CNR1 | ENSG00000118432 | NCBI 1268

Details for: CNR1

Gene ID: 1268

Symbol: CNR1

Ensembl ID: ENSG00000118432

Description: cannabinoid receptor 1

Associated with

Class a/1 (rhodopsin-like receptors)
(R-HSA-373076)
G alpha (i) signalling events
(R-HSA-418594)
Gpcr downstream signalling
(R-HSA-388396)
Gpcr ligand binding
(R-HSA-500792)
Signaling by gpcr
(R-HSA-372790)
Signal transduction
(R-HSA-162582)
Actin cytoskeleton
(GO:0015629)
Adenylate cyclase-activating g protein-coupled receptor signaling pathway
(GO:0007189)
Adenylate cyclase-modulating g protein-coupled receptor signaling pathway
(GO:0007188)
Axonal fasciculation
(GO:0007413)
Cannabinoid receptor activity
(GO:0004949)
Cannabinoid signaling pathway
(GO:0038171)
Cytoplasm
(GO:0005737)
Gaba-ergic synapse
(GO:0098982)
Glucose homeostasis
(GO:0042593)
Glutamatergic synapse
(GO:0098978)
G protein-coupled receptor activity
(GO:0004930)
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
(GO:0007187)
Growth cone
(GO:0030426)
Identical protein binding
(GO:0042802)
Maternal process involved in female pregnancy
(GO:0060135)
Membrane raft
(GO:0045121)
Memory
(GO:0007613)
Mitochondrial outer membrane
(GO:0005741)
Negative regulation of action potential
(GO:0045759)
Negative regulation of blood pressure
(GO:0045776)
Negative regulation of dopamine secretion
(GO:0033602)
Negative regulation of fatty acid beta-oxidation
(GO:0031999)
Negative regulation of mast cell activation
(GO:0033004)
Negative regulation of serotonin secretion
(GO:0014063)
Plasma membrane
(GO:0005886)
Positive regulation of acute inflammatory response to antigenic stimulus
(GO:0002866)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of blood pressure
(GO:0045777)
Positive regulation of fever generation
(GO:0031622)
Positive regulation of neuron projection development
(GO:0010976)
Presynaptic membrane
(GO:0042734)
Protein binding
(GO:0005515)
Regulation of feeding behavior
(GO:0060259)
Regulation of insulin secretion
(GO:0050796)
Regulation of metabolic process
(GO:0019222)
Regulation of penile erection
(GO:0060405)
Regulation of presynaptic cytosolic calcium ion concentration
(GO:0099509)
Regulation of synaptic transmission, gabaergic
(GO:0032228)
Regulation of synaptic transmission, glutamatergic
(GO:0051966)
Response to cocaine
(GO:0042220)
Response to ethanol
(GO:0045471)
Response to lipopolysaccharide
(GO:0032496)
Response to nicotine
(GO:0035094)
Response to nutrient
(GO:0007584)
Retrograde trans-synaptic signaling by endocannabinoid
(GO:0098921)
Spermatogenesis
(GO:0007283)
Trans-synaptic signaling by endocannabinoid, modulating synaptic transmission
(GO:0099553)

Other Information

Proteins

Cannabinoid receptor 1
V5KA96_HUMAN

Genular Protein ID: 258803468

Symbol: CNR1_HUMAN

Name: Cannabinoid receptor 1

UniProtKB Accession Codes:

P21554 B2R9T4 E1P512 Q13949 Q495Z0 Q4PLI4 Q4VBM6 Q5JVL5 Q5UB37 Q9UNN0

Database IDs:

Citations:

PubMed ID: 2263478

Title: Nucleotide sequence of a human cannabinoid receptor cDNA.

PubMed ID: 2263478

DOI: 10.1093/nar/18.23.7142

PubMed ID: 1718258

Title: Molecular cloning of a human cannabinoid receptor which is also expressed in testis.

PubMed ID: 1718258

DOI: 10.1042/bj2790129

PubMed ID: 7876112

Title: An amino-terminal variant of the central cannabinoid receptor resulting from alternative splicing.

PubMed ID: 7876112

DOI: 10.1074/jbc.270.8.3726

PubMed ID: 15620723

Title: Identification and characterisation of a novel splice variant of the human CB1 receptor.

PubMed ID: 15620723

DOI: 10.1016/j.febslet.2004.11.085

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 32549916

Title: Targeting the endocannabinoid system: a predictive, preventive, and personalized medicine-directed approach to the management of brain pathologies.

PubMed ID: 32549916

DOI: 10.1007/s13167-020-00203-4

PubMed ID: 8255419

Title: Loss of cannabinoid receptors in the substantia nigra in Huntington's disease.

PubMed ID: 8255419

DOI: 10.1016/0306-4522(93)90352-g

PubMed ID: 10828533

Title: The pattern of neurodegeneration in Huntington's disease: a comparative study of cannabinoid, dopamine, adenosine and GABA(A) receptor alterations in the human basal ganglia in Huntington's disease.

PubMed ID: 10828533

DOI: 10.1016/s0306-4522(00)00008-7

PubMed ID: 17895407

Title: CB1 cannabinoid receptor activity is modulated by the cannabinoid receptor interacting protein CRIP 1a.

PubMed ID: 17895407

DOI: 10.1124/mol.107.039263

PubMed ID: 18077343

Title: Hemopressin is an inverse agonist of CB1 cannabinoid receptors.

PubMed ID: 18077343

DOI: 10.1073/pnas.0706980105

PubMed ID: 21895628

Title: Effects of palmitoylation of Cys(415) in helix 8 of the CB(1) cannabinoid receptor on membrane localization and signalling.

PubMed ID: 21895628

DOI: 10.1111/j.1476-5381.2011.01658.x

PubMed ID: 18177726

Title: The acyclic CB1R inverse agonist taranabant mediates weight loss by increasing energy expenditure and decreasing caloric intake.

PubMed ID: 18177726

DOI: 10.1016/j.cmet.2007.11.012

PubMed ID: 19524019

Title: Altered CB1 receptor and endocannabinoid levels precede motor symptom onset in a transgenic mouse model of Huntington's disease.

PubMed ID: 19524019

DOI: 10.1016/j.neuroscience.2009.06.014

PubMed ID: 23955712

Title: Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes.

PubMed ID: 23955712

DOI: 10.1038/nm.3265

PubMed ID: 30096288

Title: Genetic deletion of CB1 cannabinoid receptors exacerbates the Alzheimer-like symptoms in a transgenic animal model.

PubMed ID: 30096288

DOI: 10.1016/j.bcp.2018.08.007

PubMed ID: 31342135

Title: Regional changes in the type 1 cannabinoid receptor are associated with cognitive dysfunction in Parkinson's disease.

PubMed ID: 31342135

DOI: 10.1007/s00259-019-04445-x

PubMed ID: 12237474

Title: Cannabinoid receptor-G protein interactions: G(alphai1)-bound structures of IC3 and a mutant with altered G protein specificity.

PubMed ID: 12237474

DOI: 10.1110/ps.0218402

PubMed ID: 27768894

Title: Crystal structure of the human cannabinoid receptor CB1.

PubMed ID: 27768894

DOI: 10.1016/j.cell.2016.10.004

PubMed ID: 27851727

Title: High-resolution crystal structure of the human CB1 cannabinoid receptor.

PubMed ID: 27851727

DOI: 10.1038/nature20613

Sequence Information:

Length: 472
Mass: 52858
Checksum: 1D2E49061D12ABF2
Sequence:

MKSILDGLAD TTFRTITTDL LYVGSNDIQY EDIKGDMASK LGYFPQKFPL TSFRGSPFQE 
KMTAGDNPQL VPADQVNITE FYNKSLSSFK ENEENIQCGE NFMDIECFMV LNPSQQLAIA 
VLSLTLGTFT VLENLLVLCV ILHSRSLRCR PSYHFIGSLA VADLLGSVIF VYSFIDFHVF 
HRKDSRNVFL FKLGGVTASF TASVGSLFLT AIDRYISIHR PLAYKRIVTR PKAVVAFCLM 
WTIAIVIAVL PLLGWNCEKL QSVCSDIFPH IDETYLMFWI GVTSVLLLFI VYAYMYILWK 
AHSHAVRMIQ RGTQKSIIIH TSEDGKVQVT RPDQARMDIR LAKTLVLILV VLIICWGPLL 
AIMVYDVFGK MNKLIKTVFA FCSMLCLLNS TVNPIIYALR SKDLRHAFRS MFPSCEGTAQ 
PLDNSMGDSD CLHKHANNAA SVHRAAESCI KSTVKIAKVT MSVSTDTSAE AL

Genular Protein ID: 1653229834

Symbol: V5KA96_HUMAN

Name: N/A

UniProtKB Accession Codes:

V5KA96

Database IDs:

Sequence Information:

Length: 439
Mass: 49060
Checksum: C80C6B8D640412C1
Sequence:

MKSILDGLAD TTFRTITTDL LGSPFQEKMT AGDNPQLVPA DQVNITEFYN KSLSSFKENE 
ENIQCGENFM DIECFMVLNP SQQLAIAVLS LTLGTFTVLE NLLVLCVILH SRSLRCRPSY 
HFIGSLAVAD LLGSVIFVYS FIDFHVFHRK DSRNVFLFKL GGVTASFTAS VGSLFLTAID 
RYISIHRPLA YKRIVTRPKA VVAFCLMWTI AIVIAVLPLL GWNCEKLQSV CSDIFPHIDE 
TYLMFWIGVT SVLLLFIVYA YMYILWKAHS HAVRMIQRGT QKSIIIHTSE DGKVQVTRPD 
QARMDIRLAK TLVLILVVLI ICWGPLLAIM VYDVFGKMNK LIKTVFAFCS MLCLLNSTVN 
PIIYALRSKD LRHAFRSMFP SCEGTAQPLD NSMGDSDCLH KHANNAASVH RAAESCIKST 
VKIAKVTMSV STDTSAEAL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CNR1

Associated with

Other Information

Nucleotide sequence of a human cannabinoid receptor cDNA. PubMed ID: 2263478

Molecular cloning of a human cannabinoid receptor which is also expressed in testis. PubMed ID: 1718258

An amino-terminal variant of the central cannabinoid receptor resulting from alternative splicing. PubMed ID: 7876112

Identification and characterisation of a novel splice variant of the human CB1 receptor. PubMed ID: 15620723

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and analysis of human chromosome 6. PubMed ID: 14574404

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Targeting the endocannabinoid system: a predictive, preventive, and personalized medicine-directed approach to the management of brain pathologies. PubMed ID: 32549916

Loss of cannabinoid receptors in the substantia nigra in Huntington's disease. PubMed ID: 8255419

The pattern of neurodegeneration in Huntington's disease: a comparative study of cannabinoid, dopamine, adenosine and GABA(A) receptor alterations in the human basal ganglia in Huntington's disease. PubMed ID: 10828533

CB1 cannabinoid receptor activity is modulated by the cannabinoid receptor interacting protein CRIP 1a. PubMed ID: 17895407

Hemopressin is an inverse agonist of CB1 cannabinoid receptors. PubMed ID: 18077343

Effects of palmitoylation of Cys(415) in helix 8 of the CB(1) cannabinoid receptor on membrane localization and signalling. PubMed ID: 21895628

The acyclic CB1R inverse agonist taranabant mediates weight loss by increasing energy expenditure and decreasing caloric intake. PubMed ID: 18177726

Altered CB1 receptor and endocannabinoid levels precede motor symptom onset in a transgenic mouse model of Huntington's disease. PubMed ID: 19524019

Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes. PubMed ID: 23955712

Genetic deletion of CB1 cannabinoid receptors exacerbates the Alzheimer-like symptoms in a transgenic animal model. PubMed ID: 30096288

Regional changes in the type 1 cannabinoid receptor are associated with cognitive dysfunction in Parkinson's disease. PubMed ID: 31342135

Cannabinoid receptor-G protein interactions: G(alphai1)-bound structures of IC3 and a mutant with altered G protein specificity. PubMed ID: 12237474

Crystal structure of the human cannabinoid receptor CB1. PubMed ID: 27768894

High-resolution crystal structure of the human CB1 cannabinoid receptor. PubMed ID: 27851727