Genular: Defining Cellular Identity and Function

Details for: Col4a2

Gene ID: 12827

Symbol: Col4a2

Ensembl ID: ENSMUSG00000031503

Description: collagen, type IV, alpha 2

Associated with

Assembly of collagen fibrils and other multimeric structures
(R-MMU-2022090)
Axon guidance
(R-MMU-422475)
Collagen biosynthesis and modifying enzymes
(R-MMU-1650814)
Collagen chain trimerization
(R-MMU-8948216)
Collagen degradation
(R-MMU-1442490)
Collagen formation
(R-MMU-1474290)
Crosslinking of collagen fibrils
(R-MMU-2243919)
Degradation of the extracellular matrix
(R-MMU-1474228)
Developmental biology
(R-MMU-1266738)
Integrin cell surface interactions
(R-MMU-216083)
Laminin interactions
(R-MMU-3000157)
Ncam1 interactions
(R-MMU-419037)
Ncam signaling for neurite out-growth
(R-MMU-375165)
Nervous system development
(R-MMU-9675108)
Non-integrin membrane-ecm interactions
(R-MMU-3000171)
Signaling by pdgf
(R-MMU-186797)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signal transduction
(R-MMU-162582)
Angiogenesis
(GO:0001525)
Basement membrane
(GO:0005604)
Cellular response to transforming growth factor beta stimulus
(GO:0071560)
Collagen-activated tyrosine kinase receptor signaling pathway
(GO:0038063)
Collagen-containing extracellular matrix
(GO:0062023)
Collagen trimer
(GO:0005581)
Collagen type iv trimer
(GO:0005587)
Dna-templated transcription
(GO:0006351)
Extracellular matrix organization
(GO:0030198)
Extracellular matrix structural constituent
(GO:0005201)
Extracellular matrix structural constituent conferring tensile strength
(GO:0030020)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Molecular adaptor activity
(GO:0060090)
Negative regulation of angiogenesis
(GO:0016525)

Other Information

Proteins

Canstatin

Genular Protein ID: 2123205416

Symbol: CO4A2_MOUSE

Name: Canstatin

UniProtKB Accession Codes:

P08122 Q3B7C2 Q3TPV9 Q61375 Q66JS5 Q6RCT6 Q6RCT7 Q6U9X1 Q8BPI9 Q8BPK3 Q91VI3

Database IDs:

Citations:

PubMed ID: 2703491

Title: The complete primary structure of mouse alpha 2(IV) collagen. Alignment with mouse alpha 1(IV) collagen.

PubMed ID: 2703491

DOI: 10.1016/s0021-9258(18)83350-6

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3200851

Title: Alpha 1(IV) and alpha 2(IV) collagen genes are regulated by a bidirectional promoter and a shared enhancer.

PubMed ID: 3200851

DOI: 10.1073/pnas.85.24.9679

PubMed ID: 3198626

Title: Head-to-head arrangement of murine type IV collagen genes.

PubMed ID: 3198626

DOI: 10.1016/s0021-9258(19)77629-7

PubMed ID: 3839908

Title: Characterization of 64-, 123- and 182-base-pair exons in the mouse alpha 2(IV) collagen gene.

PubMed ID: 3839908

DOI: 10.1038/317177a0

PubMed ID: 3011432

Title: Structure of mouse type IV collagen. Amino-acid sequence of the C-terminal 511-residue-long triple-helical segment of the alpha 2(IV) chain and its comparison with the alpha 1(IV) chain.

PubMed ID: 3011432

DOI: 10.1111/j.1432-1033.1986.tb09636.x

PubMed ID: 3758345

Title: Proposed alignment of helical interruptions in the two subunits of the basement membrane (type IV) collagen.

PubMed ID: 3758345

DOI: 10.1016/0014-5793(86)81334-5

PubMed ID: 3780963

Title: cDNA and protein sequence of the NC1 domain of the alpha 2-chain of collagen IV and its comparison with alpha 1(IV).

PubMed ID: 3780963

DOI: 10.1016/0014-5793(86)81018-3

PubMed ID: 3597383

Title: Extensive homology between the carboxyl-terminal peptides of mouse alpha 1(IV) and alpha 2(IV) collagen.

PubMed ID: 3597383

DOI: 10.1016/s0021-9258(18)47441-8

PubMed ID: 15592653

Title: Recombinant mouse canstatin inhibits chicken embryo chorioallantoic membrane angiogenesis and endothelial cell proliferation.

PubMed ID: 15592653

DOI: 10.1093/abbs/36.12.845

PubMed ID: 17324935

Title: A comparative analysis of the fibulin protein family. Biochemical characterization, binding interactions, and tissue localization.

PubMed ID: 17324935

DOI: 10.1074/jbc.m611029200

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 32571911

Title: Peroxidasin-mediated bromine enrichment of basement membranes.

PubMed ID: 32571911

DOI: 10.1073/pnas.2007749117

Sequence Information:

Length: 1707
Mass: 167325
Checksum: 67CB3E3CB2A5B1F6
Sequence:

MDRVRFKASG PPLRGWLLLA TVTVGLLAQS VLGGVKKLDV PCGGRDCSGG CQCYPEKGAR 
GQPGAVGPQG YNGPPGLQGF PGLQGRKGDK GERGVPGPTG PKGDVGARGV SGFPGADGIP 
GHPGQGGPRG RPGYDGCNGT RGDAGPQGPS GSGGFPGLPG PQGPKGQKGE PYALSKEDRD 
KYRGEPGEPG LVGYQGPPGR PGPIGQMGPM GAPGRPGPPG PPGPKGQPGN RGLGFYGQKG 
EKGDIGQPGP NGIPSDITLV GPTTSTIHPD LYKGEKGDEG EQGIPGVISK GEEGIMGFPG 
IRGFPGLDGE KGVVGQKGSR GLDGFQGPSG PRGPKGERGE QGPPGPSVYS PHPSLAKGAR 
GDPGFQGAHG EPGSRGEPGE PGTAGPPGPS VGDEDSMRGL PGEMGPKGFS GEPGSPARYL 
GPPGADGRPG PQGVPGPAGP PGPDGFLFGL KGSEGRVGYP GPSGFPGTRG QKGWKGEAGD 
CQCGQVIGGL PGLPGPKGFP GVNGELGKKG DQGDPGLHGI PGFPGFKGAP GVAGAPGPKG 
IKGDSRTITT KGERGQPGIP GVHGMKGDDG VPGRDGLDGF PGLPGPPGDG IKGPPGDAGL 
PGVPGTKGFP GDIGPPGQGL PGPKGERGFP GDAGLPGPPG FPGPPGPPGT PGQRDCDTGV 
KRPIGGGQQV VVQPGCIEGP TGSPGQPGPP GPTGAKGVRG MPGFPGASGE QGLKGFPGDP 
GREGFPGPPG FMGPRGSKGT TGLPGPDGPP GPIGLPGPAG PPGDRGIPGE VLGAQPGTRG 
DAGLPGQPGL KGLPGETGAP GFRGSQGMPG MPGLKGQPGF PGPSGQPGQS GPPGQHGFPG 
TPGREGPLGQ PGSPGLGGLP GDRGEPGDPG VPGPVGMKGL SGDRGDAGMS GERGHPGSPG 
FKGMAGMPGI PGQKGDRGSP GMDGFQGMLG LKGRQGFPGT KGEAGFFGVP GLKGLPGEPG 
VKGNRGDRGP PGPPPLILPG MKDIKGEKGD EGPMGLKGYL GLKGIQGMPG VPGVSGFPGL 
PGRPGFIKGV KGDIGVPGTP GLPGFPGVSG PPGITGFPGF TGSRGEKGTP GVAGVFGETG 
PTGDFGDIGD TVDLPGSPGL KGERGITGIP GLKGFFGEKG AAGDIGFPGI TGMAGAQGSP 
GLKGQTGFPG LTGLQGPQGE PGRIGIPGDK GDFGWPGVPG LPGFPGIRGI SGLHGLPGTK 
GFPGSPGVDA HGDPGFPGPT GDRGDRGEAN TLPGPVGVPG QKGERGTPGE RGPAGSPGLQ 
GFPGISPPSN ISGSPGDVGA PGIFGLQGYQ GPPGPPGPNA LPGIKGDEGS SGAAGFPGQK 
GWVGDPGPQG QPGVLGLPGE KGPKGEQGFM GNTGPSGAVG DRGPKGPKGD QGFPGAPGSM 
GSPGIPGIPQ KIAVQPGTLG PQGRRGLPGA LGEIGPQGPP GDPGFRGAPG KAGPQGRGGV 
SAVPGFRGDQ GPMGHQGPVG QEGEPGRPGS PGLPGMPGRS VSIGYLLVKH SQTDQEPMCP 
VGMNKLWSGY SLLYFEGQEK AHNQDLGLAG SCLARFSTMP FLYCNPGDVC YYASRNDKSY 
WLSTTAPLPM MPVAEEEIKP YISRCSVCEA PAVAIAVHSQ DTSIPHCPAG WRSLWIGYSF 
LMHTAAGDEG GGQSLVSPGS CLEDFRATPF IECNGGRGTC HYFANKYSFW LTTIPEQNFQ 
STPSADTLKA GLIRTHISRC QVCMKNL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Col4a2

Associated with

Other Information

The complete primary structure of mouse alpha 2(IV) collagen. Alignment with mouse alpha 1(IV) collagen. PubMed ID: 2703491

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Alpha 1(IV) and alpha 2(IV) collagen genes are regulated by a bidirectional promoter and a shared enhancer. PubMed ID: 3200851

Head-to-head arrangement of murine type IV collagen genes. PubMed ID: 3198626

Characterization of 64-, 123- and 182-base-pair exons in the mouse alpha 2(IV) collagen gene. PubMed ID: 3839908

Structure of mouse type IV collagen. Amino-acid sequence of the C-terminal 511-residue-long triple-helical segment of the alpha 2(IV) chain and its comparison with the alpha 1(IV) chain. PubMed ID: 3011432

Proposed alignment of helical interruptions in the two subunits of the basement membrane (type IV) collagen. PubMed ID: 3758345

cDNA and protein sequence of the NC1 domain of the alpha 2-chain of collagen IV and its comparison with alpha 1(IV). PubMed ID: 3780963

Extensive homology between the carboxyl-terminal peptides of mouse alpha 1(IV) and alpha 2(IV) collagen. PubMed ID: 3597383

Recombinant mouse canstatin inhibits chicken embryo chorioallantoic membrane angiogenesis and endothelial cell proliferation. PubMed ID: 15592653

A comparative analysis of the fibulin protein family. Biochemical characterization, binding interactions, and tissue localization. PubMed ID: 17324935

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Peroxidasin-mediated bromine enrichment of basement membranes. PubMed ID: 32571911