Details for: CNR1
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 4.8963
Cell Significance Index: 1756.2200 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 3.6757
Cell Significance Index: 139.1900 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 2.9010
Cell Significance Index: 178.3100 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 2.8470
Cell Significance Index: 100.0400 - Cell Name: cortical interneuron (CL0008031)
Fold Change: 2.3838
Cell Significance Index: 57.1700 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 2.3725
Cell Significance Index: 104.9400 - Cell Name: hippocampal interneuron (CL1001569)
Fold Change: 2.2323
Cell Significance Index: 28.9500 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 1.2319
Cell Significance Index: 35.1600 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.7284
Cell Significance Index: 15.9500 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.6921
Cell Significance Index: 138.8400 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.6137
Cell Significance Index: 13.3000 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.5141
Cell Significance Index: 355.5800 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 0.4174
Cell Significance Index: 6.2900 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.3847
Cell Significance Index: 73.2100 - Cell Name: myometrial cell (CL0002366)
Fold Change: 0.2101
Cell Significance Index: 2.4200 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.2013
Cell Significance Index: 3.4500 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1861
Cell Significance Index: 18.4100 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.1829
Cell Significance Index: 165.1900 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 0.1113
Cell Significance Index: 1.3800 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.0956
Cell Significance Index: 15.5500 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.0452
Cell Significance Index: 8.1500 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: 0.0314
Cell Significance Index: 0.6300 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0014
Cell Significance Index: -0.0700 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0042
Cell Significance Index: -0.5200 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0055
Cell Significance Index: -10.4000 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: -0.0072
Cell Significance Index: -0.7800 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: -0.0121
Cell Significance Index: -5.3300 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0122
Cell Significance Index: -18.8100 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0134
Cell Significance Index: -10.1500 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0144
Cell Significance Index: -26.5800 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0171
Cell Significance Index: -23.2000 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0210
Cell Significance Index: -1.2900 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.0212
Cell Significance Index: -0.6100 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0245
Cell Significance Index: -15.5300 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0314
Cell Significance Index: -23.2900 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.0324
Cell Significance Index: -0.8100 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0423
Cell Significance Index: -23.8700 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0428
Cell Significance Index: -23.3500 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0434
Cell Significance Index: -19.6800 - Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0539
Cell Significance Index: -10.7100 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0576
Cell Significance Index: -16.5700 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0736
Cell Significance Index: -8.6800 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.0745
Cell Significance Index: -1.9600 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.0954
Cell Significance Index: -6.6000 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1064
Cell Significance Index: -15.4700 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1147
Cell Significance Index: -24.1600 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.1248
Cell Significance Index: -16.0000 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: -0.1291
Cell Significance Index: -7.7500 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.1339
Cell Significance Index: -9.4700 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.1381
Cell Significance Index: -2.7300 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.1415
Cell Significance Index: -24.1600 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1597
Cell Significance Index: -16.3200 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.1668
Cell Significance Index: -3.4600 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.1673
Cell Significance Index: -22.9800 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.1699
Cell Significance Index: -21.9500 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1735
Cell Significance Index: -20.2200 - Cell Name: neuron (CL0000540)
Fold Change: -0.1920
Cell Significance Index: -1.8200 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: -0.1936
Cell Significance Index: -3.8100 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.1990
Cell Significance Index: -5.5600 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2005
Cell Significance Index: -22.9700 - Cell Name: neural cell (CL0002319)
Fold Change: -0.2083
Cell Significance Index: -2.4300 - Cell Name: glutamatergic neuron (CL0000679)
Fold Change: -0.2084
Cell Significance Index: -2.2700 - Cell Name: GABAergic neuron (CL0000617)
Fold Change: -0.2130
Cell Significance Index: -2.6900 - Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -0.2143
Cell Significance Index: -1.8000 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2243
Cell Significance Index: -23.3600 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.2264
Cell Significance Index: -15.2200 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.2285
Cell Significance Index: -12.8200 - Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
Fold Change: -0.2327
Cell Significance Index: -4.6400 - Cell Name: inhibitory interneuron (CL0000498)
Fold Change: -0.2584
Cell Significance Index: -3.0900 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.2612
Cell Significance Index: -8.3700 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.2968
Cell Significance Index: -22.1200 - Cell Name: melanocyte of skin (CL1000458)
Fold Change: -0.3011
Cell Significance Index: -4.2200 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.3036
Cell Significance Index: -23.3000 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.3128
Cell Significance Index: -4.4800 - Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: -0.3166
Cell Significance Index: -2.0600 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.3176
Cell Significance Index: -6.7400 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.3297
Cell Significance Index: -10.5000 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.3408
Cell Significance Index: -21.4800 - Cell Name: decidual cell (CL2000002)
Fold Change: -0.3444
Cell Significance Index: -5.5300 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: -0.3514
Cell Significance Index: -3.5400 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.3552
Cell Significance Index: -16.5600 - Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: -0.3573
Cell Significance Index: -3.7300 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.3602
Cell Significance Index: -9.2600 - Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: -0.3659
Cell Significance Index: -6.2600 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.3908
Cell Significance Index: -4.4400 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.3938
Cell Significance Index: -9.5400 - Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
Fold Change: -0.3958
Cell Significance Index: -5.2800 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.3982
Cell Significance Index: -13.9500 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.3993
Cell Significance Index: -20.7400 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.4052
Cell Significance Index: -8.6300 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.4068
Cell Significance Index: -8.7900 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.4172
Cell Significance Index: -13.6600 - Cell Name: neural progenitor cell (CL0011020)
Fold Change: -0.4194
Cell Significance Index: -4.1500 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.4287
Cell Significance Index: -22.5100 - Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: -0.4405
Cell Significance Index: -3.8100 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.4534
Cell Significance Index: -21.3100 - Cell Name: intratelencephalic-projecting glutamatergic cortical neuron (CL4023008)
Fold Change: -0.4951
Cell Significance Index: -5.0900 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.4953
Cell Significance Index: -17.2100 - Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: -0.5139
Cell Significance Index: -4.8900 - Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
Fold Change: -0.5334
Cell Significance Index: -7.1100
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 258803468
Symbol: CNR1_HUMAN
Name: Cannabinoid receptor 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2263478
Title: Nucleotide sequence of a human cannabinoid receptor cDNA.
PubMed ID: 2263478
PubMed ID: 1718258
Title: Molecular cloning of a human cannabinoid receptor which is also expressed in testis.
PubMed ID: 1718258
DOI: 10.1042/bj2790129
PubMed ID: 7876112
Title: An amino-terminal variant of the central cannabinoid receptor resulting from alternative splicing.
PubMed ID: 7876112
PubMed ID: 15620723
Title: Identification and characterisation of a novel splice variant of the human CB1 receptor.
PubMed ID: 15620723
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 14574404
Title: The DNA sequence and analysis of human chromosome 6.
PubMed ID: 14574404
DOI: 10.1038/nature02055
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 32549916
Title: Targeting the endocannabinoid system: a predictive, preventive, and personalized medicine-directed approach to the management of brain pathologies.
PubMed ID: 32549916
PubMed ID: 8255419
Title: Loss of cannabinoid receptors in the substantia nigra in Huntington's disease.
PubMed ID: 8255419
PubMed ID: 10828533
Title: The pattern of neurodegeneration in Huntington's disease: a comparative study of cannabinoid, dopamine, adenosine and GABA(A) receptor alterations in the human basal ganglia in Huntington's disease.
PubMed ID: 10828533
PubMed ID: 17895407
Title: CB1 cannabinoid receptor activity is modulated by the cannabinoid receptor interacting protein CRIP 1a.
PubMed ID: 17895407
PubMed ID: 18077343
Title: Hemopressin is an inverse agonist of CB1 cannabinoid receptors.
PubMed ID: 18077343
PubMed ID: 21895628
Title: Effects of palmitoylation of Cys(415) in helix 8 of the CB(1) cannabinoid receptor on membrane localization and signalling.
PubMed ID: 21895628
PubMed ID: 18177726
Title: The acyclic CB1R inverse agonist taranabant mediates weight loss by increasing energy expenditure and decreasing caloric intake.
PubMed ID: 18177726
PubMed ID: 19524019
Title: Altered CB1 receptor and endocannabinoid levels precede motor symptom onset in a transgenic mouse model of Huntington's disease.
PubMed ID: 19524019
PubMed ID: 23955712
Title: Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes.
PubMed ID: 23955712
DOI: 10.1038/nm.3265
PubMed ID: 30096288
Title: Genetic deletion of CB1 cannabinoid receptors exacerbates the Alzheimer-like symptoms in a transgenic animal model.
PubMed ID: 30096288
PubMed ID: 31342135
Title: Regional changes in the type 1 cannabinoid receptor are associated with cognitive dysfunction in Parkinson's disease.
PubMed ID: 31342135
PubMed ID: 12237474
Title: Cannabinoid receptor-G protein interactions: G(alphai1)-bound structures of IC3 and a mutant with altered G protein specificity.
PubMed ID: 12237474
DOI: 10.1110/ps.0218402
PubMed ID: 27768894
Title: Crystal structure of the human cannabinoid receptor CB1.
PubMed ID: 27768894
PubMed ID: 27851727
Title: High-resolution crystal structure of the human CB1 cannabinoid receptor.
PubMed ID: 27851727
DOI: 10.1038/nature20613
Sequence Information:
- Length: 472
- Mass: 52858
- Checksum: 1D2E49061D12ABF2
- Sequence:
MKSILDGLAD TTFRTITTDL LYVGSNDIQY EDIKGDMASK LGYFPQKFPL TSFRGSPFQE KMTAGDNPQL VPADQVNITE FYNKSLSSFK ENEENIQCGE NFMDIECFMV LNPSQQLAIA VLSLTLGTFT VLENLLVLCV ILHSRSLRCR PSYHFIGSLA VADLLGSVIF VYSFIDFHVF HRKDSRNVFL FKLGGVTASF TASVGSLFLT AIDRYISIHR PLAYKRIVTR PKAVVAFCLM WTIAIVIAVL PLLGWNCEKL QSVCSDIFPH IDETYLMFWI GVTSVLLLFI VYAYMYILWK AHSHAVRMIQ RGTQKSIIIH TSEDGKVQVT RPDQARMDIR LAKTLVLILV VLIICWGPLL AIMVYDVFGK MNKLIKTVFA FCSMLCLLNS TVNPIIYALR SKDLRHAFRS MFPSCEGTAQ PLDNSMGDSD CLHKHANNAA SVHRAAESCI KSTVKIAKVT MSVSTDTSAE AL
Genular Protein ID: 1653229834
Symbol: V5KA96_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 439
- Mass: 49060
- Checksum: C80C6B8D640412C1
- Sequence:
MKSILDGLAD TTFRTITTDL LGSPFQEKMT AGDNPQLVPA DQVNITEFYN KSLSSFKENE ENIQCGENFM DIECFMVLNP SQQLAIAVLS LTLGTFTVLE NLLVLCVILH SRSLRCRPSY HFIGSLAVAD LLGSVIFVYS FIDFHVFHRK DSRNVFLFKL GGVTASFTAS VGSLFLTAID RYISIHRPLA YKRIVTRPKA VVAFCLMWTI AIVIAVLPLL GWNCEKLQSV CSDIFPHIDE TYLMFWIGVT SVLLLFIVYA YMYILWKAHS HAVRMIQRGT QKSIIIHTSE DGKVQVTRPD QARMDIRLAK TLVLILVVLI ICWGPLLAIM VYDVFGKMNK LIKTVFAFCS MLCLLNSTVN PIIYALRSKD LRHAFRSMFP SCEGTAQPLD NSMGDSDCLH KHANNAASVH RAAESCIKST VKIAKVTMSV STDTSAEAL
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.