Genular: Defining Cellular Identity and Function

Details for: Cnr1

Gene ID: 12801

Symbol: Cnr1

Ensembl ID: ENSMUSG00000044288

Description: cannabinoid receptor 1

Associated with

Class a/1 (rhodopsin-like receptors)
(R-MMU-373076)
G alpha (i) signalling events
(R-MMU-418594)
Gpcr downstream signalling
(R-MMU-388396)
Gpcr ligand binding
(R-MMU-500792)
Signaling by gpcr
(R-MMU-372790)
Actin cytoskeleton
(GO:0015629)
Adenylate cyclase-activating g protein-coupled receptor signaling pathway
(GO:0007189)
Adenylate cyclase-modulating g protein-coupled receptor signaling pathway
(GO:0007188)
Axon
(GO:0030424)
Axonal fasciculation
(GO:0007413)
Cannabinoid receptor activity
(GO:0004949)
Cannabinoid signaling pathway
(GO:0038171)
Cell projection
(GO:0042995)
Cytoplasm
(GO:0005737)
Gaba-ergic synapse
(GO:0098982)
Glucose homeostasis
(GO:0042593)
Glutamatergic synapse
(GO:0098978)
G protein-coupled receptor activity
(GO:0004930)
G protein-coupled receptor signaling pathway
(GO:0007186)
Growth cone
(GO:0030426)
Identical protein binding
(GO:0042802)
Learning or memory
(GO:0007611)
Membrane
(GO:0016020)
Membrane raft
(GO:0045121)
Memory
(GO:0007613)
Mitochondrial outer membrane
(GO:0005741)
Mitochondrion
(GO:0005739)
Negative regulation of action potential
(GO:0045759)
Negative regulation of blood pressure
(GO:0045776)
Negative regulation of dopamine secretion
(GO:0033602)
Negative regulation of fatty acid beta-oxidation
(GO:0031999)
Negative regulation of mast cell activation
(GO:0033004)
Negative regulation of monoatomic ion transport
(GO:0043271)
Negative regulation of serotonin secretion
(GO:0014063)
Plasma membrane
(GO:0005886)
Positive regulation of acute inflammatory response to antigenic stimulus
(GO:0002866)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of blood pressure
(GO:0045777)
Positive regulation of fever generation
(GO:0031622)
Positive regulation of neuron projection development
(GO:0010976)
Presynaptic membrane
(GO:0042734)
Regulation of feeding behavior
(GO:0060259)
Regulation of insulin secretion
(GO:0050796)
Regulation of lipid metabolic process
(GO:0019216)
Regulation of metabolic process
(GO:0019222)
Regulation of penile erection
(GO:0060405)
Regulation of presynaptic cytosolic calcium ion concentration
(GO:0099509)
Regulation of synaptic transmission, gabaergic
(GO:0032228)
Regulation of synaptic transmission, glutamatergic
(GO:0051966)
Response to cocaine
(GO:0042220)
Response to ethanol
(GO:0045471)
Response to lipopolysaccharide
(GO:0032496)
Response to nicotine
(GO:0035094)
Retrograde trans-synaptic signaling by endocannabinoid
(GO:0098921)
Signal transduction
(GO:0007165)
Synapse
(GO:0045202)
Trans-synaptic signaling by endocannabinoid, modulating synaptic transmission
(GO:0099553)

Other Information

Proteins

Cannabinoid receptor 1

Genular Protein ID: 1285342016

Symbol: CNR1_MOUSE

Name: Cannabinoid receptor 1

UniProtKB Accession Codes:

P47746 Q5SF33

Database IDs:

Citations:

PubMed ID: 8777318

Title: Cloning and sequencing of a cDNA encoding the mouse brain-type cannabinoid receptor protein.

PubMed ID: 8777318

DOI: 10.3109/10425179509020870

PubMed ID: 8832654

Title: Determination of the cannabinoid receptors in mouse x rat hybridoma NG108-15 cells and rat GH4C1 cells.

PubMed ID: 8832654

DOI: 10.1016/0304-3940(96)12792-0

PubMed ID: 9888857

Title: Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice.

PubMed ID: 9888857

DOI: 10.1126/science.283.5400.401

PubMed ID: 15606779

Title: Structure, expression and regulation of the cannabinoid receptor gene (CB1) in Huntington's disease transgenic mice.

PubMed ID: 15606779

DOI: 10.1111/j.1432-1033.2004.04460.x

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10891614

Title: Cannabinoid receptor messenger RNA levels decrease in a subset of neurons of the lateral striatum, cortex and hippocampus of transgenic Huntington's disease mice.

PubMed ID: 10891614

DOI: 10.1016/s0306-4522(00)00157-3

PubMed ID: 15864349

Title: Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity.

PubMed ID: 15864349

DOI: 10.1172/jci23057

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 22841573

Title: Peripheral cannabinoid-1 receptor inverse agonism reduces obesity by reversing leptin resistance.

PubMed ID: 22841573

DOI: 10.1016/j.cmet.2012.07.002

PubMed ID: 21987372

Title: Antagonism of peripheral hepatic cannabinoid receptor-1 improves liver lipid metabolism in mice: evidence from cultured explants.

PubMed ID: 21987372

DOI: 10.1002/hep.24733

PubMed ID: 22388959

Title: Mitochondrial CB(1) receptors regulate neuronal energy metabolism.

PubMed ID: 22388959

DOI: 10.1038/nn.3053

PubMed ID: 23955712

Title: Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes.

PubMed ID: 23955712

DOI: 10.1038/nm.3265

PubMed ID: 25869131

Title: Negative regulation of leptin-induced reactive oxygen species (ROS) formation by cannabinoid CB1 receptor activation in hypothalamic neurons.

PubMed ID: 25869131

DOI: 10.1074/jbc.m115.646885

PubMed ID: 25707796

Title: Hypothalamic POMC neurons promote cannabinoid-induced feeding.

PubMed ID: 25707796

DOI: 10.1038/nature14260

PubMed ID: 26671069

Title: Pharmacological blockade of cannabinoid CB1 receptors in diet-induced obesity regulates mitochondrial dihydrolipoamide dehydrogenase in muscle.

PubMed ID: 26671069

DOI: 10.1371/journal.pone.0145244

PubMed ID: 27826249

Title: Cannabinoid CB1 receptors are localized in striated muscle mitochondria and regulate mitochondrial respiration.

PubMed ID: 27826249

DOI: 10.3389/fphys.2016.00476

PubMed ID: 27828947

Title: A cannabinoid link between mitochondria and memory.

PubMed ID: 27828947

DOI: 10.1038/nature20127

Sequence Information:

Length: 473
Mass: 52831
Checksum: E504168191CB6429
Sequence:

MKSILDGLAD TTFRTITTDL LYVGSNDIQY EDIKGDMASK LGYFPQKFPL TSFRGSPFQE 
KMTAGDNSPL VPAGDTTNIT EFYNKSLSSF KENEDNIQCG ENFMDMECFM ILNPSQQLAI 
AVLSLTLGTF TVLENLLVLC VILHSRSLRC RPSYHFIGSL AVADLLGSVI FVYSFVDFHV 
FHRKDSPNVF LFKLGGVTAS FTASVGSLFL TAIDRYISIH RPLAYKRIVT RPKAVVAFCL 
MWTIAIVIAV LPLLGWNCKK LQSVCSDIFP LIDETYLMFW IGVTSVLLLF IVYAYMYILW 
KAHSHAVRMI QRGTQKSIII HTSEDGKVQV TRPDQARMDI RLAKTLVLIL VVLIICWGPL 
LAIMVYDVFG KMNKLIKTVF AFCSMLCLLN STVNPIIYAL RSKDLRHAFR SMFPSCEGTA 
QPLDNSMGDS DCLHKHANNT ASMHRAAESC IKSTVKIAKV TMSVSTDTSA EAL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Cnr1

Associated with

Other Information

Cloning and sequencing of a cDNA encoding the mouse brain-type cannabinoid receptor protein. PubMed ID: 8777318

Determination of the cannabinoid receptors in mouse x rat hybridoma NG108-15 cells and rat GH4C1 cells. PubMed ID: 8832654

Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice. PubMed ID: 9888857

Structure, expression and regulation of the cannabinoid receptor gene (CB1) in Huntington's disease transgenic mice. PubMed ID: 15606779

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Cannabinoid receptor messenger RNA levels decrease in a subset of neurons of the lateral striatum, cortex and hippocampus of transgenic Huntington's disease mice. PubMed ID: 10891614

Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity. PubMed ID: 15864349

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Peripheral cannabinoid-1 receptor inverse agonism reduces obesity by reversing leptin resistance. PubMed ID: 22841573

Antagonism of peripheral hepatic cannabinoid receptor-1 improves liver lipid metabolism in mice: evidence from cultured explants. PubMed ID: 21987372

Mitochondrial CB(1) receptors regulate neuronal energy metabolism. PubMed ID: 22388959

Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes. PubMed ID: 23955712

Negative regulation of leptin-induced reactive oxygen species (ROS) formation by cannabinoid CB1 receptor activation in hypothalamic neurons. PubMed ID: 25869131

Hypothalamic POMC neurons promote cannabinoid-induced feeding. PubMed ID: 25707796

Pharmacological blockade of cannabinoid CB1 receptors in diet-induced obesity regulates mitochondrial dihydrolipoamide dehydrogenase in muscle. PubMed ID: 26671069

Cannabinoid CB1 receptors are localized in striated muscle mitochondria and regulate mitochondrial respiration. PubMed ID: 27826249

A cannabinoid link between mitochondria and memory. PubMed ID: 27828947