Gene CNTFR - ENSG00000122756 | NCBI Gene ID: 1271

Details for: CNTFR

Gene ID: 1271

Symbol: CNTFR

Ensembl ID: ENSG00000122756

Description: ciliary neurotrophic factor receptor

Associated with

Cytokine signaling in immune system
(R-HSA-1280215)
Il-6-type cytokine receptor ligand interactions
(R-HSA-6788467)
Immune system
(R-HSA-168256)
Interleukin-6 family signaling
(R-HSA-6783589)
Signaling by interleukins
(R-HSA-449147)
Apical plasma membrane
(GO:0016324)
Brainstem development
(GO:0003360)
Ciliary neurotrophic factor-mediated signaling pathway
(GO:0070120)
Ciliary neurotrophic factor receptor activity
(GO:0004897)
Ciliary neurotrophic factor receptor complex
(GO:0070110)
Cntfr-clcf1 complex
(GO:0097059)
Cytokine binding
(GO:0019955)
Cytokine receptor activity
(GO:0004896)
External side of plasma membrane
(GO:0009897)
Extrinsic component of membrane
(GO:0019898)
Motor neuron apoptotic process
(GO:0097049)
Negative regulation of motor neuron apoptotic process
(GO:2000672)
Negative regulation of neuron apoptotic process
(GO:0043524)
Nervous system development
(GO:0007399)
Plasma membrane
(GO:0005886)
Positive regulation of cell population proliferation
(GO:0008284)
Protein binding
(GO:0005515)
Sex differentiation
(GO:0007548)
Signaling receptor binding
(GO:0005102)
Signal transduction
(GO:0007165)
Skeletal muscle organ development
(GO:0060538)
Suckling behavior
(GO:0001967)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 2.27
Marker Score: 1816
Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 2.23
Marker Score: 4617
Cell Name: mesangial cell (CL0000650)
Fold Change: 1.75
Marker Score: 2110
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 1.7
Marker Score: 6301
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 1.68
Marker Score: 1891
Cell Name: chromaffin cell (CL0000166)
Fold Change: 1.68
Marker Score: 2363
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 1.63
Marker Score: 3316
Cell Name: Sertoli cell (CL0000216)
Fold Change: 1.59
Marker Score: 9439.5
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 1.49
Marker Score: 31845
Cell Name: germ cell (CL0000586)
Fold Change: 1.46
Marker Score: 2555
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.37
Marker Score: 869
Cell Name: interstitial cell of Cajal (CL0002088)
Fold Change: 1.32
Marker Score: 457
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 1.3
Marker Score: 8449
Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
Fold Change: 1.22
Marker Score: 409
Cell Name: mesodermal cell (CL0000222)
Fold Change: 1.21
Marker Score: 16016
Cell Name: keratocyte (CL0002363)
Fold Change: 1.21
Marker Score: 278
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 1.17
Marker Score: 487
Cell Name: goblet cell (CL0000160)
Fold Change: 1.13
Marker Score: 7538
Cell Name: inhibitory motor neuron (CL0008015)
Fold Change: 1.12
Marker Score: 529
Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.12
Marker Score: 4311
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 1.09
Marker Score: 1321
Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 1.05
Marker Score: 986
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 1.04
Marker Score: 795
Cell Name: fat cell (CL0000136)
Fold Change: 1.02
Marker Score: 572
Cell Name: motor neuron (CL0000100)
Fold Change: 1.02
Marker Score: 603
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71814
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48039
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.99
Marker Score: 509
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30407
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.98
Marker Score: 463
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.96
Marker Score: 441
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2411
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.95
Marker Score: 1793.5
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.94
Marker Score: 14767
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.93
Marker Score: 374
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.93
Marker Score: 5321
Cell Name: mature astrocyte (CL0002627)
Fold Change: 0.93
Marker Score: 613.5
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 0.91
Marker Score: 13660
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2736
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.91
Marker Score: 326
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.88
Marker Score: 337
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5284
Cell Name: Mueller cell (CL0000636)
Fold Change: 0.87
Marker Score: 1204.5
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.85
Marker Score: 421
Cell Name: astrocyte (CL0000127)
Fold Change: 0.83
Marker Score: 723
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 0.81
Marker Score: 1255
Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 0.8
Marker Score: 30312
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 0.79
Marker Score: 1218.5
Cell Name: neural progenitor cell (CL0011020)
Fold Change: 0.79
Marker Score: 3041
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 0.78
Marker Score: 28951
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 0.78
Marker Score: 5964
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.78
Marker Score: 3263
Cell Name: brush cell (CL0002204)
Fold Change: 0.78
Marker Score: 708
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1259
Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
Fold Change: 0.77
Marker Score: 203.5
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.77
Marker Score: 1309
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.77
Marker Score: 397
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 0.76
Marker Score: 6545
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.76
Marker Score: 501
Cell Name: adventitial cell (CL0002503)
Fold Change: 0.75
Marker Score: 186
Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.73
Marker Score: 232.5
Cell Name: Unknown (CL0002371)
Fold Change: 0.73
Marker Score: 773
Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 0.71
Marker Score: 347
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 0.71
Marker Score: 447
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.7
Marker Score: 180
Cell Name: neuron (CL0000540)
Fold Change: 0.7
Marker Score: 2837
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 0.69
Marker Score: 591
Cell Name: cerebellar granule cell precursor (CL0002362)
Fold Change: 0.69
Marker Score: 387
Cell Name: subcutaneous fat cell (CL0002521)
Fold Change: 0.69
Marker Score: 252
Cell Name: cardiac neuron (CL0010022)
Fold Change: 0.68
Marker Score: 848
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.68
Marker Score: 1379
Cell Name: male germ cell (CL0000015)
Fold Change: 0.67
Marker Score: 194
Cell Name: oogonial cell (CL0000024)
Fold Change: 0.67
Marker Score: 961
Cell Name: primordial germ cell (CL0000670)
Fold Change: 0.67
Marker Score: 835
Cell Name: epithelial cell of glomerular capsule (CL1000450)
Fold Change: 0.66
Marker Score: 169
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.65
Marker Score: 417
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.64
Marker Score: 1513
Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 0.62
Marker Score: 226
Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
Fold Change: 0.62
Marker Score: 3256
Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.6
Marker Score: 267
Cell Name: enteric neuron (CL0007011)
Fold Change: 0.6
Marker Score: 319
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.6
Marker Score: 476
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.59
Marker Score: 1466
Cell Name: fibroblast (CL0000057)
Fold Change: 0.58
Marker Score: 564
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: 0.57
Marker Score: 391
Cell Name: neural crest cell (CL0011012)
Fold Change: 0.57
Marker Score: 605
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.56
Marker Score: 149
Cell Name: plasma cell (CL0000786)
Fold Change: 0.56
Marker Score: 627
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.56
Marker Score: 233
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 0.56
Marker Score: 565
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 0.56
Marker Score: 1160
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.55
Marker Score: 175
Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 0.55
Marker Score: 393
Cell Name: neural cell (CL0002319)
Fold Change: 0.53
Marker Score: 256
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.52
Marker Score: 377
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.52
Marker Score: 5352
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 0.49
Marker Score: 2045
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.49
Marker Score: 475
Cell Name: stellate neuron (CL0000122)
Fold Change: 0.48
Marker Score: 2604
Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 0.48
Marker Score: 2230

Hover over a box to see details here...

**Key characteristics:** * CNTFR is a single-pass membrane protein with a molecular weight of approximately 140 kDa. * It is a type I cytokine receptor, meaning it is a receptor for cytokines. * CNTFR is expressed in high levels in the developing brain and spinal cord during gestation and early postnatal life. * It is also expressed in adult brain and spinal cord, where it is involved in maintaining neuronal survival, growth, and differentiation. **Pathways and functions:** * CNTFR signaling is involved in a variety of cellular processes, including neuronal survival, differentiation, growth, and survival. * It is a key regulator of ciliary neurogenesis, the process of new nerve cell formation. * CNTFR signaling is also involved in the regulation of glial cell survival and migration. * It is a key regulator of synaptic plasticity, the changes in synaptic strength that occur during learning and memory. * CNTFR signaling is also involved in the regulation of inflammation and apoptosis. **Clinical significance:** * Mutations in the CNTFR gene have been linked to several neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. * CNTFR agonists have been shown to be effective in protecting neurons from death and disease in animal models of neurodegenerative diseases. * Therefore, CNTFR is a promising target for the treatment of neurodegenerative diseases. **Additional notes:** * CNTFR is a highly conserved protein, with similar sequences found in mammals, birds, and fish. * It is a member of the cytokine receptor superfamily, which also includes receptors for other cytokines such as IL-1, IL-2, and IL-6. * CNTFR signaling is a complex process that involves multiple signaling pathways, including the JAK/STAT pathway, the PI3K/Akt pathway, and the MAPK pathway.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Ciliary neurotrophic factor receptor subunit alpha

Genular Protein ID: 3441002583

Symbol: CNTFR_HUMAN

Name: Ciliary neurotrophic factor receptor subunit alpha

UniProtKB Accession Codes:

P26992 Q5U050

Database IDs:

Citations:

PubMed ID: 1648265

Title: The receptor for ciliary neurotrophic factor.

PubMed ID: 1648265

DOI: 10.1126/science.1648265

PubMed ID: 7774913

Title: Genomic organization and chromosomal localization of the human and mouse genes encoding the alpha receptor component for ciliary neurotrophic factor.

PubMed ID: 7774913

DOI: 10.1016/0888-7543(95)80121-2

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19386761

Title: Humanin inhibits neuronal cell death by interacting with a cytokine receptor complex or complexes involving CNTF receptor alpha/WSX-1/gp130.

PubMed ID: 19386761

DOI: 10.1091/mbc.e09-02-0168

PubMed ID: 26858303

Title: Cytokine-like factor 1, an essential facilitator of cardiotrophin-like cytokine:ciliary neurotrophic factor receptor alpha signaling and sorLA-mediated turnover.

PubMed ID: 26858303

DOI: 10.1128/mcb.00917-15

PubMed ID: 12707266

Title: Solution structure of the C-terminal domain of the ciliary neurotrophic factor (CNTF) receptor and ligand free associations among components of the CNTF receptor complex.

PubMed ID: 12707266

DOI: 10.1074/jbc.m301976200

Sequence Information:

Length: 372
Mass: 40633
Checksum: B2F3F73DE8F8750E
Sequence:

MAAPVPWACC AVLAAAAAVV YAQRHSPQEA PHVQYERLGS DVTLPCGTAN WDAAVTWRVN 
GTDLAPDLLN GSQLVLHGLE LGHSGLYACF HRDSWHLRHQ VLLHVGLPPR EPVLSCRSNT 
YPKGFYCSWH LPTPTYIPNT FNVTVLHGSK IMVCEKDPAL KNRCHIRYMH LFSTIKYKVS 
ISVSNALGHN ATAITFDEFT IVKPDPPENV VARPVPSNPR RLEVTWQTPS TWPDPESFPL 
KFFLRYRPLI LDQWQHVELS DGTAHTITDA YAGKEYIIQV AAKDNEIGTW SDWSVAAHAT 
PWTEEPRHLT TEAQAAETTT STTSSLAPPP TTKICDPGEL GSGGGPSAPF LVSVPITLAL 
AAAAATASSL LI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: CNTFR

Associated with

Cells (max top 100)

Other Information

The receptor for ciliary neurotrophic factor. PubMed ID: 1648265

Genomic organization and chromosomal localization of the human and mouse genes encoding the alpha receptor component for ciliary neurotrophic factor. PubMed ID: 7774913

DNA sequence and analysis of human chromosome 9. PubMed ID: 15164053

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Humanin inhibits neuronal cell death by interacting with a cytokine receptor complex or complexes involving CNTF receptor alpha/WSX-1/gp130. PubMed ID: 19386761

Cytokine-like factor 1, an essential facilitator of cardiotrophin-like cytokine:ciliary neurotrophic factor receptor alpha signaling and sorLA-mediated turnover. PubMed ID: 26858303

Solution structure of the C-terminal domain of the ciliary neurotrophic factor (CNTF) receptor and ligand free associations among components of the CNTF receptor complex. PubMed ID: 12707266