Genular: Defining Cellular Identity and Function

Details for: Cldn3

Gene ID: 12739

Symbol: Cldn3

Ensembl ID: ENSMUSG00000070473

Description: claudin 3

Associated with

Actin cytoskeleton organization
(GO:0030036)
Anchoring junction
(GO:0070161)
Apical junction complex
(GO:0043296)
Apicolateral plasma membrane
(GO:0016327)
Bicellular tight junction
(GO:0005923)
Bicellular tight junction assembly
(GO:0070830)
Calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules
(GO:0016338)
Cell-cell junction
(GO:0005911)
Cell adhesion
(GO:0007155)
Cell junction maintenance
(GO:0034331)
Epithelial cell morphogenesis
(GO:0003382)
Establishment of endothelial blood-brain barrier
(GO:0014045)
Identical protein binding
(GO:0042802)
Lateral plasma membrane
(GO:0016328)
Membrane
(GO:0016020)
Negative regulation of cell migration
(GO:0030336)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of wound healing
(GO:0061045)
Plasma membrane
(GO:0005886)
Positive regulation of bicellular tight junction assembly
(GO:1903348)
Positive regulation of cell junction assembly
(GO:1901890)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of metallopeptidase activity
(GO:1905050)
Positive regulation of protein phosphorylation
(GO:0001934)
Positive regulation of wound healing
(GO:0090303)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Regulation of cell morphogenesis
(GO:0022604)
Regulation of membrane permeability
(GO:0090559)
Regulation of transepithelial transport
(GO:0150111)
Structural molecule activity
(GO:0005198)
Tight junction
(GO:0070160)

Other Information

Proteins

Claudin-3

Genular Protein ID: 3235146065

Symbol: CLD3_MOUSE

Name: Claudin-3

UniProtKB Accession Codes:

Q9Z0G9 Q91X40

Database IDs:

Citations:

PubMed ID: 9878248

Title: Genes for the CPE receptor (CPETR1) and the human homolog of RVP1 (CPETR2) are localized within the Williams-Beuren syndrome deletion.

PubMed ID: 9878248

DOI: 10.1006/geno.1998.5619

PubMed ID: 9892664

Title: Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands.

PubMed ID: 9892664

DOI: 10.1073/pnas.96.2.511

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10508613

Title: Ca(2+)-independent cell-adhesion activity of claudins, a family of integral membrane proteins localized at tight junctions.

PubMed ID: 10508613

DOI: 10.1016/s0960-9822(99)80452-7

PubMed ID: 10562289

Title: Manner of interaction of heterogeneous claudin species within and between tight junction strands.

PubMed ID: 10562289

DOI: 10.1083/jcb.147.4.891

PubMed ID: 10601346

Title: Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins.

PubMed ID: 10601346

DOI: 10.1083/jcb.147.6.1351

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 24588076

Title: Knockout mice reveal key roles for claudin 18 in alveolar barrier properties and fluid homeostasis.

PubMed ID: 24588076

DOI: 10.1165/rcmb.2013-0353oc

PubMed ID: 25678664

Title: Tight junctions. Structural insight into tight junction disassembly by Clostridium perfringens enterotoxin.

PubMed ID: 25678664

DOI: 10.1126/science.1261833

Sequence Information:

Length: 219
Mass: 23285
Checksum: 62F67810D9B9BD37
Sequence:

MSMGLEITGT SLAVLGWLCT IVCCALPMWR VSAFIGSSII TAQITWEGLW MNCVVQSTGQ 
MQCKMYDSLL ALPQDLQAAR ALIVVSILLA AFGLLVALVG AQCTNCVQDE TAKAKITIVA 
GVLFLLAALL TLVPVSWSAN TIIRDFYNPL VPEAQKREMG AGLYVGWAAA ALQLLGGALL 
CCSCPPRDKY APTKILYSAP RSTGPGTGTG TAYDRKDYV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Cldn3

Associated with

Other Information

Genes for the CPE receptor (CPETR1) and the human homolog of RVP1 (CPETR2) are localized within the Williams-Beuren syndrome deletion. PubMed ID: 9878248

Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands. PubMed ID: 9892664

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Ca(2+)-independent cell-adhesion activity of claudins, a family of integral membrane proteins localized at tight junctions. PubMed ID: 10508613

Manner of interaction of heterogeneous claudin species within and between tight junction strands. PubMed ID: 10562289

Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins. PubMed ID: 10601346

Large-scale phosphorylation analysis of mouse liver. PubMed ID: 17242355

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Knockout mice reveal key roles for claudin 18 in alveolar barrier properties and fluid homeostasis. PubMed ID: 24588076

Tight junctions. Structural insight into tight junction disassembly by Clostridium perfringens enterotoxin. PubMed ID: 25678664