Details for: CNR2

Gene ID: 1269

Symbol: CNR2

Ensembl ID: ENSG00000188822

Description: cannabinoid receptor 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 11.5722
    Cell Significance Index: -1.8000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 6.9389
    Cell Significance Index: -1.7600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 5.4153
    Cell Significance Index: -2.2000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.7993
    Cell Significance Index: 110.3200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 1.4518
    Cell Significance Index: -1.7900
  • Cell Name: centroblast (CL0009112)
    Fold Change: 1.3737
    Cell Significance Index: 3.2100
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.7010
    Cell Significance Index: 3.1400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.6913
    Cell Significance Index: 17.6600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5120
    Cell Significance Index: 97.4500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.5049
    Cell Significance Index: 16.1700
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 0.3789
    Cell Significance Index: 1.0200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3630
    Cell Significance Index: 35.9100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.3154
    Cell Significance Index: 7.8700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2955
    Cell Significance Index: 266.8100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2776
    Cell Significance Index: 32.7400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2592
    Cell Significance Index: 5.5200
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.2397
    Cell Significance Index: 2.5500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.2285
    Cell Significance Index: 3.9200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1870
    Cell Significance Index: 20.3400
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: 0.1847
    Cell Significance Index: 2.9700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1846
    Cell Significance Index: 30.0300
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.1689
    Cell Significance Index: 1.0200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1293
    Cell Significance Index: 7.7600
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.1286
    Cell Significance Index: 1.1300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0964
    Cell Significance Index: 6.6700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0497
    Cell Significance Index: 1.0300
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.0490
    Cell Significance Index: 0.6200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0489
    Cell Significance Index: 3.1600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0437
    Cell Significance Index: 1.1700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0382
    Cell Significance Index: 10.9900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0316
    Cell Significance Index: 0.9100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0259
    Cell Significance Index: 0.5700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0256
    Cell Significance Index: 3.2800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0239
    Cell Significance Index: 4.7500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0211
    Cell Significance Index: 3.8000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0210
    Cell Significance Index: 4.2200
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.0183
    Cell Significance Index: 0.1000
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.0160
    Cell Significance Index: 0.0800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0132
    Cell Significance Index: 0.6000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0091
    Cell Significance Index: 3.2700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0089
    Cell Significance Index: 0.5600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0070
    Cell Significance Index: 1.0200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0049
    Cell Significance Index: 0.6000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0028
    Cell Significance Index: 5.2900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0028
    Cell Significance Index: 0.2200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0026
    Cell Significance Index: 4.7700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0022
    Cell Significance Index: 3.3500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0022
    Cell Significance Index: 3.0000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0017
    Cell Significance Index: 0.0600
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.0015
    Cell Significance Index: 0.0200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0013
    Cell Significance Index: -0.8200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0014
    Cell Significance Index: -0.6500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0014
    Cell Significance Index: -0.0300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0015
    Cell Significance Index: -0.0300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0021
    Cell Significance Index: -1.5200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0022
    Cell Significance Index: -1.6800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0028
    Cell Significance Index: -2.0200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0028
    Cell Significance Index: -1.5400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0028
    Cell Significance Index: -1.2400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0029
    Cell Significance Index: -1.6500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0031
    Cell Significance Index: -1.9100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0033
    Cell Significance Index: -0.5700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0060
    Cell Significance Index: -0.1100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0068
    Cell Significance Index: -0.1700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0070
    Cell Significance Index: -0.8100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0077
    Cell Significance Index: -0.1100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0078
    Cell Significance Index: -0.3400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0085
    Cell Significance Index: -1.7900
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0101
    Cell Significance Index: -0.1600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0106
    Cell Significance Index: -0.1600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0108
    Cell Significance Index: -1.4900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0122
    Cell Significance Index: -1.4000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0146
    Cell Significance Index: -1.5200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0152
    Cell Significance Index: -1.0200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0164
    Cell Significance Index: -1.6800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0166
    Cell Significance Index: -2.1400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0172
    Cell Significance Index: -0.7600
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: -0.0199
    Cell Significance Index: -0.1000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0209
    Cell Significance Index: -0.7900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0233
    Cell Significance Index: -1.4300
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0235
    Cell Significance Index: -0.2500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0237
    Cell Significance Index: -1.2300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0258
    Cell Significance Index: -1.9200
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.0259
    Cell Significance Index: -0.3100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0262
    Cell Significance Index: -1.4700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0263
    Cell Significance Index: -0.4400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0269
    Cell Significance Index: -0.7200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0276
    Cell Significance Index: -0.7700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0291
    Cell Significance Index: -1.5300
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0309
    Cell Significance Index: -0.5200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0315
    Cell Significance Index: -0.8100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0324
    Cell Significance Index: -1.5100
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0335
    Cell Significance Index: -0.4300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0348
    Cell Significance Index: -1.6400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0353
    Cell Significance Index: -1.1300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0401
    Cell Significance Index: -1.0700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0402
    Cell Significance Index: -1.4100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0406
    Cell Significance Index: -1.3300
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0406
    Cell Significance Index: -0.9900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0415
    Cell Significance Index: -1.1300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Expression Pattern**: CB2 is predominantly expressed in immune cells, including macrophages, microglia, and immature innate lymphoid cells. It is also found in other tissues, such as the colon, small intestine, and cerebral cortex. 2. **Ligand-Binding Specificity**: CB2 is activated by endocannabinoids, such as anandamide and 2-AG, as well as phytocannabinoids, such as THC. It is also responsive to synthetic cannabinoids, such as JZL-184. 3. **Signal Transduction**: CB2 activates Gαi proteins, which inhibit adenylate cyclase and reduce cyclic AMP (cAMP) levels. This leads to the suppression of downstream signaling pathways, including those involved in inflammation and immune responses. 4. **Regulatory Functions**: CB2 modulates immune responses, including leukocyte chemotaxis, mast cell activation, and the regulation of metabolic processes. It also plays a role in the negative regulation of synaptic transmission and the modulation of GABAergic signaling. **Pathways and Functions** 1. **Immune Response**: CB2 modulates immune responses by regulating the activation of immune cells, including macrophages and T cells. It also modulates the production of pro-inflammatory cytokines, such as TNF-α and IL-1β. 2. **Leukocyte Chemotaxis**: CB2 regulates the migration of leukocytes to sites of inflammation, which is essential for the resolution of inflammation. 3. **Mast Cell Activation**: CB2 inhibits the activation of mast cells, which is crucial for the regulation of allergic responses and inflammation. 4. **Metabolic Regulation**: CB2 modulates metabolic processes, including glucose and lipid metabolism, which is relevant to the pathogenesis of metabolic disorders. 5. **Neuroprotection**: CB2 has neuroprotective effects, particularly in the context of neuroinflammation and oxidative stress. **Clinical Significance** 1. **Inflammatory Disorders**: CB2 has potential therapeutic applications in the treatment of inflammatory disorders, such as rheumatoid arthritis, multiple sclerosis, and inflammatory bowel disease. 2. **Cancer**: CB2 may play a role in the regulation of cancer cell proliferation and metastasis, particularly in the context of immune evasion. 3. **Neurological Disorders**: CB2 may have therapeutic applications in the treatment of neurological disorders, such as Parkinson's disease, Alzheimer's disease, and multiple sclerosis. 4. **Metabolic Disorders**: CB2 may have therapeutic applications in the treatment of metabolic disorders, such as obesity and type 2 diabetes. In conclusion, CB2 is a multifunctional receptor that plays a crucial role in regulating immune responses, inflammation, and metabolic processes. Its therapeutic potential is vast, and further research is needed to fully explore its applications in various diseases.

Genular Protein ID: 316181730

Symbol: CNR2_HUMAN

Name: Cannabinoid receptor 2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7689702

Title: Molecular characterization of a peripheral receptor for cannabinoids.

PubMed ID: 7689702

DOI: 10.1038/365061a0

PubMed ID: 19496827

Title: Species differences in cannabinoid receptor 2 (CNR2 gene): identification of novel human and rodent CB2 isoforms, differential tissue expression and regulation by cannabinoid receptor ligands.

PubMed ID: 19496827

DOI: 10.1111/j.1601-183x.2009.00498.x

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7556170

Title: Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations.

PubMed ID: 7556170

DOI: 10.1111/j.1432-1033.1995.tb20780.x

PubMed ID: 10400664

Title: Regulation of peripheral cannabinoid receptor CB2 phosphorylation by the inverse agonist SR 144528. Implications for receptor biological responses.

PubMed ID: 10400664

DOI: 10.1074/jbc.274.29.20397

PubMed ID: 10051546

Title: Role of a conserved lysine residue in the peripheral cannabinoid receptor (CB2): evidence for subtype specificity.

PubMed ID: 10051546

PubMed ID: 10617657

Title: Evidence that 2-arachidonoylglycerol but not N-palmitoylethanolamine or anandamide is the physiological ligand for the cannabinoid CB2 receptor. Comparison of the agonistic activities of various cannabinoid receptor ligands in HL-60 cells.

PubMed ID: 10617657

DOI: 10.1074/jbc.275.1.605

PubMed ID: 12153574

Title: Presence and regulation of the endocannabinoid system in human dendritic cells.

PubMed ID: 12153574

DOI: 10.1046/j.1432-1033.2002.03078.x

PubMed ID: 12417328

Title: Absence of a conserved proline and presence of a conserved tyrosine in the CB2 cannabinoid receptor are crucial for its function.

PubMed ID: 12417328

DOI: 10.1016/s0014-5793(02)03537-8

PubMed ID: 12663043

Title: Effects of D3.49A, R3.50A, and A6.34E mutations on ligand binding and activation of the cannabinoid-2 (CB2) receptor.

PubMed ID: 12663043

DOI: 10.1016/s0006-2952(03)00005-4

PubMed ID: 12711605

Title: 2-arachidonoylglycerol induces the migration of HL-60 cells differentiated into macrophage-like cells and human peripheral blood monocytes through the cannabinoid CB2 receptor-dependent mechanism.

PubMed ID: 12711605

DOI: 10.1074/jbc.m301359200

PubMed ID: 12511587

Title: Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors.

PubMed ID: 12511587

DOI: 10.1172/jci16116

PubMed ID: 14657172

Title: Cannabinoid CB2 receptors and fatty acid amide hydrolase are selectively overexpressed in neuritic plaque-associated glia in Alzheimer's disease brains.

PubMed ID: 14657172

DOI: 10.1523/jneurosci.23-35-11136.2003

PubMed ID: 15266552

Title: Cannabinoid CB2 receptors are expressed by perivascular microglial cells in the human brain: an immunohistochemical study.

PubMed ID: 15266552

DOI: 10.1002/syn.20050

PubMed ID: 18692962

Title: Cannabinoid receptor CB2 localisation and agonist-mediated inhibition of capsaicin responses in human sensory neurons.

PubMed ID: 18692962

DOI: 10.1016/j.pain.2008.06.007

PubMed ID: 23955712

Title: Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes.

PubMed ID: 23955712

DOI: 10.1038/nm.3265

PubMed ID: 19397896

Title: Structural biology of human cannabinoid receptor-2 helix 6 in membrane-mimetic environments.

PubMed ID: 19397896

DOI: 10.1016/j.bbrc.2009.04.099

PubMed ID: 18286196

Title: Brain neuronal CB2 cannabinoid receptors in drug abuse and depression: from mice to human subjects.

PubMed ID: 18286196

DOI: 10.1371/journal.pone.0001640

Sequence Information:

  • Length: 360
  • Mass: 39681
  • Checksum: A7ECF68C16E7514B
  • Sequence:
  • MEECWVTEIA NGSKDGLDSN PMKDYMILSG PQKTAVAVLC TLLGLLSALE NVAVLYLILS 
    SHQLRRKPSY LFIGSLAGAD FLASVVFACS FVNFHVFHGV DSKAVFLLKI GSVTMTFTAS 
    VGSLLLTAID RYLCLRYPPS YKALLTRGRA LVTLGIMWVL SALVSYLPLM GWTCCPRPCS 
    ELFPLIPNDY LLSWLLFIAF LFSGIIYTYG HVLWKAHQHV ASLSGHQDRQ VPGMARMRLD 
    VRLAKTLGLV LAVLLICWFP VLALMAHSLA TTLSDQVKKA FAFCSMLCLI NSMVNPVIYA 
    LRSGEIRSSA HHCLAHWKKC VRGLGSEAKE EAPRSSVTET EADGKITPWP DSRDLDLSDC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.