Genular: Defining Cellular Identity and Function

Details for: Cnr2

Gene ID: 12802

Symbol: Cnr2

Ensembl ID: ENSMUSG00000062585

Description: cannabinoid receptor 2

Associated with

Class a/1 (rhodopsin-like receptors)
(R-MMU-373076)
G alpha (i) signalling events
(R-MMU-418594)
Gpcr downstream signalling
(R-MMU-388396)
Gpcr ligand binding
(R-MMU-500792)
Signaling by gpcr
(R-MMU-372790)
Adenylate cyclase-activating g protein-coupled receptor signaling pathway
(GO:0007189)
Cannabinoid receptor activity
(GO:0004949)
Cell projection
(GO:0042995)
Cytoplasm
(GO:0005737)
Dendrite
(GO:0030425)
Endoplasmic reticulum
(GO:0005783)
Extrinsic component of cytoplasmic side of plasma membrane
(GO:0031234)
G protein-coupled receptor activity
(GO:0004930)
G protein-coupled receptor signaling pathway
(GO:0007186)
Inflammatory response
(GO:0006954)
Leukocyte chemotaxis
(GO:0030595)
Membrane
(GO:0016020)
Negative regulation of action potential
(GO:0045759)
Negative regulation of mast cell activation
(GO:0033004)
Negative regulation of synaptic transmission, gabaergic
(GO:0032229)
Neuronal cell body
(GO:0043025)
Plasma membrane
(GO:0005886)
Regulation of metabolic process
(GO:0019222)
Response to lipopolysaccharide
(GO:0032496)
Signal transduction
(GO:0007165)

Other Information

Proteins

Cannabinoid receptor 2

Genular Protein ID: 2328229770

Symbol: CNR2_MOUSE

Name: Cannabinoid receptor 2

UniProtKB Accession Codes:

P47936 Q544H5

Database IDs:

Citations:

PubMed ID: 8679694

Title: Molecular cloning, expression and function of the murine CB2 peripheral cannabinoid receptor.

PubMed ID: 8679694

DOI: 10.1016/0167-4781(96)00047-4

PubMed ID: 9261404

Title: The genes encoding the peripheral cannabinoid receptor and alpha-L-fucosidase are located near a newly identified common virus integration site, Evi11.

PubMed ID: 9261404

DOI: 10.1128/jvi.71.9.6796-6804.1997

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10822068

Title: Immunomodulation by cannabinoids is absent in mice deficient for the cannabinoid CB(2) receptor.

PubMed ID: 10822068

DOI: 10.1016/s0014-2999(00)00211-9

PubMed ID: 11929767

Title: Hematopoietic cells expressing the peripheral cannabinoid receptor migrate in response to the endocannabinoid 2-arachidonoylglycerol.

PubMed ID: 11929767

DOI: 10.1182/blood.v99.8.2786

PubMed ID: 12511587

Title: Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors.

PubMed ID: 12511587

DOI: 10.1172/jci16116

PubMed ID: 16924491

Title: Formation of B and T cell subsets require the cannabinoid receptor CB2.

PubMed ID: 16924491

DOI: 10.1007/s00251-006-0138-x

PubMed ID: 16563625

Title: CB2 cannabinoid receptor mediation of antinociception.

PubMed ID: 16563625

DOI: 10.1016/j.pain.2005.12.018

PubMed ID: 16407142

Title: Peripheral cannabinoid receptor, CB2, regulates bone mass.

PubMed ID: 16407142

DOI: 10.1073/pnas.0504187103

PubMed ID: 17401376

Title: Direct suppression of CNS autoimmune inflammation via the cannabinoid receptor CB1 on neurons and CB2 on autoreactive T cells.

PubMed ID: 17401376

DOI: 10.1038/nm1561

PubMed ID: 18286196

Title: Brain neuronal CB2 cannabinoid receptors in drug abuse and depression: from mice to human subjects.

PubMed ID: 18286196

DOI: 10.1371/journal.pone.0001640

PubMed ID: 19144319

Title: The phagosomal proteome in interferon-gamma-activated macrophages.

PubMed ID: 19144319

DOI: 10.1016/j.immuni.2008.11.006

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 347
Mass: 38213
Checksum: 10747611D41FF442
Sequence:

MEGCRETEVT NGSNGGLEFN PMKEYMILSS GQQIAVAVLC TLMGLLSALE NMAVLYIILS 
SRRLRRKPSY LFISSLAGAD FLASVIFACN FVIFHVFHGV DSNAIFLLKI GSVTMTFTAS 
VGSLLLTAVD RYLCLCYPPT YKALVTRGRA LVALCVMWVL SALISYLPLM GWTCCPSPCS 
ELFPLIPNDY LLGWLLFIAI LFSGIIYTYG YVLWKAHRHV ATLAEHQDRQ VPGIARMRLD 
VRLAKTLGLV LAVLLICWFP ALALMGHSLV TTLSDQVKEA FAFCSMLCLV NSMVNPIIYA 
LRSGEIRSAA QHCLIGWKKY LQGLGPEGKE EGPRSSVTET EADVKTT

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Cnr2

Associated with

Other Information

Molecular cloning, expression and function of the murine CB2 peripheral cannabinoid receptor. PubMed ID: 8679694

The genes encoding the peripheral cannabinoid receptor and alpha-L-fucosidase are located near a newly identified common virus integration site, Evi11. PubMed ID: 9261404

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Immunomodulation by cannabinoids is absent in mice deficient for the cannabinoid CB(2) receptor. PubMed ID: 10822068

Hematopoietic cells expressing the peripheral cannabinoid receptor migrate in response to the endocannabinoid 2-arachidonoylglycerol. PubMed ID: 11929767

Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors. PubMed ID: 12511587

Formation of B and T cell subsets require the cannabinoid receptor CB2. PubMed ID: 16924491

CB2 cannabinoid receptor mediation of antinociception. PubMed ID: 16563625

Peripheral cannabinoid receptor, CB2, regulates bone mass. PubMed ID: 16407142

Direct suppression of CNS autoimmune inflammation via the cannabinoid receptor CB1 on neurons and CB2 on autoreactive T cells. PubMed ID: 17401376

Brain neuronal CB2 cannabinoid receptors in drug abuse and depression: from mice to human subjects. PubMed ID: 18286196

The phagosomal proteome in interferon-gamma-activated macrophages. PubMed ID: 19144319

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079