Details for: Socs1
Associated with
Other Information
Genular Protein ID: 3596307628
Symbol: SOCS1_MOUSE
Name: JAK-binding protein
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9202125
Title: A family of cytokine-inducible inhibitors of signaling.
PubMed ID: 9202125
DOI: 10.1038/43206
PubMed ID: 9202126
Title: A new protein containing an SH2 domain that inhibits JAK kinases.
PubMed ID: 9202126
DOI: 10.1038/43213
PubMed ID: 9202127
Title: Structure and function of a new STAT-induced STAT inhibitor.
PubMed ID: 9202127
DOI: 10.1038/43219
PubMed ID: 10022833
Title: SOCS-1 binds to multiple signaling proteins and suppresses Steel factor-dependent proliferation.
PubMed ID: 10022833
PubMed ID: 10764816
Title: Regulation of SOCS-1 expression by translational repression.
PubMed ID: 10764816
PubMed ID: 16141072
Title: The transcriptional landscape of the mammalian genome.
PubMed ID: 16141072
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9869640
Title: The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families.
PubMed ID: 9869640
PubMed ID: 10051596
Title: The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation.
PubMed ID: 10051596
PubMed ID: 12163497
Title: TRIM8/GERP RING finger protein interacts with SOCS-1.
PubMed ID: 12163497
PubMed ID: 9789053
Title: Three distinct domains of SSI-1/SOCS-1/JAB protein are required for its suppression of interleukin 6 signaling.
PubMed ID: 9789053
PubMed ID: 9826711
Title: Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1.
PubMed ID: 9826711
PubMed ID: 9889194
Title: Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction.
PubMed ID: 9889194
PubMed ID: 10064597
Title: The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop.
PubMed ID: 10064597
PubMed ID: 11522790
Title: A mutant form of JAB/SOCS1 augments the cytokine-induced JAK/STAT pathway by accelerating degradation of wild-type JAB/CIS family proteins through the SOCS-box.
PubMed ID: 11522790
PubMed ID: 12242343
Title: Expression of the suppressor of cytokine signaling-5 (SOCS5) negatively regulates IL-4-dependent STAT6 activation and Th2 differentiation.
PubMed ID: 12242343
PubMed ID: 15169905
Title: Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms.
PubMed ID: 15169905
PubMed ID: 15522878
Title: Role of tyrosine 441 of interferon-gamma receptor subunit 1 in SOCS-1-mediated attenuation of STAT1 activation.
PubMed ID: 15522878
PubMed ID: 24880459
Title: The transcription factor ThPOK suppresses Runx3 and imposes CD4(+) lineage fate by inducing the SOCS suppressors of cytokine signaling.
PubMed ID: 24880459
DOI: 10.1038/ni.2917
Sequence Information:
- Length: 212
- Mass: 23715
- Checksum: 4621E05DC3D44C69
- Sequence:
MVARNQVAAD NAISPAAEPR RRSEPSSSSS SSSPAAPVRP RPCPAVPAPA PGDTHFRTFR SHSDYRRITR TSALLDACGF YWGPLSVHGA HERLRAEPVG TFLVRDSRQR NCFFALSVKM ASGPTSIRVH FQAGRFHLDG SRETFDCLFE LLEHYVAAPR RMLGAPLRQR RVRPLQELCR QRIVAAVGRE NLARIPLNPV LRDYLSSFPF QI
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.