Details for: ADH5

Gene ID: 128

Symbol: ADH5

Ensembl ID: ENSG00000197894

Description: alcohol dehydrogenase 5 (class III), chi polypeptide

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.51
    Marker Score: 33156
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.37
    Marker Score: 15404
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.37
    Marker Score: 10200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.3
    Marker Score: 25939
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.29
    Marker Score: 79208
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.26
    Marker Score: 4728
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.16
    Marker Score: 8483
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.14
    Marker Score: 5831
  • Cell Name: Unknown (CL0002371)
    Fold Change: 2.08
    Marker Score: 2205
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.07
    Marker Score: 7361
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.07
    Marker Score: 15398
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 2.06
    Marker Score: 2204
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 2.04
    Marker Score: 12070.5
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 2.02
    Marker Score: 1903
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 2.02
    Marker Score: 3431.5
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 2.01
    Marker Score: 462
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2
    Marker Score: 20139
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.97
    Marker Score: 1122
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.96
    Marker Score: 1230
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.96
    Marker Score: 2068
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 1.93
    Marker Score: 2509
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.92
    Marker Score: 2070
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 1.92
    Marker Score: 726
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.92
    Marker Score: 3602
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 1.9
    Marker Score: 702
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.9
    Marker Score: 1270
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.89
    Marker Score: 2679
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.86
    Marker Score: 2866
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.85
    Marker Score: 2725
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.82
    Marker Score: 1001
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.8
    Marker Score: 4548
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.79
    Marker Score: 1805
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.78
    Marker Score: 2192.5
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.77
    Marker Score: 4751
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.76
    Marker Score: 906
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.75
    Marker Score: 7150
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.74
    Marker Score: 6442
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.74
    Marker Score: 4549
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.7
    Marker Score: 1220
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.7
    Marker Score: 5343
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.69
    Marker Score: 2774
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.69
    Marker Score: 10800
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.69
    Marker Score: 3971
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 1.69
    Marker Score: 1109
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.68
    Marker Score: 57079
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.66
    Marker Score: 7961
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.65
    Marker Score: 1038.5
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.64
    Marker Score: 4471
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.63
    Marker Score: 3881
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.63
    Marker Score: 403
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.63
    Marker Score: 2620
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.62
    Marker Score: 2576
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 1.61
    Marker Score: 1938
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.61
    Marker Score: 378
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.61
    Marker Score: 18720
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.6
    Marker Score: 2010
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.59
    Marker Score: 2633
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.59
    Marker Score: 2047
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.58
    Marker Score: 507
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.58
    Marker Score: 2098
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 1.56
    Marker Score: 1506
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.53
    Marker Score: 1798
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.53
    Marker Score: 1115
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.52
    Marker Score: 9920
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.52
    Marker Score: 1708
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.51
    Marker Score: 429
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.51
    Marker Score: 1602
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.5
    Marker Score: 2151
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.49
    Marker Score: 704
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.49
    Marker Score: 1507
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.47
    Marker Score: 425
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.46
    Marker Score: 992
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 1.46
    Marker Score: 1411
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 1.46
    Marker Score: 505
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 1.46
    Marker Score: 2854
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 1.45
    Marker Score: 411
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 1.45
    Marker Score: 1028
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.44
    Marker Score: 1043
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.42
    Marker Score: 783
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.42
    Marker Score: 1339
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 1.41
    Marker Score: 748
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.39
    Marker Score: 333
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 1.39
    Marker Score: 1644.5
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.38
    Marker Score: 14035
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.38
    Marker Score: 444
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 1.38
    Marker Score: 1329.5
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 1.38
    Marker Score: 817
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.38
    Marker Score: 1429
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 1.37
    Marker Score: 671
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.37
    Marker Score: 8322
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.36
    Marker Score: 2414
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.35
    Marker Score: 265
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.35
    Marker Score: 712
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.35
    Marker Score: 641
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.35
    Marker Score: 473
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.35
    Marker Score: 1631
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.34
    Marker Score: 13299
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.34
    Marker Score: 784
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.33
    Marker Score: 1185
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.32
    Marker Score: 6491

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Other Information

**Key characteristics:** - The ADH5 gene is located on chromosome 15q26.1. - It is a protein of 1148 amino acids. - It is expressed in a variety of cell types, including mesodermal cells, interstitial cells of the ovary, decidual cells, stromal cells of the ovary, cells in vitro, epithelial cells of the nephron, placental villous trophoblast, ovarian surface epithelial cells, and epithelial cells of the proximal tubule. **Pathways and functions:** - ADH5 is involved in the metabolism of ethanol and other organic compounds. - It is a key enzyme in the ethanol metabolism pathway, which is responsible for the breakdown of ethanol into harmless metabolites. - It is also involved in the metabolism of other organic compounds, including acetaldehyde, lactate, and pyruvate. - ADH5 also plays a role in the detoxification of reactive oxygen species (ROS), which can damage cells and tissues. **Clinical significance:** - Mutations in the ADH5 gene have been linked to an increased risk of certain diseases, including liver cirrhosis, kidney disease, and cancer. - ADH5 inhibitors are being investigated as potential treatments for these diseases. **Additional notes:** - ADH5 is a highly conserved protein, with a similar sequence found in organisms from yeast to humans. - It is a heterodimeric protein, with two identical subunits that come together to form a functional enzyme. - It is a regulated gene, with its expression being controlled by a variety of factors, including alcohol levels, growth factors, and cytokines.

Genular Protein ID: 2945466517

Symbol: ADHX_HUMAN

Name: Alcohol dehydrogenase 5

UniProtKB Accession Codes:

P11766 Q6FHR2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 CarbonylDB 1 ChEBI 39 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 8 EC 5 EMBL 13 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 21 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 12 PDBsum 10 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 8 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissLipids 1 SwissPalm 1 TreeFam 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2818582

Title: cDNA sequence of human class III alcohol dehydrogenase.

PubMed ID: 2818582

DOI: 10.1016/0006-291x(89)91507-6

PubMed ID: 2679557

Title: Cloning and comparative mapping of a human class III (chi) alcohol dehydrogenase cDNA.

PubMed ID: 2679557

DOI: 10.1016/0006-291x(89)91741-5

PubMed ID: 1446828

Title: Cloning and characterization of the ADH5 gene encoding human alcohol dehydrogenase 5, formaldehyde dehydrogenase.

PubMed ID: 1446828

DOI: 10.1016/0378-1119(92)90135-c

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3365377

Title: Class III human liver alcohol dehydrogenase: a novel structural type equidistantly related to the class I and class II enzymes.

PubMed ID: 3365377

DOI: 10.1021/bi00404a009

PubMed ID: 8494891

Title: Role of arginine 115 in fatty acid activation and formaldehyde dehydrogenase activity of human class III alcohol dehydrogenase.

PubMed ID: 8494891

DOI: 10.1021/bi00070a024

PubMed ID: 8460164

Title: Mutation of Arg-115 of human class III alcohol dehydrogenase: a binding site required for formaldehyde dehydrogenase activity and fatty acid activation.

PubMed ID: 8460164

DOI: 10.1073/pnas.90.6.2491

PubMed ID: 16081420

Title: Omega-oxidation of 20-hydroxyeicosatetraenoic acid (20-HETE) in cerebral microvascular smooth muscle and endothelium by alcohol dehydrogenase 4.

PubMed ID: 16081420

DOI: 10.1074/jbc.m504055200

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 9018047

Title: Structure of human chi chi alcohol dehydrogenase: a glutathione-dependent formaldehyde dehydrogenase.

PubMed ID: 9018047

DOI: 10.1006/jmbi.1996.0731

PubMed ID: 33355142

Title: Digenic mutations in ALDH2 and ADH5 impair formaldehyde clearance and cause a multisystem disorder, AMeD syndrome.

PubMed ID: 33355142

DOI: 10.1126/sciadv.abd7197

Sequence Information:

  • Length: 374
  • Mass: 39724
  • Checksum: F4F823B4A609C952
  • Sequence:
    • MANEVIKCKA AVAWEAGKPL SIEEIEVAPP KAHEVRIKII ATAVCHTDAY TLSGADPEGC 
FPVILGHEGA GIVESVGEGV TKLKAGDTVI PLYIPQCGEC KFCLNPKTNL CQKIRVTQGK 
GLMPDGTSRF TCKGKTILHY MGTSTFSEYT VVADISVAKI DPLAPLDKVC LLGCGISTGY 
GAAVNTAKLE PGSVCAVFGL GGVGLAVIMG CKVAGASRII GVDINKDKFA RAKEFGATEC 
INPQDFSKPI QEVLIEMTDG GVDYSFECIG NVKVMRAALE ACHKGWGVSV VVGVAASGEE 
IATRPFQLVT GRTWKGTAFG GWKSVESVPK LVSEYMSKKI KVDEFVTHNL SFDEINKAFE 
LMHSGKSIRT VVKI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.