Details for: CNTN1

Gene ID: 1272

Symbol: CNTN1

Ensembl ID: ENSG00000018236

Description: contactin 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 624.7701
    Cell Significance Index: -97.1800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 383.1364
    Cell Significance Index: -97.1800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 215.5796
    Cell Significance Index: -101.7800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 24.6196
    Cell Significance Index: -97.1500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 13.4653
    Cell Significance Index: -29.4700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 7.8292
    Cell Significance Index: 134.1700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 5.6384
    Cell Significance Index: 379.1300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 5.3801
    Cell Significance Index: 153.5300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 4.8887
    Cell Significance Index: 1753.4800
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 4.8708
    Cell Significance Index: 68.1100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 3.4496
    Cell Significance Index: 2385.8600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 3.3776
    Cell Significance Index: 127.9000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 3.2940
    Cell Significance Index: 145.7000
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.4727
    Cell Significance Index: 30.6700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.9015
    Cell Significance Index: 41.6400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.8306
    Cell Significance Index: 112.5200
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 1.1204
    Cell Significance Index: 14.5300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.1125
    Cell Significance Index: 2094.7600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.8873
    Cell Significance Index: 21.2800
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 0.6202
    Cell Significance Index: 6.4600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.6174
    Cell Significance Index: 280.2300
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.3426
    Cell Significance Index: 4.5700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1237
    Cell Significance Index: 78.5400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1039
    Cell Significance Index: 5.8300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0587
    Cell Significance Index: 11.7700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0410
    Cell Significance Index: 7.4000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0009
    Cell Significance Index: 0.6500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0005
    Cell Significance Index: 0.7200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0023
    Cell Significance Index: -0.3300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0560
    Cell Significance Index: -103.2100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0611
    Cell Significance Index: -38.1800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0642
    Cell Significance Index: -98.8200
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0754
    Cell Significance Index: -0.9400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0880
    Cell Significance Index: -49.6100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.1053
    Cell Significance Index: -77.1900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.1467
    Cell Significance Index: -111.0600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.1618
    Cell Significance Index: -71.5200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.1784
    Cell Significance Index: -2.7600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.1828
    Cell Significance Index: -99.8400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2560
    Cell Significance Index: -53.9300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2928
    Cell Significance Index: -84.2400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.3846
    Cell Significance Index: -52.8200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4236
    Cell Significance Index: -44.1100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.4659
    Cell Significance Index: -79.5600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.4985
    Cell Significance Index: -98.9300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.5872
    Cell Significance Index: -16.4100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.6019
    Cell Significance Index: -74.0100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.6166
    Cell Significance Index: -79.0400
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.6394
    Cell Significance Index: -8.0700
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.6535
    Cell Significance Index: -7.1200
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.6695
    Cell Significance Index: -6.3700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.7499
    Cell Significance Index: -96.8800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.9189
    Cell Significance Index: -107.0900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.9531
    Cell Significance Index: -108.7900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.9576
    Cell Significance Index: -97.8200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.9725
    Cell Significance Index: -50.5200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.9755
    Cell Significance Index: -111.7600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -1.1808
    Cell Significance Index: -16.9100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.1835
    Cell Significance Index: -93.7300
  • Cell Name: neural cell (CL0002319)
    Fold Change: -1.2078
    Cell Significance Index: -14.0900
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -1.2134
    Cell Significance Index: -18.4600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -1.2246
    Cell Significance Index: -25.9900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -1.2491
    Cell Significance Index: -88.3400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -1.3007
    Cell Significance Index: -96.9400
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -1.3030
    Cell Significance Index: -22.5300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.3115
    Cell Significance Index: -42.9400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.3154
    Cell Significance Index: -100.9400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -1.3291
    Cell Significance Index: -26.2800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -1.3350
    Cell Significance Index: -58.0500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -1.4530
    Cell Significance Index: -76.2900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.4738
    Cell Significance Index: -46.9400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -1.5900
    Cell Significance Index: -82.8200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -1.6034
    Cell Significance Index: -32.1900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.7362
    Cell Significance Index: -109.4300
  • Cell Name: neuron (CL0000540)
    Fold Change: -1.7533
    Cell Significance Index: -16.6200
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -1.7720
    Cell Significance Index: -20.2800
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -1.8090
    Cell Significance Index: -28.7000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -1.9411
    Cell Significance Index: -91.2300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -2.2126
    Cell Significance Index: -77.5100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -2.4103
    Cell Significance Index: -112.3800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -2.4156
    Cell Significance Index: -52.1900
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -2.4802
    Cell Significance Index: -29.6600
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -2.5604
    Cell Significance Index: -32.3100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -2.5879
    Cell Significance Index: -95.0000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -2.6278
    Cell Significance Index: -65.5500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -2.7787
    Cell Significance Index: -96.5600
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -2.8333
    Cell Significance Index: -31.2600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -2.9279
    Cell Significance Index: -83.9300
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -3.1208
    Cell Significance Index: -25.7600
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -3.1291
    Cell Significance Index: -37.9300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -3.1364
    Cell Significance Index: -110.2100
  • Cell Name: granule cell (CL0000120)
    Fold Change: -3.1959
    Cell Significance Index: -36.3900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -3.2059
    Cell Significance Index: -77.6600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -3.2524
    Cell Significance Index: -67.8800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -3.2640
    Cell Significance Index: -83.9000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -3.3897
    Cell Significance Index: -99.8400
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -3.5204
    Cell Significance Index: -111.3500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -3.5429
    Cell Significance Index: -93.1600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -3.6351
    Cell Significance Index: -90.6500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -3.6362
    Cell Significance Index: -77.7300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** CNTN1 is a transmembrane protein with four immunoglobulin-like domains, which enable it to form homophilic or heterophilic interactions with other contactin family members. This protein is specifically expressed in neurons and neural precursors, where it plays a critical role in axon guidance, neuronal migration, and synaptogenesis. CNTN1 is also involved in the regulation of gene expression, particularly in the context of Notch signaling, which is a key pathway in neuronal development. **Pathways and Functions** CNTN1 is integral to several signaling pathways, including: 1. **Notch signaling pathway**: CNTN1 interacts with Notch1 and Notch2, which are key receptors in the Notch signaling pathway. This interaction transmits signals to the nucleus, regulating gene expression and neuronal development. 2. **Axon guidance**: CNTN1 is involved in the guidance of axons during neuronal development, where it interacts with other axonal guidance molecules, such as L1cam and neurofascin. 3. **Cell-cell adhesion**: CNTN1 mediates cell-cell adhesion, particularly between neurons and glial cells, which is essential for maintaining the integrity of the nervous system. 4. **Gene expression regulation**: CNTN1 regulates gene expression through its interaction with Notch signaling, which is critical for neuronal development and differentiation. **Clinical Significance** CNTN1 has been implicated in several neurological disorders, including: 1. **Autism spectrum disorder**: Studies have shown that mutations in CNTN1 are associated with autism spectrum disorder, highlighting its role in neuronal development and synaptic function. 2. **Schizophrenia**: CNTN1 has been implicated in schizophrenia, where it is thought to contribute to the disruption of normal neuronal function and connectivity. 3. **Neurodegenerative diseases**: CNTN1 has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where it is thought to contribute to the disruption of normal neuronal function and connectivity. In conclusion, CNTN1 is a critical protein involved in cell-cell adhesion, axon guidance, and gene expression regulation in the nervous system. Its dysregulation has been implicated in several neurological disorders, highlighting its importance in maintaining normal neuronal function and connectivity. Further research is needed to fully elucidate the role of CNTN1 in neurological disorders and to explore its potential as a therapeutic target. **Additional Considerations** * CNTN1 is also expressed in other tissues, including the immune system, where it may play a role in modulating immune responses. * The protein has been shown to interact with other molecules, such as L1cam and neurofascin, which are involved in axon guidance and neuronal development. * CNTN1 has been implicated in the regulation of sodium ion transport, which is critical for maintaining normal neuronal function. Overall, CNTN1 is a complex protein with multiple roles in the nervous system, and its dysregulation has significant implications for human health. Further research is needed to fully elucidate its role in neurological disorders and to explore its potential as a therapeutic target.

Genular Protein ID: 2609706408

Symbol: CNTN1_HUMAN

Name: Contactin-1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8164510

Title: Identification and characterization of the human cell adhesion molecule contactin.

PubMed ID: 8164510

DOI: 10.1016/0169-328x(94)90372-7

PubMed ID: 7959734

Title: Molecular cloning and in situ localization of the human contactin gene (CNTN1) on chromosome 12q11-q12.

PubMed ID: 7959734

DOI: 10.1006/geno.1994.1316

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2026173

Title: Isolation and characterization of a membrane glycoprotein from human brain with sequence similarities to cell adhesion proteins from chicken and mouse.

PubMed ID: 2026173

DOI: 10.1111/j.1432-1033.1991.tb15943.x

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 19139490

Title: A strategy for precise and large scale identification of core fucosylated glycoproteins.

PubMed ID: 19139490

DOI: 10.1074/mcp.m800504-mcp200

PubMed ID: 20133774

Title: The protein tyrosine phosphatases PTPRZ and PTPRG bind to distinct members of the contactin family of neural recognition molecules.

PubMed ID: 20133774

DOI: 10.1073/pnas.0911235107

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 19026398

Title: Mutations in contactin-1, a neural adhesion and neuromuscular junction protein, cause a familial form of lethal congenital myopathy.

PubMed ID: 19026398

DOI: 10.1016/j.ajhg.2008.10.022

Sequence Information:

  • Length: 1018
  • Mass: 113320
  • Checksum: 4B8FDC5BFD434ED5
  • Sequence:
  • MKMWLLVSHL VIISITTCLA EFTWYRRYGH GVSEEDKGFG PIFEEQPINT IYPEESLEGK 
    VSLNCRARAS PFPVYKWRMN NGDVDLTSDR YSMVGGNLVI NNPDKQKDAG IYYCLASNNY 
    GMVRSTEATL SFGYLDPFPP EERPEVRVKE GKGMVLLCDP PYHFPDDLSY RWLLNEFPVF 
    ITMDKRRFVS QTNGNLYIAN VEASDKGNYS CFVSSPSITK SVFSKFIPLI PIPERTTKPY 
    PADIVVQFKD VYALMGQNVT LECFALGNPV PDIRWRKVLE PMPSTAEIST SGAVLKIFNI 
    QLEDEGIYEC EAENIRGKDK HQARIYVQAF PEWVEHINDT EVDIGSDLYW PCVATGKPIP 
    TIRWLKNGYA YHKGELRLYD VTFENAGMYQ CIAENTYGAI YANAELKILA LAPTFEMNPM 
    KKKILAAKGG RVIIECKPKA APKPKFSWSK GTEWLVNSSR ILIWEDGSLE INNITRNDGG 
    IYTCFAENNR GKANSTGTLV ITDPTRIILA PINADITVGE NATMQCAASF DPALDLTFVW 
    SFNGYVIDFN KENIHYQRNF MLDSNGELLI RNAQLKHAGR YTCTAQTIVD NSSASADLVV 
    RGPPGPPGGL RIEDIRATSV ALTWSRGSDN HSPISKYTIQ TKTILSDDWK DAKTDPPIIE 
    GNMEAARAVD LIPWMEYEFR VVATNTLGRG EPSIPSNRIK TDGAAPNVAP SDVGGGGGRN 
    RELTITWAPL SREYHYGNNF GYIVAFKPFD GEEWKKVTVT NPDTGRYVHK DETMSPSTAF 
    QVKVKAFNNK GDGPYSLVAV INSAQDAPSE APTEVGVKVL SSSEISVHWE HVLEKIVESY 
    QIRYWAAHDK EEAANRVQVT SQEYSARLEN LLPDTQYFIE VGACNSAGCG PPSDMIEAFT 
    KKAPPSQPPR IISSVRSGSR YIITWDHVVA LSNESTVTGY KVLYRPDGQH DGKLYSTHKH 
    SIEVPIPRDG EYVVEVRAHS DGGDGVVSQV KISGAPTLSP SLLGLLLPAF GILVYLEF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.