Details for: CNTF

Gene ID: 1270

Symbol: CNTF

Ensembl ID: ENSG00000242689

Description: ciliary neurotrophic factor

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.21
    Marker Score: 2228
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.62
    Marker Score: 1179
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.51
    Marker Score: 1509
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 878
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 863
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.19
    Marker Score: 493
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7688
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.11
    Marker Score: 509
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.05
    Marker Score: 804
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1
    Marker Score: 515
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71841
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48066
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.99
    Marker Score: 468
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.95
    Marker Score: 379
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5354
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.92
    Marker Score: 331
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2744
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5292
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.84
    Marker Score: 487
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1269
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 713
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.78
    Marker Score: 402
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 468
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.71
    Marker Score: 2980
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.71
    Marker Score: 182
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.7
    Marker Score: 460.5
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.65
    Marker Score: 515
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.62
    Marker Score: 992
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.58
    Marker Score: 548
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.56
    Marker Score: 177
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.54
    Marker Score: 142
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.53
    Marker Score: 222.5
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.51
    Marker Score: 8036
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.5
    Marker Score: 481
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.37
    Marker Score: 758
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.35
    Marker Score: 203.5
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.28
    Marker Score: 532
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.26
    Marker Score: 544
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 66
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 76
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 43
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.16
    Marker Score: 73
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.15
    Marker Score: 91
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.14
    Marker Score: 82
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.13
    Marker Score: 78
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.11
    Marker Score: 392
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.1
    Marker Score: 50
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.1
    Marker Score: 45
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.09
    Marker Score: 102
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.09
    Marker Score: 79
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.09
    Marker Score: 86
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.07
    Marker Score: 171.5
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.07
    Marker Score: 67
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.07
    Marker Score: 121
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.07
    Marker Score: 158
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.06
    Marker Score: 97
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.06
    Marker Score: 14
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.06
    Marker Score: 143
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.06
    Marker Score: 22
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.05
    Marker Score: 29
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.05
    Marker Score: 18
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.05
    Marker Score: 27
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.05
    Marker Score: 30
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.05
    Marker Score: 33
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.05
    Marker Score: 27
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.05
    Marker Score: 430
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.05
    Marker Score: 71
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.05
    Marker Score: 37
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.04
    Marker Score: 25
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.04
    Marker Score: 376
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.04
    Marker Score: 68
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.04
    Marker Score: 18
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.04
    Marker Score: 31
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.03
    Marker Score: 2050
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.03
    Marker Score: 41
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.03
    Marker Score: 8
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.03
    Marker Score: 278
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.03
    Marker Score: 99
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.03
    Marker Score: 10
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.03
    Marker Score: 8
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.03
    Marker Score: 290
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 0.03
    Marker Score: 8
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.03
    Marker Score: 11
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.03
    Marker Score: 14
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.03
    Marker Score: 10
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.03
    Marker Score: 13
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.03
    Marker Score: 7
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.03
    Marker Score: 9
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.03
    Marker Score: 964
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.03
    Marker Score: 9
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.03
    Marker Score: 17
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.02
    Marker Score: 17
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.02
    Marker Score: 24
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.02
    Marker Score: 66
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.02
    Marker Score: 8
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.02
    Marker Score: 89
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.02
    Marker Score: 41
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.02
    Marker Score: 93

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics** - CNTF is a glycoprotein with a molecular weight of approximately 180 kDa. - It is produced by a variety of cell types in the eye, including retinal cells, vascular endothelial cells, and immune cells. - CNTF is a potent neurotrophic factor, which means that it can promote the survival and growth of neurons. - It is also a cytokine, which is a protein that can bind to receptors on cells and trigger a signaling cascade. **Pathways and functions** - CNTF binds to the ciliary neurotrophic factor receptor (CNTFR) on the surface of retinal cells. - Activation of the CNTFR leads to the phosphorylation of a number of intracellular proteins, including STAT3 and MAPK. - These phosphorylation events promote the survival and growth of retinal cells. - CNTF also inhibits the apoptosis of retinal cells, which helps to maintain their health. **Clinical significance** - Mutations in the CNTF gene have been linked to a number of eye diseases, including retinitis pigmentosa and macular degeneration. - CNTF is a potential therapeutic for these diseases, as it can be used to protect retinal cells from damage and promote their growth. - Clinical trials of CNTF have shown promise in restoring vision in patients with retinitis pigmentosa. **Other important points** - CNTF is a highly conserved protein, with a similar protein found in humans and other mammals. - It is a key factor in the development of the retina during embryonic development. - CNTF is also involved in the regulation of inflammation in the eye.

Genular Protein ID: 2214813036

Symbol: CNTF_HUMAN

Name: Ciliary neurotrophic factor

UniProtKB Accession Codes:

P26441 B2RAB2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 1 EvolutionaryTrace 1 GO 22 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 1861138

Title: Recombinant human and rat ciliary neurotrophic factors.

PubMed ID: 1861138

DOI: 10.1111/j.1471-4159.1991.tb08250.x

PubMed ID: 1915374

Title: Cloning and expression of human ciliary neurotrophic factor.

PubMed ID: 1915374

DOI: 10.1111/j.1432-1033.1991.tb16286.x

PubMed ID: 1840538

Title: Sequence and structural organization of the human gene encoding ciliary neurotrophic factor.

PubMed ID: 1840538

DOI: 10.1016/0378-1119(91)90089-t

PubMed ID: 1883844

Title: Expression and characterization of recombinant human ciliary neurotrophic factor from Escherichia coli.

PubMed ID: 1883844

DOI: 10.1016/0167-4781(91)90038-n

PubMed ID: 8075647

Title: A null mutation in the human CNTF gene is not causally related to neurological diseases.

PubMed ID: 8075647

DOI: 10.1038/ng0594-79

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7796798

Title: Crystal structure of dimeric human ciliary neurotrophic factor determined by MAD phasing.

PubMed ID: 7796798

DOI: 10.1002/j.1460-2075.1995.tb07269.x

PubMed ID: 10391209

Title: Characterization of single-nucleotide polymorphisms in coding regions of human genes.

PubMed ID: 10391209

DOI: 10.1038/10290

Sequence Information:

  • Length: 200
  • Mass: 22931
  • Checksum: EDD9D895BDA6F35A
  • Sequence:
    • MAFTEHSPLT PHRRDLCSRS IWLARKIRSD LTALTESYVK HQGLNKNINL DSADGMPVAS 
TDQWSELTEA ERLQENLQAY RTFHVLLARL LEDQQVHFTP TEGDFHQAIH TLLLQVAAFA 
YQIEELMILL EYKIPRNEAD GMPINVGDGG LFEKKLWGLK VLQELSQWTV RSIHDLRFIS 
SHQTGIPARG SHYIANNKKM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.