Details for: Clock
Associated with
Other Information
Genular Protein ID: 2994017796
Symbol: CLOCK_MOUSE
Name: Circadian locomoter output cycles protein kaput
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9160756
Title: Functional identification of the mouse circadian clock gene by transgenic BAC rescue.
PubMed ID: 9160756
PubMed ID: 9160755
Title: Positional cloning of the mouse circadian clock gene.
PubMed ID: 9160755
PubMed ID: 11116088
Title: The mouse Clock locus: sequence and comparative analysis of 204 kb from mouse chromosome 5.
PubMed ID: 11116088
PubMed ID: 9616112
Title: Role of the CLOCK protein in the mammalian circadian mechanism.
PubMed ID: 9616112
PubMed ID: 11779462
Title: Posttranslational mechanisms regulate the mammalian circadian clock.
PubMed ID: 11779462
PubMed ID: 12897057
Title: BMAL1-dependent circadian oscillation of nuclear CLOCK: posttranslational events induced by dimerization of transcriptional activators of the mammalian clock system.
PubMed ID: 12897057
DOI: 10.1101/gad.1099503
PubMed ID: 12738229
Title: Regulation of the PAI-1 promoter by circadian clock components: differential activation by BMAL1 and BMAL2.
PubMed ID: 12738229
PubMed ID: 14672706
Title: A novel autofeedback loop of Dec1 transcription involved in circadian rhythm regulation.
PubMed ID: 14672706
PubMed ID: 14645221
Title: Histone acetyltransferase-dependent chromatin remodeling and the vascular clock.
PubMed ID: 14645221
PubMed ID: 16678094
Title: Circadian regulator CLOCK is a histone acetyltransferase.
PubMed ID: 16678094
PubMed ID: 16717091
Title: The polycomb group protein EZH2 is required for mammalian circadian clock function.
PubMed ID: 16717091
PubMed ID: 16980631
Title: BMAL1 shuttling controls transactivation and degradation of the CLOCK/BMAL1 heterodimer.
PubMed ID: 16980631
DOI: 10.1128/mcb.00337-06
PubMed ID: 17310242
Title: CIPC is a mammalian circadian clock protein without invertebrate homologues.
PubMed ID: 17310242
DOI: 10.1038/ncb1539
PubMed ID: 17417633
Title: CLOCK and NPAS2 have overlapping roles in the suprachiasmatic circadian clock.
PubMed ID: 17417633
DOI: 10.1038/nn1884
PubMed ID: 18075593
Title: CLOCK-mediated acetylation of BMAL1 controls circadian function.
PubMed ID: 18075593
DOI: 10.1038/nature06394
PubMed ID: 17242355
Title: Large-scale phosphorylation analysis of mouse liver.
PubMed ID: 17242355
PubMed ID: 18430226
Title: Interaction of circadian clock proteins PER2 and CRY with BMAL1 and CLOCK.
PubMed ID: 18430226
PubMed ID: 18662546
Title: SIRT1 regulates circadian clock gene expression through PER2 deacetylation.
PubMed ID: 18662546
PubMed ID: 18662547
Title: The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control.
PubMed ID: 18662547
PubMed ID: 18316400
Title: Evidence for an overlapping role of CLOCK and NPAS2 transcription factors in liver circadian oscillators.
PubMed ID: 18316400
DOI: 10.1128/mcb.01931-07
PubMed ID: 19946213
Title: A serine cluster mediates BMAL1-dependent CLOCK phosphorylation and degradation.
PubMed ID: 19946213
PubMed ID: 19141540
Title: Circadian rhythm transcription factor CLOCK regulates the transcriptional activity of the glucocorticoid receptor by acetylating its hinge region lysine cluster: potential physiological implications.
PubMed ID: 19141540
DOI: 10.1096/fj.08-117697
PubMed ID: 19605937
Title: Preferential inhibition of BMAL2-CLOCK activity by PER2 reemphasizes its negative role and a positive role of BMAL2 in the circadian transcription.
PubMed ID: 19605937
PubMed ID: 19414601
Title: Roles of CLOCK phosphorylation in suppression of E-box-dependent transcription.
PubMed ID: 19414601
DOI: 10.1128/mcb.01864-08
PubMed ID: 19129230
Title: Molecular characterization of Mybbp1a as a co-repressor on the Period2 promoter.
PubMed ID: 19129230
DOI: 10.1093/nar/gkn1013
PubMed ID: 19299583
Title: Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis.
PubMed ID: 19299583
PubMed ID: 19286518
Title: Circadian control of the NAD+ salvage pathway by CLOCK-SIRT1.
PubMed ID: 19286518
PubMed ID: 20430893
Title: CLOCK regulates circadian rhythms of hepatic glycogen synthesis through transcriptional activation of Gys2.
PubMed ID: 20430893
PubMed ID: 20861012
Title: The transcriptional repressor ID2 can interact with the canonical clock components CLOCK and BMAL1 and mediate inhibitory effects on mPer1 expression.
PubMed ID: 20861012
PubMed ID: 20385766
Title: Kruppel-like factor KLF10 is a link between the circadian clock and metabolism in liver.
PubMed ID: 20385766
DOI: 10.1128/mcb.01141-09
PubMed ID: 20562852
Title: Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes.
PubMed ID: 20562852
DOI: 10.1038/nature09253
PubMed ID: 21113167
Title: The histone methyltransferase MLL1 permits the oscillation of circadian gene expression.
PubMed ID: 21113167
DOI: 10.1038/nsmb.1961
PubMed ID: 20956306
Title: CLOCK and BMAL1 regulate MyoD and are necessary for maintenance of skeletal muscle phenotype and function.
PubMed ID: 20956306
PubMed ID: 21768648
Title: cAMP-response element (CRE)-mediated transcription by activating transcription factor-4 (ATF4) is essential for circadian expression of the Period2 gene.
PubMed ID: 21768648
PubMed ID: 20658528
Title: Deficiency in core circadian protein Bmal1 is associated with a prothrombotic and vascular phenotype.
PubMed ID: 20658528
DOI: 10.1002/jcp.22314
PubMed ID: 21930935
Title: The period of the circadian oscillator is primarily determined by the balance between casein kinase 1 and protein phosphatase 1.
PubMed ID: 21930935
PubMed ID: 21960634
Title: Histone lysine demethylase JARID1a activates CLOCK-BMAL1 and influences the circadian clock.
PubMed ID: 21960634
PubMed ID: 22284746
Title: Diurnal expression of the thrombopoietin gene is regulated by CLOCK.
PubMed ID: 22284746
PubMed ID: 22981862
Title: Circadian Dbp transcription relies on highly dynamic BMAL1-CLOCK interaction with E boxes and requires the proteasome.
PubMed ID: 22981862
PubMed ID: 22900038
Title: Circadian proteins CLOCK and BMAL1 in the chromatoid body, a RNA processing granule of male germ cells.
PubMed ID: 22900038
PubMed ID: 22895791
Title: Core circadian protein CLOCK is a positive regulator of NF-kappaB-mediated transcription.
PubMed ID: 22895791
PubMed ID: 24154698
Title: A role for the circadian clock protein Per1 in the regulation of aldosterone levels and renal Na+ retention.
PubMed ID: 24154698
PubMed ID: 23576606
Title: Mechanism of the circadian clock in physiology.
PubMed ID: 23576606
PubMed ID: 23291174
Title: The molecular clock regulates circadian transcription of tissue factor gene.
PubMed ID: 23291174
PubMed ID: 23395175
Title: Glucose sensor O-GlcNAcylation coordinates with phosphorylation to regulate circadian clock.
PubMed ID: 23395175
PubMed ID: 23395176
Title: O-GlcNAc signaling entrains the circadian clock by inhibiting BMAL1/CLOCK ubiquitination.
PubMed ID: 23395176
PubMed ID: 23756047
Title: A role for clock genes in sleep homeostasis.
PubMed ID: 23756047
PubMed ID: 24235147
Title: Cyclin-dependent kinase 5 (Cdk5) regulates the function of CLOCK protein by direct phosphorylation.
PubMed ID: 24235147
PubMed ID: 24270424
Title: Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration.
PubMed ID: 24270424
DOI: 10.1172/jci70317
PubMed ID: 23785138
Title: p75 neurotrophin receptor is a clock gene that regulates oscillatory components of circadian and metabolic networks.
PubMed ID: 23785138
PubMed ID: 24089055
Title: Metastasis-associated protein 1 is an integral component of the circadian molecular machinery.
PubMed ID: 24089055
DOI: 10.1038/ncomms3545
PubMed ID: 23160374
Title: CLOCK is a substrate of SUMO and sumoylation of CLOCK upregulates the transcriptional activity of estrogen receptor-alpha.
PubMed ID: 23160374
DOI: 10.1038/onc.2012.518
PubMed ID: 23303907
Title: Metabolism and the circadian clock converge.
PubMed ID: 23303907
PubMed ID: 24043798
Title: A positive feedback loop links circadian clock factor CLOCK-BMAL1 to the basic transcriptional machinery.
PubMed ID: 24043798
PubMed ID: 24333415
Title: Clock upregulates intercellular adhesion molecule-1 expression and promotes mononuclear cells adhesion to endothelial cells.
PubMed ID: 24333415
PubMed ID: 24529706
Title: SRC-2 is an essential coactivator for orchestrating metabolism and circadian rhythm.
PubMed ID: 24529706
PubMed ID: 24395244
Title: CLOCK:BMAL1 is a pioneer-like transcription factor.
PubMed ID: 24395244
PubMed ID: 24442997
Title: CLOCK/BMAL1 regulates circadian change of mouse hepatic insulin sensitivity via SIRT1.
PubMed ID: 24442997
DOI: 10.1002/hep.26992
PubMed ID: 24385426
Title: Gene model 129 (Gm129) encodes a novel transcriptional repressor that modulates circadian gene expression.
PubMed ID: 24385426
PubMed ID: 24378737
Title: Modulation of glucocorticoid receptor induction properties by core circadian clock proteins.
PubMed ID: 24378737
PubMed ID: 23916625
Title: Molecular architecture of the mammalian circadian clock.
PubMed ID: 23916625
PubMed ID: 28985504
Title: CLOCK acetylates ASS1 to drive circadian rhythm of ureagenesis.
PubMed ID: 28985504
PubMed ID: 28903391
Title: Cancer/testis antigen PIWIL2 suppresses circadian rhythms by regulating the stability and activity of BMAL1 and CLOCK.
PubMed ID: 28903391
PubMed ID: 29937374
Title: Autophagy regulates the liver clock and glucose metabolism by degrading CRY1.
PubMed ID: 29937374
PubMed ID: 30012868
Title: Dec1 and CLOCK regulate Na+/K+-ATPase beta1 subunit expression and blood pressure.
PubMed ID: 30012868
PubMed ID: 22653727
Title: Crystal structure of the heterodimeric CLOCK:BMAL1 transcriptional activator complex.
PubMed ID: 22653727
Sequence Information:
- Length: 855
- Mass: 96393
- Checksum: 9864D947049742F4
- Sequence:
MVFTVSCSKM SSIVDRDDSS IFDGLVEEDD KDKAKRVSRN KSEKKRRDQF NVLIKELGSM LPGNARKMDK STVLQKSIDF LRKHKETTAQ SDASEIRQDW KPTFLSNEEF TQLMLEALDG FFLAIMTDGS IIYVSESVTS LLEHLPSDLV DQSIFNFIPE GEHSEVYKIL STHLLESDSL TPEYLKSKNQ LEFCCHMLRG TIDPKEPSTY EYVRFIGNFK SLTSVSTSTH NGFEGTIQRT HRPSYEDRVC FVATVRLATP QFIKEMCTVE EPNEEFTSRH SLEWKFLFLD HRAPPIIGYL PFEVLGTSGY DYYHVDDLEN LAKCHEHLMQ YGKGKSCYYR FLTKGQQWIW LQTHYYITYH QWNSRPEFIV CTHTVVSYAE VRAERRRELG IEESLPETAA DKSQDSGSDN RINTVSLKEA LERFDHSPTP SASSRSSRKS SHTAVSDPSS TPTKIPTDTS TPPRQHLPAH EKMTQRRSSF SSQSINSQSV GPSLTQPAMS QAANLPIPQG MSQFQFSAQL GAMQHLKDQL EQRTRMIEAN IHRQQEELRK IQEQLQMVHG QGLQMFLQQS NPGLNFGSVQ LSSGNSNIQQ LTPVNMQGQV VPANQVQSGH ISTGQHMIQQ QTLQSTSTQQ SQQSVMSGHS QQTSLPSQTP STLTAPLYNT MVISQPAAGS MVQIPSSMPQ NSTQSATVTT FTQDRQIRFS QGQQLVTKLV TAPVACGAVM VPSTMLMGQV VTAYPTFATQ QQQAQTLSVT QQQQQQQQQP PQQQQQQQQS SQEQQLPSVQ QPAQAQLGQP PQQFLQTSRL LHGNPSTQLI LSAAFPLQQS TFPPSHHQQH QPQQQQQLPR HRTDSLTDPS KVQPQ
Genular Protein ID: 1526408650
Symbol: A0A0J9YU61_MOUSE
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 17242355
Title: Large-scale phosphorylation analysis of mouse liver.
PubMed ID: 17242355
PubMed ID: 19468303
Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.
PubMed ID: 19468303
Sequence Information:
- Length: 854
- Mass: 96265
- Checksum: 07DA24E0E681FFD4
- Sequence:
MVFTVSCSKM SSIVDRDDSS IFDGLVEEDD KDKAKRVSRN KSEKKRRDQF NVLIKELGSM LPGNARKMDK STVLQKSIDF LRKHKETTAQ SDASEIRQDW KPTFLSNEEF TQLMLEALDG FFLAIMTDGS IIYVSESVTS LLEHLPSDLV DQSIFNFIPE GEHSEVYKIL STHLLESDSL TPEYLKSKNQ LEFCCHMLRG TIDPKEPSTY EYVRFIGNFK SLTSVSTSTH NGFEGTIQRT HRPSYEDRVC FVATVRLATP QFIKEMCTVE EPNEEFTSRH SLEWKFLFLD HRAPPIIGYL PFEVLGTSGY DYYHVDDLEN LAKCHEHLMQ YGKGKSCYYR FLTKGQQWIW LQTHYYITYH QWNSRPEFIV CTHTVVSYAE VRAERRRELG IEESLPETAA DKSQDSGSDN RINTVSLKEA LERFDHSPTP SASSRSSRKS SHTAVSDPSS TPTKIPTDTS TPPRQHLPAH EKMTQRRSSF SSQSINSQSV GPSLTQPAMS QAANLPIPQG MSQFQFSAQL GAMQHLKDQL EQRTRMIEAN IHRQQEELRK IQEQLQMVHG QGLQMFLQQS NPGLNFGSVQ LSSGNSNIQQ LTPVNMQGQV VPANQVQSGH ISTGQHMIQQ QTLQSTSTQS QQSVMSGHSQ QTSLPSQTPS TLTAPLYNTM VISQPAAGSM VQIPSSMPQN STQSATVTTF TQDRQIRFSQ GQQLVTKLVT APVACGAVMV PSTMLMGQVV TAYPTFATQQ QQAQTLSVTQ QQQQQQQQPP QQQQQQQQSS QEQQLPSVQQ PAQAQLGQPP QQFLQTSRLL HGNPSTQLIL SAAFPLQQST FPPSHHQQHQ PQQQQQLPRH RTDSLTDPSK VQPQ
Genular Protein ID: 1501560275
Symbol: Q8C9W6_MOUSE
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10349636
Title: High-efficiency full-length cDNA cloning.
PubMed ID: 10349636
PubMed ID: 11042159
Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
PubMed ID: 11042159
DOI: 10.1101/gr.145100
PubMed ID: 11076861
Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
PubMed ID: 11076861
DOI: 10.1101/gr.152600
PubMed ID: 11217851
Title: Functional annotation of a full-length mouse cDNA collection.
PubMed ID: 11217851
DOI: 10.1038/35055500
PubMed ID: 12466851
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
PubMed ID: 12466851
DOI: 10.1038/nature01266
PubMed ID: 16141073
Title: Antisense Transcription in the Mammalian Transcriptome.
PubMed ID: 16141073
Sequence Information:
- Length: 272
- Mass: 31095
- Checksum: 0B751C1F6EC2478A
- Sequence:
MVFTVSCSKM SSIVDRDDSS IFDGLVEEDD KDKAKRVSRN KSEKKRRDQF NVLIKELGSM LPGNARKMDK STVLQKSIDF LRKHKETTAQ SDASEIRQDW KPTFLSNEEF TQLMLEALDG FFLAIMTDGS IIYVSESVTS LLEHLPSDLV DQSIFNFIPE GEHSEVYKIL STHLLESDSL TPEYLKSKNQ LEFCCHMLRG TIDPKEPSTY EYVRFIGNFK SLTSVSTSTH NGFEGTIQRT HRPSYEDRVC FVATVRLATP QFIKEMCTVE EP
Genular Protein ID: 298481385
Symbol: Q3UWG6_MOUSE
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10349636
Title: High-efficiency full-length cDNA cloning.
PubMed ID: 10349636
PubMed ID: 11042159
Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
PubMed ID: 11042159
DOI: 10.1101/gr.145100
PubMed ID: 11076861
Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
PubMed ID: 11076861
DOI: 10.1101/gr.152600
PubMed ID: 11217851
Title: Functional annotation of a full-length mouse cDNA collection.
PubMed ID: 11217851
DOI: 10.1038/35055500
PubMed ID: 12466851
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
PubMed ID: 12466851
DOI: 10.1038/nature01266
PubMed ID: 16141073
Title: Antisense Transcription in the Mammalian Transcriptome.
PubMed ID: 16141073
Sequence Information:
- Length: 33
- Mass: 3833
- Checksum: 5C2C89AA523F5420
- Sequence:
MFAFKSVKTN CDIALRNDFS NVLSWPVLVH IYC
Genular Protein ID: 3549594587
Symbol: Q6ZQD6_MOUSE
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 14621295
Title: Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.
PubMed ID: 14621295
Sequence Information:
- Length: 857
- Mass: 96595
- Checksum: A663650C84A94847
- Sequence:
CVMVFTVSCS KMSSIVDRDD SSIFDGLVEE DDKDKAKRVS RNKSEKKRRD QFNVLIKELG SMLPGNARKM DKSTVLQKSI DFLRKHKETT AQSDASEIRQ DWKPTFLSNE EFTQLMLEAL DGFFLAIMTD GSIIYVSESV TSLLEHLPSD LVDQSIFNFI PEGEHSEVYK ILSTHLLESD SLTPEYLKSK NQLEFCCHML RGTIDPKEPS TYEYVRFIGN FKSLTSVSTS THNGFEGTIQ RTHRPSYEDR VCFVATVRLA TPQFIKEMCT VEEPNEEFTS RHSLEWKFLF LDHRAPPIIG YLPFEVLGTS GYDYYHVDDL ENLAKCHEHL MQYGKGKSCY YRFLTKGQQW IWLQTHYYIT YHQWNSRPEF IVCTHTVVSY AEVRAERRRE LGIEESLPET AADKSQDSGS DNRINTVSLK EALERFDHSP TPSASSRSSR KSSHTAVSDP SSTPTKIPTD TSTPPRQHLP AHEKMTQRRS SFSSQSINSQ SVGPSLTQPA MSQAANLPIP QGMSQFQFSA QLGAMQHLKD QLEQRTRMIE ANIHRQQEEL RKIQEQLQMV HGQGLQMFLQ QSNPGLNFGS VQLSSGNSNI QQLTPVNMQG QVVPANQVQS GHISTGQHMI QQQTLQSTST QQSQQSVMSG HSQQTSLPSQ TPSTLTAPLY NTMVISQPAA GSMVQIPSSM PQNSTQSATV TTFTQDRQIR FSQGQQLVTK LVTAPVACGA VMVPSTMLMG QVVTAYPTFA TQQQQAQTLS VTQQQQQQQQ QPPQQQQQQQ QSSQEQQLPS VQQPAQAQLG QPPQQFLQTS RLLHGNPSTQ LILSAAFPLQ QSTFPPSHHQ QHQPQQQQQL PRHRTDSLTD PSKVQPQ
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.