Genular: Defining Cellular Identity and Function

Details for: Chka

Gene ID: 12660

Symbol: Chka

Ensembl ID: ENSMUSG00000024843

Description: choline kinase alpha

Associated with

Glycerophospholipid biosynthesis
(R-MMU-1483206)
Metabolism
(R-MMU-1430728)
Metabolism of lipids
(R-MMU-556833)
Phospholipid metabolism
(R-MMU-1483257)
Synthesis of pc
(R-MMU-1483191)
Synthesis of pe
(R-MMU-1483213)
Atp binding
(GO:0005524)
Cdp-choline pathway
(GO:0006657)
Cellular response to glucose starvation
(GO:0042149)
Choline binding
(GO:0033265)
Choline kinase activity
(GO:0004103)
Choline metabolic process
(GO:0019695)
Cholinesterase activity
(GO:0004104)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Ethanolamine kinase activity
(GO:0004305)
Ethanolamine metabolic process
(GO:0006580)
Identical protein binding
(GO:0042802)
Kinase activity
(GO:0016301)
Lipid droplet
(GO:0005811)
Lipid droplet disassembly
(GO:1905691)
Lipid metabolic process
(GO:0006629)
Nucleotide binding
(GO:0000166)
Phosphatidylcholine biosynthetic process
(GO:0006656)
Phosphatidylethanolamine biosynthetic process
(GO:0006646)
Phospholipid biosynthetic process
(GO:0008654)
Phosphorylation
(GO:0016310)
Protein homodimerization activity
(GO:0042803)
Protein tyrosine kinase activity
(GO:0004713)
Transferase activity
(GO:0016740)

Other Information

Proteins

Choline kinase alpha

Genular Protein ID: 63647759

Symbol: CHKA_MOUSE

Name: Choline kinase alpha

UniProtKB Accession Codes:

O54804 G5E853 Q8BPL3 Q8BPW6 Q9CXP3 Q9QX56

Database IDs:

Citations:

PubMed ID: 9714798

Title: Molecular cloning of mouse choline kinase and choline/ethanolamine kinase: their sequence comparison to the respective rat homologs.

PubMed ID: 9714798

DOI: 10.1016/s0005-2760(98)00062-9

PubMed ID: 10706593

Title: Structure and characterization of the genes for murine choline/ethanolamine kinase isozymes alpha and beta.

PubMed ID: 10706593

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 16490392

Title: Deletion and alanine mutation analyses for the formation of active homo- or hetero-dimer complexes of mouse choline kinase-alpha and -beta.

PubMed ID: 16490392

DOI: 10.1016/j.bbalip.2006.01.005

PubMed ID: 18029352

Title: Early embryonic lethality caused by disruption of the gene for choline kinase alpha, the first enzyme in phosphatidylcholine biosynthesis.

PubMed ID: 18029352

DOI: 10.1074/jbc.m708766200

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 453
Mass: 51985
Checksum: 66042FEE92C333D4
Sequence:

MKTKFCTGGE AEPSPLGLLL SCGGNAAPTP GVGQQRDAAG ELESKQLGGR TQPLALPPPP 
PPPLPLPPPP SPPLADEQPE PRTRRRAYLW CKEFLPGAWR GLREDQFHIS VIRGGLSNML 
FQCSLPDSIA SVGDEPRKVL LRLYGAILKM RSCNKEGSEQ AQNENEFQGA EAMVLESVMF 
AILAERSLGP KLFGIFPQGR LEQFIPSRRL DTEELRLPDI SAEIAEKMAT FHGMKMPFNK 
EPKWLFGTME KYLNQVLRLK FSREARVQQL HKILSYNLPL ELENLRSLLQ YTRSPVVFCH 
NDCQEGNILL LEGQENSERR KLMLIDFEYS SYNYRGFDIG NHFCEWMYDY TYEKYPFFRA 
NIQKYPSRKQ QLHFISSYLT TFQNDFESLS SEEQFATKED MLLEVNRFAL ASHFLWGLWS 
IVQAKISSIE FGYMEYAQAR FEAYFDQKRK LGV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Chka

Associated with

Other Information

Molecular cloning of mouse choline kinase and choline/ethanolamine kinase: their sequence comparison to the respective rat homologs. PubMed ID: 9714798

Structure and characterization of the genes for murine choline/ethanolamine kinase isozymes alpha and beta. PubMed ID: 10706593

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Deletion and alanine mutation analyses for the formation of active homo- or hetero-dimer complexes of mouse choline kinase-alpha and -beta. PubMed ID: 16490392

Early embryonic lethality caused by disruption of the gene for choline kinase alpha, the first enzyme in phosphatidylcholine biosynthesis. PubMed ID: 18029352

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079