Genular: Defining Cellular Identity and Function

Details for: Chrm3

Gene ID: 12671

Symbol: Chrm3

Ensembl ID: ENSMUSG00000046159

Description: cholinergic receptor, muscarinic 3, cardiac

Associated with

Amine ligand-binding receptors
(R-MMU-375280)
Class a/1 (rhodopsin-like receptors)
(R-MMU-373076)
G alpha (q) signalling events
(R-MMU-416476)
Gpcr downstream signalling
(R-MMU-388396)
Gpcr ligand binding
(R-MMU-500792)
Muscarinic acetylcholine receptors
(R-MMU-390648)
Signaling by gpcr
(R-MMU-372790)
Acetylcholine binding
(GO:0042166)
Acetylcholine receptor signaling pathway
(GO:0095500)
Adenylate cyclase-inhibiting g protein-coupled acetylcholine receptor signaling pathway
(GO:0007197)
Asymmetric synapse
(GO:0032279)
Axon terminus
(GO:0043679)
Basal plasma membrane
(GO:0009925)
Calcium-mediated signaling
(GO:0019722)
Chemical synaptic transmission
(GO:0007268)
Dendrite
(GO:0030425)
Endoplasmic reticulum
(GO:0005783)
Glutamatergic synapse
(GO:0098978)
G protein-coupled acetylcholine receptor activity
(GO:0016907)
G protein-coupled acetylcholine receptor binding
(GO:0031789)
G protein-coupled acetylcholine receptor signaling pathway
(GO:0007213)
G protein-coupled receptor activity
(GO:0004930)
G protein-coupled receptor signaling pathway
(GO:0007186)
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
(GO:0007187)
G protein-coupled serotonin receptor activity
(GO:0004993)
Ion channel modulating, g protein-coupled receptor signaling pathway
(GO:0099105)
Ligand-gated ion channel signaling pathway
(GO:1990806)
Membrane
(GO:0016020)
Negative regulation of heart rate by acetylcholine
(GO:0003063)
Phospholipase c-activating g protein-coupled acetylcholine receptor signaling pathway
(GO:0007207)
Plasma membrane
(GO:0005886)
Positive regulation of insulin secretion
(GO:0032024)
Positive regulation of smooth muscle contraction
(GO:0045987)
Positive regulation of vascular associated smooth muscle contraction
(GO:1904695)
Positive regulation of vasoconstriction
(GO:0045907)
Postsynaptic density membrane
(GO:0098839)
Postsynaptic membrane
(GO:0045211)
Presynaptic membrane
(GO:0042734)
Protein binding
(GO:0005515)
Quaternary ammonium group binding
(GO:0050997)
Regulation of monoatomic ion transmembrane transporter activity
(GO:0032412)
Regulation of vascular associated smooth muscle contraction
(GO:0003056)
Response to acetylcholine
(GO:1905144)
Saliva secretion
(GO:0046541)
Signal transduction
(GO:0007165)
Smooth muscle contraction
(GO:0006939)
Synapse
(GO:0045202)
Synaptic transmission, cholinergic
(GO:0007271)

Other Information

Proteins

Muscarinic acetylcholine receptor M3

Genular Protein ID: 949731168

Symbol: ACM3_MOUSE

Name: Muscarinic acetylcholine receptor M3

UniProtKB Accession Codes:

Q9ERZ3 Q64055

Database IDs:

Citations:

PubMed ID: 7874308

Title: Cultured neurons from mouse brain reproduce the muscarinic receptor profile of their tissue of origin.

PubMed ID: 7874308

DOI: 10.1111/j.1460-9568.1994.tb00561.x

PubMed ID: 19575010

Title: The NALCN ion channel is activated by M3 muscarinic receptors in a pancreatic beta-cell line.

PubMed ID: 19575010

DOI: 10.1038/embor.2009.125

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21056967

Title: Regulation of M(3) muscarinic receptor expression and function by transmembrane protein 147.

PubMed ID: 21056967

DOI: 10.1124/mol.110.067363

Sequence Information:

Length: 589
Mass: 66212
Checksum: AB782149EBEE7804
Sequence:

MTLHSNSTTS PLFPNISSSW VHSPSEAGLP LGTVSQLDSY NISQTSGNFS SNDTSSDPLG 
GHTIWQVVFI AFLTGFLALV TIIGNILVIV AFKVNKQLKT VNNYFLLSLA CADLIIGVIS 
MNLFTTYIIM NRWALGNLAC DLWLSIDYVA SNASVMNLLV ISFDRYFSIT RPLTYRAKRT 
TKRAGVMIGL AWVISFVLWA PAILFWQYFV GKRTVPPGEC FIQFLSEPTI TFGTAIAAFY 
MPVTIMTILY WRIYKETEKR TKELAGLQAS GTEAEAENFV HPTGSSRSCS SYELQQQGTK 
RSSRRKYGGC HFWFTTKSWK PSAEQMDQDH SSSDSWNNND AAASLENSAS SDEEDIGSET 
RAIYSIVLKL PGHSTILNST KLPSSDNLQV PDKDLGTMDV ERNAHKLQAQ KSMDDRDNCQ 
KDFSKLPIQL ESAVDTAKTS DTNSSVDKTT AALPLSFKEA TLAKRFALKT RSQITKRKRM 
SLIKEKKAAQ TLSAILLAFI ITWTPYNIMV LVNTFCDSCI PKTYWNLGYW LCYINSTVNP 
VCYALCNKTF RTTFKMLLLC QCDKRKRRKQ QYQQRQSVIF HKRVPEQAL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Chrm3

Associated with

Other Information

Cultured neurons from mouse brain reproduce the muscarinic receptor profile of their tissue of origin. PubMed ID: 7874308

The NALCN ion channel is activated by M3 muscarinic receptors in a pancreatic beta-cell line. PubMed ID: 19575010

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Regulation of M(3) muscarinic receptor expression and function by transmembrane protein 147. PubMed ID: 21056967

Database document:

PubMed ID: 7874308

PubMed ID: 19575010

PubMed ID: 21183079

PubMed ID: 21056967