Details for: CNR2

Gene ID: 1269

Symbol: CNR2

Ensembl ID: ENSG00000188822

Description: cannabinoid receptor 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1167
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 852
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.16
    Marker Score: 483
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4813
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.13
    Marker Score: 2291
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71826
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48051
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 505
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 458
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 370
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5258
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2739
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 322
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5291
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.87
    Marker Score: 836
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.81
    Marker Score: 371
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1259
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 707
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.76
    Marker Score: 341
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 393
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.74
    Marker Score: 11503
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.72
    Marker Score: 434
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 458
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.7
    Marker Score: 536
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.68
    Marker Score: 637
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.67
    Marker Score: 1174
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.67
    Marker Score: 238
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 0.63
    Marker Score: 146
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.61
    Marker Score: 307
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.61
    Marker Score: 542
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.56
    Marker Score: 553
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.55
    Marker Score: 419
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 172
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.54
    Marker Score: 174
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 0.52
    Marker Score: 319
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.51
    Marker Score: 963
  • Cell Name: B-1a B cell (CL0000820)
    Fold Change: 0.46
    Marker Score: 111
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 0.46
    Marker Score: 152
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.44
    Marker Score: 264
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.43
    Marker Score: 895
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.43
    Marker Score: 135
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 0.4
    Marker Score: 475.5
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.4
    Marker Score: 1619
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.39
    Marker Score: 423
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 0.36
    Marker Score: 763
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.36
    Marker Score: 1066
  • Cell Name: centroblast (CL0009112)
    Fold Change: 0.35
    Marker Score: 173
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.35
    Marker Score: 184
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.32
    Marker Score: 188
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.3
    Marker Score: 285
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.29
    Marker Score: 189.5
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.27
    Marker Score: 222
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.26
    Marker Score: 190
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 0.25
    Marker Score: 60
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.23
    Marker Score: 111
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.22
    Marker Score: 127
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.22
    Marker Score: 59
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.22
    Marker Score: 93
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.21
    Marker Score: 54
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.19
    Marker Score: 1265
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.19
    Marker Score: 112
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.19
    Marker Score: 81
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.18
    Marker Score: 122
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.18
    Marker Score: 73
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 0.18
    Marker Score: 45
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.17
    Marker Score: 9702
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.17
    Marker Score: 78
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.17
    Marker Score: 59
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.17
    Marker Score: 148
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.17
    Marker Score: 471
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.16
    Marker Score: 159
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.16
    Marker Score: 59
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.16
    Marker Score: 142
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.16
    Marker Score: 2121
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.16
    Marker Score: 65
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.15
    Marker Score: 53.5
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.14
    Marker Score: 180
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.13
    Marker Score: 49
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.13
    Marker Score: 191
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.13
    Marker Score: 130
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.13
    Marker Score: 424
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.13
    Marker Score: 327
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.13
    Marker Score: 72
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 0.13
    Marker Score: 157
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.13
    Marker Score: 372
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.13
    Marker Score: 350
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.13
    Marker Score: 163
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.12
    Marker Score: 84
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.12
    Marker Score: 83
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.12
    Marker Score: 173
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.12
    Marker Score: 1394
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.12
    Marker Score: 336
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.12
    Marker Score: 24

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Other Information

**Key characteristics:** * CNR2 is a type of GPCR that is expressed on the surface of immune cells, particularly macrophages and dendritic cells. * It is a ligand-gated channel that is permeable to calcium ions. * When CNR2 binds to its ligand, an increase in calcium ion concentration downstream of the receptor is triggered. * This signaling cascade leads to the activation of downstream signaling pathways, including the activation of the MAPK pathway, which is a major regulator of immune responses. **Pathways and functions:** * The CNR2 gene is involved in a variety of immune responses, including inflammation, leukocyte chemotaxis, and the regulation of synaptic transmission. * In inflammation, CNR2 is expressed on immune cells and is activated by inflammatory stimuli, such as lipopolysaccharide. * This activation of CNR2 leads to the recruitment of immune cells to the site of inflammation and the production of inflammatory cytokines. * In synaptic transmission, CNR2 is expressed on presynaptic neurons and is involved in regulating the release of neurotransmitters. * In the context of cancer, CNR2 is a potential target for therapeutic intervention, as it is often overexpressed on tumor cells and can promote tumor growth and metastasis. **Clinical significance:** * Mutations in the CNR2 gene have been linked to a number of human diseases, including multiple sclerosis, inflammatory bowel disease, and cancer. * CNR2 is a potential therapeutic target for diseases that are characterized by inflammation or cancer. * For example, CNR2 inhibitors are being investigated as a treatment for multiple sclerosis, as they have been shown to be effective in reducing inflammation and slowing disease progression.

Genular Protein ID: 316181730

Symbol: CNR2_HUMAN

Name: Cannabinoid receptor 2

UniProtKB Accession Codes:

P34972 C6ES44 Q4VBK8 Q5JRH7 Q6B0G7 Q6NSY0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 9 DrugCentral 1 EMBL 13 EMDB 6 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 13 PDBsum 9 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 3 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7689702

Title: Molecular characterization of a peripheral receptor for cannabinoids.

PubMed ID: 7689702

DOI: 10.1038/365061a0

PubMed ID: 19496827

Title: Species differences in cannabinoid receptor 2 (CNR2 gene): identification of novel human and rodent CB2 isoforms, differential tissue expression and regulation by cannabinoid receptor ligands.

PubMed ID: 19496827

DOI: 10.1111/j.1601-183x.2009.00498.x

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7556170

Title: Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations.

PubMed ID: 7556170

DOI: 10.1111/j.1432-1033.1995.tb20780.x

PubMed ID: 10400664

Title: Regulation of peripheral cannabinoid receptor CB2 phosphorylation by the inverse agonist SR 144528. Implications for receptor biological responses.

PubMed ID: 10400664

DOI: 10.1074/jbc.274.29.20397

PubMed ID: 10051546

Title: Role of a conserved lysine residue in the peripheral cannabinoid receptor (CB2): evidence for subtype specificity.

PubMed ID: 10051546

PubMed ID: 10617657

Title: Evidence that 2-arachidonoylglycerol but not N-palmitoylethanolamine or anandamide is the physiological ligand for the cannabinoid CB2 receptor. Comparison of the agonistic activities of various cannabinoid receptor ligands in HL-60 cells.

PubMed ID: 10617657

DOI: 10.1074/jbc.275.1.605

PubMed ID: 12153574

Title: Presence and regulation of the endocannabinoid system in human dendritic cells.

PubMed ID: 12153574

DOI: 10.1046/j.1432-1033.2002.03078.x

PubMed ID: 12417328

Title: Absence of a conserved proline and presence of a conserved tyrosine in the CB2 cannabinoid receptor are crucial for its function.

PubMed ID: 12417328

DOI: 10.1016/s0014-5793(02)03537-8

PubMed ID: 12663043

Title: Effects of D3.49A, R3.50A, and A6.34E mutations on ligand binding and activation of the cannabinoid-2 (CB2) receptor.

PubMed ID: 12663043

DOI: 10.1016/s0006-2952(03)00005-4

PubMed ID: 12711605

Title: 2-arachidonoylglycerol induces the migration of HL-60 cells differentiated into macrophage-like cells and human peripheral blood monocytes through the cannabinoid CB2 receptor-dependent mechanism.

PubMed ID: 12711605

DOI: 10.1074/jbc.m301359200

PubMed ID: 12511587

Title: Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors.

PubMed ID: 12511587

DOI: 10.1172/jci16116

PubMed ID: 14657172

Title: Cannabinoid CB2 receptors and fatty acid amide hydrolase are selectively overexpressed in neuritic plaque-associated glia in Alzheimer's disease brains.

PubMed ID: 14657172

DOI: 10.1523/jneurosci.23-35-11136.2003

PubMed ID: 15266552

Title: Cannabinoid CB2 receptors are expressed by perivascular microglial cells in the human brain: an immunohistochemical study.

PubMed ID: 15266552

DOI: 10.1002/syn.20050

PubMed ID: 18692962

Title: Cannabinoid receptor CB2 localisation and agonist-mediated inhibition of capsaicin responses in human sensory neurons.

PubMed ID: 18692962

DOI: 10.1016/j.pain.2008.06.007

PubMed ID: 23955712

Title: Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes.

PubMed ID: 23955712

DOI: 10.1038/nm.3265

PubMed ID: 19397896

Title: Structural biology of human cannabinoid receptor-2 helix 6 in membrane-mimetic environments.

PubMed ID: 19397896

DOI: 10.1016/j.bbrc.2009.04.099

PubMed ID: 18286196

Title: Brain neuronal CB2 cannabinoid receptors in drug abuse and depression: from mice to human subjects.

PubMed ID: 18286196

DOI: 10.1371/journal.pone.0001640

Sequence Information:

  • Length: 360
  • Mass: 39681
  • Checksum: A7ECF68C16E7514B
  • Sequence:
    • MEECWVTEIA NGSKDGLDSN PMKDYMILSG PQKTAVAVLC TLLGLLSALE NVAVLYLILS 
SHQLRRKPSY LFIGSLAGAD FLASVVFACS FVNFHVFHGV DSKAVFLLKI GSVTMTFTAS 
VGSLLLTAID RYLCLRYPPS YKALLTRGRA LVTLGIMWVL SALVSYLPLM GWTCCPRPCS 
ELFPLIPNDY LLSWLLFIAF LFSGIIYTYG HVLWKAHQHV ASLSGHQDRQ VPGMARMRLD 
VRLAKTLGLV LAVLLICWFP VLALMAHSLA TTLSDQVKKA FAFCSMLCLI NSMVNPVIYA 
LRSGEIRSSA HHCLAHWKKC VRGLGSEAKE EAPRSSVTET EADGKITPWP DSRDLDLSDC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.