Details for: CNR2
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 11.5722
Cell Significance Index: -1.8000 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 6.9389
Cell Significance Index: -1.7600 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 5.4153
Cell Significance Index: -2.2000 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 1.7993
Cell Significance Index: 110.3200 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 1.4518
Cell Significance Index: -1.7900 - Cell Name: centroblast (CL0009112)
Fold Change: 1.3737
Cell Significance Index: 3.2100 - Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 0.7010
Cell Significance Index: 3.1400 - Cell Name: pro-T cell (CL0000827)
Fold Change: 0.6913
Cell Significance Index: 17.6600 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.5120
Cell Significance Index: 97.4500 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.5049
Cell Significance Index: 16.1700 - Cell Name: hepatic pit cell (CL2000054)
Fold Change: 0.3789
Cell Significance Index: 1.0200 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.3630
Cell Significance Index: 35.9100 - Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.3154
Cell Significance Index: 7.8700 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.2955
Cell Significance Index: 266.8100 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.2776
Cell Significance Index: 32.7400 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.2592
Cell Significance Index: 5.5200 - Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 0.2397
Cell Significance Index: 2.5500 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.2285
Cell Significance Index: 3.9200 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.1870
Cell Significance Index: 20.3400 - Cell Name: suprabasal keratinocyte (CL4033013)
Fold Change: 0.1847
Cell Significance Index: 2.9700 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.1846
Cell Significance Index: 30.0300 - Cell Name: IgG memory B cell (CL0000979)
Fold Change: 0.1689
Cell Significance Index: 1.0200 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.1293
Cell Significance Index: 7.7600 - Cell Name: transitional stage B cell (CL0000818)
Fold Change: 0.1286
Cell Significance Index: 1.1300 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.0964
Cell Significance Index: 6.6700 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.0497
Cell Significance Index: 1.0300 - Cell Name: mesangial cell (CL0000650)
Fold Change: 0.0490
Cell Significance Index: 0.6200 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.0489
Cell Significance Index: 3.1600 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.0437
Cell Significance Index: 1.1700 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.0382
Cell Significance Index: 10.9900 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.0316
Cell Significance Index: 0.9100 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.0259
Cell Significance Index: 0.5700 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.0256
Cell Significance Index: 3.2800 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.0239
Cell Significance Index: 4.7500 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.0211
Cell Significance Index: 3.8000 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0210
Cell Significance Index: 4.2200 - Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 0.0183
Cell Significance Index: 0.1000 - Cell Name: follicular B cell (CL0000843)
Fold Change: 0.0160
Cell Significance Index: 0.0800 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.0132
Cell Significance Index: 0.6000 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0091
Cell Significance Index: 3.2700 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.0089
Cell Significance Index: 0.5600 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.0070
Cell Significance Index: 1.0200 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.0049
Cell Significance Index: 0.6000 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0028
Cell Significance Index: 5.2900 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.0028
Cell Significance Index: 0.2200 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0026
Cell Significance Index: 4.7700 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0022
Cell Significance Index: 3.3500 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0022
Cell Significance Index: 3.0000 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0017
Cell Significance Index: 0.0600 - Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: 0.0015
Cell Significance Index: 0.0200 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0013
Cell Significance Index: -0.8200 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0014
Cell Significance Index: -0.6500 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.0014
Cell Significance Index: -0.0300 - Cell Name: preadipocyte (CL0002334)
Fold Change: -0.0015
Cell Significance Index: -0.0300 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0021
Cell Significance Index: -1.5200 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0022
Cell Significance Index: -1.6800 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0028
Cell Significance Index: -2.0200 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0028
Cell Significance Index: -1.5400 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: -0.0028
Cell Significance Index: -1.2400 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0029
Cell Significance Index: -1.6500 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0031
Cell Significance Index: -1.9100 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0033
Cell Significance Index: -0.5700 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.0060
Cell Significance Index: -0.1100 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.0068
Cell Significance Index: -0.1700 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0070
Cell Significance Index: -0.8100 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.0077
Cell Significance Index: -0.1100 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.0078
Cell Significance Index: -0.3400 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0085
Cell Significance Index: -1.7900 - Cell Name: keratocyte (CL0002363)
Fold Change: -0.0101
Cell Significance Index: -0.1600 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.0106
Cell Significance Index: -0.1600 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0108
Cell Significance Index: -1.4900 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0122
Cell Significance Index: -1.4000 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0146
Cell Significance Index: -1.5200 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0152
Cell Significance Index: -1.0200 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0164
Cell Significance Index: -1.6800 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0166
Cell Significance Index: -2.1400 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.0172
Cell Significance Index: -0.7600 - Cell Name: B-1b B cell (CL0000821)
Fold Change: -0.0199
Cell Significance Index: -0.1000 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.0209
Cell Significance Index: -0.7900 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0233
Cell Significance Index: -1.4300 - Cell Name: memory B cell (CL0000787)
Fold Change: -0.0235
Cell Significance Index: -0.2500 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.0237
Cell Significance Index: -1.2300 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0258
Cell Significance Index: -1.9200 - Cell Name: common myeloid progenitor (CL0000049)
Fold Change: -0.0259
Cell Significance Index: -0.3100 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0262
Cell Significance Index: -1.4700 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.0263
Cell Significance Index: -0.4400 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.0269
Cell Significance Index: -0.7200 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0276
Cell Significance Index: -0.7700 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.0291
Cell Significance Index: -1.5300 - Cell Name: hepatoblast (CL0005026)
Fold Change: -0.0309
Cell Significance Index: -0.5200 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.0315
Cell Significance Index: -0.8100 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0324
Cell Significance Index: -1.5100 - Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: -0.0335
Cell Significance Index: -0.4300 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0348
Cell Significance Index: -1.6400 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.0353
Cell Significance Index: -1.1300 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0401
Cell Significance Index: -1.0700 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.0402
Cell Significance Index: -1.4100 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.0406
Cell Significance Index: -1.3300 - Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.0406
Cell Significance Index: -0.9900 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.0415
Cell Significance Index: -1.1300
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 316181730
Symbol: CNR2_HUMAN
Name: Cannabinoid receptor 2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7689702
Title: Molecular characterization of a peripheral receptor for cannabinoids.
PubMed ID: 7689702
DOI: 10.1038/365061a0
PubMed ID: 19496827
Title: Species differences in cannabinoid receptor 2 (CNR2 gene): identification of novel human and rodent CB2 isoforms, differential tissue expression and regulation by cannabinoid receptor ligands.
PubMed ID: 19496827
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 7556170
Title: Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations.
PubMed ID: 7556170
PubMed ID: 10400664
Title: Regulation of peripheral cannabinoid receptor CB2 phosphorylation by the inverse agonist SR 144528. Implications for receptor biological responses.
PubMed ID: 10400664
PubMed ID: 10051546
Title: Role of a conserved lysine residue in the peripheral cannabinoid receptor (CB2): evidence for subtype specificity.
PubMed ID: 10051546
PubMed ID: 10617657
Title: Evidence that 2-arachidonoylglycerol but not N-palmitoylethanolamine or anandamide is the physiological ligand for the cannabinoid CB2 receptor. Comparison of the agonistic activities of various cannabinoid receptor ligands in HL-60 cells.
PubMed ID: 10617657
PubMed ID: 12153574
Title: Presence and regulation of the endocannabinoid system in human dendritic cells.
PubMed ID: 12153574
PubMed ID: 12417328
Title: Absence of a conserved proline and presence of a conserved tyrosine in the CB2 cannabinoid receptor are crucial for its function.
PubMed ID: 12417328
PubMed ID: 12663043
Title: Effects of D3.49A, R3.50A, and A6.34E mutations on ligand binding and activation of the cannabinoid-2 (CB2) receptor.
PubMed ID: 12663043
PubMed ID: 12711605
Title: 2-arachidonoylglycerol induces the migration of HL-60 cells differentiated into macrophage-like cells and human peripheral blood monocytes through the cannabinoid CB2 receptor-dependent mechanism.
PubMed ID: 12711605
PubMed ID: 12511587
Title: Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors.
PubMed ID: 12511587
DOI: 10.1172/jci16116
PubMed ID: 14657172
Title: Cannabinoid CB2 receptors and fatty acid amide hydrolase are selectively overexpressed in neuritic plaque-associated glia in Alzheimer's disease brains.
PubMed ID: 14657172
PubMed ID: 15266552
Title: Cannabinoid CB2 receptors are expressed by perivascular microglial cells in the human brain: an immunohistochemical study.
PubMed ID: 15266552
DOI: 10.1002/syn.20050
PubMed ID: 18692962
Title: Cannabinoid receptor CB2 localisation and agonist-mediated inhibition of capsaicin responses in human sensory neurons.
PubMed ID: 18692962
PubMed ID: 23955712
Title: Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes.
PubMed ID: 23955712
DOI: 10.1038/nm.3265
PubMed ID: 19397896
Title: Structural biology of human cannabinoid receptor-2 helix 6 in membrane-mimetic environments.
PubMed ID: 19397896
PubMed ID: 18286196
Title: Brain neuronal CB2 cannabinoid receptors in drug abuse and depression: from mice to human subjects.
PubMed ID: 18286196
Sequence Information:
- Length: 360
- Mass: 39681
- Checksum: A7ECF68C16E7514B
- Sequence:
MEECWVTEIA NGSKDGLDSN PMKDYMILSG PQKTAVAVLC TLLGLLSALE NVAVLYLILS SHQLRRKPSY LFIGSLAGAD FLASVVFACS FVNFHVFHGV DSKAVFLLKI GSVTMTFTAS VGSLLLTAID RYLCLRYPPS YKALLTRGRA LVTLGIMWVL SALVSYLPLM GWTCCPRPCS ELFPLIPNDY LLSWLLFIAF LFSGIIYTYG HVLWKAHQHV ASLSGHQDRQ VPGMARMRLD VRLAKTLGLV LAVLLICWFP VLALMAHSLA TTLSDQVKKA FAFCSMLCLI NSMVNPVIYA LRSGEIRSSA HHCLAHWKKC VRGLGSEAKE EAPRSSVTET EADGKITPWP DSRDLDLSDC
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.