Details for: CNP

Gene ID: 1267

Symbol: CNP

Ensembl ID: ENSG00000173786

Description: 2',3'-cyclic nucleotide 3' phosphodiesterase

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 3.52
    Marker Score: 8434
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 2.38
    Marker Score: 2122
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 2.35
    Marker Score: 2507
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 2.11
    Marker Score: 1982
  • Cell Name: neural cell (CL0002319)
    Fold Change: 1.88
    Marker Score: 907
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 1.66
    Marker Score: 884
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.52
    Marker Score: 956
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 1.4
    Marker Score: 938
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.27
    Marker Score: 1430
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 1.26
    Marker Score: 1745
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.2
    Marker Score: 4454
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.2
    Marker Score: 3212
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.19
    Marker Score: 1642
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.19
    Marker Score: 10234
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.18
    Marker Score: 2055
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.09
    Marker Score: 739
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.08
    Marker Score: 1142
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.08
    Marker Score: 2250
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.06
    Marker Score: 2493
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 1.06
    Marker Score: 278
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.01
    Marker Score: 2043
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.99
    Marker Score: 664
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.99
    Marker Score: 1678
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.98
    Marker Score: 4241
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.98
    Marker Score: 1019
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30392
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.97
    Marker Score: 988
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.97
    Marker Score: 389
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2390.5
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 476
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.92
    Marker Score: 7188
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.92
    Marker Score: 10367
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.91
    Marker Score: 432
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.91
    Marker Score: 610
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.91
    Marker Score: 507
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.91
    Marker Score: 5381
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2693
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.89
    Marker Score: 2101
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.89
    Marker Score: 898
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.89
    Marker Score: 261
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.88
    Marker Score: 1443.5
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5280
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 307
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 0.85
    Marker Score: 516
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.84
    Marker Score: 2296.5
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.84
    Marker Score: 283
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.84
    Marker Score: 463
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.84
    Marker Score: 1116
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.84
    Marker Score: 592
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.84
    Marker Score: 3290
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.83
    Marker Score: 625
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.83
    Marker Score: 4747
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.83
    Marker Score: 195
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.83
    Marker Score: 1027
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.82
    Marker Score: 1328
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.82
    Marker Score: 1257
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.81
    Marker Score: 551
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.81
    Marker Score: 10704
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.81
    Marker Score: 229
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.8
    Marker Score: 298
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.8
    Marker Score: 2366
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.79
    Marker Score: 196
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.79
    Marker Score: 43991
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.78
    Marker Score: 465
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.78
    Marker Score: 403
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.78
    Marker Score: 3197
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.78
    Marker Score: 313
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.78
    Marker Score: 367
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.77
    Marker Score: 2748
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 584.5
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.75
    Marker Score: 173
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.74
    Marker Score: 1944
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.74
    Marker Score: 11614
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.73
    Marker Score: 164
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.73
    Marker Score: 1073
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.73
    Marker Score: 777
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.72
    Marker Score: 24981
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.72
    Marker Score: 786.5
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.71
    Marker Score: 668
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.7
    Marker Score: 512
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.7
    Marker Score: 753
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.7
    Marker Score: 1928
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.7
    Marker Score: 4527
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.7
    Marker Score: 325
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.69
    Marker Score: 1307.5
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.69
    Marker Score: 650
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.69
    Marker Score: 1376
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.69
    Marker Score: 389
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.69
    Marker Score: 627
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.68
    Marker Score: 1553
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.68
    Marker Score: 1279
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.68
    Marker Score: 821
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2851
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.68
    Marker Score: 373
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 173
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.67
    Marker Score: 571
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.67
    Marker Score: 727
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.67
    Marker Score: 723
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.67
    Marker Score: 441
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.67
    Marker Score: 333

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Other Information

**Key characteristics:** - CNP is a protein that is highly expressed in the brain and nervous system. - It is involved in a variety of cellular processes, including cell migration, differentiation, and signaling. - CNP is a key regulator of mitochondrial function and apoptosis. **Pathways and functions:** - CNP is involved in a variety of cellular processes, including cell migration, differentiation, and signaling. - It is a key regulator of mitochondrial function and apoptosis. - CNP is also involved in the regulation of synaptic plasticity and learning and memory. **Clinical significance:** - Mutations in the CNP gene have been linked to a number of neurological disorders, including autism, schizophrenia, and Alzheimer's disease. - CNP inhibitors are being investigated as potential treatments for these disorders. **Additional information:** - CNP is a multi-functional protein that can be expressed in different cellular compartments, including the nucleus, cytoplasm, and extracellular space. - It is a key regulator of mitochondrial function and apoptosis. - CNP is also involved in the regulation of synaptic plasticity and learning and memory.

Genular Protein ID: 1016882423

Symbol: CN37_HUMAN

Name: N/A

UniProtKB Accession Codes:

P09543

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChEBI 4 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 16 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 27 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 3 Rhea 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCD-2DPAGE 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1385234

Title: 2',3'-cyclic nucleotide-3'-phosphohydrolase and signal transduction in central nervous system myelin.

PubMed ID: 1385234

DOI: 10.1042/bst0200621

PubMed ID: 2835044

Title: cDNA cloning and amino acid sequence of human brain 2',3'-cyclic-nucleotide 3'-phosphodiesterase.

PubMed ID: 2835044

DOI: 10.1016/s0006-291x(88)80114-1

PubMed ID: 8392017

Title: Structure, expression and chromosomal localization of the gene encoding human 2',3'-cyclic-nucleotide 3'-phosphodiesterase.

PubMed ID: 8392017

DOI: 10.1016/0378-1119(93)90283-9

PubMed ID: 1360194

Title: Structure and chromosomal localization of the human 2',3'-cyclic nucleotide 3'-phosphodiesterase gene.

PubMed ID: 1360194

DOI: 10.1111/j.1469-1809.1992.tb01149.x

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9268698

Title: The epitope recognized by a monoclonal antibody in the myelin-associated protein CNP.

PubMed ID: 9268698

DOI: 10.1006/bbrc.1997.7125

PubMed ID: 12643545

Title: Proteomic analysis of early melanosomes: identification of novel melanosomal proteins.

PubMed ID: 12643545

DOI: 10.1021/pr025562r

PubMed ID: 17081065

Title: Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.

PubMed ID: 17081065

DOI: 10.1021/pr060363j

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 15713463

Title: Crystal structure of the catalytic fragment of human brain 2',3'-cyclic-nucleotide 3'-phosphodiesterase.

PubMed ID: 15713463

DOI: 10.1016/j.jmb.2004.12.024

PubMed ID: 32128616

Title: CNP deficiency causes severe hypomyelinating leukodystrophy in humans.

PubMed ID: 32128616

DOI: 10.1007/s00439-020-02144-4

Sequence Information:

  • Length: 421
  • Mass: 47579
  • Checksum: CA6D0097DFD87255
  • Sequence:
    • MNRGFSRKSH TFLPKIFFRK MSSSGAKDKP ELQFPFLQDE DTVATLLECK TLFILRGLPG 
SGKSTLARVI VDKYRDGTKM VSADAYKITP GARGAFSEEY KRLDEDLAAY CRRRDIRILV 
LDDTNHERER LEQLFEMADQ YQYQVVLVEP KTAWRLDCAQ LKEKNQWQLS ADDLKKLKPG 
LEKDFLPLYF GWFLTKKSSE TLRKAGQVFL EELGNHKAFK KELRQFVPGD EPREKMDLVT 
YFGKRPPGVL HCTTKFCDYG KAPGAEEYAQ QDVLKKSYSK AFTLTISALF VTPKTTGARV 
ELSEQQLQLW PSDVDKLSPT DNLPRGSRAH ITLGCAADVE AVQTGLDLLE ILRQEKGGSR 
GEEVGELSRG KLYSLGNGRW MLTLAKNMEV RAIFTGYYGK GKPVPTQGSR KGGALQSCTI 
I

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.