Details for: ADH4

Gene ID: 127

Symbol: ADH4

Ensembl ID: ENSG00000198099

Description: alcohol dehydrogenase 4 (class II), pi polypeptide

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.87
    Marker Score: 10055
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.87
    Marker Score: 12004
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1167
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.59
    Marker Score: 6873
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 170213
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.29
    Marker Score: 1994
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.17
    Marker Score: 2419
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 1.08
    Marker Score: 262
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71823
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48047
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 506
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 460
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 372
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5293
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.92
    Marker Score: 3015
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 325
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.89
    Marker Score: 607
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5296
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.87
    Marker Score: 931
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.78
    Marker Score: 295
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1262
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 708
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 395
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.69
    Marker Score: 2874
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.65
    Marker Score: 626
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.59
    Marker Score: 1120
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.59
    Marker Score: 374.5
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.49
    Marker Score: 153
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.49
    Marker Score: 486
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 277
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.42
    Marker Score: 861
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.39
    Marker Score: 177
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.39
    Marker Score: 519
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.37
    Marker Score: 1542
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.34
    Marker Score: 338
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.32
    Marker Score: 157
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.32
    Marker Score: 193
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.31
    Marker Score: 183
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.31
    Marker Score: 86
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.3
    Marker Score: 367
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3
    Marker Score: 4721
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.3
    Marker Score: 95
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.27
    Marker Score: 633
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.27
    Marker Score: 253
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.26
    Marker Score: 98
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.26
    Marker Score: 1550
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.25
    Marker Score: 61
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.24
    Marker Score: 73
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.22
    Marker Score: 71
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.21
    Marker Score: 491
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.2
    Marker Score: 206
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.2
    Marker Score: 118
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.2
    Marker Score: 84
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2
    Marker Score: 137
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.2
    Marker Score: 51
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.2
    Marker Score: 94
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.19
    Marker Score: 156
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.19
    Marker Score: 101
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.19
    Marker Score: 130
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.19
    Marker Score: 88
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.18
    Marker Score: 281
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.17
    Marker Score: 114
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.17
    Marker Score: 2287
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.17
    Marker Score: 152
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.17
    Marker Score: 1129
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.17
    Marker Score: 147
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.16
    Marker Score: 55
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.15
    Marker Score: 742
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.15
    Marker Score: 437
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.14
    Marker Score: 67
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.14
    Marker Score: 90
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.14
    Marker Score: 28
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.14
    Marker Score: 61
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.14
    Marker Score: 77
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.13
    Marker Score: 120
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.13
    Marker Score: 255
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.13
    Marker Score: 29
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.13
    Marker Score: 53
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.13
    Marker Score: 40
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.12
    Marker Score: 38
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.12
    Marker Score: 119
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.12
    Marker Score: 192
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.12
    Marker Score: 61
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.11
    Marker Score: 40
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.1
    Marker Score: 38
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.1
    Marker Score: 79
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.1
    Marker Score: 56
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.1
    Marker Score: 60
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.1
    Marker Score: 38
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 0.1
    Marker Score: 29
  • Cell Name: bronchial smooth muscle cell (CL0002598)
    Fold Change: 0.1
    Marker Score: 28
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.1
    Marker Score: 33
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.09
    Marker Score: 46
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.09
    Marker Score: 27
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.09
    Marker Score: 25

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Other Information

**Key characteristics:** - ADH4 is a multi-functional enzyme that can act as an alcohol dehydrogenase, alditol:NADP+ 1-oxidoreductase, and NADPH:quinone reductase. - It is involved in various cellular processes, including alcohol metabolism, lipid metabolism, and bile acid synthesis. - It is a key regulator of NADPH production, which is essential for the reduction of various aldehydes and ketones. - It is also involved in the biosynthesis of retinal, which is a key component of the eye's retina. **Pathways and functions:** - ADH4 is involved in the metabolism of various substances, including ethanol, acetaldehyde, and other aldehydes. - It is also involved in the synthesis of retinal from precursors such as 9-cis-retinal. - It plays a role in the regulation of energy metabolism, as it is involved in the production of NADPH, which is a key electron carrier. - It is also involved in the detoxification of reactive oxygen species, which can damage cells and DNA. **Clinical significance:** - Mutations in the ADH4 gene have been linked to several human diseases, including liver disease, kidney disease, and eye diseases. - The most common type of ADH4 mutation is a frameshift mutation that results in a truncated protein that is unable to function properly. - These mutations can lead to the accumulation of abnormal ADH4 proteins, which can damage cells and tissues. - Targeting ADH4 has been investigated as a potential therapeutic strategy for these diseases.

Genular Protein ID: 2603725701

Symbol: ADH4_HUMAN

Name: Alcohol dehydrogenase 4

UniProtKB Accession Codes:

P08319 A8K470 B4DIE7 C9J4A9 Q8TCD7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 41 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 DrugCentral 1 EC 1 EMBL 16 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 23 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 2 RefSeq 3 Rhea 10 SABIO-RK 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 3036213

Title: Structure of the class II enzyme of human liver alcohol dehydrogenase: combined cDNA and protein sequence determination of the pi subunit.

PubMed ID: 3036213

DOI: 10.1021/bi00381a021

PubMed ID: 1889753

Title: Cloning and characterization of the human ADH4 gene.

PubMed ID: 1889753

DOI: 10.1016/0378-1119(91)90285-j

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10514444

Title: A novel subtype of class II alcohol dehydrogenase in rodents. Unique Pro(47) and Ser(182) modulates hydride transfer in the mouse enzyme.

PubMed ID: 10514444

DOI: 10.1074/jbc.274.42.29712

PubMed ID: 16081420

Title: Omega-oxidation of 20-hydroxyeicosatetraenoic acid (20-HETE) in cerebral microvascular smooth muscle and endothelium by alcohol dehydrogenase 4.

PubMed ID: 16081420

DOI: 10.1074/jbc.m504055200

PubMed ID: 17279314

Title: Alcohol dehydrogenase 2 is a major hepatic enzyme for human retinol metabolism.

PubMed ID: 17279314

DOI: 10.1007/s00018-007-6449-8

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 380
  • Mass: 40222
  • Checksum: 45721A08197629F1
  • Sequence:
    • MGTKGKVIKC KAAIAWEAGK PLCIEEVEVA PPKAHEVRIQ IIATSLCHTD ATVIDSKFEG 
LAFPVIVGHE AAGIVESIGP GVTNVKPGDK VIPLYAPLCR KCKFCLSPLT NLCGKISNLK 
SPASDQQLME DKTSRFTCKG KPVYHFFGTS TFSQYTVVSD INLAKIDDDA NLERVCLLGC 
GFSTGYGAAI NNAKVTPGST CAVFGLGGVG LSAVMGCKAA GASRIIGIDI NSEKFVKAKA 
LGATDCLNPR DLHKPIQEVI IELTKGGVDF ALDCAGGSET MKAALDCTTA GWGSCTFIGV 
AAGSKGLTIF PEELIIGRTI NGTFFGGWKS VDSIPKLVTD YKNKKFNLDA LVTHTLPFDK 
ISEAFDLMNQ GKSVRTILIF

Genular Protein ID: 2985519914

Symbol: V9HVX7_HUMAN

Name: N/A

UniProtKB Accession Codes:

V9HVX7

Database IDs:

ARBA 4 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 3 Gene3D 2 GenomeRNAi 1 InterPro 6 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 Pfam 2 RefSeq 3 RuleBase 1 SMART 2 SUPFAM 2

Sequence Information:

  • Length: 392
  • Mass: 41641
  • Checksum: C7ADA6A4F278C522
  • Sequence:
    • MGTKGKVIKC KAAIAWEAGK PLCIEEVEVA PPKAHEVRIQ IIATSLCHTD ASVIDSKFEG 
LAFPVIVGHE AAGIVESIGP GVTNVKPGDK VIPLYAPLCR KCKFCLSPLT NLCGKISNLK 
SPASDQQLME DKTSRFTCKG KPVYHFFGTS TFSQYTVVSD INLAKIDDDA NLERVCLLGC 
GFSTGYGAAI NNAKVTPGST CAVFGLGGVG LSAVMGCKAA GASRIIGIDI NSEKFVKAKA 
LGATDCLNPR DLHKPIQEVI IELTKGGVDF ALDCAGGSET MKAALDCTTA GWGSCTFIGV 
AAGSKGLTIF PEELIIGRTI NGTFFGGWKS VDSIPKLVTD YKNKKFNLDA LVTHTLPFDK 
ISEAFDLMNQ GKSVRTILIF GRCQEQFRIL SD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.