Genular: Defining Cellular Identity and Function

Details for: Chga

Gene ID: 12652

Symbol: Chga

Ensembl ID: ENSMUSG00000021194

Description: chromogranin A

Associated with

Antimicrobial peptides
(R-MMU-6803157)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Adenylate cyclase-activating adrenergic receptor signaling pathway involved in cardiac muscle relaxation
(GO:0086030)
Chromaffin granule
(GO:0042583)
Cytoplasmic vesicle
(GO:0031410)
Defense response to bacterium
(GO:0042742)
Defense response to gram-negative bacterium
(GO:0050829)
Defense response to gram-positive bacterium
(GO:0050830)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Mast cell activation
(GO:0045576)
Mast cell chemotaxis
(GO:0002551)
Mast cell degranulation
(GO:0043303)
Negative regulation of catecholamine secretion
(GO:0033604)
Negative regulation of insulin secretion
(GO:0046676)
Neuronal dense core vesicle
(GO:0098992)
Perinuclear region of cytoplasm
(GO:0048471)
Positive regulation of camp-mediated signaling
(GO:0043950)
Positive regulation of cardiac muscle contraction
(GO:0060452)
Positive regulation of dense core granule biogenesis
(GO:2000707)
Positive regulation of phospholipase c-activating g protein-coupled receptor signaling pathway
(GO:1900738)
Positive regulation of protein phosphorylation
(GO:0001934)
Positive regulation of relaxation of cardiac muscle
(GO:1901899)
Positive regulation of vasoconstriction
(GO:0045907)
Protein binding
(GO:0005515)
Protein localization to secretory granule
(GO:0033366)
Regulation of cytosolic calcium ion concentration
(GO:0051480)
Regulation of the force of heart contraction
(GO:0002026)
Secretory granule
(GO:0030141)

Other Information

Proteins

Chromogranin-A

Genular Protein ID: 1083526036

Symbol: CMGA_MOUSE

Name: Chromogranin-A

UniProtKB Accession Codes:

P26339

Database IDs:

Citations:

PubMed ID: 2071596

Title: Structure and function of the chromogranin A gene. Clues to evolution and tissue-specific expression.

PubMed ID: 2071596

DOI: 10.1016/s0021-9258(18)98814-9

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12388744

Title: Identification of a chromogranin A domain that mediates binding to secretogranin III and targeting to secretory granules in pituitary cells and pancreatic beta-cells.

PubMed ID: 12388744

DOI: 10.1091/mbc.02-03-0040

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21537909

Title: Role of pGlu-serpinin, a novel chromogranin A-derived peptide in inhibition of cell death.

PubMed ID: 21537909

DOI: 10.1007/s12031-011-9521-7

PubMed ID: 21436258

Title: Serpinin: a novel chromogranin A-derived, secreted peptide up-regulates protease nexin-1 expression and granule biogenesis in endocrine cells.

PubMed ID: 21436258

DOI: 10.1210/me.2010-0124

Sequence Information:

Length: 463
Mass: 51789
Checksum: 1AB3C5FF433C39E4
Sequence:

MRSTAVLALL LCAGQVFALP VNSPMTKGDT KVMKCVLEVI SDSLSKPSPM PVSPECLETL 
QGDERILSIL RHQNLLKELQ DLALQGAKER AQQPLKQQQP PKQQQQQQQQ QQQEQQHSSF 
EDELSEVFEN QSPDAKHRDA AAEVPSRDTM EKRKDSDKGQ QDGFEATTEG PRPQAFPEPN 
QESPMMGDSE SPGEDTATNT QSPTSLPSQE HVDPQATGDS ERGLSAQQQA RKAKQEEKEE 
EEEEEAVARE KAGPEEVPTA ASSSHFHAGY KAIQKDDGQS DSQAVDGDGK TEASEALPSE 
GKGELEHSQQ EEDGEEAMVG TPQGLFPQGG KGRELEHKQE EEEEEEERLS REWEDKRWSR 
MDQLAKELTA EKRLEGEDDP DRSMKLSFRT RAYGFRDPGP QLRRGWRPSS REDSVEARSD 
FEEKKEEEGS ANRRAEDQEL ESLSAIEAEL EKVAHQLQAL RRG

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Chga

Associated with

Other Information

Structure and function of the chromogranin A gene. Clues to evolution and tissue-specific expression. PubMed ID: 2071596

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Identification of a chromogranin A domain that mediates binding to secretogranin III and targeting to secretory granules in pituitary cells and pancreatic beta-cells. PubMed ID: 12388744

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Role of pGlu-serpinin, a novel chromogranin A-derived peptide in inhibition of cell death. PubMed ID: 21537909