Details for: Clk1

Gene ID: 12747

Symbol: Clk1

Ensembl ID: ENSMUSG00000026034

Description: CDC-like kinase 1

Associated with

Other Information

Genular Protein ID: 3949835004

Symbol: CLK1_MOUSE

Name: N/A

UniProtKB Accession Codes:

P22518 A6H6K2 Q3UXB6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CTD 1 ChEBI 17 ChEMBL 1 ChiTaRS 1 DNASU 1 EC 3 EMBL 8 EPD 1 Ensembl 3 GO 8 Gene3D 1 GeneTree 1 Genevisible 1 GuidetoPHARMACOLOGY 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MGI 2 MINT 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 2 PRO 1 PROSITE 3 PROSITE-ProRule 2 PaxDb 1 PeptideAtlas 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 1 Rhea 12 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1

Citations:

PubMed ID: 1825055

Title: A mammalian protein kinase with potential for serine/threonine and tyrosine phosphorylation is related to cell cycle regulators.

PubMed ID: 1825055

DOI: 10.1002/j.1460-2075.1991.tb07952.x

PubMed ID: 1986248

Title: STY, a tyrosine-phosphorylating enzyme with sequence homology to serine/threonine kinases.

PubMed ID: 1986248

DOI: 10.1128/mcb.11.1.568-572.1991

PubMed ID: 7665564

Title: Alternative splicing of STY, a nuclear dual specificity kinase.

PubMed ID: 7665564

DOI: 10.1074/jbc.270.37.21524

PubMed ID: 7990150

Title: Characterization by cDNA cloning of two new human protein kinases. Evidence by sequence comparison of a new family of mammalian protein kinases.

PubMed ID: 7990150

DOI: 10.1006/jmbi.1994.1763

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8617202

Title: The Clk/Sty protein kinase phosphorylates SR splicing factors and regulates their intranuclear distribution.

PubMed ID: 8617202

DOI: 10.1002/j.1460-2075.1996.tb00357.x

PubMed ID: 9307018

Title: Characterization and comparison of four serine- and arginine-rich (SR) protein kinases.

PubMed ID: 9307018

DOI: 10.1042/bj3260693

PubMed ID: 9315658

Title: In vivo regulation of alternative pre-mRNA splicing by the Clk1 protein kinase.

PubMed ID: 9315658

DOI: 10.1128/mcb.17.10.5996

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21615147

Title: Leucettines, a class of potent inhibitors of cdc2-like kinases and dual specificity, tyrosine phosphorylation regulated kinases derived from the marine sponge leucettamine B: modulation of alternative pre-RNA splicing.

PubMed ID: 21615147

DOI: 10.1021/jm200274d

Sequence Information:

  • Length: 483
  • Mass: 57093
  • Checksum: 96FEBC20EC90D8E8
  • Sequence:
    • MRHSKRTYCP DWDERDWDYG TWRSSSSHKR KKRSHSSARE QKRCRYDHSK TTDSYYLESR 
SINEKAYHSR RYVDEYRNDY MGYEPGHPYG EPGSRYQMHS SKSSGRSGRS SYKSKHRSRH 
HTSQHHSHGK SHRRKRSRSV EDDEEGHLIC QSGDVLSARY EIVDTLGEGA FGKVVECIDH 
KVGGRRVAVK IVKNVDRYCE AAQSEIQVLE HLNTTDPHST FRCVQMLEWF EHRGHICIVF 
ELLGLSTYDF IKENSFLPFR MDHIRKMAYQ ICKSVNFLHS NKLTHTDLKP ENILFVKSDY 
TEAYNPKMKR DERTIVNPDI KVVDFGSATY DDEHHSTLVS TRHYRAPEVI LALGWSQPCD 
VWSIGCILIE YYLGFTVFPT HDSREHLAMM ERILGPLPKH MIQKTRKRRY FHHDRLDWDE 
HSSAGRYVSR RCKPLKEFML SQDAEHELLF DLIGKMLEYD PAKRITLKEA LKHPFFYPLK 
KHT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.