Genular: Defining Cellular Identity and Function

Details for: Ccr5

Gene ID: 12774

Symbol: Ccr5

Ensembl ID: ENSMUSG00000079227

Description: C-C motif chemokine receptor 5

Associated with

Chemokine receptors bind chemokines
(R-MMU-380108)
Class a/1 (rhodopsin-like receptors)
(R-MMU-373076)
G alpha (i) signalling events
(R-MMU-418594)
Gpcr downstream signalling
(R-MMU-388396)
Gpcr ligand binding
(R-MMU-500792)
Peptide ligand-binding receptors
(R-MMU-375276)
Signaling by gpcr
(R-MMU-372790)
Actin binding
(GO:0003779)
C-c chemokine binding
(GO:0019957)
C-c chemokine receptor activity
(GO:0016493)
Calcium-mediated signaling
(GO:0019722)
Calcium ion transport
(GO:0006816)
Cell-cell signaling
(GO:0007267)
Cell chemotaxis
(GO:0060326)
Cell surface
(GO:0009986)
Chemokine (c-c motif) ligand 5 binding
(GO:0071791)
Chemokine receptor activity
(GO:0004950)
Chemotaxis
(GO:0006935)
Cytoplasm
(GO:0005737)
Defense response
(GO:0006952)
Endosome
(GO:0005768)
External side of plasma membrane
(GO:0009897)
G protein-coupled receptor activity
(GO:0004930)
G protein-coupled receptor signaling pathway
(GO:0007186)
Identical protein binding
(GO:0042802)
Immune response
(GO:0006955)
Inflammatory response
(GO:0006954)
Membrane
(GO:0016020)
Negative regulation of axon extension
(GO:0030517)
Negative regulation of macrophage apoptotic process
(GO:2000110)
Negative regulation of neural precursor cell proliferation
(GO:2000178)
Plasma membrane
(GO:0005886)
Positive regulation of cell-cell adhesion
(GO:0022409)
Positive regulation of cell killing
(GO:0031343)
Positive regulation of cytosolic calcium ion concentration
(GO:0007204)
Positive regulation of fever generation
(GO:0031622)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of interleukin-1 beta production
(GO:0032731)
Positive regulation of interleukin-6 production
(GO:0032755)
Positive regulation of neuron differentiation
(GO:0045666)
Positive regulation of tumor necrosis factor production
(GO:0032760)
Protein kinase binding
(GO:0019901)
Regulation of cell migration
(GO:0030334)
Release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
(GO:0014808)
Response to cholesterol
(GO:0070723)
Signal transduction
(GO:0007165)

Other Information

Proteins

C-C chemokine receptor type 5

Genular Protein ID: 2279592277

Symbol: CCR5_MOUSE

Name: C-C chemokine receptor type 5

UniProtKB Accession Codes:

P51682 O35313 O35891 P97308 P97405 Q3ZAZ8 Q61867

Database IDs:

Citations:

PubMed ID: 8631787

Title: Molecular cloning and functional expression of murine JE (monocyte chemoattractant protein 1) and murine macrophage inflammatory protein 1alpha receptors: evidence for two closely linked C-C chemokine receptors on chromosome 9.

PubMed ID: 8631787

DOI: 10.1074/jbc.271.13.7551

PubMed ID: 8662890

Title: Cloning and characterization of a novel murine macrophage inflammatory protein-1 alpha receptor.

PubMed ID: 8662890

DOI: 10.1074/jbc.271.24.14445

PubMed ID: 9343222

Title: Polymorphisms in the CCR5 genes of African green monkeys and mice implicate specific amino acids in infections by simian and human immunodeficiency viruses.

PubMed ID: 9343222

DOI: 10.1128/jvi.71.11.8642-8656.1997

PubMed ID: 9261347

Title: Two distinct CCR5 domains can mediate coreceptor usage by human immunodeficiency virus type 1.

PubMed ID: 9261347

DOI: 10.1128/jvi.71.9.6305-6314.1997

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

Length: 354
Mass: 40785
Checksum: D91F50EC9C956795
Sequence:

MDFQGSVPTY SYDIDYGMSA PCQKINVKQI AAQLLPPLYS LVFIFGFVGN MMVFLILISC 
KKLKSVTDIY LLNLAISDLL FLLTLPFWAH YAANEWVFGN IMCKVFTGLY HIGYFGGIFF 
IILLTIDRYL AIVHAVFALK VRTVNFGVIT SVVTWAVAVF ASLPEIIFTR SQKEGFHYTC 
SPHFPHTQYH FWKSFQTLKM VILSLILPLL VMVICYSGIL HTLFRCRNEK KRHRAVRLIF 
AIMIVYFLFW TPYNIVLLLT TFQEFFGLNN CSSSNRLDQA MQATETLGMT HCCLNPVIYA 
FVGEKFRSYL SVFFRKHMVK RFCKRCSIFQ QDNPDRASSV YTRSTGEHEV STGL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ccr5

Associated with

Other Information

Molecular cloning and functional expression of murine JE (monocyte chemoattractant protein 1) and murine macrophage inflammatory protein 1alpha receptors: evidence for two closely linked C-C chemokine receptors on chromosome 9. PubMed ID: 8631787

Cloning and characterization of a novel murine macrophage inflammatory protein-1 alpha receptor. PubMed ID: 8662890

Polymorphisms in the CCR5 genes of African green monkeys and mice implicate specific amino acids in infections by simian and human immunodeficiency viruses. PubMed ID: 9343222

Two distinct CCR5 domains can mediate coreceptor usage by human immunodeficiency virus type 1. PubMed ID: 9261347

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072