Details for: Ccr7

Gene ID: 12775

Symbol: Ccr7

Ensembl ID: ENSMUSG00000037944

Description: C-C motif chemokine receptor 7

Associated with

  • Chemokine receptors bind chemokines
    (R-MMU-380108)
  • Class a/1 (rhodopsin-like receptors)
    (R-MMU-373076)
  • G alpha (i) signalling events
    (R-MMU-418594)
  • Gpcr downstream signalling
    (R-MMU-388396)
  • Gpcr ligand binding
    (R-MMU-500792)
  • Peptide ligand-binding receptors
    (R-MMU-375276)
  • Signaling by gpcr
    (R-MMU-372790)
  • Actin cytoskeleton organization
    (GO:0030036)
  • C-c chemokine receptor activity
    (GO:0016493)
  • C-c motif chemokine 19 receptor activity
    (GO:0038117)
  • C-c motif chemokine 21 receptor activity
    (GO:0038121)
  • Calcium-mediated signaling
    (GO:0019722)
  • Cell chemotaxis
    (GO:0060326)
  • Cell surface
    (GO:0009986)
  • Cellular response to cytokine stimulus
    (GO:0071345)
  • Chemokine (c-c motif) ligand 19 binding
    (GO:0035757)
  • Chemokine (c-c motif) ligand 21 binding
    (GO:0035758)
  • Chemokine receptor activity
    (GO:0004950)
  • Chemotaxis
    (GO:0006935)
  • Establishment of t cell polarity
    (GO:0001768)
  • External side of plasma membrane
    (GO:0009897)
  • G protein-coupled receptor activity
    (GO:0004930)
  • G protein-coupled receptor signaling pathway
    (GO:0007186)
  • Homeostasis of number of cells
    (GO:0048872)
  • Immune response
    (GO:0006955)
  • Inflammatory response
    (GO:0006954)
  • Lymph node development
    (GO:0048535)
  • Lymphocyte chemotaxis across high endothelial venule
    (GO:0002518)
  • Lymphocyte migration into lymph node
    (GO:0097022)
  • Mature conventional dendritic cell differentiation
    (GO:0097029)
  • Membrane
    (GO:0016020)
  • Mitochondrion
    (GO:0005739)
  • Myeloid dendritic cell chemotaxis
    (GO:0002408)
  • Negative regulation of interleukin-12 production
    (GO:0032695)
  • Negative regulation of leukocyte apoptotic process
    (GO:2000107)
  • Negative thymic t cell selection
    (GO:0045060)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of cell motility
    (GO:2000147)
  • Positive regulation of cytosolic calcium ion concentration
    (GO:0007204)
  • Positive regulation of dendritic cell antigen processing and presentation
    (GO:0002606)
  • Positive regulation of dendritic cell chemotaxis
    (GO:2000510)
  • Positive regulation of filopodium assembly
    (GO:0051491)
  • Positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation
    (GO:2000526)
  • Positive regulation of gtpase activity
    (GO:0043547)
  • Positive regulation of humoral immune response
    (GO:0002922)
  • Positive regulation of hypersensitivity
    (GO:0002885)
  • Positive regulation of immunological synapse formation
    (GO:2000522)
  • Positive regulation of interleukin-1 beta production
    (GO:0032731)
  • Positive regulation of interleukin-12 production
    (GO:0032735)
  • Positive regulation of jun kinase activity
    (GO:0043507)
  • Positive regulation of macrophage chemotaxis
    (GO:0010759)
  • Positive regulation of neutrophil chemotaxis
    (GO:0090023)
  • Positive regulation of phagocytosis
    (GO:0050766)
  • Positive regulation of receptor-mediated endocytosis
    (GO:0048260)
  • Positive regulation of t-helper 1 cell differentiation
    (GO:0045627)
  • Positive regulation of t cell chemotaxis
    (GO:0010820)
  • Positive regulation of t cell costimulation
    (GO:2000525)
  • Positive regulation of t cell proliferation
    (GO:0042102)
  • Positive regulation of t cell receptor signaling pathway
    (GO:0050862)
  • Positive regulation of thymocyte migration
    (GO:2000412)
  • Positive regulation of tumor necrosis factor production
    (GO:0032760)
  • Protein binding
    (GO:0005515)
  • Regulation of dendritic cell dendrite assembly
    (GO:2000547)
  • Regulation of interleukin-1 beta production
    (GO:0032651)
  • Regulation of tolerance induction to self antigen
    (GO:0002649)
  • Regulation of type ii interferon production
    (GO:0032649)
  • Response to lipopolysaccharide
    (GO:0032496)
  • Response to nitric oxide
    (GO:0071731)
  • Response to prostaglandin e
    (GO:0034695)
  • Signal transduction
    (GO:0007165)

Other Information

Genular Protein ID: 3540551668

Symbol: CCR7_MOUSE

Name: C-C chemokine receptor type 7

UniProtKB Accession Codes:

P47774 Q8CAS2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CCDS 1 CTD 1 DNASU 1 EMBL 6 EPD 1 Ensembl 1 GO 58 Gene3D 1 GeneTree 1 Genevisible 1 GlyCosmos 1 GlyGen 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MGI 1 MINT 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PROSITE-ProRule 1 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 2 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1

Citations:

PubMed ID: 7851893

Title: Cloning of human and mouse EBI1, a lymphoid-specific G-protein-coupled receptor encoded on human chromosome 17q12-q21.2.

PubMed ID: 7851893

DOI: 10.1006/geno.1994.1553

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

  • Length: 378
  • Mass: 42856
  • Checksum: F027451989B59683
  • Sequence:
    • MDPGKPRKNV LVVALLVIFQ VCFCQDEVTD DYIGENTTVD YTLYESVCFK KDVRNFKAWF 
LPLMYSVICF VGLLGNGLVI LTYIYFKRLK TMTDTYLLNL AVADILFLLI LPFWAYSEAK 
SWIFGVYLCK GIFGIYKLSF FSGMLLLLCI SIDRYVAIVQ AVSAHRHRAR VLLISKLSCV 
GIWMLALFLS IPELLYSGLQ KNSGEDTLRC SLVSAQVEAL ITIQVAQMVF GFLVPMLAMS 
FCYLIIIRTL LQARNFERNK AIKVIIAVVV VFIVFQLPYN GVVLAQTVAN FNITNSSCET 
SKQLNIAYDV TYSLASVRCC VNPFLYAFIG VKFRSDLFKL FKDLGCLSQE RLRHWSSCRH 
VRNASVSMEA ETTTTFSP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.