Details for: CNTFR

Gene ID: 1271

Symbol: CNTFR

Ensembl ID: ENSG00000122756

Description: ciliary neurotrophic factor receptor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 27.2744
    Cell Significance Index: -26.0400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.5781
    Cell Significance Index: -10.9900
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.1926
    Cell Significance Index: 18.9200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.9870
    Cell Significance Index: 12.6400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.9240
    Cell Significance Index: 19.3400
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.8840
    Cell Significance Index: 12.4000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.6921
    Cell Significance Index: 24.0500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5484
    Cell Significance Index: 196.7100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.5293
    Cell Significance Index: 27.7900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5017
    Cell Significance Index: 95.4700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4873
    Cell Significance Index: 337.0600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3117
    Cell Significance Index: 19.1600
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.2769
    Cell Significance Index: 2.2900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1879
    Cell Significance Index: 37.6900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1492
    Cell Significance Index: 134.7200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1366
    Cell Significance Index: 2.9600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0394
    Cell Significance Index: 0.6600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0200
    Cell Significance Index: 2.5700
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.0117
    Cell Significance Index: 0.0900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0099
    Cell Significance Index: 0.7000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0064
    Cell Significance Index: 0.6300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0012
    Cell Significance Index: 2.1500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0066
    Cell Significance Index: -1.0700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0083
    Cell Significance Index: -15.6400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0100
    Cell Significance Index: -4.4200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0123
    Cell Significance Index: -19.0000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0202
    Cell Significance Index: -0.8800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0206
    Cell Significance Index: -2.2400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0210
    Cell Significance Index: -0.6100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0222
    Cell Significance Index: -0.7800
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.0223
    Cell Significance Index: -0.1400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0251
    Cell Significance Index: -13.7200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0280
    Cell Significance Index: -38.1400
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0320
    Cell Significance Index: -0.1900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0357
    Cell Significance Index: -2.1500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0384
    Cell Significance Index: -28.1300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0403
    Cell Significance Index: -30.4700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0433
    Cell Significance Index: -27.5300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0450
    Cell Significance Index: -33.3100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0490
    Cell Significance Index: -0.8400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0566
    Cell Significance Index: -31.9000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0646
    Cell Significance Index: -1.6200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0678
    Cell Significance Index: -30.7900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0692
    Cell Significance Index: -19.9100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0802
    Cell Significance Index: -3.6400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0951
    Cell Significance Index: -13.0700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0996
    Cell Significance Index: -5.5900
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.1083
    Cell Significance Index: -1.2100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1097
    Cell Significance Index: -21.7700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1347
    Cell Significance Index: -24.2900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.1464
    Cell Significance Index: -10.1300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1596
    Cell Significance Index: -33.6100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1628
    Cell Significance Index: -21.0300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1826
    Cell Significance Index: -26.5400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1971
    Cell Significance Index: -33.6500
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.2029
    Cell Significance Index: -1.2700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.2078
    Cell Significance Index: -25.5600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2194
    Cell Significance Index: -25.5700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2199
    Cell Significance Index: -13.4800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2269
    Cell Significance Index: -23.1800
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.2318
    Cell Significance Index: -1.9700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2542
    Cell Significance Index: -26.4700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2556
    Cell Significance Index: -6.1300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2781
    Cell Significance Index: -6.0900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2930
    Cell Significance Index: -33.5700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2986
    Cell Significance Index: -20.0800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3480
    Cell Significance Index: -8.9500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3515
    Cell Significance Index: -26.2000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.3557
    Cell Significance Index: -5.3300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3631
    Cell Significance Index: -28.7600
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.3733
    Cell Significance Index: -4.6300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.3820
    Cell Significance Index: -6.6100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3856
    Cell Significance Index: -29.5900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3935
    Cell Significance Index: -24.8000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4063
    Cell Significance Index: -17.9700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.4098
    Cell Significance Index: -19.2600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.4148
    Cell Significance Index: -5.9400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.4287
    Cell Significance Index: -11.9800
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.4555
    Cell Significance Index: -2.7900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4909
    Cell Significance Index: -18.5900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4931
    Cell Significance Index: -25.6800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.4980
    Cell Significance Index: -10.7600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.5006
    Cell Significance Index: -14.3500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.5053
    Cell Significance Index: -26.2500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5438
    Cell Significance Index: -19.0500
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.5451
    Cell Significance Index: -7.6400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5728
    Cell Significance Index: -18.7600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5800
    Cell Significance Index: -12.3100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.6643
    Cell Significance Index: -14.2000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6751
    Cell Significance Index: -19.8900
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: -0.6857
    Cell Significance Index: -3.2800
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.6859
    Cell Significance Index: -7.8500
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.6952
    Cell Significance Index: -9.5200
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.6973
    Cell Significance Index: -9.7500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.7018
    Cell Significance Index: -22.3500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.7239
    Cell Significance Index: -33.7500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.7242
    Cell Significance Index: -14.5400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.7295
    Cell Significance Index: -23.3700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.7500
    Cell Significance Index: -18.3000
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.7578
    Cell Significance Index: -11.5100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structure:** The CNTFR gene encodes a subunit of the ciliary neurotrophic factor receptor, which is a transmembrane receptor composed of two subunits: a ligand-binding alpha subunit and a signal-transducing beta subunit. 2. **Expression:** CNTFR is expressed in various cell types, including pulmonary interstitial fibroblasts, kidney proximal convoluted tubule epithelial cells, mesangial cells, cortical thymic epithelial cells, peripheral nervous system neurons, chromaffin cells, GABAergic amacrine cells, Sertoli cells, astrocytes of the cerebral cortex, and germ cells. 3. **Function:** CNTFR is involved in neurotrophic signaling pathways, regulating the development, survival, and function of various neuronal populations. It also plays a role in immune regulation, particularly in cytokine signaling and immune cell development. **Pathways and Functions:** 1. **Ciliary Neurotrophic Factor-Mediated Signaling Pathway:** CNTFR is the primary receptor for ciliary neurotrophic factor (CNTF), a cytokine that promotes the survival and differentiation of neurons. The CNTF-CNTFR signaling pathway is involved in the development and maintenance of motor neurons, neurons of the central nervous system, and peripheral nervous system neurons. 2. **Cytokine Signaling in Immune System:** CNTFR is expressed on immune cells, including T cells and B cells, and plays a role in cytokine signaling, particularly in the context of interleukin-6 (IL-6) family signaling. This signaling pathway is involved in the regulation of immune responses, including the activation of immune cells and the production of cytokines. 3. **Negative Regulation of Motor Neuron Apoptotic Process:** CNTFR has been shown to negatively regulate the apoptotic process in motor neurons, suggesting a role in the maintenance of motor neuron survival and function. 4. **Positive Regulation of Cell Population Proliferation:** CNTFR has been implicated in the positive regulation of cell population proliferation, suggesting a role in the development and maintenance of various cell types. **Clinical Significance:** 1. **Neurodegenerative Diseases:** Dysregulation of CNTFR signaling has been implicated in various neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS). Therapeutic strategies targeting CNTFR signaling may offer novel approaches to treating these diseases. 2. **Immune System Disorders:** Abnormalities in CNTFR expression and signaling have been linked to immune system disorders, including autoimmune diseases and immunodeficiency syndromes. Understanding the role of CNTFR in immune regulation may lead to the development of novel therapeutic strategies for these conditions. 3. **Cancer:** CNTFR has been implicated in the regulation of cell proliferation and survival in various cancer types, including breast cancer and colon cancer. Further research is needed to understand the role of CNTFR in cancer development and progression. In conclusion, the CNTFR gene plays a critical role in neurotrophic signaling and immune regulation, and its dysregulation has been implicated in various diseases. Further research is needed to fully understand the mechanisms by which CNTFR regulates cell function and to develop novel therapeutic strategies targeting this receptor.

Genular Protein ID: 3441002583

Symbol: CNTFR_HUMAN

Name: Ciliary neurotrophic factor receptor subunit alpha

UniProtKB Accession Codes:

P26992 Q5U050

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 12 EMDB 5 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 21 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 6 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1648265

Title: The receptor for ciliary neurotrophic factor.

PubMed ID: 1648265

DOI: 10.1126/science.1648265

PubMed ID: 7774913

Title: Genomic organization and chromosomal localization of the human and mouse genes encoding the alpha receptor component for ciliary neurotrophic factor.

PubMed ID: 7774913

DOI: 10.1016/0888-7543(95)80121-2

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19386761

Title: Humanin inhibits neuronal cell death by interacting with a cytokine receptor complex or complexes involving CNTF receptor alpha/WSX-1/gp130.

PubMed ID: 19386761

DOI: 10.1091/mbc.e09-02-0168

PubMed ID: 26858303

Title: Cytokine-like factor 1, an essential facilitator of cardiotrophin-like cytokine:ciliary neurotrophic factor receptor alpha signaling and sorLA-mediated turnover.

PubMed ID: 26858303

DOI: 10.1128/mcb.00917-15

PubMed ID: 12707266

Title: Solution structure of the C-terminal domain of the ciliary neurotrophic factor (CNTF) receptor and ligand free associations among components of the CNTF receptor complex.

PubMed ID: 12707266

DOI: 10.1074/jbc.m301976200

Sequence Information:

  • Length: 372
  • Mass: 40633
  • Checksum: B2F3F73DE8F8750E
  • Sequence:
    • MAAPVPWACC AVLAAAAAVV YAQRHSPQEA PHVQYERLGS DVTLPCGTAN WDAAVTWRVN 
GTDLAPDLLN GSQLVLHGLE LGHSGLYACF HRDSWHLRHQ VLLHVGLPPR EPVLSCRSNT 
YPKGFYCSWH LPTPTYIPNT FNVTVLHGSK IMVCEKDPAL KNRCHIRYMH LFSTIKYKVS 
ISVSNALGHN ATAITFDEFT IVKPDPPENV VARPVPSNPR RLEVTWQTPS TWPDPESFPL 
KFFLRYRPLI LDQWQHVELS DGTAHTITDA YAGKEYIIQV AAKDNEIGTW SDWSVAAHAT 
PWTEEPRHLT TEAQAAETTT STTSSLAPPP TTKICDPGEL GSGGGPSAPF LVSVPITLAL 
AAAAATASSL LI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.