Details for: CNR1

Gene ID: 1268

Symbol: CNR1

Ensembl ID: ENSG00000118432

Description: cannabinoid receptor 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 4.63
    Marker Score: 2439
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.67
    Marker Score: 20475
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 2.4
    Marker Score: 5520
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.26
    Marker Score: 8754
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 2.1
    Marker Score: 11039
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.02
    Marker Score: 76658
  • Cell Name: granule cell (CL0000120)
    Fold Change: 2.01
    Marker Score: 15119
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.93
    Marker Score: 805
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 1.62
    Marker Score: 5440
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1171
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.55
    Marker Score: 23220
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.48
    Marker Score: 2284
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 169191
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 1.44
    Marker Score: 7711
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.41
    Marker Score: 13439
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 870
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.32
    Marker Score: 44526.5
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.3
    Marker Score: 525
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 1.28
    Marker Score: 743
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.22
    Marker Score: 24180
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.19
    Marker Score: 5491
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.18
    Marker Score: 397
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.17
    Marker Score: 4850
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4813
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.11
    Marker Score: 68552
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.11
    Marker Score: 1247
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.01
    Marker Score: 4192
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71822.5
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48047
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 0.99
    Marker Score: 478
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.99
    Marker Score: 3835
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.99
    Marker Score: 409
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 508
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 462
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.96
    Marker Score: 1813
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.94
    Marker Score: 528
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5347
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.93
    Marker Score: 997
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 373
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2739
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 325
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5287
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.86
    Marker Score: 1756
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.86
    Marker Score: 332
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.85
    Marker Score: 31446
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1263
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 592
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.77
    Marker Score: 6635
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 703
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 396
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.71
    Marker Score: 2886
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.69
    Marker Score: 7087
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.68
    Marker Score: 401
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.65
    Marker Score: 1085
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.64
    Marker Score: 384
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6
    Marker Score: 384
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.58
    Marker Score: 466
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.57
    Marker Score: 3802
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.57
    Marker Score: 8899
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.56
    Marker Score: 1150.5
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.52
    Marker Score: 3406
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.52
    Marker Score: 280
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.51
    Marker Score: 4806
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.5
    Marker Score: 288.5
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 475
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.48
    Marker Score: 4846
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.41
    Marker Score: 651
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.4
    Marker Score: 191
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.4
    Marker Score: 192
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.39
    Marker Score: 160
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.39
    Marker Score: 183
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.38
    Marker Score: 167
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 371
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.33
    Marker Score: 353
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 0.33
    Marker Score: 100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.32
    Marker Score: 102
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 0.29
    Marker Score: 83
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.29
    Marker Score: 582
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.26
    Marker Score: 176.5
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.26
    Marker Score: 82
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.26
    Marker Score: 145
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.26
    Marker Score: 317
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.26
    Marker Score: 319
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.25
    Marker Score: 2581
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.24
    Marker Score: 139
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.24
    Marker Score: 3860
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.24
    Marker Score: 127.5
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.23
    Marker Score: 535
  • Cell Name: visceromotor neuron (CL0005025)
    Fold Change: 0.23
    Marker Score: 66
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.22
    Marker Score: 66
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.22
    Marker Score: 623
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.21
    Marker Score: 266
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.21
    Marker Score: 111
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.21
    Marker Score: 363

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Other Information

## Summary CNR1 is a G protein-coupled receptor (GPCR) that plays a crucial role in the regulation of various physiological processes, including inflammation, memory, and neuronal development. It is expressed in a wide range of cell types, including hematopoietic stem cells, neurons, and immune cells. ## Key characteristics * CNR1 is a member of the GPCR superfamily, which are ligand-gated ion channels or receptors that are activated by the binding of endogenous or exogenous ligands. * It is a type of rhodopsin-like GPCR, which are characterized by the presence of a conserved cysteine-rich domain. * CNR1 is a negatively regulated protein, meaning that its activity is inhibited by the binding of an endogenous ligand. * It is a key regulator of the inflammatory response, and its expression is upregulated in conditions such as spinal cord injury, arthritis, and sepsis. * It is also involved in memory formation and learning, and its expression is altered in conditions such as Alzheimer's disease. ## Pathways and functions * CNR1 is involved in the regulation of inflammation through its interaction with cannabinoids, which are endogenous ligands for GPCRs. * It is also involved in the regulation of memory through its interaction with the neurotransmitter serotonin. * It is involved in the development and maintenance of the nervous system, and its expression is altered in conditions such as autism and schizophrenia. ## Clinical significance * Mutations in CNR1 have been linked to a number of neurological and psychiatric disorders, including schizophrenia, autism, and epilepsy. * CNR1 blockers are being investigated as potential treatments for these disorders. ## Conclusion CNR1 is a key regulator of inflammation, memory, and neuronal development. Its expression and activity are altered in a variety of diseases, suggesting that it may play a role in the development of these disorders. Further research is needed to understand the role of CNR1 in health and disease.

Genular Protein ID: 258803468

Symbol: CNR1_HUMAN

Name: Cannabinoid receptor 1

UniProtKB Accession Codes:

P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 13 DrugCentral 1 EMBL 20 EMDB 3 Ensembl 6 EvolutionaryTrace 1 ExpressionAtlas 1 GO 46 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 24 PDBsum 18 PIR 1 PIRSF 1 PRINTS 3 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 2 RefSeq 13 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 SwissPalm 1 TCDB 1 TreeFam 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2263478

Title: Nucleotide sequence of a human cannabinoid receptor cDNA.

PubMed ID: 2263478

DOI: 10.1093/nar/18.23.7142

PubMed ID: 1718258

Title: Molecular cloning of a human cannabinoid receptor which is also expressed in testis.

PubMed ID: 1718258

DOI: 10.1042/bj2790129

PubMed ID: 7876112

Title: An amino-terminal variant of the central cannabinoid receptor resulting from alternative splicing.

PubMed ID: 7876112

DOI: 10.1074/jbc.270.8.3726

PubMed ID: 15620723

Title: Identification and characterisation of a novel splice variant of the human CB1 receptor.

PubMed ID: 15620723

DOI: 10.1016/j.febslet.2004.11.085

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 32549916

Title: Targeting the endocannabinoid system: a predictive, preventive, and personalized medicine-directed approach to the management of brain pathologies.

PubMed ID: 32549916

DOI: 10.1007/s13167-020-00203-4

PubMed ID: 8255419

Title: Loss of cannabinoid receptors in the substantia nigra in Huntington's disease.

PubMed ID: 8255419

DOI: 10.1016/0306-4522(93)90352-g

PubMed ID: 10828533

Title: The pattern of neurodegeneration in Huntington's disease: a comparative study of cannabinoid, dopamine, adenosine and GABA(A) receptor alterations in the human basal ganglia in Huntington's disease.

PubMed ID: 10828533

DOI: 10.1016/s0306-4522(00)00008-7

PubMed ID: 17895407

Title: CB1 cannabinoid receptor activity is modulated by the cannabinoid receptor interacting protein CRIP 1a.

PubMed ID: 17895407

DOI: 10.1124/mol.107.039263

PubMed ID: 18077343

Title: Hemopressin is an inverse agonist of CB1 cannabinoid receptors.

PubMed ID: 18077343

DOI: 10.1073/pnas.0706980105

PubMed ID: 21895628

Title: Effects of palmitoylation of Cys(415) in helix 8 of the CB(1) cannabinoid receptor on membrane localization and signalling.

PubMed ID: 21895628

DOI: 10.1111/j.1476-5381.2011.01658.x

PubMed ID: 18177726

Title: The acyclic CB1R inverse agonist taranabant mediates weight loss by increasing energy expenditure and decreasing caloric intake.

PubMed ID: 18177726

DOI: 10.1016/j.cmet.2007.11.012

PubMed ID: 19524019

Title: Altered CB1 receptor and endocannabinoid levels precede motor symptom onset in a transgenic mouse model of Huntington's disease.

PubMed ID: 19524019

DOI: 10.1016/j.neuroscience.2009.06.014

PubMed ID: 23955712

Title: Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes.

PubMed ID: 23955712

DOI: 10.1038/nm.3265

PubMed ID: 30096288

Title: Genetic deletion of CB1 cannabinoid receptors exacerbates the Alzheimer-like symptoms in a transgenic animal model.

PubMed ID: 30096288

DOI: 10.1016/j.bcp.2018.08.007

PubMed ID: 31342135

Title: Regional changes in the type 1 cannabinoid receptor are associated with cognitive dysfunction in Parkinson's disease.

PubMed ID: 31342135

DOI: 10.1007/s00259-019-04445-x

PubMed ID: 12237474

Title: Cannabinoid receptor-G protein interactions: G(alphai1)-bound structures of IC3 and a mutant with altered G protein specificity.

PubMed ID: 12237474

DOI: 10.1110/ps.0218402

PubMed ID: 27768894

Title: Crystal structure of the human cannabinoid receptor CB1.

PubMed ID: 27768894

DOI: 10.1016/j.cell.2016.10.004

PubMed ID: 27851727

Title: High-resolution crystal structure of the human CB1 cannabinoid receptor.

PubMed ID: 27851727

DOI: 10.1038/nature20613

Sequence Information:

  • Length: 472
  • Mass: 52858
  • Checksum: 1D2E49061D12ABF2
  • Sequence:
    • MKSILDGLAD TTFRTITTDL LYVGSNDIQY EDIKGDMASK LGYFPQKFPL TSFRGSPFQE 
KMTAGDNPQL VPADQVNITE FYNKSLSSFK ENEENIQCGE NFMDIECFMV LNPSQQLAIA 
VLSLTLGTFT VLENLLVLCV ILHSRSLRCR PSYHFIGSLA VADLLGSVIF VYSFIDFHVF 
HRKDSRNVFL FKLGGVTASF TASVGSLFLT AIDRYISIHR PLAYKRIVTR PKAVVAFCLM 
WTIAIVIAVL PLLGWNCEKL QSVCSDIFPH IDETYLMFWI GVTSVLLLFI VYAYMYILWK 
AHSHAVRMIQ RGTQKSIIIH TSEDGKVQVT RPDQARMDIR LAKTLVLILV VLIICWGPLL 
AIMVYDVFGK MNKLIKTVFA FCSMLCLLNS TVNPIIYALR SKDLRHAFRS MFPSCEGTAQ 
PLDNSMGDSD CLHKHANNAA SVHRAAESCI KSTVKIAKVT MSVSTDTSAE AL

Genular Protein ID: 1653229834

Symbol: V5KA96_HUMAN

Name: N/A

UniProtKB Accession Codes:

V5KA96

Database IDs:

ARBA 17 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 ExpressionAtlas 1 GO 7 Gene3D 1 GenomeRNAi 1 HOGENOM 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRNR 1 PIRSF 1 PRINTS 3 PROSITE 3 Pfam 1 RefSeq 1 RuleBase 1 SAM 1 SMART 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Sequence Information:

  • Length: 439
  • Mass: 49060
  • Checksum: C80C6B8D640412C1
  • Sequence:
    • MKSILDGLAD TTFRTITTDL LGSPFQEKMT AGDNPQLVPA DQVNITEFYN KSLSSFKENE 
ENIQCGENFM DIECFMVLNP SQQLAIAVLS LTLGTFTVLE NLLVLCVILH SRSLRCRPSY 
HFIGSLAVAD LLGSVIFVYS FIDFHVFHRK DSRNVFLFKL GGVTASFTAS VGSLFLTAID 
RYISIHRPLA YKRIVTRPKA VVAFCLMWTI AIVIAVLPLL GWNCEKLQSV CSDIFPHIDE 
TYLMFWIGVT SVLLLFIVYA YMYILWKAHS HAVRMIQRGT QKSIIIHTSE DGKVQVTRPD 
QARMDIRLAK TLVLILVVLI ICWGPLLAIM VYDVFGKMNK LIKTVFAFCS MLCLLNSTVN 
PIIYALRSKD LRHAFRSMFP SCEGTAQPLD NSMGDSDCLH KHANNAASVH RAAESCIKST 
VKIAKVTMSV STDTSAEAL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.