Details for: CNN3

Gene ID: 1266

Symbol: CNN3

Ensembl ID: ENSG00000117519

Description: calponin 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 544.4076
    Cell Significance Index: -84.6800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 331.2919
    Cell Significance Index: -84.0300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 208.2789
    Cell Significance Index: -85.8000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 178.5341
    Cell Significance Index: -84.2900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 173.1908
    Cell Significance Index: -70.3600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 126.3595
    Cell Significance Index: -84.7900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 73.7895
    Cell Significance Index: -70.4500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 69.5078
    Cell Significance Index: -85.7000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 30.9124
    Cell Significance Index: -82.8100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 21.6951
    Cell Significance Index: -85.6100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 15.3889
    Cell Significance Index: -33.6800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 6.4013
    Cell Significance Index: 133.9900
  • Cell Name: theca cell (CL0000503)
    Fold Change: 4.3736
    Cell Significance Index: 25.7000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 4.1881
    Cell Significance Index: 45.5300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 3.6375
    Cell Significance Index: 466.3000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 3.5855
    Cell Significance Index: 63.3600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.1951
    Cell Significance Index: 91.5900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.1316
    Cell Significance Index: 85.2400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.7674
    Cell Significance Index: 144.1500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.6686
    Cell Significance Index: 70.1700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.5224
    Cell Significance Index: 346.3900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.2941
    Cell Significance Index: 170.9800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 2.1760
    Cell Significance Index: 24.7200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 2.1680
    Cell Significance Index: 130.1600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.0267
    Cell Significance Index: 261.8300
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 1.2317
    Cell Significance Index: 7.5800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.1572
    Cell Significance Index: 30.9000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.1162
    Cell Significance Index: 14.3000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.1115
    Cell Significance Index: 62.3700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.0818
    Cell Significance Index: 50.8500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0634
    Cell Significance Index: 115.6700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.9498
    Cell Significance Index: 518.7100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.9259
    Cell Significance Index: 43.1700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.8483
    Cell Significance Index: 104.3100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8375
    Cell Significance Index: 166.2100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7092
    Cell Significance Index: 127.8600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.5697
    Cell Significance Index: 361.8000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5643
    Cell Significance Index: 91.7700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.5473
    Cell Significance Index: 1030.4800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5390
    Cell Significance Index: 238.3100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.4461
    Cell Significance Index: 822.7500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4238
    Cell Significance Index: 41.9200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3856
    Cell Significance Index: 11.1100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3771
    Cell Significance Index: 8.1700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.3531
    Cell Significance Index: 12.2700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3485
    Cell Significance Index: 66.3200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3376
    Cell Significance Index: 121.1000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.3324
    Cell Significance Index: 511.6800
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.2979
    Cell Significance Index: 1.8000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2821
    Cell Significance Index: 56.5900
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.1920
    Cell Significance Index: 2.0400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1843
    Cell Significance Index: 11.3300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1737
    Cell Significance Index: 2.3700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1270
    Cell Significance Index: 57.6500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1094
    Cell Significance Index: 148.7000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0989
    Cell Significance Index: 1.6600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0715
    Cell Significance Index: 3.2400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0312
    Cell Significance Index: 23.5800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0205
    Cell Significance Index: 0.7200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0200
    Cell Significance Index: 3.4200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0066
    Cell Significance Index: 4.8500
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.0282
    Cell Significance Index: -0.1300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0426
    Cell Significance Index: -31.5300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0468
    Cell Significance Index: -32.4000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0502
    Cell Significance Index: -1.1600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0959
    Cell Significance Index: -59.8800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1397
    Cell Significance Index: -78.7600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1883
    Cell Significance Index: -27.3700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2016
    Cell Significance Index: -20.5900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2594
    Cell Significance Index: -6.9500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2660
    Cell Significance Index: -76.5400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3116
    Cell Significance Index: -35.7000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3313
    Cell Significance Index: -69.7900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3506
    Cell Significance Index: -40.8600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.3657
    Cell Significance Index: -2.9200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.4921
    Cell Significance Index: -12.3000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.5219
    Cell Significance Index: -40.0500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.5309
    Cell Significance Index: -37.5500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.5577
    Cell Significance Index: -28.9700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.6477
    Cell Significance Index: -73.9400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6874
    Cell Significance Index: -54.4400
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.7007
    Cell Significance Index: -4.4000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.7020
    Cell Significance Index: -73.0900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.7072
    Cell Significance Index: -5.9400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.7111
    Cell Significance Index: -83.8600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.7857
    Cell Significance Index: -41.2500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.8575
    Cell Significance Index: -18.2600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.9566
    Cell Significance Index: -30.6400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.9621
    Cell Significance Index: -8.8600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.0260
    Cell Significance Index: -30.2200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.1474
    Cell Significance Index: -77.1500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -1.1823
    Cell Significance Index: -33.0400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -1.2701
    Cell Significance Index: -81.9400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.3370
    Cell Significance Index: -84.2700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.3633
    Cell Significance Index: -83.5800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -1.5047
    Cell Significance Index: -76.0400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -1.5475
    Cell Significance Index: -26.5200
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -1.6705
    Cell Significance Index: -17.4400
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -1.7382
    Cell Significance Index: -25.0000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.7685
    Cell Significance Index: -64.9200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Actin-binding protein**: Calponin 3 is a member of the calponin family, which are actin-binding proteins that interact with actin filaments to regulate their dynamics and organization. 2. **Regulation of actin filament organization**: CNN3 influences the organization and dynamics of actin filaments, which is essential for various cellular processes such as contraction, motility, and cell adhesion. 3. **Cell-cell adhesion**: Calponin 3 contributes to cell-cell adhesion by interacting with cadherins and other adhesion molecules to regulate the interaction between cells. 4. **Regulation of cell differentiation**: The expression of CNN3 is observed in epithelial cells, where it contributes to cell differentiation and the maintenance of tissue architecture. **Pathways and Functions:** 1. **Actin cytoskeleton pathway**: Calponin 3 regulates the organization and dynamics of actin filaments, which is essential for various cellular processes such as contraction, motility, and cell adhesion. 2. **Adherens junction pathway**: CNN3 contributes to cell-cell adhesion by interacting with cadherins and other adhesion molecules to regulate the interaction between cells. 3. **Cell differentiation pathway**: The expression of CNN3 is observed in epithelial cells, where it contributes to cell differentiation and the maintenance of tissue architecture. 4. **Muscle contraction pathway**: Calponin 3 is expressed in smooth muscle cells, where it regulates muscle contraction and relaxation. **Clinical Significance:** 1. **Prostate cancer**: The expression of CNN3 is observed in prostate cancer cells, where it may contribute to the development and progression of the disease. 2. **Cardiovascular disease**: Calponin 3 is expressed in smooth muscle cells, where it regulates blood pressure and vascular tone. Alterations in CNN3 expression may contribute to the development of cardiovascular disease. 3. **Muscle disorders**: The expression of CNN3 is observed in skeletal muscle cells, where it regulates muscle contraction and relaxation. Alterations in CNN3 expression may contribute to the development of muscle disorders such as muscular dystrophy. 4. **Endothelial dysfunction**: Calponin 3 is expressed in endothelial cells, where it regulates blood vessel function and endothelial cell adhesion. Alterations in CNN3 expression may contribute to endothelial dysfunction and the development of cardiovascular disease. In conclusion, calponin 3 is a key regulator of actin filament dynamics and cell adhesion in various tissues, and its expression is observed in a range of cell types, including endothelial cells, smooth muscle cells, and epithelial cells. The protein encoded by the CNN3 gene interacts with calmodulin and other actin-binding proteins to modulate the actin cytoskeleton and regulate cellular processes such as contraction, motility, and adhesion. Alterations in CNN3 expression may contribute to the development of various diseases, including prostate cancer, cardiovascular disease, muscle disorders, and endothelial dysfunction.

Genular Protein ID: 916227462

Symbol: CNN3_HUMAN

Name: Calponin-3

UniProtKB Accession Codes:

Q15417 B4DFK6 B4DP09 F8WA86 Q6FHA7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 11 Ensembl 3 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 RefSeq 4 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8526917

Title: Molecular cloning and gene mapping of human basic and acidic calponins.

PubMed ID: 8526917

DOI: 10.1006/bbrc.1995.2769

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

Sequence Information:

  • Length: 329
  • Mass: 36414
  • Checksum: F024E169E821A8D8
  • Sequence:
    • MTHFNKGPSY GLSAEVKNKI ASKYDHQAEE DLRNWIEEVT GMSIGPNFQL GLKDGIILCE 
LINKLQPGSV KKVNESSLNW PQLENIGNFI KAIQAYGMKP HDIFEANDLF ENGNMTQVQT 
TLVALAGLAK TKGFHTTIDI GVKYAEKQTR RFDEGKLKAG QSVIGLQMGT NKCASQAGMT 
AYGTRRHLYD PKMQTDKPFD QTTISLQMGT NKGASQAGML APGTRRDIYD QKLTLQPVDN 
STISLQMGTN KVASQKGMSV YGLGRQVYDP KYCAAPTEPV IHNGSQGTGT NGSEISDSDY 
QAEYPDEYHG EYQDDYPRDY QYSDQGIDY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.