Details for: COL4A2
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 138.2376
Cell Significance Index: -56.1600 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 131.7031
Cell Significance Index: -62.1800 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 59.0107
Cell Significance Index: -56.3400 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 24.2155
Cell Significance Index: -64.8700 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 20.3602
Cell Significance Index: -44.5600 - Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 16.2940
Cell Significance Index: 110.4000 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 9.8283
Cell Significance Index: 511.9400 - Cell Name: adipocyte of breast (CL0002617)
Fold Change: 6.9968
Cell Significance Index: 88.1100 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 5.1080
Cell Significance Index: 136.3900 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 4.8378
Cell Significance Index: 69.5800 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 4.7442
Cell Significance Index: 266.2200 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 3.6632
Cell Significance Index: 91.5700 - Cell Name: preadipocyte (CL0002334)
Fold Change: 3.4708
Cell Significance Index: 67.7400 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 3.2830
Cell Significance Index: 94.1100 - Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 3.2285
Cell Significance Index: 20.0600 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 2.9666
Cell Significance Index: 227.6600 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 2.8210
Cell Significance Index: 61.7700 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 2.7712
Cell Significance Index: 74.2600 - Cell Name: perivascular cell (CL4033054)
Fold Change: 2.5600
Cell Significance Index: 11.8200 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 2.4628
Cell Significance Index: 14.8800 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 2.2176
Cell Significance Index: 31.8500 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: 2.1143
Cell Significance Index: 31.2200 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 2.0809
Cell Significance Index: 26.6500 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.8465
Cell Significance Index: 253.5700 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 1.6430
Cell Significance Index: 34.3900 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 1.6267
Cell Significance Index: 18.4800 - Cell Name: subcutaneous adipocyte (CL0002521)
Fold Change: 1.4541
Cell Significance Index: 6.3300 - Cell Name: granulosa cell (CL0000501)
Fold Change: 1.4516
Cell Significance Index: 38.1700 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 1.2957
Cell Significance Index: 2389.5700 - Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 1.1592
Cell Significance Index: 6.1000 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 1.0305
Cell Significance Index: 467.7300 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 1.0025
Cell Significance Index: 1543.3400 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.9541
Cell Significance Index: 521.0300 - Cell Name: embryonic fibroblast (CL2000042)
Fold Change: 0.8027
Cell Significance Index: 3.8400 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.7851
Cell Significance Index: 149.4100 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.7221
Cell Significance Index: 981.8900 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.5164
Cell Significance Index: 103.6000 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.4180
Cell Significance Index: 787.1300 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.3970
Cell Significance Index: 252.1300 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.3614
Cell Significance Index: 129.6300 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.3519
Cell Significance Index: 317.7000 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: 0.3318
Cell Significance Index: 37.8800 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.2645
Cell Significance Index: 182.9600 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 0.2288
Cell Significance Index: 23.8200 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 0.1555
Cell Significance Index: 4.5800 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.1425
Cell Significance Index: 9.5800 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.1206
Cell Significance Index: 19.6200 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.1052
Cell Significance Index: 1.7600 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 0.0743
Cell Significance Index: 2.1200 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0479
Cell Significance Index: 21.1900 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.0091
Cell Significance Index: 0.9000 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: -0.0170
Cell Significance Index: -1.8500 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.0295
Cell Significance Index: -3.7800 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0325
Cell Significance Index: -24.0400 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0457
Cell Significance Index: -33.5300 - Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0579
Cell Significance Index: -11.5000 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0601
Cell Significance Index: -37.5200 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0802
Cell Significance Index: -60.7400 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0816
Cell Significance Index: -46.0200 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0874
Cell Significance Index: -3.0700 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.1127
Cell Significance Index: -6.9300 - Cell Name: kidney cell (CL1000497)
Fold Change: -0.1440
Cell Significance Index: -1.1500 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1529
Cell Significance Index: -22.2300 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1862
Cell Significance Index: -53.5800 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.1885
Cell Significance Index: -32.1800 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.2064
Cell Significance Index: -37.2100 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.2147
Cell Significance Index: -45.2300 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.2804
Cell Significance Index: -6.0700 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.2836
Cell Significance Index: -19.6200 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.3017
Cell Significance Index: -35.1600 - Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -0.3405
Cell Significance Index: -2.8600 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.3580
Cell Significance Index: -41.0200 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.3839
Cell Significance Index: -39.2200 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.3992
Cell Significance Index: -49.0900 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.4182
Cell Significance Index: -54.0300 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.4495
Cell Significance Index: -12.9500 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.4824
Cell Significance Index: -21.8700 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.5315
Cell Significance Index: -37.5900 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.5966
Cell Significance Index: -36.5800 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.6678
Cell Significance Index: -17.1700 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.6821
Cell Significance Index: -32.0600 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.7006
Cell Significance Index: -22.4400 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.7898
Cell Significance Index: -62.5600 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.8171
Cell Significance Index: -41.2900 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.8352
Cell Significance Index: -62.2500 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -0.9447
Cell Significance Index: -10.2700 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -1.0121
Cell Significance Index: -53.1400 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -1.0157
Cell Significance Index: -65.5300 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -1.0267
Cell Significance Index: -64.7100 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -1.0420
Cell Significance Index: -36.2100 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -1.1016
Cell Significance Index: -23.3800 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -1.2253
Cell Significance Index: -63.6500 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -1.2307
Cell Significance Index: -26.5900 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: -1.2378
Cell Significance Index: -19.1500 - Cell Name: mesodermal cell (CL0000222)
Fold Change: -1.2620
Cell Significance Index: -7.9000 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -1.2701
Cell Significance Index: -59.2200 - Cell Name: peg cell (CL4033014)
Fold Change: -1.2942
Cell Significance Index: -29.9000 - Cell Name: lens fiber cell (CL0011004)
Fold Change: -1.3023
Cell Significance Index: -41.1900 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -1.3152
Cell Significance Index: -18.8400 - Cell Name: mural cell (CL0008034)
Fold Change: -1.3628
Cell Significance Index: -16.5900
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3149821679
Symbol: CO4A2_HUMAN
Name: Canstatin
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 3198637
Title: The complete primary structure of the alpha 2 chain of human type IV collagen and comparison with the alpha 1(IV) chain.
PubMed ID: 3198637
PubMed ID: 15057823
Title: The DNA sequence and analysis of human chromosome 13.
PubMed ID: 15057823
DOI: 10.1038/nature02379
PubMed ID: 3345760
Title: Human basement membrane collagen (type IV). The amino acid sequence of the alpha 2(IV) chain and its comparison with the alpha 1(IV) chain reveals deletions in the alpha 1(IV) chain.
PubMed ID: 3345760
PubMed ID: 2846280
Title: The genes for the alpha 1(IV) and alpha 2(IV) chains of human basement membrane collagen type IV are arranged head-to-head and separated by a bidirectional promoter of unique structure.
PubMed ID: 2846280
PubMed ID: 3182844
Title: The structural genes for alpha 1 and alpha 2 chains of human type IV collagen are divergently encoded on opposite DNA strands and have an overlapping promoter region.
PubMed ID: 3182844
PubMed ID: 8317999
Title: Identification of a novel sequence element in the common promoter region of human collagen type IV genes, involved in the regulation of divergent transcription.
PubMed ID: 8317999
DOI: 10.1042/bj2920687
PubMed ID: 3692475
Title: Partial structure of the human alpha 2(IV) collagen chain and chromosomal localization of the gene (COL4A2).
PubMed ID: 3692475
DOI: 10.1007/bf00291418
PubMed ID: 3582677
Title: Nucleotide sequence coding for the human type IV collagen alpha 2 chain cDNA reveals extensive homology with the NC-1 domain of alpha 1 (IV) but not with the collagenous domain or 3'-untranslated region.
PubMed ID: 3582677
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 3025878
Title: Human collagen genes encoding basement membrane alpha 1 (IV) and alpha 2 (IV) chains map to the distal long arm of chromosome 13.
PubMed ID: 3025878
PubMed ID: 2844531
Title: The arrangement of intra- and intermolecular disulfide bonds in the carboxyterminal, non-collagenous aggregation and cross-linking domain of basement-membrane type IV collagen.
PubMed ID: 2844531
PubMed ID: 2439508
Title: Duplication of type IV collagen COOH-terminal repeats and species-specific expression of alpha 1(IV) and alpha 2(IV) collagen genes.
PubMed ID: 2439508
PubMed ID: 10625665
Title: Canstatin, a novel matrix-derived inhibitor of angiogenesis and tumor growth.
PubMed ID: 10625665
PubMed ID: 12876280
Title: Canstatin inhibits Akt activation and induces Fas-dependent apoptosis in endothelial cells.
PubMed ID: 12876280
PubMed ID: 15899827
Title: Canstatin acts on endothelial and tumor cells via mitochondrial damage initiated through interaction with alphavbeta3 and alphavbeta5 integrins.
PubMed ID: 15899827
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 32571911
Title: Peroxidasin-mediated bromine enrichment of basement membranes.
PubMed ID: 32571911
PubMed ID: 12011424
Title: The 1.9-A crystal structure of the noncollagenous (NC1) domain of human placenta collagen IV shows stabilization via a novel type of covalent Met-Lys cross-link.
PubMed ID: 12011424
PubMed ID: 21527998
Title: Sequence variants in COL4A1 and COL4A2 genes in Ecuadorian families with keratoconus.
PubMed ID: 21527998
PubMed ID: 22209246
Title: De novo and inherited mutations in COL4A2, encoding the type IV collagen alpha2 chain cause porencephaly.
PubMed ID: 22209246
PubMed ID: 22209247
Title: COL4A2 mutations impair COL4A1 and COL4A2 secretion and cause hemorrhagic stroke.
PubMed ID: 22209247
PubMed ID: 22333902
Title: COL4A2 mutation associated with familial porencephaly and small-vessel disease.
PubMed ID: 22333902
DOI: 10.1038/ejhg.2012.20
Sequence Information:
- Length: 1712
- Mass: 167553
- Checksum: E0DABEEAB349D8AF
- Sequence:
MGRDQRAVAG PALRRWLLLG TVTVGFLAQS VLAGVKKFDV PCGGRDCSGG CQCYPEKGGR GQPGPVGPQG YNGPPGLQGF PGLQGRKGDK GERGAPGVTG PKGDVGARGV SGFPGADGIP GHPGQGGPRG RPGYDGCNGT QGDSGPQGPP GSEGFTGPPG PQGPKGQKGE PYALPKEERD RYRGEPGEPG LVGFQGPPGR PGHVGQMGPV GAPGRPGPPG PPGPKGQQGN RGLGFYGVKG EKGDVGQPGP NGIPSDTLHP IIAPTGVTFH PDQYKGEKGS EGEPGIRGIS LKGEEGIMGF PGLRGYPGLS GEKGSPGQKG SRGLDGYQGP DGPRGPKGEA GDPGPPGLPA YSPHPSLAKG ARGDPGFPGA QGEPGSQGEP GDPGLPGPPG LSIGDGDQRR GLPGEMGPKG FIGDPGIPAL YGGPPGPDGK RGPPGPPGLP GPPGPDGFLF GLKGAKGRAG FPGLPGSPGA RGPKGWKGDA GECRCTEGDE AIKGLPGLPG PKGFAGINGE PGRKGDRGDP GQHGLPGFPG LKGVPGNIGA PGPKGAKGDS RTITTKGERG QPGVPGVPGM KGDDGSPGRD GLDGFPGLPG PPGDGIKGPP GDPGYPGIPG TKGTPGEMGP PGLGLPGLKG QRGFPGDAGL PGPPGFLGPP GPAGTPGQID CDTDVKRAVG GDRQEAIQPG CIGGPKGLPG LPGPPGPTGA KGLRGIPGFA GADGGPGPRG LPGDAGREGF PGPPGFIGPR GSKGAVGLPG PDGSPGPIGL PGPDGPPGER GLPGEVLGAQ PGPRGDAGVP GQPGLKGLPG DRGPPGFRGS QGMPGMPGLK GQPGLPGPSG QPGLYGPPGL HGFPGAPGQE GPLGLPGIPG REGLPGDRGD PGDTGAPGPV GMKGLSGDRG DAGFTGEQGH PGSPGFKGID GMPGTPGLKG DRGSPGMDGF QGMPGLKGRP GFPGSKGEAG FFGIPGLKGL AGEPGFKGSR GDPGPPGPPP VILPGMKDIK GEKGDEGPMG LKGYLGAKGI QGMPGIPGLS GIPGLPGRPG HIKGVKGDIG VPGIPGLPGF PGVAGPPGIT GFPGFIGSRG DKGAPGRAGL YGEIGATGDF GDIGDTINLP GRPGLKGERG TTGIPGLKGF FGEKGTEGDI GFPGITGVTG VQGPPGLKGQ TGFPGLTGPP GSQGELGRIG LPGGKGDDGW PGAPGLPGFP GLRGIRGLHG LPGTKGFPGS PGSDIHGDPG FPGPPGERGD PGEANTLPGP VGVPGQKGDQ GAPGERGPPG SPGLQGFPGI TPPSNISGAP GDKGAPGIFG LKGYRGPPGP PGSAALPGSK GDTGNPGAPG TPGTKGWAGD SGPQGRPGVF GLPGEKGPRG EQGFMGNTGP TGAVGDRGPK GPKGDPGFPG APGTVGAPGI AGIPQKIAVQ PGTVGPQGRR GPPGAPGEMG PQGPPGEPGF RGAPGKAGPQ GRGGVSAVPG FRGDEGPIGH QGPIGQEGAP GRPGSPGLPG MPGRSVSIGY LLVKHSQTDQ EPMCPVGMNK LWSGYSLLYF EGQEKAHNQD LGLAGSCLAR FSTMPFLYCN PGDVCYYASR NDKSYWLSTT APLPMMPVAE DEIKPYISRC SVCEAPAIAI AVHSQDVSIP HCPAGWRSLW IGYSFLMHTA AGDEGGGQSL VSPGSCLEDF RATPFIECNG GRGTCHYYAN KYSFWLTTIP EQSFQGSPSA DTLKAGLIRT HISRCQVCMK NL
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.