Genular: Defining Cellular Identity and Function

Details for: Cxcr2

Gene ID: 12765

Symbol: Cxcr2

Ensembl ID: ENSMUSG00000026180

Description: C-X-C motif chemokine receptor 2

Associated with

Chemokine receptors bind chemokines
(R-MMU-380108)
Class a/1 (rhodopsin-like receptors)
(R-MMU-373076)
G alpha (i) signalling events
(R-MMU-418594)
Gpcr downstream signalling
(R-MMU-388396)
Gpcr ligand binding
(R-MMU-500792)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Neutrophil degranulation
(R-MMU-6798695)
Peptide ligand-binding receptors
(R-MMU-375276)
Signaling by gpcr
(R-MMU-372790)
Acute inflammatory response to antigenic stimulus
(GO:0002438)
C-c chemokine binding
(GO:0019957)
C-c chemokine receptor activity
(GO:0016493)
C-x-c chemokine receptor activity
(GO:0016494)
Calcium-mediated signaling
(GO:0019722)
Cell surface
(GO:0009986)
Cell surface receptor signaling pathway
(GO:0007166)
Cellular defense response
(GO:0006968)
Chemokine receptor activity
(GO:0004950)
Chemotaxis
(GO:0006935)
External side of plasma membrane
(GO:0009897)
G protein-coupled receptor activity
(GO:0004930)
G protein-coupled receptor signaling pathway
(GO:0007186)
Immune response
(GO:0006955)
Interleukin-8 binding
(GO:0019959)
Interleukin-8 receptor activity
(GO:0004918)
Interleukin-8-mediated signaling pathway
(GO:0038112)
Mast cell granule
(GO:0042629)
Membrane
(GO:0016020)
Metanephric tubule morphogenesis
(GO:0072173)
Microtubule cytoskeleton
(GO:0015630)
Mitotic spindle
(GO:0072686)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of neutrophil apoptotic process
(GO:0033030)
Neutrophil activation
(GO:0042119)
Neutrophil chemotaxis
(GO:0030593)
Nucleoplasm
(GO:0005654)
Phospholipase c-activating g protein-coupled receptor signaling pathway
(GO:0007200)
Plasma membrane
(GO:0005886)
Positive regulation of angiogenesis
(GO:0045766)
Positive regulation of cardiac muscle cell apoptotic process
(GO:0010666)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of cytosolic calcium ion concentration
(GO:0007204)
Positive regulation of leukocyte chemotaxis
(GO:0002690)
Positive regulation of neutrophil chemotaxis
(GO:0090023)
Positive regulation of vascular permeability
(GO:0043117)
Protein binding
(GO:0005515)
Receptor internalization
(GO:0031623)
Signal transduction
(GO:0007165)

Other Information

Proteins

C-X-C chemokine receptor type 2

Genular Protein ID: 721370258

Symbol: CXCR2_MOUSE

Name: C-X-C chemokine receptor type 2

UniProtKB Accession Codes:

P35343 Q53X27

Database IDs:

Citations:

PubMed ID: 8288247

Title: The murine homologue of the human interleukin-8 receptor type B maps near the Ity-Lsh-Bcg disease resistance locus.

PubMed ID: 8288247

DOI: 10.1006/geno.1993.1486

PubMed ID: 7518426

Title: The N-terminus of interleukin-8 (IL-8) receptor confers high affinity binding to human IL-8.

PubMed ID: 7518426

DOI: 10.1016/s0021-9258(17)32295-0

PubMed ID: 7961909

Title: The murine interleukin 8 type B receptor homologue and its ligands. Expression and biological characterization.

PubMed ID: 7961909

DOI: 10.1016/s0021-9258(18)43882-3

PubMed ID: 7636264

Title: Chemokine binding and activities mediated by the mouse IL-8 receptor.

PubMed ID: 7636264

PubMed ID: 8194768

Title: Cloning of a cDNA encoding a mouse homolog of the interleukin-8 receptor.

PubMed ID: 8194768

DOI: 10.1016/0378-1119(94)90278-x

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8288218

Title: Identification, chromosomal location, and genome organization of mammalian G-protein-coupled receptors.

PubMed ID: 8288218

DOI: 10.1006/geno.1993.1452

PubMed ID: 14764687

Title: IL-10-conditioned dendritic cells, decommissioned for recruitment of adaptive immunity, elicit innate inflammatory gene products in response to danger signals.

PubMed ID: 14764687

DOI: 10.4049/jimmunol.172.4.2201

Sequence Information:

Length: 359
Mass: 40425
Checksum: 74BD166E9B679F88
Sequence:

MGEFKVDKFN IEDFFSGDLD IFNYSSGMPS ILPDAVPCHS ENLEINSYAV VVIYVLVTLL 
SLVGNSLVML VILYNRSTCS VTDVYLLNLA IADLFFALTL PVWAASKVNG WTFGSTLCKI 
FSYVKEVTFY SSVLLLACIS MDRYLAIVHA TSTLIQKRHL VKFVCIAMWL LSVILALPIL 
ILRNPVKVNL STLVCYEDVG NNTSRLRVVL RILPQTFGFL VPLLIMLFCY GFTLRTLFKA 
HMGQKHRAMR VIFAVVLVFL LCWLPYNLVL FTDTLMRTKL IKETCERRDD IDKALNATEI 
LGFLHSCLNP IIYAFIGQKF RHGLLKIMAT YGLVSKEFLA KEGRPSFVSS SSANTSTTL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Cxcr2

Associated with

Other Information

The murine homologue of the human interleukin-8 receptor type B maps near the Ity-Lsh-Bcg disease resistance locus. PubMed ID: 8288247

The N-terminus of interleukin-8 (IL-8) receptor confers high affinity binding to human IL-8. PubMed ID: 7518426

The murine interleukin 8 type B receptor homologue and its ligands. Expression and biological characterization. PubMed ID: 7961909

Chemokine binding and activities mediated by the mouse IL-8 receptor. PubMed ID: 7636264

Cloning of a cDNA encoding a mouse homolog of the interleukin-8 receptor. PubMed ID: 8194768

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Identification, chromosomal location, and genome organization of mammalian G-protein-coupled receptors. PubMed ID: 8288218

IL-10-conditioned dendritic cells, decommissioned for recruitment of adaptive immunity, elicit innate inflammatory gene products in response to danger signals. PubMed ID: 14764687