CNR2 | ENSG00000188822 | NCBI 1269

Details for: CNR2

Gene ID: 1269

Symbol: CNR2

Ensembl ID: ENSG00000188822

Description: cannabinoid receptor 2

Associated with

Class a/1 (rhodopsin-like receptors)
(R-HSA-373076)
G alpha (i) signalling events
(R-HSA-418594)
Gpcr downstream signalling
(R-HSA-388396)
Gpcr ligand binding
(R-HSA-500792)
Signaling by gpcr
(R-HSA-372790)
Signal transduction
(R-HSA-162582)
Adenylate cyclase-activating g protein-coupled receptor signaling pathway
(GO:0007189)
Cannabinoid receptor activity
(GO:0004949)
Cannabinoid signaling pathway
(GO:0038171)
Cytoplasm
(GO:0005737)
Dendrite
(GO:0030425)
Endoplasmic reticulum
(GO:0005783)
Extrinsic component of cytoplasmic side of plasma membrane
(GO:0031234)
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
(GO:0007187)
Immune response
(GO:0006955)
Inflammatory response
(GO:0006954)
Leukocyte chemotaxis
(GO:0030595)
Negative regulation of action potential
(GO:0045759)
Negative regulation of mast cell activation
(GO:0033004)
Negative regulation of synaptic transmission, gabaergic
(GO:0032229)
Perikaryon
(GO:0043204)
Plasma membrane
(GO:0005886)
Protein binding
(GO:0005515)
Regulation of metabolic process
(GO:0019222)
Response to amphetamine
(GO:0001975)
Response to lipopolysaccharide
(GO:0032496)

Other Information

Proteins

Cannabinoid receptor 2

Genular Protein ID: 316181730

Symbol: CNR2_HUMAN

Name: Cannabinoid receptor 2

UniProtKB Accession Codes:

P34972 C6ES44 Q4VBK8 Q5JRH7 Q6B0G7 Q6NSY0

Database IDs:

Citations:

PubMed ID: 7689702

Title: Molecular characterization of a peripheral receptor for cannabinoids.

PubMed ID: 7689702

DOI: 10.1038/365061a0

PubMed ID: 19496827

Title: Species differences in cannabinoid receptor 2 (CNR2 gene): identification of novel human and rodent CB2 isoforms, differential tissue expression and regulation by cannabinoid receptor ligands.

PubMed ID: 19496827

DOI: 10.1111/j.1601-183x.2009.00498.x

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7556170

Title: Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations.

PubMed ID: 7556170

DOI: 10.1111/j.1432-1033.1995.tb20780.x

PubMed ID: 10400664

Title: Regulation of peripheral cannabinoid receptor CB2 phosphorylation by the inverse agonist SR 144528. Implications for receptor biological responses.

PubMed ID: 10400664

DOI: 10.1074/jbc.274.29.20397

PubMed ID: 10051546

Title: Role of a conserved lysine residue in the peripheral cannabinoid receptor (CB2): evidence for subtype specificity.

PubMed ID: 10051546

PubMed ID: 10617657

Title: Evidence that 2-arachidonoylglycerol but not N-palmitoylethanolamine or anandamide is the physiological ligand for the cannabinoid CB2 receptor. Comparison of the agonistic activities of various cannabinoid receptor ligands in HL-60 cells.

PubMed ID: 10617657

DOI: 10.1074/jbc.275.1.605

PubMed ID: 12153574

Title: Presence and regulation of the endocannabinoid system in human dendritic cells.

PubMed ID: 12153574

DOI: 10.1046/j.1432-1033.2002.03078.x

PubMed ID: 12417328

Title: Absence of a conserved proline and presence of a conserved tyrosine in the CB2 cannabinoid receptor are crucial for its function.

PubMed ID: 12417328

DOI: 10.1016/s0014-5793(02)03537-8

PubMed ID: 12663043

Title: Effects of D3.49A, R3.50A, and A6.34E mutations on ligand binding and activation of the cannabinoid-2 (CB2) receptor.

PubMed ID: 12663043

DOI: 10.1016/s0006-2952(03)00005-4

PubMed ID: 12711605

Title: 2-arachidonoylglycerol induces the migration of HL-60 cells differentiated into macrophage-like cells and human peripheral blood monocytes through the cannabinoid CB2 receptor-dependent mechanism.

PubMed ID: 12711605

DOI: 10.1074/jbc.m301359200

PubMed ID: 12511587

Title: Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors.

PubMed ID: 12511587

DOI: 10.1172/jci16116

PubMed ID: 14657172

Title: Cannabinoid CB2 receptors and fatty acid amide hydrolase are selectively overexpressed in neuritic plaque-associated glia in Alzheimer's disease brains.

PubMed ID: 14657172

DOI: 10.1523/jneurosci.23-35-11136.2003

PubMed ID: 15266552

Title: Cannabinoid CB2 receptors are expressed by perivascular microglial cells in the human brain: an immunohistochemical study.

PubMed ID: 15266552

DOI: 10.1002/syn.20050

PubMed ID: 18692962

Title: Cannabinoid receptor CB2 localisation and agonist-mediated inhibition of capsaicin responses in human sensory neurons.

PubMed ID: 18692962

DOI: 10.1016/j.pain.2008.06.007

PubMed ID: 23955712

Title: Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes.

PubMed ID: 23955712

DOI: 10.1038/nm.3265

PubMed ID: 19397896

Title: Structural biology of human cannabinoid receptor-2 helix 6 in membrane-mimetic environments.

PubMed ID: 19397896

DOI: 10.1016/j.bbrc.2009.04.099

PubMed ID: 18286196

Title: Brain neuronal CB2 cannabinoid receptors in drug abuse and depression: from mice to human subjects.

PubMed ID: 18286196

DOI: 10.1371/journal.pone.0001640

Sequence Information:

Length: 360
Mass: 39681
Checksum: A7ECF68C16E7514B
Sequence:

MEECWVTEIA NGSKDGLDSN PMKDYMILSG PQKTAVAVLC TLLGLLSALE NVAVLYLILS 
SHQLRRKPSY LFIGSLAGAD FLASVVFACS FVNFHVFHGV DSKAVFLLKI GSVTMTFTAS 
VGSLLLTAID RYLCLRYPPS YKALLTRGRA LVTLGIMWVL SALVSYLPLM GWTCCPRPCS 
ELFPLIPNDY LLSWLLFIAF LFSGIIYTYG HVLWKAHQHV ASLSGHQDRQ VPGMARMRLD 
VRLAKTLGLV LAVLLICWFP VLALMAHSLA TTLSDQVKKA FAFCSMLCLI NSMVNPVIYA 
LRSGEIRSSA HHCLAHWKKC VRGLGSEAKE EAPRSSVTET EADGKITPWP DSRDLDLSDC

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CNR2

Associated with

Other Information

Molecular characterization of a peripheral receptor for cannabinoids. PubMed ID: 7689702

Species differences in cannabinoid receptor 2 (CNR2 gene): identification of novel human and rodent CB2 isoforms, differential tissue expression and regulation by cannabinoid receptor ligands. PubMed ID: 19496827

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations. PubMed ID: 7556170

Regulation of peripheral cannabinoid receptor CB2 phosphorylation by the inverse agonist SR 144528. Implications for receptor biological responses. PubMed ID: 10400664

Role of a conserved lysine residue in the peripheral cannabinoid receptor (CB2): evidence for subtype specificity. PubMed ID: 10051546

Evidence that 2-arachidonoylglycerol but not N-palmitoylethanolamine or anandamide is the physiological ligand for the cannabinoid CB2 receptor. Comparison of the agonistic activities of various cannabinoid receptor ligands in HL-60 cells. PubMed ID: 10617657

Presence and regulation of the endocannabinoid system in human dendritic cells. PubMed ID: 12153574

Absence of a conserved proline and presence of a conserved tyrosine in the CB2 cannabinoid receptor are crucial for its function. PubMed ID: 12417328

Effects of D3.49A, R3.50A, and A6.34E mutations on ligand binding and activation of the cannabinoid-2 (CB2) receptor. PubMed ID: 12663043

2-arachidonoylglycerol induces the migration of HL-60 cells differentiated into macrophage-like cells and human peripheral blood monocytes through the cannabinoid CB2 receptor-dependent mechanism. PubMed ID: 12711605

Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors. PubMed ID: 12511587

Cannabinoid CB2 receptors and fatty acid amide hydrolase are selectively overexpressed in neuritic plaque-associated glia in Alzheimer's disease brains. PubMed ID: 14657172

Cannabinoid CB2 receptors are expressed by perivascular microglial cells in the human brain: an immunohistochemical study. PubMed ID: 15266552

Cannabinoid receptor CB2 localisation and agonist-mediated inhibition of capsaicin responses in human sensory neurons. PubMed ID: 18692962

Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes. PubMed ID: 23955712

Structural biology of human cannabinoid receptor-2 helix 6 in membrane-mimetic environments. PubMed ID: 19397896

Brain neuronal CB2 cannabinoid receptors in drug abuse and depression: from mice to human subjects. PubMed ID: 18286196