Details for: CNN3

Gene ID: 1266

Symbol: CNN3

Ensembl ID: ENSG00000117519

Description: calponin 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 3.88
    Marker Score: 5615
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 3.72
    Marker Score: 9460
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 3.6
    Marker Score: 3070.5
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.44
    Marker Score: 3675
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 3.31
    Marker Score: 4311
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 3.28
    Marker Score: 4415
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 3.22
    Marker Score: 1341
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.19
    Marker Score: 108666
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 3.16
    Marker Score: 41617
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.04
    Marker Score: 7425
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 3.02
    Marker Score: 5676
  • Cell Name: theca cell (CL0000503)
    Fold Change: 2.76
    Marker Score: 1978
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.76
    Marker Score: 7217
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 2.73
    Marker Score: 2920
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 2.69
    Marker Score: 1692
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 2.65
    Marker Score: 3678
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 2.65
    Marker Score: 2494
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 2.64
    Marker Score: 3198
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.64
    Marker Score: 5267.5
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 2.63
    Marker Score: 3612
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.61
    Marker Score: 4331
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 2.61
    Marker Score: 3792
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 2.59
    Marker Score: 3981
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.54
    Marker Score: 16546.5
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.54
    Marker Score: 10935
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.52
    Marker Score: 6361
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.51
    Marker Score: 4441
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 2.47
    Marker Score: 616
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.47
    Marker Score: 52644
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.46
    Marker Score: 9474
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 2.45
    Marker Score: 616
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 2.41
    Marker Score: 561
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.39
    Marker Score: 9986
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.37
    Marker Score: 20816
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 2.37
    Marker Score: 920
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.37
    Marker Score: 8403.5
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.36
    Marker Score: 690.5
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.35
    Marker Score: 1848.5
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 2.32
    Marker Score: 8996
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 2.32
    Marker Score: 734
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 2.31
    Marker Score: 2854
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 2.31
    Marker Score: 1344.5
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 2.29
    Marker Score: 2184
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 2.28
    Marker Score: 862
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 2.26
    Marker Score: 2719.5
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.25
    Marker Score: 25321.5
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 2.23
    Marker Score: 1587
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.23
    Marker Score: 5247.5
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 2.23
    Marker Score: 791.5
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.23
    Marker Score: 3769
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 2.21
    Marker Score: 625
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 2.2
    Marker Score: 1241
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 2.17
    Marker Score: 616
  • Cell Name: pericyte (CL0000669)
    Fold Change: 2.16
    Marker Score: 1260
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.15
    Marker Score: 2410
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 2.14
    Marker Score: 10532
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.11
    Marker Score: 7807
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 2.11
    Marker Score: 2230
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 2.11
    Marker Score: 2235
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 2.11
    Marker Score: 2034
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 2.09
    Marker Score: 1967
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.08
    Marker Score: 8161
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 2.07
    Marker Score: 1364
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 2.07
    Marker Score: 466
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.05
    Marker Score: 1200
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 2.05
    Marker Score: 5495
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.04
    Marker Score: 15202
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.03
    Marker Score: 2335
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.01
    Marker Score: 4204
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.01
    Marker Score: 4417
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 2
    Marker Score: 2825
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.99
    Marker Score: 482
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.99
    Marker Score: 1307
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.99
    Marker Score: 2136
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.98
    Marker Score: 1321
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.97
    Marker Score: 2118
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.94
    Marker Score: 2013.5
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.93
    Marker Score: 16663
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 1.93
    Marker Score: 410
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.92
    Marker Score: 3086
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 1.92
    Marker Score: 1651.5
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.91
    Marker Score: 5207.5
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.9
    Marker Score: 3111.5
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.89
    Marker Score: 1706
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.88
    Marker Score: 1074
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.88
    Marker Score: 1188
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.87
    Marker Score: 1677
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.86
    Marker Score: 597
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.85
    Marker Score: 875
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.85
    Marker Score: 1019
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.84
    Marker Score: 1538
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 1.83
    Marker Score: 535
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 1.8
    Marker Score: 1066
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 1.79
    Marker Score: 772
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 1.78
    Marker Score: 1588
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.78
    Marker Score: 3243
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 1.77
    Marker Score: 450
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 1.77
    Marker Score: 613
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.76
    Marker Score: 28323
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.76
    Marker Score: 2993

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Other Information

**Key characteristics**: - Calponin 3 is a transmembrane protein with a molecular weight of approximately 130 kDa. - It is a key component of the cytoskeleton, where it helps to maintain cell adhesion and shape. - It is also involved in cell signaling pathways, including those involved in cell migration and adhesion. - It is expressed in a variety of cell types, including endothelial cells, fibroblasts, and muscle cells. **Pathways and functions**: - Calponin 3 is involved in several important cellular processes, including: - Cell adhesion: It is a key component of cell adhesion junctions, where cells are held together by adhesive molecules. - Cell migration: It helps cells to migrate by interacting with the cytoskeleton. - Cell signaling: It is involved in cell signaling pathways, including those involved in cell migration and adhesion. - Tissue development: It is expressed in developing tissues, such as the lungs, skin, and blood vessels. **Clinical significance**: Mutations in the CNN3 gene have been linked to several human diseases, including: - Vascular diseases: Mutations in CNN3 have been linked to pulmonary hypertension, a condition characterized by high blood pressure in the lungs. - Cancer: Mutations in CNN3 have also been linked to several types of cancer, including lung cancer and breast cancer. **Additional information**: - The CNN3 gene is also known as CD9, as it is expressed on the surface of immune cells. - It is a highly conserved protein, with a similar protein found in other mammals. - It is a well-studied protein, and its role in cell adhesion and signaling is well-established.

Genular Protein ID: 916227462

Symbol: CNN3_HUMAN

Name: Calponin-3

UniProtKB Accession Codes:

Q15417 B4DFK6 B4DP09 F8WA86 Q6FHA7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 11 EPD 1 Ensembl 3 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 RefSeq 4 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8526917

Title: Molecular cloning and gene mapping of human basic and acidic calponins.

PubMed ID: 8526917

DOI: 10.1006/bbrc.1995.2769

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

Sequence Information:

  • Length: 329
  • Mass: 36414
  • Checksum: F024E169E821A8D8
  • Sequence:
    • MTHFNKGPSY GLSAEVKNKI ASKYDHQAEE DLRNWIEEVT GMSIGPNFQL GLKDGIILCE 
LINKLQPGSV KKVNESSLNW PQLENIGNFI KAIQAYGMKP HDIFEANDLF ENGNMTQVQT 
TLVALAGLAK TKGFHTTIDI GVKYAEKQTR RFDEGKLKAG QSVIGLQMGT NKCASQAGMT 
AYGTRRHLYD PKMQTDKPFD QTTISLQMGT NKGASQAGML APGTRRDIYD QKLTLQPVDN 
STISLQMGTN KVASQKGMSV YGLGRQVYDP KYCAAPTEPV IHNGSQGTGT NGSEISDSDY 
QAEYPDEYHG EYQDDYPRDY QYSDQGIDY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.