Details for: CNTF

Gene ID: 1270

Symbol: CNTF

Ensembl ID: ENSG00000242689

Description: ciliary neurotrophic factor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 2.8532
    Cell Significance Index: 91.3900
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.5921
    Cell Significance Index: 8.6300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2278
    Cell Significance Index: 4.9400
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.2190
    Cell Significance Index: 2.8300
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: 0.1087
    Cell Significance Index: 1.3500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.1070
    Cell Significance Index: 2.2200
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.0991
    Cell Significance Index: 1.4200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0562
    Cell Significance Index: 1.6200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0488
    Cell Significance Index: 1.0400
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.0371
    Cell Significance Index: 0.5200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0251
    Cell Significance Index: 0.3600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0187
    Cell Significance Index: 3.7600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0113
    Cell Significance Index: 0.5100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.0084
    Cell Significance Index: 0.1800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0081
    Cell Significance Index: 0.5100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0075
    Cell Significance Index: 2.7100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0050
    Cell Significance Index: 0.2600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0019
    Cell Significance Index: 0.2300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0014
    Cell Significance Index: 0.4000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0002
    Cell Significance Index: 0.1300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0004
    Cell Significance Index: -0.7500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0005
    Cell Significance Index: -0.0200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0010
    Cell Significance Index: -0.7100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0010
    Cell Significance Index: -0.7700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0011
    Cell Significance Index: -0.7200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0014
    Cell Significance Index: -0.2500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0015
    Cell Significance Index: -0.8400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0021
    Cell Significance Index: -0.9600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0024
    Cell Significance Index: -0.0600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0025
    Cell Significance Index: -0.3100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0025
    Cell Significance Index: -0.5000
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0025
    Cell Significance Index: -0.0300
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0027
    Cell Significance Index: -0.0300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0028
    Cell Significance Index: -0.4000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0037
    Cell Significance Index: -0.1900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0039
    Cell Significance Index: -0.8300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0040
    Cell Significance Index: -0.6800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0041
    Cell Significance Index: -0.1800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0043
    Cell Significance Index: -0.5900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0045
    Cell Significance Index: -0.5200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0046
    Cell Significance Index: -0.3500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0050
    Cell Significance Index: -0.5900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0051
    Cell Significance Index: -0.6500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0058
    Cell Significance Index: -0.2200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0064
    Cell Significance Index: -0.3600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0064
    Cell Significance Index: -0.3000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0071
    Cell Significance Index: -0.2500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0081
    Cell Significance Index: -0.8300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0093
    Cell Significance Index: -0.2500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0104
    Cell Significance Index: -0.4200
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0106
    Cell Significance Index: -0.2200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0107
    Cell Significance Index: -0.3400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0107
    Cell Significance Index: -0.7200
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: -0.0114
    Cell Significance Index: -0.1200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0119
    Cell Significance Index: -0.3900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0121
    Cell Significance Index: -0.4300
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0123
    Cell Significance Index: -0.1700
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.0124
    Cell Significance Index: -0.1200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0126
    Cell Significance Index: -0.5900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0132
    Cell Significance Index: -0.8500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0132
    Cell Significance Index: -0.1800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0135
    Cell Significance Index: -0.8300
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0138
    Cell Significance Index: -0.1800
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0149
    Cell Significance Index: -0.2500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0150
    Cell Significance Index: -0.7900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0152
    Cell Significance Index: -0.3800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0169
    Cell Significance Index: -0.3700
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0176
    Cell Significance Index: -0.2100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0191
    Cell Significance Index: -0.5100
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: -0.0207
    Cell Significance Index: -0.2100
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0211
    Cell Significance Index: -0.2900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0212
    Cell Significance Index: -0.4900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0220
    Cell Significance Index: -0.4400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0225
    Cell Significance Index: -0.4700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0226
    Cell Significance Index: -0.4800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0237
    Cell Significance Index: -0.5200
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0243
    Cell Significance Index: -0.4200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0244
    Cell Significance Index: -0.4900
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.0253
    Cell Significance Index: -0.3200
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0253
    Cell Significance Index: -0.3600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0255
    Cell Significance Index: -0.7500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0255
    Cell Significance Index: -0.7500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0259
    Cell Significance Index: -0.6600
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0262
    Cell Significance Index: -0.3300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0262
    Cell Significance Index: -0.7000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0264
    Cell Significance Index: -0.9700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0270
    Cell Significance Index: -0.7100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0272
    Cell Significance Index: -0.7800
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0273
    Cell Significance Index: -0.4500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0279
    Cell Significance Index: -0.8000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0280
    Cell Significance Index: -0.7200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0283
    Cell Significance Index: -0.7700
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0284
    Cell Significance Index: -0.3600
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0292
    Cell Significance Index: -0.5700
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0300
    Cell Significance Index: -0.5900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0301
    Cell Significance Index: -0.7700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0320
    Cell Significance Index: -0.8000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0330
    Cell Significance Index: -0.8000
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0334
    Cell Significance Index: -0.5000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0338
    Cell Significance Index: -0.8100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** CNTF is a dimeric protein composed of two subunits, each consisting of an alpha and a beta chain. The protein is highly conserved across species and has been identified in various tissues, including the CNS, peripheral nervous system, and immune cells. CNTF is secreted by astrocytes and other cells of the CNS and acts through a specific receptor, CNTF receptor (CNTFR), which is expressed on the surface of neurons and immune cells. The CNTFR is a heterodimeric receptor composed of a signal-transducing component, gp130, and a ligand-binding component, LIFRβ. **Pathways and Functions** CNTF signaling pathway involves the binding of CNTF to its receptor, CNTFR, which triggers a series of downstream signaling events. The CNTF receptor is a member of the gp130 family of receptors and is characterized by its ability to associate with the JAK/STAT signaling pathway. Upon binding of CNTF to CNTFR, the receptor undergoes dimerization and recruits JAK2, a tyrosine kinase, which phosphorylates and activates STAT proteins. The activated STAT proteins then translocate to the nucleus and regulate the expression of target genes involved in neuronal development, survival, and regeneration. CNTF has been shown to regulate various biological processes, including: 1. **Neuronal survival and regeneration**: CNTF has been shown to promote neuronal survival and regeneration by activating the JAK/STAT signaling pathway and regulating the expression of genes involved in neuronal development and survival. 2. **Axon regeneration**: CNTF has been implicated in the regulation of axon regeneration by activating the CNTFR receptor and triggering a series of downstream signaling events that promote axonal growth and regeneration. 3. **Immune responses**: CNTF has been shown to modulate immune responses by activating the CNTFR receptor and regulating the expression of genes involved in immune cell development and function. **Clinical Significance** CNTF has been implicated in various neurological and immunological disorders, including: 1. **Multiple Sclerosis**: CNTF has been shown to promote neuronal survival and regeneration in the CNS, and its dysregulation has been implicated in the pathogenesis of multiple sclerosis. 2. **Amyotrophic Lateral Sclerosis**: CNTF has been shown to regulate axon regeneration and neuronal survival in the peripheral nervous system, and its dysregulation has been implicated in the pathogenesis of amyotrophic lateral sclerosis. 3. **Neuropathic Pain**: CNTF has been shown to modulate pain transmission and has been investigated as a potential therapeutic agent for the treatment of neuropathic pain. In conclusion, CNTF is a multifunctional cytokine that plays a crucial role in various biological processes, including neuronal development, survival, and regeneration. Its dysregulation has been implicated in various neurological and immunological disorders, and its therapeutic potential has been explored in the context of regenerative medicine and immunology.

Genular Protein ID: 2214813036

Symbol: CNTF_HUMAN

Name: Ciliary neurotrophic factor

UniProtKB Accession Codes:

P26441 B2RAB2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 10 EMDB 1 Ensembl 1 EvolutionaryTrace 1 GO 22 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 1861138

Title: Recombinant human and rat ciliary neurotrophic factors.

PubMed ID: 1861138

DOI: 10.1111/j.1471-4159.1991.tb08250.x

PubMed ID: 1915374

Title: Cloning and expression of human ciliary neurotrophic factor.

PubMed ID: 1915374

DOI: 10.1111/j.1432-1033.1991.tb16286.x

PubMed ID: 1840538

Title: Sequence and structural organization of the human gene encoding ciliary neurotrophic factor.

PubMed ID: 1840538

DOI: 10.1016/0378-1119(91)90089-t

PubMed ID: 1883844

Title: Expression and characterization of recombinant human ciliary neurotrophic factor from Escherichia coli.

PubMed ID: 1883844

DOI: 10.1016/0167-4781(91)90038-n

PubMed ID: 8075647

Title: A null mutation in the human CNTF gene is not causally related to neurological diseases.

PubMed ID: 8075647

DOI: 10.1038/ng0594-79

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7796798

Title: Crystal structure of dimeric human ciliary neurotrophic factor determined by MAD phasing.

PubMed ID: 7796798

DOI: 10.1002/j.1460-2075.1995.tb07269.x

PubMed ID: 10391209

Title: Characterization of single-nucleotide polymorphisms in coding regions of human genes.

PubMed ID: 10391209

DOI: 10.1038/10290

Sequence Information:

  • Length: 200
  • Mass: 22931
  • Checksum: EDD9D895BDA6F35A
  • Sequence:
    • MAFTEHSPLT PHRRDLCSRS IWLARKIRSD LTALTESYVK HQGLNKNINL DSADGMPVAS 
TDQWSELTEA ERLQENLQAY RTFHVLLARL LEDQQVHFTP TEGDFHQAIH TLLLQVAAFA 
YQIEELMILL EYKIPRNEAD GMPINVGDGG LFEKKLWGLK VLQELSQWTV RSIHDLRFIS 
SHQTGIPARG SHYIANNKKM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.