Genular: Defining Cellular Identity and Function

Details for: Ackr3

Gene ID: 12778

Symbol: Ackr3

Ensembl ID: ENSMUSG00000044337

Description: atypical chemokine receptor 3

Associated with

Chemokine receptors bind chemokines
(R-MMU-380108)
Class a/1 (rhodopsin-like receptors)
(R-MMU-373076)
G alpha (i) signalling events
(R-MMU-418594)
Gpcr downstream signalling
(R-MMU-388396)
Gpcr ligand binding
(R-MMU-500792)
Peptide ligand-binding receptors
(R-MMU-375276)
Signaling by gpcr
(R-MMU-372790)
Angiogenesis
(GO:0001525)
C-c chemokine binding
(GO:0019957)
C-c chemokine receptor activity
(GO:0016493)
C-x-c chemokine binding
(GO:0019958)
C-x-c chemokine receptor activity
(GO:0016494)
Calcium-mediated signaling
(GO:0019722)
Cell adhesion
(GO:0007155)
Cell chemotaxis
(GO:0060326)
Cell surface
(GO:0009986)
Chemokine-mediated signaling pathway
(GO:0070098)
Chemokine binding
(GO:0019956)
Chemotaxis
(GO:0006935)
Clathrin-coated pit
(GO:0005905)
Coreceptor activity
(GO:0015026)
Endosome
(GO:0005768)
External side of plasma membrane
(GO:0009897)
G protein-coupled receptor activity
(GO:0004930)
G protein-coupled receptor signaling pathway
(GO:0007186)
Immune response
(GO:0006955)
Intracellular membrane-bounded organelle
(GO:0043231)
Membrane
(GO:0016020)
Multicellular organism development
(GO:0007275)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of intrinsic apoptotic signaling pathway in response to dna damage
(GO:1902230)
Oculomotor nerve development
(GO:0021557)
Plasma membrane
(GO:0005886)
Positive regulation of cytosolic calcium ion concentration
(GO:0007204)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of mesenchymal stem cell migration
(GO:1905322)
Receptor internalization
(GO:0031623)
Scavenger receptor activity
(GO:0005044)
Signal transduction
(GO:0007165)
Vasculogenesis
(GO:0001570)

Other Information

Proteins

C-X-C chemokine receptor type 7

Genular Protein ID: 1536523108

Symbol: ACKR3_MOUSE

Name: C-X-C chemokine receptor type 7

UniProtKB Accession Codes:

P56485 Q91WI0

Database IDs:

Citations:

PubMed ID: 9510554

Title: Cloning and chromosomal mapping of an orphan chemokine receptor: mouse RDC1.

PubMed ID: 9510554

DOI: 10.1007/s002510050371

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16940167

Title: A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development.

PubMed ID: 16940167

DOI: 10.1084/jem.20052144

PubMed ID: 17804806

Title: Disrupted cardiac development but normal hematopoiesis in mice deficient in the second CXCL12/SDF-1 receptor, CXCR7.

PubMed ID: 17804806

DOI: 10.1073/pnas.0702229104

PubMed ID: 18442043

Title: Early postnatal lethality and cardiovascular defects in CXCR7-deficient mice.

PubMed ID: 18442043

DOI: 10.1002/dvg.20387

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20681075

Title: Expression and function of CXCR7 in the mouse forebrain.

PubMed ID: 20681075

DOI: 10.1016/j.jneuroim.2010.05.011

PubMed ID: 20161793

Title: CXCR7 functions as a scavenger for CXCL12 and CXCL11.

PubMed ID: 20161793

DOI: 10.1371/journal.pone.0009175

PubMed ID: 21246655

Title: The chemokine receptor CXCR7 functions to regulate cardiac valve remodeling.

PubMed ID: 21246655

DOI: 10.1002/dvdy.22549

PubMed ID: 21220100

Title: Cxcr7 controls neuronal migration by regulating chemokine responsiveness.

PubMed ID: 21220100

DOI: 10.1016/j.neuron.2010.12.006

PubMed ID: 31211835

Title: Decreased ACKR3 (CXCR7) function causes oculomotor synkinesis in mice and humans.

PubMed ID: 31211835

DOI: 10.1093/hmg/ddz137

Sequence Information:

Length: 362
Mass: 41636
Checksum: 7A0399DED5B73E66
Sequence:

MDVHLFDYAE PGNYSDINWP CNSSDCIVVD TVQCPTMPNK NVLLYTLSFI YIFIFVIGMI 
ANSVVVWVNI QAKTTGYDTH CYILNLAIAD LWVVITIPVW VVSLVQHNQW PMGELTCKIT 
HLIFSINLFG SIFFLACMSV DRYLSITYFT GTSSYKKKMV RRVVCILVWL LAFFVSLPDT 
YYLKTVTSAS NNETYCRSFY PEHSIKEWLI GMELVSVILG FAVPFTIIAI FYFLLARAMS 
ASGDQEKHSS RKIIFSYVVV FLVCWLPYHF VVLLDIFSIL HYIPFTCQLE NVLFTALHVT 
QCLSLVHCCV NPVLYSFINR NYRYELMKAF IFKYSAKTGL TKLIDASRVS ETEYSALEQN 
TK

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ackr3

Associated with

Other Information

Cloning and chromosomal mapping of an orphan chemokine receptor: mouse RDC1. PubMed ID: 9510554

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development. PubMed ID: 16940167

Disrupted cardiac development but normal hematopoiesis in mice deficient in the second CXCL12/SDF-1 receptor, CXCR7. PubMed ID: 17804806

Early postnatal lethality and cardiovascular defects in CXCR7-deficient mice. PubMed ID: 18442043

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Expression and function of CXCR7 in the mouse forebrain. PubMed ID: 20681075

CXCR7 functions as a scavenger for CXCL12 and CXCL11. PubMed ID: 20161793

The chemokine receptor CXCR7 functions to regulate cardiac valve remodeling. PubMed ID: 21246655

Cxcr7 controls neuronal migration by regulating chemokine responsiveness. PubMed ID: 21220100

Decreased ACKR3 (CXCR7) function causes oculomotor synkinesis in mice and humans. PubMed ID: 31211835