Details for: ADH5

Gene ID: 128

Symbol: ADH5

Ensembl ID: ENSG00000197894

Description: alcohol dehydrogenase 5 (class III), chi polypeptide

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 330.1934
    Cell Significance Index: -51.3600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 171.4316
    Cell Significance Index: -43.4800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 135.6240
    Cell Significance Index: -55.8700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 116.4410
    Cell Significance Index: -47.3100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 116.1351
    Cell Significance Index: -54.8300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 104.5909
    Cell Significance Index: -53.8000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 82.0837
    Cell Significance Index: -55.0800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 49.8825
    Cell Significance Index: -47.6300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 44.4541
    Cell Significance Index: -54.8100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 15.0736
    Cell Significance Index: -40.3800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 14.1965
    Cell Significance Index: -56.0200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 12.7464
    Cell Significance Index: -39.1500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 12.3093
    Cell Significance Index: -26.9400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 4.7051
    Cell Significance Index: 548.3300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 3.1617
    Cell Significance Index: 434.1900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.6565
    Cell Significance Index: 21.2100
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.5577
    Cell Significance Index: 32.7600
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 2.3203
    Cell Significance Index: 14.3600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 2.2294
    Cell Significance Index: 46.6700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.8809
    Cell Significance Index: 65.3600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.8717
    Cell Significance Index: 1022.1900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.8289
    Cell Significance Index: 329.6900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.6739
    Cell Significance Index: 205.8200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.5151
    Cell Significance Index: 300.6800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.4063
    Cell Significance Index: 99.4600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.3603
    Cell Significance Index: 35.7700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.2749
    Cell Significance Index: 11.7400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.2403
    Cell Significance Index: 85.7700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.2102
    Cell Significance Index: 535.0700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.1655
    Cell Significance Index: 34.2300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.1478
    Cell Significance Index: 15.6600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.1057
    Cell Significance Index: 12.0200
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.9795
    Cell Significance Index: 22.6300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.9412
    Cell Significance Index: 48.9000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.9325
    Cell Significance Index: 24.9000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.8617
    Cell Significance Index: 55.6000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.8567
    Cell Significance Index: 109.8200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.7570
    Cell Significance Index: 20.6100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6912
    Cell Significance Index: 112.4200
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.6843
    Cell Significance Index: 4.0200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.6296
    Cell Significance Index: 13.6400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5971
    Cell Significance Index: 27.8400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.5463
    Cell Significance Index: 15.6600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5340
    Cell Significance Index: 62.9800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.5105
    Cell Significance Index: 26.5900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5091
    Cell Significance Index: 96.8900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5027
    Cell Significance Index: 100.8500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4711
    Cell Significance Index: 46.6000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3709
    Cell Significance Index: 17.4300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3463
    Cell Significance Index: 124.2200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2691
    Cell Significance Index: 45.9600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2063
    Cell Significance Index: 5.9500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.1222
    Cell Significance Index: 89.6200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1197
    Cell Significance Index: 15.4700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0952
    Cell Significance Index: 3.0500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0663
    Cell Significance Index: 1.1100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0558
    Cell Significance Index: 105.0900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0472
    Cell Significance Index: 29.9900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0448
    Cell Significance Index: 33.9100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0128
    Cell Significance Index: 0.4500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0021
    Cell Significance Index: -0.1100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0080
    Cell Significance Index: -0.4900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0144
    Cell Significance Index: -26.5100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0237
    Cell Significance Index: -36.5100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0280
    Cell Significance Index: -20.7700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0295
    Cell Significance Index: -18.4300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0397
    Cell Significance Index: -4.0600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0399
    Cell Significance Index: -54.2300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0575
    Cell Significance Index: -32.4100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0737
    Cell Significance Index: -5.4900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0751
    Cell Significance Index: -34.0900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1176
    Cell Significance Index: -6.6000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1212
    Cell Significance Index: -25.5200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1239
    Cell Significance Index: -9.8200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1496
    Cell Significance Index: -2.9200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1537
    Cell Significance Index: -44.2300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1701
    Cell Significance Index: -13.0600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1987
    Cell Significance Index: -28.8900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2298
    Cell Significance Index: -26.3300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2383
    Cell Significance Index: -6.6600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2489
    Cell Significance Index: -15.6900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2516
    Cell Significance Index: -3.7700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2748
    Cell Significance Index: -7.0200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.3009
    Cell Significance Index: -13.6400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3072
    Cell Significance Index: -35.0700
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.3941
    Cell Significance Index: -2.6700
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.4893
    Cell Significance Index: -4.1100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4945
    Cell Significance Index: -51.4900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5430
    Cell Significance Index: -14.5300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.5581
    Cell Significance Index: -37.5300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.5611
    Cell Significance Index: -11.9500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.6540
    Cell Significance Index: -6.7700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.8229
    Cell Significance Index: -20.5700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8932
    Cell Significance Index: -54.7600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.9403
    Cell Significance Index: -41.5900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.9634
    Cell Significance Index: -25.8200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.9635
    Cell Significance Index: -48.6900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.0932
    Cell Significance Index: -32.2000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -1.1291
    Cell Significance Index: -19.0200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -1.1294
    Cell Significance Index: -12.8300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ADH5 belongs to the class III alcohol dehydrogenase family, which is distinguished by its structural and functional properties. This enzyme is characterized by its ability to catalyze the oxidation of alcohols, including ethanol, and its involvement in various metabolic pathways. ADH5 is also notable for its zinc-dependent activity, which is essential for its catalytic function. Additionally, its expression in diverse cell types indicates a potential role in maintaining cellular homeostasis and responding to environmental stimuli. **Pathways and Functions:** ADH5 is involved in multiple biochemical pathways, including: 1. **Alcohol Oxidation:** ADH5 catalyzes the oxidation of ethanol, producing acetaldehyde, which is then further metabolized by other enzymes. 2. **Electron Transport Chain:** ADH5 contributes to the electron transport chain, which is crucial for generating energy in cells. 3. **Formaldehyde Catabolism:** ADH5 plays a role in the catabolism of formaldehyde, a toxic metabolite produced during ethanol metabolism. 4. **Zinc Ion Binding:** ADH5's zinc-dependent activity is essential for its catalytic function, suggesting a regulatory role in zinc homeostasis. 5. **Redox Balance:** ADH5's involvement in electron transfer and antioxidant defenses indicates its potential role in maintaining cellular redox balance. **Clinical Significance:** ADH5's expression in various cell types and its involvement in multiple metabolic pathways make it a valuable target for understanding human disease. Some potential clinical implications of ADH5 include: 1. **Alcohol Metabolism:** ADH5's role in ethanol metabolism suggests its involvement in alcohol-related disorders, such as alcohol dependence and liver disease. 2. **Oxidative Stress:** ADH5's antioxidant functions may contribute to the development of oxidative stress-related diseases, such as cancer and neurodegenerative disorders. 3. **Cardiovascular Disease:** ADH5's involvement in blood pressure regulation and the electron transport chain may have implications for cardiovascular health. 4. **Reproductive Health:** ADH5's expression in ovarian cells and its role in formaldehyde catabolism suggest its potential involvement in reproductive health and disorders. In conclusion, ADH5 is a multifunctional enzyme with diverse cellular expression and physiological roles. Further research on ADH5's functions and its involvement in human disease will provide valuable insights into its clinical significance and potential therapeutic applications.

Genular Protein ID: 2945466517

Symbol: ADHX_HUMAN

Name: Alcohol dehydrogenase 5

UniProtKB Accession Codes:

P11766 Q6FHR2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 CarbonylDB 1 ChEBI 44 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 8 EC 5 EMBL 13 EMDB 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 20 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 10 PDBsum 10 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 10 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissLipids 1 SwissPalm 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2818582

Title: cDNA sequence of human class III alcohol dehydrogenase.

PubMed ID: 2818582

DOI: 10.1016/0006-291x(89)91507-6

PubMed ID: 2679557

Title: Cloning and comparative mapping of a human class III (chi) alcohol dehydrogenase cDNA.

PubMed ID: 2679557

DOI: 10.1016/0006-291x(89)91741-5

PubMed ID: 1446828

Title: Cloning and characterization of the ADH5 gene encoding human alcohol dehydrogenase 5, formaldehyde dehydrogenase.

PubMed ID: 1446828

DOI: 10.1016/0378-1119(92)90135-c

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3365377

Title: Class III human liver alcohol dehydrogenase: a novel structural type equidistantly related to the class I and class II enzymes.

PubMed ID: 3365377

DOI: 10.1021/bi00404a009

PubMed ID: 8494891

Title: Role of arginine 115 in fatty acid activation and formaldehyde dehydrogenase activity of human class III alcohol dehydrogenase.

PubMed ID: 8494891

DOI: 10.1021/bi00070a024

PubMed ID: 8460164

Title: Mutation of Arg-115 of human class III alcohol dehydrogenase: a binding site required for formaldehyde dehydrogenase activity and fatty acid activation.

PubMed ID: 8460164

DOI: 10.1073/pnas.90.6.2491

PubMed ID: 16081420

Title: Omega-oxidation of 20-hydroxyeicosatetraenoic acid (20-HETE) in cerebral microvascular smooth muscle and endothelium by alcohol dehydrogenase 4.

PubMed ID: 16081420

DOI: 10.1074/jbc.m504055200

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 9018047

Title: Structure of human chi chi alcohol dehydrogenase: a glutathione-dependent formaldehyde dehydrogenase.

PubMed ID: 9018047

DOI: 10.1006/jmbi.1996.0731

PubMed ID: 33355142

Title: Digenic mutations in ALDH2 and ADH5 impair formaldehyde clearance and cause a multisystem disorder, AMeD syndrome.

PubMed ID: 33355142

DOI: 10.1126/sciadv.abd7197

Sequence Information:

  • Length: 374
  • Mass: 39724
  • Checksum: F4F823B4A609C952
  • Sequence:
    • MANEVIKCKA AVAWEAGKPL SIEEIEVAPP KAHEVRIKII ATAVCHTDAY TLSGADPEGC 
FPVILGHEGA GIVESVGEGV TKLKAGDTVI PLYIPQCGEC KFCLNPKTNL CQKIRVTQGK 
GLMPDGTSRF TCKGKTILHY MGTSTFSEYT VVADISVAKI DPLAPLDKVC LLGCGISTGY 
GAAVNTAKLE PGSVCAVFGL GGVGLAVIMG CKVAGASRII GVDINKDKFA RAKEFGATEC 
INPQDFSKPI QEVLIEMTDG GVDYSFECIG NVKVMRAALE ACHKGWGVSV VVGVAASGEE 
IATRPFQLVT GRTWKGTAFG GWKSVESVPK LVSEYMSKKI KVDEFVTHNL SFDEINKAFE 
LMHSGKSIRT VVKI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.