling. - It is involved in the regulation of inflammation and cell death. **Clinical significance:** - Mutations in the CNN2 gene have been linked to several human diseases, including psoriasis, rheumatoid arthritis, and cancer. - CNN2 is a potential target for the treatment of these diseases.

Genular Protein ID: 2423105035

Symbol: CNN2_HUMAN

Name: Calponin-2

UniProtKB Accession Codes:

Q99439 A5D8U8 A6NFI4 D6W5X9 Q92578

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CPTAC 2 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 27 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 NIAGADS 1 OGP 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRIDE 1 PRINTS 2 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 4 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8889829

Title: Molecular cloning and characterization of human non-smooth muscle calponin.

PubMed ID: 8889829

DOI: 10.1093/oxfordjournals.jbchem.a021428

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9001224

Title: A unique downregulation of h2-calponin gene expression in Down syndrome: a possible attenuation mechanism for fetal survival by methylation at the CpG island in the trisomic chromosome 21.

PubMed ID: 9001224

DOI: 10.1128/mcb.17.2.707

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 309
  • Mass: 33697
  • Checksum: 0D767E9040190A5F
  • Sequence:
    • MSSTQFNKGP SYGLSAEVKN RLLSKYDPQK EAELRTWIEG LTGLSIGPDF QKGLKDGTIL 
CTLMNKLQPG SVPKINRSMQ NWHQLENLSN FIKAMVSYGM NPVDLFEAND LFESGNMTQV 
QVSLLALAGK AKTKGLQSGV DIGVKYSEKQ ERNFDDATMK AGQCVIGLQM GTNKCASQSG 
MTAYGTRRHL YDPKNHILPP MDHSTISLQM GTNKCASQVG MTAPGTRRHI YDTKLGTDKC 
DNSSMSLQMG YTQGANQSGQ VFGLGRQIYD PKYCPQGTVA DGAPSGTGDC PDPGEVPEYP 
PYYQEEAGY

Genular Protein ID: 3322928949

Symbol: B4DUT8_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DUT8

Database IDs:

ARBA 5 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 4 EPD 1 Ensembl 2 GO 3 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 5 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NIAGADS 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 4 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 RuleBase 1 SAM 1 SMART 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 330
  • Mass: 35944
  • Checksum: CB7E8A74CA422FD7
  • Sequence:
    • MSSTQFNKGP SYGLSAEVKN RLLSKYDPQK EAELRTWIEG LTGLSIGPDF QKGLKDGTIL 
CTLMNKLQPG SVPKINRSMQ NWHQLENLSN FIKAMVSYGM NPVDLFEAND LFESGNMTQV 
QVSLLALAGK GLDLGSLAAL CWYSRPLSLT QAKTKGLQSG VDIGVKYSEK QERNFDDATM 
KAGQCVIGLQ MGTNKCASQS GMTAYGTRRH LYDPKNHILP PMDHSTISLQ MGTNKCASQV 
GMTAPGTRRH IYDTKLGTDK CDNSSMSLQM GYTQGANQSG QVFGLGRQIY DPKYCPQGTV 
ADGAPSGTGD CPDPGEVPEY PPYYQEEAGY

Genular Protein ID: 2645582836

Symbol: B4DDF4_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DDF4

Database IDs:

ARBA 5 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 4 EPD 1 Ensembl 2 GO 3 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 5 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NIAGADS 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 4 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 RuleBase 1 SAM 1 SMART 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 298
  • Mass: 32617
  • Checksum: 0EFA23584C630B2D
  • Sequence:
    • MSSTQFNKGP SYGLSAEVKN RLLSKYDPQK EAELRTWIEG LTGLSIGPDF QKGLKDGTIL 
CTLMNKLQPG SVPKINRSMQ NWHQLENLSN FIKAMVSYGM NPVDLFEAND LFESGNMTQA 
KTKGLQSGVD IGVKYSEKQE RNFDDATMKA GQCVIGLQMG TNKCASQSGM TAYGTRRHLY 
DPKNHILPPM DHSTISLQMG TNKCASQVGM TAPGTRRHIY DTKLGTDKCD NSSMSLQMGY 
TQGANQSGQV FGLGRQIYDP KYCPQGTVAD GAPSGTGDCP DPGEVPEYPP YYQEEAGY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.