Genular: Defining Cellular Identity and Function

Details for: Clu

Gene ID: 12759

Symbol: Clu

Ensembl ID: ENSMUSG00000022037

Description: clusterin

Associated with

Antimicrobial peptides
(R-MMU-6803157)
Complement cascade
(R-MMU-166658)
Hemostasis
(R-MMU-109582)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Platelet activation, signaling and aggregation
(R-MMU-76002)
Platelet degranulation
(R-MMU-114608)
Regulation of complement cascade
(R-MMU-977606)
Response to elevated platelet cytosolic ca2+
(R-MMU-76005)
Terminal pathway of complement
(R-MMU-166665)
Aggresome
(GO:0016235)
Amyloid-beta binding
(GO:0001540)
Apical dendrite
(GO:0097440)
Cell morphogenesis
(GO:0000902)
Cell periphery
(GO:0071944)
Cell surface
(GO:0009986)
Central nervous system myelin maintenance
(GO:0032286)
Chaperone-mediated protein complex assembly
(GO:0051131)
Chaperone-mediated protein folding
(GO:0061077)
Cytoplasm
(GO:0005737)
Cytoplasmic vesicle
(GO:0031410)
Cytoskeleton
(GO:0005856)
Cytosol
(GO:0005829)
Endocrine pancreas development
(GO:0031018)
Endoplasmic reticulum
(GO:0005783)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Growth cone
(GO:0030426)
Immune complex clearance
(GO:0002434)
Intracellular membrane-bounded organelle
(GO:0043231)
Intrinsic apoptotic signaling pathway
(GO:0097193)
Low-density lipoprotein particle receptor binding
(GO:0050750)
Membrane
(GO:0016020)
Microglial cell activation
(GO:0001774)
Microglial cell proliferation
(GO:0061518)
Misfolded protein binding
(GO:0051787)
Mitochondrial inner membrane
(GO:0005743)
Mitochondrion
(GO:0005739)
Negative regulation of amyloid-beta formation
(GO:1902430)
Negative regulation of amyloid fibril formation
(GO:1905907)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of intrinsic apoptotic signaling pathway in response to dna damage
(GO:1902230)
Negative regulation of neuron apoptotic process
(GO:0043524)
Negative regulation of protein-containing complex assembly
(GO:0031333)
Negative regulation of response to endoplasmic reticulum stress
(GO:1903573)
Neurofibrillary tangle
(GO:0097418)
Neuron projection morphogenesis
(GO:0048812)
Nucleus
(GO:0005634)
Perinuclear endoplasmic reticulum lumen
(GO:0099020)
Perinuclear region of cytoplasm
(GO:0048471)
Positive regulation of amyloid-beta formation
(GO:1902004)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of cell differentiation
(GO:0045597)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of intrinsic apoptotic signaling pathway
(GO:2001244)
Positive regulation of neurofibrillary tangle assembly
(GO:1902998)
Positive regulation of nf-kappab transcription factor activity
(GO:0051092)
Positive regulation of nitric oxide biosynthetic process
(GO:0045429)
Positive regulation of proteasomal ubiquitin-dependent protein catabolic process
(GO:0032436)
Positive regulation of protein-containing complex assembly
(GO:0031334)
Positive regulation of receptor-mediated endocytosis
(GO:0048260)
Positive regulation of tumor necrosis factor production
(GO:0032760)
Positive regulation of ubiquitin-dependent protein catabolic process
(GO:2000060)
Protein-containing complex
(GO:0032991)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein carrier chaperone
(GO:0140597)
Protein import
(GO:0017038)
Protein stabilization
(GO:0050821)
Protein targeting to lysosome involved in chaperone-mediated autophagy
(GO:0061740)
Regulation of amyloid-beta clearance
(GO:1900221)
Regulation of apoptotic process
(GO:0042981)
Regulation of cell population proliferation
(GO:0042127)
Regulation of neuronal signal transduction
(GO:1902847)
Response to misfolded protein
(GO:0051788)
Signaling receptor binding
(GO:0005102)
Spherical high-density lipoprotein particle
(GO:0034366)
Synapse
(GO:0045202)
Tau protein binding
(GO:0048156)
Ubiquitin protein ligase binding
(GO:0031625)
Unfolded protein binding
(GO:0051082)

Other Information

Proteins

Clusterin beta chain

Genular Protein ID: 244949328

Symbol: CLUS_MOUSE

Name: Clusterin beta chain

UniProtKB Accession Codes:

Q06890

Database IDs:

Citations:

PubMed ID: 8352774

Title: Molecular cloning and sequencing of sulfated glycoprotein-2 cDNA from testis of mouse: implications of two different mRNAs of SGP-2.

PubMed ID: 8352774

DOI: 10.1006/bbrc.1993.1946

PubMed ID: 8354695

Title: Murine clusterin: molecular cloning and mRNA localization of a gene associated with epithelial differentiation processes during embryogenesis.

PubMed ID: 8354695

DOI: 10.1083/jcb.122.5.1119

PubMed ID: 8169523

Title: Mouse apolipoprotein J: characterization of a gene implicated in atherosclerosis.

PubMed ID: 8169523

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11067863

Title: Apolipoprotein J/clusterin limits the severity of murine autoimmune myocarditis.

PubMed ID: 11067863

DOI: 10.1172/jci9037

PubMed ID: 11865066

Title: Apolipoprotein J/clusterin prevents a progressive glomerulopathy of aging.

PubMed ID: 11865066

DOI: 10.1128/mcb.22.6.1893-1902.2002

PubMed ID: 12551933

Title: Synthesis and functional analyses of nuclear clusterin, a cell death protein.

PubMed ID: 12551933

DOI: 10.1074/jbc.m209233200

PubMed ID: 14741101

Title: ApoE and clusterin cooperatively suppress Abeta levels and deposition: evidence that ApoE regulates extracellular Abeta metabolism in vivo.

PubMed ID: 14741101

DOI: 10.1016/s0896-6273(03)00850-x

PubMed ID: 16944957

Title: Proteome-wide characterization of N-glycosylation events by diagonal chromatography.

PubMed ID: 16944957

DOI: 10.1021/pr060186m

PubMed ID: 17330941

Title: Enhanced analysis of the mouse plasma proteome using cysteine-containing tryptic glycopeptides.

PubMed ID: 17330941

DOI: 10.1021/pr0604559

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 448
Mass: 51656
Checksum: A860600A6F8D47F6
Sequence:

MKILLLCVAL LLIWDNGMVL GEQEVSDNEL QELSTQGSRY INKEIQNAVQ GVKHIKTLIE 
KTNAERKSLL NSLEEAKKKK EDALEDTRDS EMKLKAFPEV CNETMMALWE ECKPCLKHTC 
MKFYARVCRS GSGLVGQQLE EFLNQSSPFY FWMNGDRIDS LLESDRQQSQ VLDAMQDSFA 
RASGIIDTLF QDRFFARELH DPHYFSPIGF PHKRPHFLYP KSRLVRSLMS PSHYGPPSFH 
NMFQPFFEMI HQAQQAMDVQ LHSPAFQFPD VDFLREGEDD RTVCKEIRRN STGCLKMKGQ 
CEKCQEILSV DCSTNNPAQA NLRQELNDSL QVAERLTEQY KELLQSFQSK MLNTSSLLEQ 
LNDQFNWVSQ LANLTQGEDK YYLRVSTVTT HSSDSEVPSR VTEVVVKLFD SDPITVVLPE 
EVSKDNPKFM DTVAEKALQE YRRKSRAE

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Clu

Associated with

Other Information

Molecular cloning and sequencing of sulfated glycoprotein-2 cDNA from testis of mouse: implications of two different mRNAs of SGP-2. PubMed ID: 8352774

Murine clusterin: molecular cloning and mRNA localization of a gene associated with epithelial differentiation processes during embryogenesis. PubMed ID: 8354695

Mouse apolipoprotein J: characterization of a gene implicated in atherosclerosis. PubMed ID: 8169523

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Apolipoprotein J/clusterin limits the severity of murine autoimmune myocarditis. PubMed ID: 11067863

Apolipoprotein J/clusterin prevents a progressive glomerulopathy of aging. PubMed ID: 11865066

Synthesis and functional analyses of nuclear clusterin, a cell death protein. PubMed ID: 12551933

ApoE and clusterin cooperatively suppress Abeta levels and deposition: evidence that ApoE regulates extracellular Abeta metabolism in vivo. PubMed ID: 14741101

Proteome-wide characterization of N-glycosylation events by diagonal chromatography. PubMed ID: 16944957

Enhanced analysis of the mouse plasma proteome using cysteine-containing tryptic glycopeptides. PubMed ID: 17330941

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079