Genular: Defining Cellular Identity and Function

Details for: Socs3

Gene ID: 12702

Symbol: Socs3

Ensembl ID: ENSMUSG00000053113

Description: suppressor of cytokine signaling 3

Associated with

Adaptive immune system
(R-MMU-1280218)
Antigen processing: ubiquitination & proteasome degradation
(R-MMU-983168)
Class i mhc mediated antigen processing & presentation
(R-MMU-983169)
Cytokine signaling in immune system
(R-MMU-1280215)
Immune system
(R-MMU-168256)
Inactivation of csf3 (g-csf) signaling
(R-MMU-9705462)
Interferon alpha/beta signaling
(R-MMU-909733)
Interferon gamma signaling
(R-MMU-877300)
Interferon signaling
(R-MMU-913531)
Interleukin-6 family signaling
(R-MMU-6783589)
Interleukin-6 signaling
(R-MMU-1059683)
Metabolism of proteins
(R-MMU-392499)
Neddylation
(R-MMU-8951664)
Post-translational protein modification
(R-MMU-597592)
Ptk6 activates stat3
(R-MMU-8849474)
Regulation of ifng signaling
(R-MMU-877312)
Signaling by csf3 (g-csf)
(R-MMU-9674555)
Signaling by interleukins
(R-MMU-449147)
Signaling by non-receptor tyrosine kinases
(R-MMU-9006927)
Signaling by ptk6
(R-MMU-8848021)
1-phosphatidylinositol-3-kinase regulator activity
(GO:0046935)
Branching involved in labyrinthine layer morphogenesis
(GO:0060670)
Cell differentiation
(GO:0030154)
Cellular response to interleukin-17
(GO:0097398)
Cellular response to leukemia inhibitory factor
(GO:1990830)
Cytoplasmic side of plasma membrane
(GO:0009898)
Cytosol
(GO:0005829)
Intracellular signal transduction
(GO:0035556)
Mirna binding
(GO:0035198)
Negative regulation of inflammatory response
(GO:0050728)
Negative regulation of insulin receptor signaling pathway
(GO:0046627)
Negative regulation of receptor signaling pathway via jak-stat
(GO:0046426)
Negative regulation of signal transduction
(GO:0009968)
Negative regulation of tyrosine phosphorylation of stat protein
(GO:0042532)
Phosphatidylinositol 3-kinase complex
(GO:0005942)
Phosphatidylinositol phosphate biosynthetic process
(GO:0046854)
Phosphotyrosine residue binding
(GO:0001784)
Placenta blood vessel development
(GO:0060674)
Positive regulation of cell differentiation
(GO:0045597)
Protein binding
(GO:0005515)
Protein tyrosine kinase inhibitor activity
(GO:0030292)
Receptor signaling pathway via jak-stat
(GO:0007259)
Regulation of protein phosphorylation
(GO:0001932)
Signal transduction
(GO:0007165)

Other Information

Proteins

Cytokine-inducible SH2 protein 3

Genular Protein ID: 645582420

Symbol: SOCS3_MOUSE

Name: Cytokine-inducible SH2 protein 3

UniProtKB Accession Codes:

O35718 P97803 Q3U7X5

Database IDs:

Citations:

PubMed ID: 9202125

Title: A family of cytokine-inducible inhibitors of signaling.

PubMed ID: 9202125

DOI: 10.1038/43206

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10359822

Title: Autoregulation of pituitary corticotroph SOCS-3 expression: characterization of the murine SOCS-3 promoter.

PubMed ID: 10359822

DOI: 10.1073/pnas.96.12.6964

PubMed ID: 9032278

Title: E2a-Pbx1 induces aberrant expression of tissue-specific and developmentally regulated genes when expressed in NIH 3T3 fibroblasts.

PubMed ID: 9032278

DOI: 10.1128/mcb.17.3.1503

PubMed ID: 9889194

Title: Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction.

PubMed ID: 9889194

DOI: 10.1093/emboj/18.2.375

PubMed ID: 10821852

Title: SOCS-3 is an insulin-induced negative regulator of insulin signaling.

PubMed ID: 10821852

DOI: 10.1074/jbc.275.21.15985

PubMed ID: 10882725

Title: CIS3/SOCS-3 suppresses erythropoietin (EPO) signaling by binding the EPO receptor and JAK2.

PubMed ID: 10882725

DOI: 10.1074/jbc.m003456200

PubMed ID: 12242343

Title: Expression of the suppressor of cytokine signaling-5 (SOCS5) negatively regulates IL-4-dependent STAT6 activation and Th2 differentiation.

PubMed ID: 12242343

DOI: 10.1073/pnas.202477099

PubMed ID: 10490101

Title: SOCS3 is essential in the regulation of fetal liver erythropoiesis.

PubMed ID: 10490101

DOI: 10.1016/s0092-8674(00)80049-5

PubMed ID: 12754505

Title: SOCS3 negatively regulates IL-6 signaling in vivo.

PubMed ID: 12754505

DOI: 10.1038/ni931

PubMed ID: 12847520

Title: SOCS-3 regulates onset and maintenance of T(H)2-mediated allergic responses.

PubMed ID: 12847520

DOI: 10.1038/nm896

PubMed ID: 15213237

Title: BCL10 mediates lipopolysaccharide/toll-like receptor-4 signaling through interaction with Pellino2.

PubMed ID: 15213237

DOI: 10.1074/jbc.m400241200

PubMed ID: 23019338

Title: Proteasomal degradation of Nod2 protein mediates tolerance to bacterial cell wall components.

PubMed ID: 23019338

DOI: 10.1074/jbc.m112.410027

PubMed ID: 16630890

Title: The structure of SOCS3 reveals the basis of the extended SH2 domain function and identifies an unstructured insertion that regulates stability.

PubMed ID: 16630890

DOI: 10.1016/j.molcel.2006.03.024

PubMed ID: 16905102

Title: Structural basis for phosphotyrosine recognition by suppressor of cytokine signaling-3.

PubMed ID: 16905102

DOI: 10.1016/j.str.2006.06.011

Sequence Information:

Length: 225
Mass: 24776
Checksum: CD3859561D4CCDED
Sequence:

MVTHSKFPAA GMSRPLDTSL RLKTFSSKSE YQLVVNAVRK LQESGFYWSA VTGGEANLLL 
SAEPAGTFLI RDSSDQRHFF TLSVKTQSGT KNLRIQCEGG SFSLQSDPRS TQPVPRFDCV 
LKLVHHYMPP PGTPSFSLPP TEPSSEVPEQ PPAQALPGST PKRAYYIYSG GEKIPLVLSR 
PLSSNVATLQ HLCRKTVNGH LDSYEKVTQL PGPIREFLDQ YDAPL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Socs3

Associated with

Other Information

A family of cytokine-inducible inhibitors of signaling. PubMed ID: 9202125

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Autoregulation of pituitary corticotroph SOCS-3 expression: characterization of the murine SOCS-3 promoter. PubMed ID: 10359822

E2a-Pbx1 induces aberrant expression of tissue-specific and developmentally regulated genes when expressed in NIH 3T3 fibroblasts. PubMed ID: 9032278

Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction. PubMed ID: 9889194

SOCS-3 is an insulin-induced negative regulator of insulin signaling. PubMed ID: 10821852

CIS3/SOCS-3 suppresses erythropoietin (EPO) signaling by binding the EPO receptor and JAK2. PubMed ID: 10882725

Expression of the suppressor of cytokine signaling-5 (SOCS5) negatively regulates IL-4-dependent STAT6 activation and Th2 differentiation. PubMed ID: 12242343

SOCS3 is essential in the regulation of fetal liver erythropoiesis. PubMed ID: 10490101

SOCS3 negatively regulates IL-6 signaling in vivo. PubMed ID: 12754505

SOCS-3 regulates onset and maintenance of T(H)2-mediated allergic responses. PubMed ID: 12847520

BCL10 mediates lipopolysaccharide/toll-like receptor-4 signaling through interaction with Pellino2. PubMed ID: 15213237

Proteasomal degradation of Nod2 protein mediates tolerance to bacterial cell wall components. PubMed ID: 23019338

The structure of SOCS3 reveals the basis of the extended SH2 domain function and identifies an unstructured insertion that regulates stability. PubMed ID: 16630890

Structural basis for phosphotyrosine recognition by suppressor of cytokine signaling-3. PubMed ID: 16905102