Genular: Defining Cellular Identity and Function

Details for: Col1a1

Gene ID: 12842

Symbol: Col1a1

Ensembl ID: ENSMUSG00000001506

Description: collagen, type I, alpha 1

Associated with

Adaptive immune system
(R-MMU-1280218)
Assembly of collagen fibrils and other multimeric structures
(R-MMU-2022090)
Cell surface interactions at the vascular wall
(R-MMU-202733)
Collagen biosynthesis and modifying enzymes
(R-MMU-1650814)
Collagen chain trimerization
(R-MMU-8948216)
Collagen degradation
(R-MMU-1442490)
Collagen formation
(R-MMU-1474290)
Crosslinking of collagen fibrils
(R-MMU-2243919)
Degradation of the extracellular matrix
(R-MMU-1474228)
Ecm proteoglycans
(R-MMU-3000178)
Gp1b-ix-v activation signalling
(R-MMU-430116)
Gpvi-mediated activation cascade
(R-MMU-114604)
Hemostasis
(R-MMU-109582)
Immune system
(R-MMU-168256)
Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
(R-MMU-198933)
Integrin cell surface interactions
(R-MMU-216083)
Met activates ptk2 signaling
(R-MMU-8874081)
Met promotes cell motility
(R-MMU-8875878)
Non-integrin membrane-ecm interactions
(R-MMU-3000171)
Platelet activation, signaling and aggregation
(R-MMU-76002)
Platelet adhesion to exposed collagen
(R-MMU-75892)
Platelet aggregation (plug formation)
(R-MMU-76009)
Signaling by met
(R-MMU-6806834)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signal transduction
(R-MMU-162582)
Blood vessel development
(GO:0001568)
Bone trabecula formation
(GO:0060346)
Cartilage development involved in endochondral bone morphogenesis
(GO:0060351)
Cellular response to amino acid stimulus
(GO:0071230)
Cellular response to mechanical stimulus
(GO:0071260)
Collagen-activated tyrosine kinase receptor signaling pathway
(GO:0038063)
Collagen-containing extracellular matrix
(GO:0062023)
Collagen biosynthetic process
(GO:0032964)
Collagen fibril organization
(GO:0030199)
Collagen trimer
(GO:0005581)
Collagen type i trimer
(GO:0005584)
Cytoplasm
(GO:0005737)
Embryonic skeletal system development
(GO:0048706)
Endochondral ossification
(GO:0001958)
Extracellular matrix
(GO:0031012)
Extracellular matrix organization
(GO:0030198)
Extracellular matrix structural constituent
(GO:0005201)
Extracellular matrix structural constituent conferring tensile strength
(GO:0030020)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Face morphogenesis
(GO:0060325)
Identical protein binding
(GO:0042802)
Intramembranous ossification
(GO:0001957)
Metal ion binding
(GO:0046872)
Negative regulation of cell-substrate adhesion
(GO:0010812)
Ossification
(GO:0001503)
Osteoblast differentiation
(GO:0001649)
Platelet-derived growth factor binding
(GO:0048407)
Positive regulation of canonical wnt signaling pathway
(GO:0090263)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of epithelial to mesenchymal transition
(GO:0010718)
Protease binding
(GO:0002020)
Protein binding
(GO:0005515)
Protein localization to nucleus
(GO:0034504)
Protein transport
(GO:0015031)
Response to mechanical stimulus
(GO:0009612)
Secretory granule
(GO:0030141)
Sensory perception of sound
(GO:0007605)
Skeletal system development
(GO:0001501)
Skeletal system morphogenesis
(GO:0048705)
Skin development
(GO:0043588)
Skin morphogenesis
(GO:0043589)
Tooth mineralization
(GO:0034505)
Visual perception
(GO:0007601)

Other Information

Proteins

Alpha-1 type I collagen

Genular Protein ID: 2668427253

Symbol: CO1A1_MOUSE

Name: Alpha-1 type I collagen

UniProtKB Accession Codes:

P11087 Q53WT0 Q60635 Q61367 Q61427 Q63919 Q6PCL3 Q810J9

Database IDs:

Citations:

PubMed ID: 8535610

Title: The complete cDNA coding sequence for the mouse pro alpha 1(I) chain of type I procollagen.

PubMed ID: 8535610

DOI: 10.1016/s0945-053x(05)80009-5

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 6324198

Title: Insertion of retrovirus into the first intron of alpha1(I) collagen gene leads to embryonic lethal mutation in mice.

PubMed ID: 6324198

DOI: 10.1073/pnas.81.5.1504

PubMed ID: 8268229

Title: Genomic sequence of mouse COL1A1 encoding the collagen propeptides.

PubMed ID: 8268229

DOI: 10.1016/0167-4781(93)90016-7

PubMed ID: 8065328

Title: DNA methylation represses the murine alpha 1(I) collagen promoter by an indirect mechanism.

PubMed ID: 8065328

DOI: 10.1128/mcb.14.9.5950-5960.1994

PubMed ID: 3841523

Title: Nucleotide sequence of a cDNA clone for mouse pro alpha 1(I) collagen protein.

PubMed ID: 3841523

DOI: 10.1016/0378-1119(85)90329-4

PubMed ID: 6298597

Title: DNA sequence analysis of a mouse pro alpha 1 (I) procollagen gene: evidence for a mouse B1 element within the gene.

PubMed ID: 6298597

DOI: 10.1128/mcb.2.11.1362-1371.1982

PubMed ID: 6219867

Title: Identification of a Balb/c mouse pro alpha 1(I) procollagen gene: evidence for insertions or deletions in gene coding sequences.

PubMed ID: 6219867

DOI: 10.1089/dna.1.1981.1.59

PubMed ID: 3340560

Title: Two mRNAs of mouse pro alpha 1(I) collagen gene differ in the size of the 3'-untranslated region.

PubMed ID: 3340560

DOI: 10.1093/nar/16.2.773

PubMed ID: 2054384

Title: Specific hybridization probes for mouse type I, II, III and IX collagen mRNAs.

PubMed ID: 2054384

DOI: 10.1016/0167-4781(91)90014-d

PubMed ID: 17330941

Title: Enhanced analysis of the mouse plasma proteome using cysteine-containing tryptic glycopeptides.

PubMed ID: 17330941

DOI: 10.1021/pr0604559

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 24028588

Title: Msx1 regulates proliferation and differentiation of mouse dental mesenchymal cells in culture.

PubMed ID: 24028588

DOI: 10.1111/eos.12078

PubMed ID: 25645914

Title: Post-translationally abnormal collagens of prolyl 3-hydroxylase-2 null mice offer a pathobiological mechanism for the high myopia linked to human LEPREL1 mutations.

PubMed ID: 25645914

DOI: 10.1074/jbc.m114.634915

PubMed ID: 27119146

Title: Sc65-Null Mice Provide Evidence for a Novel Endoplasmic Reticulum Complex Regulating Collagen Lysyl Hydroxylation.

PubMed ID: 27119146

DOI: 10.1371/journal.pgen.1006002

PubMed ID: 29148101

Title: Homeobox protein MSX-1 inhibits expression of bone morphogenetic protein 2, bone morphogenetic protein 4, and lymphoid enhancer-binding factor 1 via Wnt/beta-catenin signaling to prevent differentiation of dental mesenchymal cells during the late bell stage.

PubMed ID: 29148101

DOI: 10.1111/eos.12390

Sequence Information:

Length: 1453
Mass: 138032
Checksum: 0B7F06BBB9A1D5EA
Sequence:

MFSFVDLRLL LLLGATALLT HGQEDIPEVS CIHNGLRVPN GETWKPEVCL ICICHNGTAV 
CDDVQCNEEL DCPNPQRREG ECCAFCPEEY VSPNSEDVGV EGPKGDPGPQ GPRGPVGPPG 
RDGIPGQPGL PGPPGPPGPP GPPGLGGNFA SQMSYGYDEK SAGVSVPGPM GPSGPRGLPG 
PPGAPGPQGF QGPPGEPGEP GGSGPMGPRG PPGPPGKNGD DGEAGKPGRP GERGPPGPQG 
ARGLPGTAGL PGMKGHRGFS GLDGAKGDAG PAGPKGEPGS PGENGAPGQM GPRGLPGERG 
RPGPPGTAGA RGNDGAVGAA GPPGPTGPTG PPGFPGAVGA KGEAGPQGAR GSEGPQGVRG 
EPGPPGPAGA AGPAGNPGAD GQPGAKGANG APGIAGAPGF PGARGPSGPQ GPSGPPGPKG 
NSGEPGAPGN KGDTGAKGEP GATGVQGPPG PAGEEGKRGA RGEPGPSGLP GPPGERGGPG 
SRGFPGADGV AGPKGPSGER GAPGPAGPKG SPGEAGRPGE AGLPGAKGLT GSPGSPGPDG 
KTGPPGPAGQ DGRPGPAGPP GARGQAGVMG FPGPKGTAGE PGKAGERGLP GPPGAVGPAG 
KDGEAGAQGA PGPAGPAGER GEQGPAGSPG FQGLPGPAGP PGEAGKPGEQ GVPGDLGAPG 
PSGARGERGF PGERGVQGPP GPAGPRGNNG APGNDGAKGD TGAPGAPGSQ GAPGLQGMPG 
ERGAAGLPGP KGDRGDAGPK GADGSPGKDG ARGLTGPIGP PGPAGAPGDK GEAGPSGPPG 
PTGARGAPGD RGEAGPPGPA GFAGPPGADG QPGAKGEPGD TGVKGDAGPP GPAGPAGPPG 
PIGNVGAPGP KGPRGAAGPP GATGFPGAAG RVGPPGPSGN AGPPGPPGPV GKEGGKGPRG 
ETGPAGRPGE VGPPGPPGPA GEKGSPGADG PAGSPGTPGP QGIAGQRGVV GLPGQRGERG 
FPGLPGPSGE PGKQGPSGSS GERGPPGPMG PPGLAGPPGE SGREGSPGAE GSPGRDGAPG 
AKGDRGETGP AGPPGAPGAP GAPGPVGPAG KNGDRGETGP AGPAGPIGPA GARGPAGPQG 
PRGDKGETGE QGDRGIKGHR GFSGLQGPPG SPGSPGEQGP SGASGPAGPR GPPGSAGSPG 
KDGLNGLPGP IGPPGPRGRT GDSGPAGPPG PPGPPGPPGP PSGGYDFSFL PQPPQEKSQD 
GGRYYRADDA NVVRDRDLEV DTTLKSLSQQ IENIRSPEGS RKNPARTCRD LKMCHSDWKS 
GEYWIDPNQG CNLDAIKVYC NMETGQTCVF PTQPSVPQKN WYISPNPKEK KHVWFGESMT 
DGFPFEYGSE GSDPADVAIQ LTFLRLMSTE ASQNITYHCK NSVAYMDQQT GNLKKALLLQ 
GSNEIELRGE GNSRFTYSTL VDGCTSHTGT WGKTVIEYKT TKTSRLPIID VAPLDIGAPD 
QEFGLDIGPA CFV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Col1a1

Associated with

Other Information

The complete cDNA coding sequence for the mouse pro alpha 1(I) chain of type I procollagen. PubMed ID: 8535610

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Insertion of retrovirus into the first intron of alpha1(I) collagen gene leads to embryonic lethal mutation in mice. PubMed ID: 6324198

Genomic sequence of mouse COL1A1 encoding the collagen propeptides. PubMed ID: 8268229

DNA methylation represses the murine alpha 1(I) collagen promoter by an indirect mechanism. PubMed ID: 8065328

Nucleotide sequence of a cDNA clone for mouse pro alpha 1(I) collagen protein. PubMed ID: 3841523

DNA sequence analysis of a mouse pro alpha 1 (I) procollagen gene: evidence for a mouse B1 element within the gene. PubMed ID: 6298597

Identification of a Balb/c mouse pro alpha 1(I) procollagen gene: evidence for insertions or deletions in gene coding sequences. PubMed ID: 6219867

Two mRNAs of mouse pro alpha 1(I) collagen gene differ in the size of the 3'-untranslated region. PubMed ID: 3340560

Specific hybridization probes for mouse type I, II, III and IX collagen mRNAs. PubMed ID: 2054384

Enhanced analysis of the mouse plasma proteome using cysteine-containing tryptic glycopeptides. PubMed ID: 17330941

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Msx1 regulates proliferation and differentiation of mouse dental mesenchymal cells in culture. PubMed ID: 24028588

Post-translationally abnormal collagens of prolyl 3-hydroxylase-2 null mice offer a pathobiological mechanism for the high myopia linked to human LEPREL1 mutations. PubMed ID: 25645914

Sc65-Null Mice Provide Evidence for a Novel Endoplasmic Reticulum Complex Regulating Collagen Lysyl Hydroxylation. PubMed ID: 27119146

Homeobox protein MSX-1 inhibits expression of bone morphogenetic protein 2, bone morphogenetic protein 4, and lymphoid enhancer-binding factor 1 via Wnt/beta-catenin signaling to prevent differentiation of dental mesenchymal cells during the late bell stage. PubMed ID: 29148101