Genular: Defining Cellular Identity and Function

Details for: Cidea

Gene ID: 12683

Symbol: Cidea

Ensembl ID: ENSMUSG00000024526

Description: cell death-inducing DNA fragmentation factor, alpha subunit-like effector A

Associated with

Lipid particle organization
(R-MMU-8964572)
Metabolism
(R-MMU-1430728)
Metabolism of lipids
(R-MMU-556833)
Apoptotic process
(GO:0006915)
Cellular response to cold
(GO:0070417)
Cytoplasm
(GO:0005737)
Lipid droplet
(GO:0005811)
Lipid droplet fusion
(GO:0160077)
Lipid metabolic process
(GO:0006629)
Lipid storage
(GO:0019915)
Lipid transfer activity
(GO:0120013)
Mitochondrial envelope
(GO:0005740)
Mitochondrion
(GO:0005739)
Negative regulation of cold-induced thermogenesis
(GO:0120163)
Negative regulation of cytokine production
(GO:0001818)
Negative regulation of execution phase of apoptosis
(GO:1900118)
Negative regulation of lipid catabolic process
(GO:0050995)
Negative regulation of transforming growth factor beta receptor signaling pathway
(GO:0030512)
Negative regulation of tumor necrosis factor production
(GO:0032720)
Nucleus
(GO:0005634)
Phosphatidic acid binding
(GO:0070300)
Positive regulation of sequestering of triglyceride
(GO:0010890)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Regulation of apoptotic dna fragmentation
(GO:1902510)
Regulation of apoptotic process
(GO:0042981)
Response to stilbenoid
(GO:0035634)
Temperature homeostasis
(GO:0001659)

Other Information

Proteins

CIDEA_MOUSE

Genular Protein ID: 296300144

Symbol: CIDEA_MOUSE

Name: N/A

UniProtKB Accession Codes:

O70302 Q4V9X2

Database IDs:

Citations:

PubMed ID: 9564035

Title: CIDE, a novel family of cell death activators with homology to the 45 kDa subunit of the DNA fragmentation factor.

PubMed ID: 9564035

DOI: 10.1093/emboj/17.9.2526

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12910269

Title: Cidea-deficient mice have lean phenotype and are resistant to obesity.

PubMed ID: 12910269

DOI: 10.1038/ng1225

PubMed ID: 18509062

Title: Cidea is associated with lipid droplets and insulin sensitivity in humans.

PubMed ID: 18509062

DOI: 10.1073/pnas.0802063105

PubMed ID: 20810722

Title: Identification of the lipid droplet targeting domain of the Cidea protein.

PubMed ID: 20810722

DOI: 10.1194/jlr.m009498

PubMed ID: 22144693

Title: Fsp27 promotes lipid droplet growth by lipid exchange and transfer at lipid droplet contact sites.

PubMed ID: 22144693

DOI: 10.1083/jcb.201104142

PubMed ID: 22245780

Title: Cidea is an essential transcriptional coactivator regulating mammary gland secretion of milk lipids.

PubMed ID: 22245780

DOI: 10.1038/nm.2614

PubMed ID: 26609809

Title: The brown adipocyte protein CIDEA promotes lipid droplet fusion via a phosphatidic acid-binding amphipathic helix.

PubMed ID: 26609809

DOI: 10.7554/elife.07485

PubMed ID: 26733203

Title: Differential roles of cell death-inducing DNA fragmentation factor-alpha-like effector (CIDE) proteins in promoting lipid droplet fusion and growth in subpopulations of hepatocytes.

PubMed ID: 26733203

DOI: 10.1074/jbc.m115.701094

PubMed ID: 36477540

Title: CLSTN3beta enforces adipocyte multilocularity to facilitate lipid utilization.

PubMed ID: 36477540

DOI: 10.1038/s41586-022-05507-1

Sequence Information:

Length: 217
Mass: 24669
Checksum: C9E406895CFD4CBA
Sequence:

METARDYAGA LIRPLTFMGL QTKKVLLTPL IHPARPFRVS NHDRSSRRGV MASSLQELIS 
KTLDVLVITT GLVTLVLEED GTVVDTEEFF QTLRDNTHFM ILEKGQKWTP GSKYVPVCKQ 
PKKSGIARVT FDLYRLNPKD FLGCLNVKAT MYEMYSVSYD IRCTSFKAVL RNLLRFMSYA 
AQMTGQFLVY AGTYMLRVLG DTEEQPSPKP STKGWFM

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Cidea

Associated with

Other Information

CIDE, a novel family of cell death activators with homology to the 45 kDa subunit of the DNA fragmentation factor. PubMed ID: 9564035

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Cidea-deficient mice have lean phenotype and are resistant to obesity. PubMed ID: 12910269

Cidea is associated with lipid droplets and insulin sensitivity in humans. PubMed ID: 18509062

Identification of the lipid droplet targeting domain of the Cidea protein. PubMed ID: 20810722

Fsp27 promotes lipid droplet growth by lipid exchange and transfer at lipid droplet contact sites. PubMed ID: 22144693

Cidea is an essential transcriptional coactivator regulating mammary gland secretion of milk lipids. PubMed ID: 22245780

The brown adipocyte protein CIDEA promotes lipid droplet fusion via a phosphatidic acid-binding amphipathic helix. PubMed ID: 26609809

Differential roles of cell death-inducing DNA fragmentation factor-alpha-like effector (CIDE) proteins in promoting lipid droplet fusion and growth in subpopulations of hepatocytes. PubMed ID: 26733203

CLSTN3beta enforces adipocyte multilocularity to facilitate lipid utilization. PubMed ID: 36477540