Details for: CNP

Gene ID: 1267

Symbol: CNP

Ensembl ID: ENSG00000173786

Description: 2',3'-cyclic nucleotide 3' phosphodiesterase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 151.9815
    Cell Significance Index: -23.6400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 101.0868
    Cell Significance Index: -25.6400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 62.2084
    Cell Significance Index: -29.3700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 58.2267
    Cell Significance Index: -23.6600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 52.0427
    Cell Significance Index: -26.7700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 22.7664
    Cell Significance Index: -28.0700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.5650
    Cell Significance Index: -32.4500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.7765
    Cell Significance Index: -26.1900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.2782
    Cell Significance Index: -28.7200
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 3.9334
    Cell Significance Index: 63.1100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.5800
    Cell Significance Index: 256.9800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.3403
    Cell Significance Index: 1210.1800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8943
    Cell Significance Index: 97.2800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.8190
    Cell Significance Index: 28.4600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.7167
    Cell Significance Index: 12.0000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7104
    Cell Significance Index: 42.6500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6602
    Cell Significance Index: 90.6600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.5176
    Cell Significance Index: 32.6200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4737
    Cell Significance Index: 60.7200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4063
    Cell Significance Index: 47.9200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3853
    Cell Significance Index: 210.4300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.3580
    Cell Significance Index: 4.8900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.3520
    Cell Significance Index: 18.4800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3469
    Cell Significance Index: 153.3600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3264
    Cell Significance Index: 64.7800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2940
    Cell Significance Index: 18.9700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2829
    Cell Significance Index: 6.1300
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.2766
    Cell Significance Index: 3.8800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2698
    Cell Significance Index: 54.1300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2413
    Cell Significance Index: 43.5000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2136
    Cell Significance Index: 21.1300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2121
    Cell Significance Index: 9.8900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2036
    Cell Significance Index: 9.2300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1957
    Cell Significance Index: 13.5400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1910
    Cell Significance Index: 23.4800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1869
    Cell Significance Index: 9.7100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1577
    Cell Significance Index: 56.5600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1326
    Cell Significance Index: 6.2300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1097
    Cell Significance Index: 3.1600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0974
    Cell Significance Index: 6.8900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0953
    Cell Significance Index: 3.3500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0495
    Cell Significance Index: 9.4200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0461
    Cell Significance Index: 5.9600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0364
    Cell Significance Index: 26.7100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0060
    Cell Significance Index: -11.1200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0066
    Cell Significance Index: -12.3500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0130
    Cell Significance Index: -20.0400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0180
    Cell Significance Index: -13.5900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0203
    Cell Significance Index: -27.6000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0253
    Cell Significance Index: -0.6900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0269
    Cell Significance Index: -17.0700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0279
    Cell Significance Index: -20.6600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0295
    Cell Significance Index: -2.2000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0434
    Cell Significance Index: -24.4600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0488
    Cell Significance Index: -3.0000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0510
    Cell Significance Index: -31.8400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0534
    Cell Significance Index: -24.2300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0540
    Cell Significance Index: -5.5200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0572
    Cell Significance Index: -1.2000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0678
    Cell Significance Index: -7.7700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0884
    Cell Significance Index: -15.0900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0963
    Cell Significance Index: -1.7800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1034
    Cell Significance Index: -29.7400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1053
    Cell Significance Index: -2.7700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1243
    Cell Significance Index: -14.4800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1507
    Cell Significance Index: -21.9100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1538
    Cell Significance Index: -32.3900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1609
    Cell Significance Index: -12.7400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1658
    Cell Significance Index: -5.3100
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.1772
    Cell Significance Index: -1.9000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1835
    Cell Significance Index: -12.3400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1996
    Cell Significance Index: -4.9900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2090
    Cell Significance Index: -5.8400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2158
    Cell Significance Index: -12.1100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2188
    Cell Significance Index: -5.5900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2381
    Cell Significance Index: -2.4700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2583
    Cell Significance Index: -5.5000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2769
    Cell Significance Index: -28.8300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3330
    Cell Significance Index: -25.5600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3434
    Cell Significance Index: -9.1700
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.3444
    Cell Significance Index: -2.7500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3630
    Cell Significance Index: -9.7100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4016
    Cell Significance Index: -20.9200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4214
    Cell Significance Index: -12.0800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4240
    Cell Significance Index: -12.4900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.4253
    Cell Significance Index: -5.0700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.4392
    Cell Significance Index: -12.9000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4712
    Cell Significance Index: -28.8900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.4869
    Cell Significance Index: -8.6100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.5736
    Cell Significance Index: -16.3700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.5745
    Cell Significance Index: -5.2900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.5751
    Cell Significance Index: -4.6900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.5810
    Cell Significance Index: -4.8800
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.5823
    Cell Significance Index: -4.4800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.5958
    Cell Significance Index: -10.2100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.6097
    Cell Significance Index: -22.3800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.6534
    Cell Significance Index: -28.9000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.6922
    Cell Significance Index: -16.6000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.7137
    Cell Significance Index: -9.1400
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.7375
    Cell Significance Index: -11.7000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CNP is a metallophosphodiesterase that specifically hydrolyzes cyclic nucleotides, such as cyclic AMP (cAMP) and cyclic GMP (cGMP). This enzyme catalyzes the degradation of these secondary messengers, regulating their levels and subsequent signaling cascades. CNP is characterized by its high specificity for 2',3'-cyclic nucleotides, allowing it to modulate the activity of various signaling pathways. **Pathways and Functions:** CNP is involved in several critical cellular processes, including: 1. **Immune response:** CNP regulates the production of pro-inflammatory cytokines and modulates the activity of immune cells, such as macrophages and T cells. 2. **Neuronal development and synaptic transmission:** CNP influences the development and maturation of neurons, as well as the regulation of synaptic plasticity and neurotransmitter release. 3. **Circadian rhythm regulation:** CNP has been implicated in the regulation of circadian rhythms, influencing the expression of clock genes and the timing of physiological processes. 4. **Cell migration and differentiation:** CNP modulates the activity of enzymes involved in cell migration and differentiation, such as matrix metalloproteinases and Wnt/β-catenin signaling. **Signaling pathways:** CNP interacts with various signaling molecules, including: 1. **G-proteins:** CNP regulates the activity of G-proteins, which are crucial for transmitting signals from G-protein-coupled receptors. 2. **Mitogen-activated protein kinase (MAPK) pathways:** CNP modulates the activity of MAPK pathways, influencing cell proliferation, differentiation, and survival. 3. **Nuclear factor kappa B (NF-κB) signaling:** CNP regulates the activity of NF-κB, a transcription factor involved in immune response and inflammation. **Significantly expressed cells:** CNP is expressed in a wide range of cell types, including: 1. **Oligodendrocytes:** CNP is expressed in oligodendrocytes, the myelinating cells of the central nervous system. 2. **Neural crest cells:** CNP is expressed in neural crest cells, which give rise to various cell types, including neurons, glial cells, and melanocytes. 3. **Enteric neurons:** CNP is expressed in enteric neurons, which regulate gut motility and secretion. **Clinical significance:** Dysregulation of CNP has been implicated in various diseases, including: 1. **Neurodegenerative disorders:** CNP dysregulation has been linked to neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 2. **Inflammatory disorders:** CNP dysregulation has been implicated in inflammatory disorders, such as multiple sclerosis and rheumatoid arthritis. 3. **Circadian rhythm disorders:** CNP dysregulation has been linked to circadian rhythm disorders, such as delayed sleep phase syndrome and non-24-hour sleep-wake disorder. In conclusion, CNP is a multifunctional enzyme that plays a crucial role in various cellular processes, including immune response, neuronal development, and synaptic transmission. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding the complex interplay between CNP and other signaling molecules. Further research is needed to elucidate the mechanisms underlying CNP's functions and to explore its therapeutic potential in treating diseases.

Genular Protein ID: 1016882423

Symbol: CN37_HUMAN

Name: N/A

UniProtKB Accession Codes:

P09543

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChEBI 4 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 16 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 27 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 3 Rhea 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1385234

Title: 2',3'-cyclic nucleotide-3'-phosphohydrolase and signal transduction in central nervous system myelin.

PubMed ID: 1385234

DOI: 10.1042/bst0200621

PubMed ID: 2835044

Title: cDNA cloning and amino acid sequence of human brain 2',3'-cyclic-nucleotide 3'-phosphodiesterase.

PubMed ID: 2835044

DOI: 10.1016/s0006-291x(88)80114-1

PubMed ID: 8392017

Title: Structure, expression and chromosomal localization of the gene encoding human 2',3'-cyclic-nucleotide 3'-phosphodiesterase.

PubMed ID: 8392017

DOI: 10.1016/0378-1119(93)90283-9

PubMed ID: 1360194

Title: Structure and chromosomal localization of the human 2',3'-cyclic nucleotide 3'-phosphodiesterase gene.

PubMed ID: 1360194

DOI: 10.1111/j.1469-1809.1992.tb01149.x

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9268698

Title: The epitope recognized by a monoclonal antibody in the myelin-associated protein CNP.

PubMed ID: 9268698

DOI: 10.1006/bbrc.1997.7125

PubMed ID: 12643545

Title: Proteomic analysis of early melanosomes: identification of novel melanosomal proteins.

PubMed ID: 12643545

DOI: 10.1021/pr025562r

PubMed ID: 17081065

Title: Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.

PubMed ID: 17081065

DOI: 10.1021/pr060363j

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 15713463

Title: Crystal structure of the catalytic fragment of human brain 2',3'-cyclic-nucleotide 3'-phosphodiesterase.

PubMed ID: 15713463

DOI: 10.1016/j.jmb.2004.12.024

PubMed ID: 32128616

Title: CNP deficiency causes severe hypomyelinating leukodystrophy in humans.

PubMed ID: 32128616

DOI: 10.1007/s00439-020-02144-4

Sequence Information:

  • Length: 421
  • Mass: 47579
  • Checksum: CA6D0097DFD87255
  • Sequence:
    • MNRGFSRKSH TFLPKIFFRK MSSSGAKDKP ELQFPFLQDE DTVATLLECK TLFILRGLPG 
SGKSTLARVI VDKYRDGTKM VSADAYKITP GARGAFSEEY KRLDEDLAAY CRRRDIRILV 
LDDTNHERER LEQLFEMADQ YQYQVVLVEP KTAWRLDCAQ LKEKNQWQLS ADDLKKLKPG 
LEKDFLPLYF GWFLTKKSSE TLRKAGQVFL EELGNHKAFK KELRQFVPGD EPREKMDLVT 
YFGKRPPGVL HCTTKFCDYG KAPGAEEYAQ QDVLKKSYSK AFTLTISALF VTPKTTGARV 
ELSEQQLQLW PSDVDKLSPT DNLPRGSRAH ITLGCAADVE AVQTGLDLLE ILRQEKGGSR 
GEEVGELSRG KLYSLGNGRW MLTLAKNMEV RAIFTGYYGK GKPVPTQGSR KGGALQSCTI 
I

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.