Details for: COL4A2
Gene ID: 1284
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: COL4A2
Ensembl ID: ENSG00000134871
Description: collagen type IV alpha 2 chain
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 64.7rCSI 83.07%PRS 73.84
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CSI 51.7rCSI 63.96%PRS 81.5
-
CSI 27.69rCSI 39.51%PRS 83.9
-
CSI 26.81rCSI 61.17%PRS 75.25
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CSI 25.05rCSI 35.5%PRS 80.39
-
CSI 24.21rCSI 31.07%PRS 79.56
-
CSI 23.04rCSI 38.67%PRS 66.29
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CSI 21.93rCSI 57.89%PRS 88.96
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CSI 21.17rCSI 28.95%PRS 87.44
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CSI 19.86rCSI 64.62%PRS 80.6
-
CSI 19.85rCSI 27.57%PRS 81.75
-
CSI 18.83rCSI 21.75%PRS 75.61
-
CSI 18.75rCSI 50.1%PRS 75.83
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CSI 16.34rCSI 21.07%PRS 67.47
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CSI 14.59rCSI 30.28%PRS 80.25
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CSI 14.58rCSI 42.22%PRS 82.51
-
CSI 14.56rCSI 71.76%PRS 89.65
-
CSI 13.86rCSI 43.35%PRS 70.23
-
CSI 13.83rCSI 31.91%PRS 71.7
-
CSI 13.49rCSI 25.72%PRS 91.43
-
CSI 13.26rCSI 12.34%PRS 84.08
-
CSI 12.57rCSI 17.41%PRS 80.06
-
CSI 12.16rCSI 33.51%PRS 78.82
-
CSI 11.91rCSI 21.84%PRS 86.3
-
CSI 11.91rCSI 38.62%PRS 81.34
-
CSI 11.86rCSI 37.08%PRS 67.94
-
CSI 11.36rCSI 31.21%PRS 88.96
-
CSI 10.84rCSI 14.49%PRS 81.33
-
CSI 10.55rCSI 9.1%PRS 83.48
-
CSI 10.36rCSI 8.19%PRS 73.22
-
CSI 10.31rCSI 34.92%PRS 79.01
-
CSI 10.19rCSI 24.3%PRS 78.69
-
CSI 9.7rCSI 36.35%PRS 76.33
-
CSI 9.63rCSI 29.67%PRS 86.83
-
CSI 9.3rCSI 54.12%PRS 86.35
-
CSI 8.99rCSI 26.07%PRS 73.17
-
CSI 8.96rCSI 10.76%PRS 81.38
-
CSI 8.93rCSI 45.76%PRS 86.1
-
CSI 8.73rCSI 41.84%PRS 83.43
-
CSI 8.47rCSI 45.02%PRS 72.99
-
CSI 8.44rCSI 8.12%PRS 82.64
-
CSI 8.43rCSI 10.73%PRS 87.92
-
CSI 8.24rCSI 10.25%PRS 64.22
-
CSI 8.2rCSI 20.73%PRS 87.42
-
CSI 8.16rCSI 45.48%PRS 85.57
-
CSI 8.07rCSI 14.15%PRS 77.68
-
CSI 7.96rCSI 6.47%PRS 82.64
-
CSI 7.91rCSI 57.83%PRS 89.83
-
CSI 7.9rCSI 45.31%PRS 88.02
-
CSI 7.89rCSI 7.01%PRS 80.99
-
CSI 7.68rCSI 24.58%PRS 81.02
-
CSI 7.64rCSI 27.12%PRS 86.27
-
CSI 7.33rCSI 35.11%PRS 79.34
-
CSI 7.1rCSI 18.51%PRS 84.32
-
CSI 6.92rCSI 9.94%PRS 73.7
-
CSI 6.9rCSI 19.61%PRS 78.93
-
CSI 6.85rCSI 15.97%PRS 92.04
-
CSI 6.84rCSI 20.19%PRS 82.28
-
CSI 6.75rCSI 6.51%PRS 77.5
-
CSI 6.75rCSI 38.13%PRS 69.67
-
CSI 6.68rCSI 6.17%PRS 84.55
-
CSI 6.66rCSI 15.91%PRS 86.56
-
CSI 6.59rCSI 18.54%PRS 78.4
-
CSI 6.47rCSI 6.76%PRS 80.87
-
CSI 6.43rCSI 18.5%PRS 76.69
-
CSI 6.43rCSI 12.74%PRS 87.4
-
CSI 6.19rCSI 15.11%PRS 75.83
-
CSI 6.16rCSI 13.57%PRS 86.47
-
CSI 6.05rCSI 16.12%PRS 60.88
-
CSI 5.99rCSI 9.25%PRS 82.17
-
CSI 5.95rCSI 25%PRS 87.13
-
CSI 5.89rCSI 6.45%PRS 85.05
-
CSI 5.61rCSI 38.5%PRS 88.57
-
CSI 5.52rCSI 15.06%PRS 89.15
-
CSI 5.47rCSI 6.53%PRS 66.34
-
CSI 5.39rCSI 14%PRS 83.25
-
CSI 5.36rCSI 13.86%PRS 79.11
-
CSI 5.24rCSI 7.14%PRS 75.31
-
CSI 5.19rCSI 13.17%PRS 74.47
-
CSI 5.17rCSI 19.68%PRS 74.82
-
CSI 5.02rCSI 27.85%PRS 90.84
-
CSI 4.94rCSI 7.89%PRS 86.48
-
CSI 4.84rCSI 8.53%PRS 87.71
-
CSI 4.83rCSI 6.57%PRS 90.41
-
CSI 4.69rCSI 19.13%PRS 90.66
-
CSI 4.5rCSI 7.78%PRS 75.51
-
CSI 4.38rCSI 10.01%PRS 84.05
-
CSI 4.36rCSI 10.6%PRS 64.23
-
CSI 4.35rCSI 8.73%PRS 74.49
-
CSI 3.92rCSI 30.06%PRS 84.18
-
CSI 3.89rCSI 25.05%PRS 90.15
-
CSI 3.78rCSI 8.48%PRS 67.22
-
CSI 3.71rCSI 5.89%PRS 76.82
-
CSI 3.7rCSI 7.19%PRS 86.14
-
CSI 3.6rCSI 11.6%PRS 80.19
-
CSI 3.57rCSI 9.27%PRS 88.64
-
CSI 3.51rCSI 13.26%PRS 66.86
-
CSI 3.45rCSI 5.28%PRS 89.38
-
CSI 3.42rCSI 48.59%PRS 74.61
-
CSI 3.35rCSI 36.73%PRS 87.5
-
CSI 0.6rCSI 11.8%PRS 74.3%
-
CSI 0.7rCSI 2.6%PRS 64.2%
-
CSI 0.8rCSI 20.3%PRS 89.6%
-
CSI 0.8rCSI 2.3%PRS 87.7%
-
CSI 0.8rCSI 16.7%PRS 73.3%
-
CSI 0.9rCSI 3.9%PRS 71.9%
-
CSI 0.9rCSI 6.8%PRS 71.4%
-
CSI 1.0rCSI 24.6%PRS 90.1%
-
CSI 1.1rCSI 5.8%PRS 84.2%
-
CSI 1.1rCSI 11.7%PRS 79.4%
-
CSI 1.2rCSI 9.9%PRS 90.0%
-
CSI 1.3rCSI 8.1%PRS 75.7%
-
CSI 1.3rCSI 2.7%PRS 79.4%
-
CSI 1.3rCSI 20.1%PRS 89.9%
-
CSI 1.4rCSI 3.7%PRS 87.6%
-
CSI 1.4rCSI 4.9%PRS 89.7%
-
CSI 1.5rCSI 2.9%PRS 90.0%
-
CSI 1.6rCSI 10.8%PRS 88.1%
-
CSI 1.7rCSI 9.4%PRS 79.8%
-
CSI 1.8rCSI 2.8%PRS 67.7%
-
CSI 1.9rCSI 17.0%PRS 89.6%
-
CSI 2.0rCSI 3.8%PRS 91.8%
-
CSI 2.0rCSI 8.8%PRS 84.0%
-
CSI 2.0rCSI 39.3%PRS 89.5%
-
CSI 2.0rCSI 12.0%PRS 88.0%
-
CSI 2.1rCSI 3.7%PRS 65.9%
-
CSI 2.1rCSI 9.5%PRS 89.3%
-
CSI 2.4rCSI 21.0%PRS 77.7%
-
CSI 2.5rCSI 3.9%PRS 84.6%
-
CSI 2.5rCSI 18.0%PRS 76.2%
-
CSI 2.6rCSI 10.3%PRS 83.4%
-
CSI 2.6rCSI 7.6%PRS 92.5%
-
CSI 2.7rCSI 21.9%PRS 78.1%
-
CSI 2.8rCSI 12.6%PRS 67.3%
-
CSI 2.8rCSI 12.6%PRS 91.4%
-
CSI 2.8rCSI 9.9%PRS 90.0%
-
CSI 2.8rCSI 7.2%PRS 77.1%
-
CSI 3.0rCSI 13.6%PRS 86.6%
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CSI 3.0rCSI 26.1%PRS 72.0%
-
CSI 3.1rCSI 18.4%PRS 84.8%
-
CSI 3.1rCSI 6.8%PRS 69.9%
-
CSI 3.1rCSI 10.3%PRS 67.5%
-
CSI 3.3rCSI 19.2%PRS 79.7%
-
CSI 3.3rCSI 8.0%PRS 86.0%
-
CSI 3.4rCSI 36.7%PRS 87.5%
-
CSI 3.4rCSI 48.6%PRS 74.6%
-
CSI 3.5rCSI 5.3%PRS 89.4%
-
CSI 3.5rCSI 13.3%PRS 66.9%
-
CSI 3.6rCSI 9.3%PRS 88.6%
-
CSI 3.6rCSI 11.6%PRS 80.2%
-
CSI 3.7rCSI 7.2%PRS 86.1%
-
CSI 3.7rCSI 5.9%PRS 76.8%
-
CSI 3.8rCSI 8.5%PRS 67.2%
-
CSI 3.9rCSI 25.1%PRS 90.2%
-
CSI 3.9rCSI 30.1%PRS 84.2%
-
CSI 4.4rCSI 8.7%PRS 74.5%
-
CSI 4.4rCSI 10.6%PRS 64.2%
-
CSI 4.4rCSI 10.0%PRS 84.1%
-
CSI 4.5rCSI 7.8%PRS 75.5%
-
CSI 4.7rCSI 19.1%PRS 90.7%
-
CSI 4.8rCSI 6.6%PRS 90.4%
-
CSI 4.8rCSI 8.5%PRS 87.7%
-
CSI 4.9rCSI 7.9%PRS 86.5%
-
CSI 5.0rCSI 27.9%PRS 90.8%
-
CSI 5.2rCSI 19.7%PRS 74.8%
-
CSI 5.2rCSI 13.2%PRS 74.5%
-
CSI 5.2rCSI 7.1%PRS 75.3%
-
CSI 5.4rCSI 13.9%PRS 79.1%
-
CSI 5.4rCSI 14.0%PRS 83.3%
-
CSI 5.5rCSI 6.5%PRS 66.3%
-
CSI 5.5rCSI 15.1%PRS 89.2%
-
CSI 5.6rCSI 38.5%PRS 88.6%
-
CSI 5.9rCSI 6.5%PRS 85.1%
-
CSI 6.0rCSI 25.0%PRS 87.1%
-
CSI 6.0rCSI 9.3%PRS 82.2%
-
CSI 6.1rCSI 16.1%PRS 60.9%
-
CSI 6.2rCSI 13.6%PRS 86.5%
-
CSI 6.2rCSI 15.1%PRS 75.8%
-
CSI 6.4rCSI 12.7%PRS 87.4%
-
CSI 6.4rCSI 18.5%PRS 76.7%
-
CSI 6.5rCSI 6.8%PRS 80.9%
-
CSI 6.6rCSI 18.5%PRS 78.4%
-
CSI 6.7rCSI 15.9%PRS 86.6%
-
CSI 6.7rCSI 6.2%PRS 84.6%
-
CSI 6.8rCSI 38.1%PRS 69.7%
-
CSI 6.8rCSI 6.5%PRS 77.5%
-
CSI 6.8rCSI 20.2%PRS 82.3%
-
CSI 6.9rCSI 16.0%PRS 92.0%
-
CSI 6.9rCSI 19.6%PRS 78.9%
-
CSI 6.9rCSI 9.9%PRS 73.7%
-
CSI 7.1rCSI 18.5%PRS 84.3%
-
CSI 7.3rCSI 35.1%PRS 79.3%
-
CSI 7.6rCSI 27.1%PRS 86.3%
-
CSI 7.7rCSI 24.6%PRS 81.0%
-
CSI 7.9rCSI 7.0%PRS 81.0%
-
CSI 7.9rCSI 45.3%PRS 88.0%
-
CSI 7.9rCSI 57.8%PRS 89.8%
-
CSI 8.0rCSI 6.5%PRS 82.6%
-
CSI 8.1rCSI 14.2%PRS 77.7%
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CSI 8.2rCSI 45.5%PRS 85.6%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 3149821679
Symbol: CO4A2_HUMAN
Name: Canstatin
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 3198637
Title: The complete primary structure of the alpha 2 chain of human type IV collagen and comparison with the alpha 1(IV) chain.
PubMed ID: 3198637
PubMed ID: 15057823
Title: The DNA sequence and analysis of human chromosome 13.
PubMed ID: 15057823
DOI: 10.1038/nature02379
PubMed ID: 3345760
Title: Human basement membrane collagen (type IV). The amino acid sequence of the alpha 2(IV) chain and its comparison with the alpha 1(IV) chain reveals deletions in the alpha 1(IV) chain.
PubMed ID: 3345760
PubMed ID: 2846280
Title: The genes for the alpha 1(IV) and alpha 2(IV) chains of human basement membrane collagen type IV are arranged head-to-head and separated by a bidirectional promoter of unique structure.
PubMed ID: 2846280
PubMed ID: 3182844
Title: The structural genes for alpha 1 and alpha 2 chains of human type IV collagen are divergently encoded on opposite DNA strands and have an overlapping promoter region.
PubMed ID: 3182844
PubMed ID: 8317999
Title: Identification of a novel sequence element in the common promoter region of human collagen type IV genes, involved in the regulation of divergent transcription.
PubMed ID: 8317999
DOI: 10.1042/bj2920687
PubMed ID: 3692475
Title: Partial structure of the human alpha 2(IV) collagen chain and chromosomal localization of the gene (COL4A2).
PubMed ID: 3692475
DOI: 10.1007/bf00291418
PubMed ID: 3582677
Title: Nucleotide sequence coding for the human type IV collagen alpha 2 chain cDNA reveals extensive homology with the NC-1 domain of alpha 1 (IV) but not with the collagenous domain or 3'-untranslated region.
PubMed ID: 3582677
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 3025878
Title: Human collagen genes encoding basement membrane alpha 1 (IV) and alpha 2 (IV) chains map to the distal long arm of chromosome 13.
PubMed ID: 3025878
PubMed ID: 2844531
Title: The arrangement of intra- and intermolecular disulfide bonds in the carboxyterminal, non-collagenous aggregation and cross-linking domain of basement-membrane type IV collagen.
PubMed ID: 2844531
PubMed ID: 2439508
Title: Duplication of type IV collagen COOH-terminal repeats and species-specific expression of alpha 1(IV) and alpha 2(IV) collagen genes.
PubMed ID: 2439508
PubMed ID: 10625665
Title: Canstatin, a novel matrix-derived inhibitor of angiogenesis and tumor growth.
PubMed ID: 10625665
PubMed ID: 12876280
Title: Canstatin inhibits Akt activation and induces Fas-dependent apoptosis in endothelial cells.
PubMed ID: 12876280
PubMed ID: 15899827
Title: Canstatin acts on endothelial and tumor cells via mitochondrial damage initiated through interaction with alphavbeta3 and alphavbeta5 integrins.
PubMed ID: 15899827
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 32571911
Title: Peroxidasin-mediated bromine enrichment of basement membranes.
PubMed ID: 32571911
PubMed ID: 12011424
Title: The 1.9-A crystal structure of the noncollagenous (NC1) domain of human placenta collagen IV shows stabilization via a novel type of covalent Met-Lys cross-link.
PubMed ID: 12011424
PubMed ID: 21527998
Title: Sequence variants in COL4A1 and COL4A2 genes in Ecuadorian families with keratoconus.
PubMed ID: 21527998
PubMed ID: 22209246
Title: De novo and inherited mutations in COL4A2, encoding the type IV collagen alpha2 chain cause porencephaly.
PubMed ID: 22209246
PubMed ID: 22209247
Title: COL4A2 mutations impair COL4A1 and COL4A2 secretion and cause hemorrhagic stroke.
PubMed ID: 22209247
PubMed ID: 22333902
Title: COL4A2 mutation associated with familial porencephaly and small-vessel disease.
PubMed ID: 22333902
DOI: 10.1038/ejhg.2012.20
Sequence Information:
- Length: 1712
- Mass: 167553
- Checksum: E0DABEEAB349D8AF
- Sequence:
MGRDQRAVAG PALRRWLLLG TVTVGFLAQS VLAGVKKFDV PCGGRDCSGG CQCYPEKGGR GQPGPVGPQG YNGPPGLQGF PGLQGRKGDK GERGAPGVTG PKGDVGARGV SGFPGADGIP GHPGQGGPRG RPGYDGCNGT QGDSGPQGPP GSEGFTGPPG PQGPKGQKGE PYALPKEERD RYRGEPGEPG LVGFQGPPGR PGHVGQMGPV GAPGRPGPPG PPGPKGQQGN RGLGFYGVKG EKGDVGQPGP NGIPSDTLHP IIAPTGVTFH PDQYKGEKGS EGEPGIRGIS LKGEEGIMGF PGLRGYPGLS GEKGSPGQKG SRGLDGYQGP DGPRGPKGEA GDPGPPGLPA YSPHPSLAKG ARGDPGFPGA QGEPGSQGEP GDPGLPGPPG LSIGDGDQRR GLPGEMGPKG FIGDPGIPAL YGGPPGPDGK RGPPGPPGLP GPPGPDGFLF GLKGAKGRAG FPGLPGSPGA RGPKGWKGDA GECRCTEGDE AIKGLPGLPG PKGFAGINGE PGRKGDRGDP GQHGLPGFPG LKGVPGNIGA PGPKGAKGDS RTITTKGERG QPGVPGVPGM KGDDGSPGRD GLDGFPGLPG PPGDGIKGPP GDPGYPGIPG TKGTPGEMGP PGLGLPGLKG QRGFPGDAGL PGPPGFLGPP GPAGTPGQID CDTDVKRAVG GDRQEAIQPG CIGGPKGLPG LPGPPGPTGA KGLRGIPGFA GADGGPGPRG LPGDAGREGF PGPPGFIGPR GSKGAVGLPG PDGSPGPIGL PGPDGPPGER GLPGEVLGAQ PGPRGDAGVP GQPGLKGLPG DRGPPGFRGS QGMPGMPGLK GQPGLPGPSG QPGLYGPPGL HGFPGAPGQE GPLGLPGIPG REGLPGDRGD PGDTGAPGPV GMKGLSGDRG DAGFTGEQGH PGSPGFKGID GMPGTPGLKG DRGSPGMDGF QGMPGLKGRP GFPGSKGEAG FFGIPGLKGL AGEPGFKGSR GDPGPPGPPP VILPGMKDIK GEKGDEGPMG LKGYLGAKGI QGMPGIPGLS GIPGLPGRPG HIKGVKGDIG VPGIPGLPGF PGVAGPPGIT GFPGFIGSRG DKGAPGRAGL YGEIGATGDF GDIGDTINLP GRPGLKGERG TTGIPGLKGF FGEKGTEGDI GFPGITGVTG VQGPPGLKGQ TGFPGLTGPP GSQGELGRIG LPGGKGDDGW PGAPGLPGFP GLRGIRGLHG LPGTKGFPGS PGSDIHGDPG FPGPPGERGD PGEANTLPGP VGVPGQKGDQ GAPGERGPPG SPGLQGFPGI TPPSNISGAP GDKGAPGIFG LKGYRGPPGP PGSAALPGSK GDTGNPGAPG TPGTKGWAGD SGPQGRPGVF GLPGEKGPRG EQGFMGNTGP TGAVGDRGPK GPKGDPGFPG APGTVGAPGI AGIPQKIAVQ PGTVGPQGRR GPPGAPGEMG PQGPPGEPGF RGAPGKAGPQ GRGGVSAVPG FRGDEGPIGH QGPIGQEGAP GRPGSPGLPG MPGRSVSIGY LLVKHSQTDQ EPMCPVGMNK LWSGYSLLYF EGQEKAHNQD LGLAGSCLAR FSTMPFLYCN PGDVCYYASR NDKSYWLSTT APLPMMPVAE DEIKPYISRC SVCEAPAIAI AVHSQDVSIP HCPAGWRSLW IGYSFLMHTA AGDEGGGQSL VSPGSCLEDF RATPFIECNG GRGTCHYYAN KYSFWLTTIP EQSFQGSPSA DTLKAGLIRT HISRCQVCMK NL