ADH4 | ENSG00000198099 | NCBI 127

Details for: ADH4

Gene ID: 127

Symbol: ADH4

Ensembl ID: ENSG00000198099

Description: alcohol dehydrogenase 4 (class II), pi polypeptide

Associated with

Biological oxidations
(R-HSA-211859)
Metabolism
(R-HSA-1430728)
Phase i - functionalization of compounds
(R-HSA-211945)
Ra biosynthesis pathway
(R-HSA-5365859)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by retinoic acid
(R-HSA-5362517)
Signal transduction
(R-HSA-162582)
Alcohol catabolic process
(GO:0046164)
Alcohol dehydrogenase (nad+) activity
(GO:0004022)
Alcohol dehydrogenase activity, zinc-dependent
(GO:0004024)
Alcohol metabolic process
(GO:0006066)
Alditol:nadp+ 1-oxidoreductase activity
(GO:0004032)
All-trans retinal binding
(GO:0005503)
Benzaldehyde dehydrogenase [nad(p)+] activity
(GO:0019115)
Cellular aldehyde metabolic process
(GO:0006081)
Cytosol
(GO:0005829)
Ethanol oxidation
(GO:0006069)
Fatty acid omega-oxidation
(GO:0010430)
Formaldehyde catabolic process
(GO:0046294)
Nad-retinol dehydrogenase activity
(GO:0004745)
Nad binding
(GO:0051287)
Nadph:quinone reductase activity
(GO:0003960)
Nucleoplasm
(GO:0005654)
Oxidoreductase activity, acting on the aldehyde or oxo group of donors, nad or nadp as acceptor
(GO:0016620)
Protein binding
(GO:0005515)
Quinone metabolic process
(GO:1901661)
Retinoid metabolic process
(GO:0001523)
Retinol binding
(GO:0019841)
Retinol metabolic process
(GO:0042572)
S-(hydroxymethyl)glutathione dehydrogenase activity
(GO:0051903)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

Alcohol dehydrogenase 4
V9HVX7_HUMAN

Genular Protein ID: 2603725701

Symbol: ADH4_HUMAN

Name: Alcohol dehydrogenase 4

UniProtKB Accession Codes:

P08319 A8K470 B4DIE7 C9J4A9 Q8TCD7

Database IDs:

Citations:

PubMed ID: 3036213

Title: Structure of the class II enzyme of human liver alcohol dehydrogenase: combined cDNA and protein sequence determination of the pi subunit.

PubMed ID: 3036213

DOI: 10.1021/bi00381a021

PubMed ID: 1889753

Title: Cloning and characterization of the human ADH4 gene.

PubMed ID: 1889753

DOI: 10.1016/0378-1119(91)90285-j

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10514444

Title: A novel subtype of class II alcohol dehydrogenase in rodents. Unique Pro(47) and Ser(182) modulates hydride transfer in the mouse enzyme.

PubMed ID: 10514444

DOI: 10.1074/jbc.274.42.29712

PubMed ID: 16081420

Title: Omega-oxidation of 20-hydroxyeicosatetraenoic acid (20-HETE) in cerebral microvascular smooth muscle and endothelium by alcohol dehydrogenase 4.

PubMed ID: 16081420

DOI: 10.1074/jbc.m504055200

PubMed ID: 17279314

Title: Alcohol dehydrogenase 2 is a major hepatic enzyme for human retinol metabolism.

PubMed ID: 17279314

DOI: 10.1007/s00018-007-6449-8

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

Length: 380
Mass: 40222
Checksum: 45721A08197629F1
Sequence:

MGTKGKVIKC KAAIAWEAGK PLCIEEVEVA PPKAHEVRIQ IIATSLCHTD ATVIDSKFEG 
LAFPVIVGHE AAGIVESIGP GVTNVKPGDK VIPLYAPLCR KCKFCLSPLT NLCGKISNLK 
SPASDQQLME DKTSRFTCKG KPVYHFFGTS TFSQYTVVSD INLAKIDDDA NLERVCLLGC 
GFSTGYGAAI NNAKVTPGST CAVFGLGGVG LSAVMGCKAA GASRIIGIDI NSEKFVKAKA 
LGATDCLNPR DLHKPIQEVI IELTKGGVDF ALDCAGGSET MKAALDCTTA GWGSCTFIGV 
AAGSKGLTIF PEELIIGRTI NGTFFGGWKS VDSIPKLVTD YKNKKFNLDA LVTHTLPFDK 
ISEAFDLMNQ GKSVRTILIF

Genular Protein ID: 2985519914

Symbol: V9HVX7_HUMAN

Name: N/A

UniProtKB Accession Codes:

V9HVX7

Database IDs:

Sequence Information:

Length: 392
Mass: 41641
Checksum: C7ADA6A4F278C522
Sequence:

MGTKGKVIKC KAAIAWEAGK PLCIEEVEVA PPKAHEVRIQ IIATSLCHTD ASVIDSKFEG 
LAFPVIVGHE AAGIVESIGP GVTNVKPGDK VIPLYAPLCR KCKFCLSPLT NLCGKISNLK 
SPASDQQLME DKTSRFTCKG KPVYHFFGTS TFSQYTVVSD INLAKIDDDA NLERVCLLGC 
GFSTGYGAAI NNAKVTPGST CAVFGLGGVG LSAVMGCKAA GASRIIGIDI NSEKFVKAKA 
LGATDCLNPR DLHKPIQEVI IELTKGGVDF ALDCAGGSET MKAALDCTTA GWGSCTFIGV 
AAGSKGLTIF PEELIIGRTI NGTFFGGWKS VDSIPKLVTD YKNKKFNLDA LVTHTLPFDK 
ISEAFDLMNQ GKSVRTILIF GRCQEQFRIL SD

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: ADH4

Associated with

Other Information

Structure of the class II enzyme of human liver alcohol dehydrogenase: combined cDNA and protein sequence determination of the pi subunit. PubMed ID: 3036213

Cloning and characterization of the human ADH4 gene. PubMed ID: 1889753

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A novel subtype of class II alcohol dehydrogenase in rodents. Unique Pro(47) and Ser(182) modulates hydride transfer in the mouse enzyme. PubMed ID: 10514444

Omega-oxidation of 20-hydroxyeicosatetraenoic acid (20-HETE) in cerebral microvascular smooth muscle and endothelium by alcohol dehydrogenase 4. PubMed ID: 16081420

Alcohol dehydrogenase 2 is a major hepatic enzyme for human retinol metabolism. PubMed ID: 17279314

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569