Details for: Vsx2

Gene ID: 12677

Symbol: Vsx2

Ensembl ID: ENSMUSG00000021239

Description: visual system homeobox 2

Associated with

  • Camera-type eye development
    (GO:0043010)
  • Cell fate commitment
    (GO:0045165)
  • Cell population proliferation
    (GO:0008283)
  • Cytoplasm
    (GO:0005737)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Dna binding
    (GO:0003677)
  • Intracellular anatomical structure
    (GO:0005622)
  • Multicellular organism development
    (GO:0007275)
  • Negative regulation of neuroblast proliferation
    (GO:0007406)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Neuroblast proliferation
    (GO:0007405)
  • Nucleus
    (GO:0005634)
  • Positive regulation of cell population proliferation
    (GO:0008284)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Response to stimulus
    (GO:0050896)
  • Retinal bipolar neuron differentiation
    (GO:0060040)
  • Retina morphogenesis in camera-type eye
    (GO:0060042)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Visual perception
    (GO:0007601)

Other Information

Genular Protein ID: 4291160540

Symbol: VSX2_MOUSE

Name: Visual system homeobox 2

UniProtKB Accession Codes:

Q61412

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 Ensembl 1 ExpressionAtlas 1 GO 18 Gene3D 1 GeneTree 1 Genevisible 1 GlyGen 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MGI 2 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 4 PROSITE-ProRule 3 PaxDb 1 Pfam 2 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 7914735

Title: Developmental expression of a novel murine homeobox gene (Chx10): evidence for roles in determination of the neuroretina and inner nuclear layer.

PubMed ID: 7914735

DOI: 10.1016/0896-6273(94)90354-9

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8630490

Title: Ocular retardation mouse caused by Chx10 homeobox null allele: impaired retinal progenitor proliferation and bipolar cell differentiation.

PubMed ID: 8630490

DOI: 10.1038/ng0496-376

PubMed ID: 16236706

Title: CHX10 targets a subset of photoreceptor genes.

PubMed ID: 16236706

DOI: 10.1074/jbc.m509470200

PubMed ID: 16547132

Title: Chx10 is required to block photoreceptor differentiation but is dispensable for progenitor proliferation in the postnatal retina.

PubMed ID: 16547132

DOI: 10.1073/pnas.0600083103

PubMed ID: 17919464

Title: Negative regulation of Vsx1 by its paralog Chx10/Vsx2 is conserved in the vertebrate retina.

PubMed ID: 17919464

DOI: 10.1016/j.brainres.2007.06.007

PubMed ID: 18417110

Title: Vsx2/Chx10 ensures the correct timing and magnitude of Hedgehog signaling in the mouse retina.

PubMed ID: 18417110

DOI: 10.1016/j.ydbio.2008.02.055

PubMed ID: 18539116

Title: A regulatory network to segregate the identity of neuronal subtypes.

PubMed ID: 18539116

DOI: 10.1016/j.devcel.2008.03.021

PubMed ID: 19843539

Title: The homeobox gene CHX10/VSX2 regulates RdCVF promoter activity in the inner retina.

PubMed ID: 19843539

DOI: 10.1093/hmg/ddp484

PubMed ID: 23028343

Title: Vsx2 controls eye organogenesis and retinal progenitor identity via homeodomain and non-homeodomain residues required for high affinity DNA binding.

PubMed ID: 23028343

DOI: 10.1371/journal.pgen.1002924

PubMed ID: 27477290

Title: Chx10 Consolidates V2a Interneuron Identity through Two Distinct Gene Repression Modes.

PubMed ID: 27477290

DOI: 10.1016/j.celrep.2016.06.100

Sequence Information:

  • Length: 361
  • Mass: 39436
  • Checksum: 2DB7FF7F8C7BE0AA
  • Sequence:
    • MTGKAGEALS KPKSETVAKS TSGGAPARCT GFGIQEILGL NKEPPSSHPR AALDGLAPGH 
LLAARSVLSP AGVGSMGLLG PGGLPGFYTQ PTFLEVLSDP QSVHLQPLGR ASGPLDTSQT 
ASSDSEDVSS SDRKMSKSAL NQTKKRKKRR HRTIFTSYQL EELEKAFNEA HYPDVYAREM 
LAMKTELPED RIQVWFQNRR AKWRKREKCW GRSSVMAEYG LYGAMVRHSI PLPESILKSA 
KDGIMDSCAP WLLGMHKKSL EAAAESGRKP EVERQALPKL DKMEQEERAP EAQAAISQEE 
LRENSIAALR AKAQEHSTKV LGTVSGPDSL ARNAEKPEEE DATEEDRPAE KLSPPQLEDM 
A

Genular Protein ID: 3176011191

Symbol: Q6PDC1_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q6PDC1

Database IDs:

AGR 1 ARBA 14 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 5 Gene3D 1 GeneTree 1 HOGENOM 1 InterPro 5 MGI 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 7 PROSITE-ProRule 1 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 RuleBase 1 SAM 1 SMART 1 SMR 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

  • Length: 380
  • Mass: 41807
  • Checksum: 870527A31F41E38E
  • Sequence:
    • MTGKAGEALS KPKSETVAKS TSGGAPARCT GFGIQEILGL NKEPPSSHPR AALDGLAPGH 
LLAARSVLSP AGVGSMGLLG PGGLPGFYTQ PTFLEVLSDP QSVHLQPLGR ASGPLDTSQT 
ASSDSEDVSS SDRKMSKSAL NQTKKRKKRR HRTIFTSYQL EELEKAFNEA HYPDVYAREM 
LAMKTELPED RIQVWFQNRR AKWRKREKCW GRSSVMAEYG LYGAMVRHSI PLPESILKSA 
KDGIMDSCAP WLLVQDGFPR RFSKPEYQQF FLGMHKKSLE AAAESGRKPE VERQALPKLD 
KMEQEERAPE AQAAISQEEL RENSIAALRA KAQEHSTKVL GTVSGPDSLA RNAEKPEEED 
ATEEDRPAEK LSPPQLEDMA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.