ADH5 | ENSG00000197894 | NCBI 128

Details for: ADH5

Gene ID: 128

Symbol: ADH5

Ensembl ID: ENSG00000197894

Description: alcohol dehydrogenase 5 (class III), chi polypeptide

Associated with

Biological oxidations
(R-HSA-211859)
Metabolism
(R-HSA-1430728)
Phase i - functionalization of compounds
(R-HSA-211945)
Alcohol dehydrogenase activity, zinc-dependent
(GO:0004024)
Cytosol
(GO:0005829)
Electron transfer activity
(GO:0009055)
Electron transport chain
(GO:0022900)
Ethanol oxidation
(GO:0006069)
Extracellular exosome
(GO:0070062)
Fatty acid binding
(GO:0005504)
Fatty acid omega-oxidation
(GO:0010430)
Formaldehyde catabolic process
(GO:0046294)
Formaldehyde dehydrogenase activity
(GO:0018467)
Identical protein binding
(GO:0042802)
Mitochondrion
(GO:0005739)
Positive regulation of blood pressure
(GO:0045777)
Respiratory system process
(GO:0003016)
Response to lipopolysaccharide
(GO:0032496)
Response to nitrosative stress
(GO:0051409)
Response to redox state
(GO:0051775)
Retinoid metabolic process
(GO:0001523)
S-(hydroxymethyl)glutathione dehydrogenase activity
(GO:0051903)
S-(hydroxymethyl)glutathione dehydrogenase nad activity
(GO:0106322)
S-(hydroxymethyl)glutathione dehydrogenase nadp activity
(GO:0106321)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

Alcohol dehydrogenase 5

Genular Protein ID: 2945466517

Symbol: ADHX_HUMAN

Name: Alcohol dehydrogenase 5

UniProtKB Accession Codes:

P11766 Q6FHR2

Database IDs:

Citations:

PubMed ID: 2818582

Title: cDNA sequence of human class III alcohol dehydrogenase.

PubMed ID: 2818582

DOI: 10.1016/0006-291x(89)91507-6

PubMed ID: 2679557

Title: Cloning and comparative mapping of a human class III (chi) alcohol dehydrogenase cDNA.

PubMed ID: 2679557

DOI: 10.1016/0006-291x(89)91741-5

PubMed ID: 1446828

Title: Cloning and characterization of the ADH5 gene encoding human alcohol dehydrogenase 5, formaldehyde dehydrogenase.

PubMed ID: 1446828

DOI: 10.1016/0378-1119(92)90135-c

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3365377

Title: Class III human liver alcohol dehydrogenase: a novel structural type equidistantly related to the class I and class II enzymes.

PubMed ID: 3365377

DOI: 10.1021/bi00404a009

PubMed ID: 8494891

Title: Role of arginine 115 in fatty acid activation and formaldehyde dehydrogenase activity of human class III alcohol dehydrogenase.

PubMed ID: 8494891

DOI: 10.1021/bi00070a024

PubMed ID: 8460164

Title: Mutation of Arg-115 of human class III alcohol dehydrogenase: a binding site required for formaldehyde dehydrogenase activity and fatty acid activation.

PubMed ID: 8460164

DOI: 10.1073/pnas.90.6.2491

PubMed ID: 16081420

Title: Omega-oxidation of 20-hydroxyeicosatetraenoic acid (20-HETE) in cerebral microvascular smooth muscle and endothelium by alcohol dehydrogenase 4.

PubMed ID: 16081420

DOI: 10.1074/jbc.m504055200

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 9018047

Title: Structure of human chi chi alcohol dehydrogenase: a glutathione-dependent formaldehyde dehydrogenase.

PubMed ID: 9018047

DOI: 10.1006/jmbi.1996.0731

PubMed ID: 33355142

Title: Digenic mutations in ALDH2 and ADH5 impair formaldehyde clearance and cause a multisystem disorder, AMeD syndrome.

PubMed ID: 33355142

DOI: 10.1126/sciadv.abd7197

Sequence Information:

Length: 374
Mass: 39724
Checksum: F4F823B4A609C952
Sequence:

MANEVIKCKA AVAWEAGKPL SIEEIEVAPP KAHEVRIKII ATAVCHTDAY TLSGADPEGC 
FPVILGHEGA GIVESVGEGV TKLKAGDTVI PLYIPQCGEC KFCLNPKTNL CQKIRVTQGK 
GLMPDGTSRF TCKGKTILHY MGTSTFSEYT VVADISVAKI DPLAPLDKVC LLGCGISTGY 
GAAVNTAKLE PGSVCAVFGL GGVGLAVIMG CKVAGASRII GVDINKDKFA RAKEFGATEC 
INPQDFSKPI QEVLIEMTDG GVDYSFECIG NVKVMRAALE ACHKGWGVSV VVGVAASGEE 
IATRPFQLVT GRTWKGTAFG GWKSVESVPK LVSEYMSKKI KVDEFVTHNL SFDEINKAFE 
LMHSGKSIRT VVKI

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: ADH5

Associated with

Other Information

cDNA sequence of human class III alcohol dehydrogenase. PubMed ID: 2818582

Cloning and comparative mapping of a human class III (chi) alcohol dehydrogenase cDNA. PubMed ID: 2679557

Cloning and characterization of the ADH5 gene encoding human alcohol dehydrogenase 5, formaldehyde dehydrogenase. PubMed ID: 1446828

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Class III human liver alcohol dehydrogenase: a novel structural type equidistantly related to the class I and class II enzymes. PubMed ID: 3365377

Role of arginine 115 in fatty acid activation and formaldehyde dehydrogenase activity of human class III alcohol dehydrogenase. PubMed ID: 8494891

Mutation of Arg-115 of human class III alcohol dehydrogenase: a binding site required for formaldehyde dehydrogenase activity and fatty acid activation. PubMed ID: 8460164

Omega-oxidation of 20-hydroxyeicosatetraenoic acid (20-HETE) in cerebral microvascular smooth muscle and endothelium by alcohol dehydrogenase 4. PubMed ID: 16081420

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Initial characterization of the human central proteome. PubMed ID: 21269460

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Structure of human chi chi alcohol dehydrogenase: a glutathione-dependent formaldehyde dehydrogenase. PubMed ID: 9018047

Digenic mutations in ALDH2 and ADH5 impair formaldehyde clearance and cause a multisystem disorder, AMeD syndrome. PubMed ID: 33355142