Details for: COL4A2
Associated with
Cells (max top 100)
(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 5.93
Marker Score: 3905.5 - Cell Name: subcutaneous fat cell (CL0002521)
Fold Change: 4.72
Marker Score: 1726 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 4.28
Marker Score: 5753.5 - Cell Name: cardiac neuron (CL0010022)
Fold Change: 4.16
Marker Score: 5188 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 4.13
Marker Score: 36232.5 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 4.08
Marker Score: 137933 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 3.89
Marker Score: 4710 - Cell Name: contractile cell (CL0000183)
Fold Change: 3.87
Marker Score: 2099 - Cell Name: fat cell (CL0000136)
Fold Change: 3.64
Marker Score: 2034 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 3.61
Marker Score: 64139 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 3.54
Marker Score: 7769 - Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 3.45
Marker Score: 6642 - Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 3.34
Marker Score: 3184.5 - Cell Name: skeletal muscle satellite cell (CL0000594)
Fold Change: 3.04
Marker Score: 2032 - Cell Name: smooth muscle cell of large intestine (CL1000279)
Fold Change: 2.84
Marker Score: 1074 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 2.72
Marker Score: 92713 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 2.71
Marker Score: 1587.5 - Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 2.68
Marker Score: 3088 - Cell Name: fibroblast of breast (CL4006000)
Fold Change: 2.66
Marker Score: 1517.5 - Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 2.56
Marker Score: 3722 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 2.54
Marker Score: 801 - Cell Name: endocardial cell (CL0002350)
Fold Change: 2.53
Marker Score: 1430.5 - Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 2.49
Marker Score: 2661.5 - Cell Name: skin fibroblast (CL0002620)
Fold Change: 2.49
Marker Score: 646 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 2.43
Marker Score: 27378 - Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
Fold Change: 2.4
Marker Score: 6097 - Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 2.37
Marker Score: 5581 - Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: 2.32
Marker Score: 1904 - Cell Name: alveolar type 2 fibroblast cell (CL4028006)
Fold Change: 2.32
Marker Score: 1289 - Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 2.29
Marker Score: 2155 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 2.28
Marker Score: 9469 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 2.23
Marker Score: 14484 - Cell Name: smooth muscle cell (CL0000192)
Fold Change: 2.2
Marker Score: 1449 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 2.14
Marker Score: 8945.5 - Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: 2.13
Marker Score: 1343.5 - Cell Name: decidual cell (CL2000002)
Fold Change: 2.11
Marker Score: 9101 - Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 2.1
Marker Score: 658 - Cell Name: pericyte (CL0000669)
Fold Change: 2.05
Marker Score: 1198 - Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: 2.04
Marker Score: 2660 - Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 2.03
Marker Score: 9964 - Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: 2.01
Marker Score: 838 - Cell Name: myofibroblast cell (CL0000186)
Fold Change: 2
Marker Score: 2463 - Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 1.99
Marker Score: 723 - Cell Name: endothelial cell of sinusoid (CL0002262)
Fold Change: 1.99
Marker Score: 482 - Cell Name: type I pneumocyte (CL0002062)
Fold Change: 1.97
Marker Score: 2378 - Cell Name: supporting cell (CL0000630)
Fold Change: 1.97
Marker Score: 3694 - Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 1.96
Marker Score: 43709 - Cell Name: bronchus fibroblast of lung (CL2000093)
Fold Change: 1.93
Marker Score: 2655 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 1.93
Marker Score: 564 - Cell Name: mesodermal cell (CL0000222)
Fold Change: 1.89
Marker Score: 24981 - Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 1.86
Marker Score: 2864.5 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 1.85
Marker Score: 27735 - Cell Name: neural cell (CL0002319)
Fold Change: 1.85
Marker Score: 893 - Cell Name: Sertoli cell (CL0000216)
Fold Change: 1.83
Marker Score: 10859.5 - Cell Name: granulosa cell (CL0000501)
Fold Change: 1.82
Marker Score: 18332 - Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 1.81
Marker Score: 4926.5 - Cell Name: capillary endothelial cell (CL0002144)
Fold Change: 1.8
Marker Score: 1931 - Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
Fold Change: 1.79
Marker Score: 403 - Cell Name: kidney cell (CL1000497)
Fold Change: 1.79
Marker Score: 1196 - Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 1.76
Marker Score: 1893 - Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 1.75
Marker Score: 1246 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 1.75
Marker Score: 64448 - Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
Fold Change: 1.71
Marker Score: 2472 - Cell Name: hematopoietic cell (CL0000988)
Fold Change: 1.7
Marker Score: 1131 - Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 1.64
Marker Score: 3875 - Cell Name: endothelial cell (CL0000115)
Fold Change: 1.64
Marker Score: 1472 - Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 1.64
Marker Score: 1394 - Cell Name: hepatic stellate cell (CL0000632)
Fold Change: 1.62
Marker Score: 612 - Cell Name: muscle cell (CL0000187)
Fold Change: 1.62
Marker Score: 459 - Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
Fold Change: 1.6
Marker Score: 422 - Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 1.59
Marker Score: 1700 - Cell Name: Leydig cell (CL0000178)
Fold Change: 1.59
Marker Score: 1709 - Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 1.58
Marker Score: 401 - Cell Name: nephron tubule epithelial cell (CL1000494)
Fold Change: 1.56
Marker Score: 367 - Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 1.56
Marker Score: 5535 - Cell Name: stromal cell (CL0000499)
Fold Change: 1.53
Marker Score: 1787 - Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 1.52
Marker Score: 3040 - Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 1.48
Marker Score: 574 - Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.47
Marker Score: 2994 - Cell Name: endothelial tip cell (CL0000704)
Fold Change: 1.46
Marker Score: 340 - Cell Name: mural cell (CL0008034)
Fold Change: 1.46
Marker Score: 166940 - Cell Name: pyramidal neuron (CL0000598)
Fold Change: 1.45
Marker Score: 2430 - Cell Name: mononuclear cell (CL0000842)
Fold Change: 1.44
Marker Score: 464 - Cell Name: fibroblast (CL0000057)
Fold Change: 1.44
Marker Score: 1388 - Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 1.43
Marker Score: 2986 - Cell Name: vein endothelial cell (CL0002543)
Fold Change: 1.43
Marker Score: 1290 - Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 1.42
Marker Score: 691.5 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.4
Marker Score: 5509 - Cell Name: cell in vitro (CL0001034)
Fold Change: 1.39
Marker Score: 48146.5 - Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 1.38
Marker Score: 3709 - Cell Name: adventitial cell (CL0002503)
Fold Change: 1.36
Marker Score: 336 - Cell Name: glomerular endothelial cell (CL0002188)
Fold Change: 1.35
Marker Score: 342 - Cell Name: renal principal cell (CL0005009)
Fold Change: 1.35
Marker Score: 1037 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.34
Marker Score: 20954 - Cell Name: neural crest cell (CL0011012)
Fold Change: 1.32
Marker Score: 1407 - Cell Name: hepatocyte (CL0000182)
Fold Change: 1.32
Marker Score: 898 - Cell Name: fibroblast of lung (CL0002553)
Fold Change: 1.31
Marker Score: 3432 - Cell Name: Schwann cell (CL0002573)
Fold Change: 1.31
Marker Score: 454 - Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: 1.29
Marker Score: 4588 - Cell Name: migratory enteric neural crest cell (CL0002607)
Fold Change: 1.28
Marker Score: 1206
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Other Information
Genular Protein ID: 3149821679
Symbol: CO4A2_HUMAN
Name: Canstatin
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 3198637
Title: The complete primary structure of the alpha 2 chain of human type IV collagen and comparison with the alpha 1(IV) chain.
PubMed ID: 3198637
PubMed ID: 15057823
Title: The DNA sequence and analysis of human chromosome 13.
PubMed ID: 15057823
DOI: 10.1038/nature02379
PubMed ID: 3345760
Title: Human basement membrane collagen (type IV). The amino acid sequence of the alpha 2(IV) chain and its comparison with the alpha 1(IV) chain reveals deletions in the alpha 1(IV) chain.
PubMed ID: 3345760
PubMed ID: 2846280
Title: The genes for the alpha 1(IV) and alpha 2(IV) chains of human basement membrane collagen type IV are arranged head-to-head and separated by a bidirectional promoter of unique structure.
PubMed ID: 2846280
PubMed ID: 3182844
Title: The structural genes for alpha 1 and alpha 2 chains of human type IV collagen are divergently encoded on opposite DNA strands and have an overlapping promoter region.
PubMed ID: 3182844
PubMed ID: 8317999
Title: Identification of a novel sequence element in the common promoter region of human collagen type IV genes, involved in the regulation of divergent transcription.
PubMed ID: 8317999
DOI: 10.1042/bj2920687
PubMed ID: 3692475
Title: Partial structure of the human alpha 2(IV) collagen chain and chromosomal localization of the gene (COL4A2).
PubMed ID: 3692475
DOI: 10.1007/bf00291418
PubMed ID: 3582677
Title: Nucleotide sequence coding for the human type IV collagen alpha 2 chain cDNA reveals extensive homology with the NC-1 domain of alpha 1 (IV) but not with the collagenous domain or 3'-untranslated region.
PubMed ID: 3582677
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 3025878
Title: Human collagen genes encoding basement membrane alpha 1 (IV) and alpha 2 (IV) chains map to the distal long arm of chromosome 13.
PubMed ID: 3025878
PubMed ID: 2844531
Title: The arrangement of intra- and intermolecular disulfide bonds in the carboxyterminal, non-collagenous aggregation and cross-linking domain of basement-membrane type IV collagen.
PubMed ID: 2844531
PubMed ID: 2439508
Title: Duplication of type IV collagen COOH-terminal repeats and species-specific expression of alpha 1(IV) and alpha 2(IV) collagen genes.
PubMed ID: 2439508
PubMed ID: 10625665
Title: Canstatin, a novel matrix-derived inhibitor of angiogenesis and tumor growth.
PubMed ID: 10625665
PubMed ID: 12876280
Title: Canstatin inhibits Akt activation and induces Fas-dependent apoptosis in endothelial cells.
PubMed ID: 12876280
PubMed ID: 15899827
Title: Canstatin acts on endothelial and tumor cells via mitochondrial damage initiated through interaction with alphavbeta3 and alphavbeta5 integrins.
PubMed ID: 15899827
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 32571911
Title: Peroxidasin-mediated bromine enrichment of basement membranes.
PubMed ID: 32571911
PubMed ID: 12011424
Title: The 1.9-A crystal structure of the noncollagenous (NC1) domain of human placenta collagen IV shows stabilization via a novel type of covalent Met-Lys cross-link.
PubMed ID: 12011424
PubMed ID: 21527998
Title: Sequence variants in COL4A1 and COL4A2 genes in Ecuadorian families with keratoconus.
PubMed ID: 21527998
PubMed ID: 22209246
Title: De novo and inherited mutations in COL4A2, encoding the type IV collagen alpha2 chain cause porencephaly.
PubMed ID: 22209246
PubMed ID: 22209247
Title: COL4A2 mutations impair COL4A1 and COL4A2 secretion and cause hemorrhagic stroke.
PubMed ID: 22209247
PubMed ID: 22333902
Title: COL4A2 mutation associated with familial porencephaly and small-vessel disease.
PubMed ID: 22333902
DOI: 10.1038/ejhg.2012.20
Sequence Information:
- Length: 1712
- Mass: 167553
- Checksum: E0DABEEAB349D8AF
- Sequence:
MGRDQRAVAG PALRRWLLLG TVTVGFLAQS VLAGVKKFDV PCGGRDCSGG CQCYPEKGGR GQPGPVGPQG YNGPPGLQGF PGLQGRKGDK GERGAPGVTG PKGDVGARGV SGFPGADGIP GHPGQGGPRG RPGYDGCNGT QGDSGPQGPP GSEGFTGPPG PQGPKGQKGE PYALPKEERD RYRGEPGEPG LVGFQGPPGR PGHVGQMGPV GAPGRPGPPG PPGPKGQQGN RGLGFYGVKG EKGDVGQPGP NGIPSDTLHP IIAPTGVTFH PDQYKGEKGS EGEPGIRGIS LKGEEGIMGF PGLRGYPGLS GEKGSPGQKG SRGLDGYQGP DGPRGPKGEA GDPGPPGLPA YSPHPSLAKG ARGDPGFPGA QGEPGSQGEP GDPGLPGPPG LSIGDGDQRR GLPGEMGPKG FIGDPGIPAL YGGPPGPDGK RGPPGPPGLP GPPGPDGFLF GLKGAKGRAG FPGLPGSPGA RGPKGWKGDA GECRCTEGDE AIKGLPGLPG PKGFAGINGE PGRKGDRGDP GQHGLPGFPG LKGVPGNIGA PGPKGAKGDS RTITTKGERG QPGVPGVPGM KGDDGSPGRD GLDGFPGLPG PPGDGIKGPP GDPGYPGIPG TKGTPGEMGP PGLGLPGLKG QRGFPGDAGL PGPPGFLGPP GPAGTPGQID CDTDVKRAVG GDRQEAIQPG CIGGPKGLPG LPGPPGPTGA KGLRGIPGFA GADGGPGPRG LPGDAGREGF PGPPGFIGPR GSKGAVGLPG PDGSPGPIGL PGPDGPPGER GLPGEVLGAQ PGPRGDAGVP GQPGLKGLPG DRGPPGFRGS QGMPGMPGLK GQPGLPGPSG QPGLYGPPGL HGFPGAPGQE GPLGLPGIPG REGLPGDRGD PGDTGAPGPV GMKGLSGDRG DAGFTGEQGH PGSPGFKGID GMPGTPGLKG DRGSPGMDGF QGMPGLKGRP GFPGSKGEAG FFGIPGLKGL AGEPGFKGSR GDPGPPGPPP VILPGMKDIK GEKGDEGPMG LKGYLGAKGI QGMPGIPGLS GIPGLPGRPG HIKGVKGDIG VPGIPGLPGF PGVAGPPGIT GFPGFIGSRG DKGAPGRAGL YGEIGATGDF GDIGDTINLP GRPGLKGERG TTGIPGLKGF FGEKGTEGDI GFPGITGVTG VQGPPGLKGQ TGFPGLTGPP GSQGELGRIG LPGGKGDDGW PGAPGLPGFP GLRGIRGLHG LPGTKGFPGS PGSDIHGDPG FPGPPGERGD PGEANTLPGP VGVPGQKGDQ GAPGERGPPG SPGLQGFPGI TPPSNISGAP GDKGAPGIFG LKGYRGPPGP PGSAALPGSK GDTGNPGAPG TPGTKGWAGD SGPQGRPGVF GLPGEKGPRG EQGFMGNTGP TGAVGDRGPK GPKGDPGFPG APGTVGAPGI AGIPQKIAVQ PGTVGPQGRR GPPGAPGEMG PQGPPGEPGF RGAPGKAGPQ GRGGVSAVPG FRGDEGPIGH QGPIGQEGAP GRPGSPGLPG MPGRSVSIGY LLVKHSQTDQ EPMCPVGMNK LWSGYSLLYF EGQEKAHNQD LGLAGSCLAR FSTMPFLYCN PGDVCYYASR NDKSYWLSTT APLPMMPVAE DEIKPYISRC SVCEAPAIAI AVHSQDVSIP HCPAGWRSLW IGYSFLMHTA AGDEGGGQSL VSPGSCLEDF RATPFIECNG GRGTCHYYAN KYSFWLTTIP EQSFQGSPSA DTLKAGLIRT HISRCQVCMK NL
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.