Genular: Defining Cellular Identity and Function

Details for: Comp

Gene ID: 12845

Symbol: Comp

Ensembl ID: ENSMUSG00000031849

Description: cartilage oligomeric matrix protein

Associated with

Ecm proteoglycans
(R-MMU-3000178)
Extracellular matrix organization
(R-MMU-1474244)
Integrin cell surface interactions
(R-MMU-216083)
Apoptotic process
(GO:0006915)
Artery morphogenesis
(GO:0048844)
Blood coagulation
(GO:0007596)
Bmp binding
(GO:0036122)
Bmp signaling pathway
(GO:0030509)
Bone growth
(GO:0098868)
Bone mineralization
(GO:0030282)
Bone morphogenesis
(GO:0060349)
Calcium ion binding
(GO:0005509)
Cartilage development
(GO:0051216)
Cartilage homeostasis
(GO:1990079)
Cell adhesion
(GO:0007155)
Cellular senescence
(GO:0090398)
Chondrocyte development
(GO:0002063)
Chondrocyte proliferation
(GO:0035988)
Collagen-containing extracellular matrix
(GO:0062023)
Collagen binding
(GO:0005518)
Collagen fibril organization
(GO:0030199)
Endochondral bone growth
(GO:0003416)
Extracellular matrix structural constituent
(GO:0005201)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Fibronectin binding
(GO:0001968)
Growth plate cartilage development
(GO:0003417)
Heparan sulfate proteoglycan binding
(GO:0043395)
Heparin binding
(GO:0008201)
Integrin binding
(GO:0005178)
Limb development
(GO:0060173)
Multicellular organism growth
(GO:0035264)
Muscle cell development
(GO:0055001)
Musculoskeletal movement
(GO:0050881)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of hemostasis
(GO:1900047)
Neuromuscular process
(GO:0050905)
Ossification
(GO:0001503)
Platelet aggregation
(GO:0070527)
Positive regulation of chondrocyte proliferation
(GO:1902732)
Protease binding
(GO:0002020)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Protein homooligomerization
(GO:0051260)
Protein processing
(GO:0016485)
Protein secretion
(GO:0009306)
Proteoglycan binding
(GO:0043394)
Regulation of bone mineralization
(GO:0030500)
Regulation of gene expression
(GO:0010468)
Response to unfolded protein
(GO:0006986)
Skeletal system development
(GO:0001501)
Skin development
(GO:0043588)
Tendon development
(GO:0035989)
Vascular associated smooth muscle cell development
(GO:0097084)
Vascular associated smooth muscle contraction
(GO:0014829)
Vitamin d binding
(GO:0005499)

Other Information

Proteins

COMP_MOUSE

Genular Protein ID: 3748763391

Symbol: COMP_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q9R0G6 G3X8Q4

Database IDs:

Citations:

PubMed ID: 11052496

Title: Molecular cloning, sequencing, and tissue and developmental expression of mouse cartilage oligomeric matrix protein (COMP).

PubMed ID: 11052496

DOI: 10.1002/jor.1100180412

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21624478

Title: Snorc is a novel cartilage specific small membrane proteoglycan expressed in differentiating and articular chondrocytes.

PubMed ID: 21624478

DOI: 10.1016/j.joca.2011.04.016

PubMed ID: 32686688

Title: Mutations in COMP cause familial carpal tunnel syndrome.

PubMed ID: 32686688

DOI: 10.1038/s41467-020-17378-z

PubMed ID: 32747625

Title: Author Correction: Mutations in COMP cause familial carpal tunnel syndrome.

PubMed ID: 32747625

DOI: 10.1038/s41467-020-17845-7

PubMed ID: 12426368

Title: Storage function of cartilage oligomeric matrix protein: the crystal structure of the coiled-coil domain in complex with vitamin D(3).

PubMed ID: 12426368

DOI: 10.1093/emboj/cdf628

Sequence Information:

Length: 755
Mass: 82342
Checksum: 24C2F113E7945C0F
Sequence:

MGPTACVLVL ALAILRATGQ GQIPLGGDLA PQMLRELQET NAALQDVREL LRQQVKEITF 
LKNTVMECDA CGMQPARTPG LSVRPVPLCA PGSCFPGVVC SETATGARCG PCPPGYTGNG 
SHCTDVNECN AHPCFPRVRC INTSPGFHCE ACPPGFSGPT HEGVGLTFAK SNKQVCTDIN 
ECETGQHNCV PNSVCVNTRG SFQCGPCQPG FVGDQTSGCQ RRGQHFCPDG SPSPCHEKAN 
CVLERDGSRS CVCAVGWAGN GLLCGRDTDL DGFPDEKLRC SERQCRKDNC VTVPNSGQED 
VDRDGIGDAC DPDADGDGVP NEQDNCPLVR NPDQRNSDSD KWGDACDNCR SKKNDDQKDT 
DLDGRGDACD DDIDGDRIRN VADNCPRVPN FDQSDSDGDG VGDACDNCPQ KDNPDQRDVD 
HDFVGDACDS DQDQDGDGHQ DSRDNCPTVP NSAQQDSDHD GKGDACDDDD DNDGVPDSRD 
NCRLVPNPGQ EDNDRDGVGD ACQGDFDADK VIDKIDVCPE NAEVTLTDFR AFQTVVLDPE 
GDAQIDPNWV VLNQGMEIVQ TMNSDPGLAV GYTAFNGVDF EGTFHVNTAT DDDYAGFIFG 
YQDSSSFYVV MWKQMEQTYW QANPFRAVAE PGIQLKAVKS STGPGEQLRN ALWHTGDTAS 
QVRLLWKDPR NVGWKDKTSY RWFLQHRPQV GYIRVRFYEG PELVADSNVV LDTAMRGGRL 
GVFCFSQENI IWANLRYRCN DTIPEDYESH RLQRV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Comp

Associated with

Other Information

Molecular cloning, sequencing, and tissue and developmental expression of mouse cartilage oligomeric matrix protein (COMP). PubMed ID: 11052496

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Snorc is a novel cartilage specific small membrane proteoglycan expressed in differentiating and articular chondrocytes. PubMed ID: 21624478

Mutations in COMP cause familial carpal tunnel syndrome. PubMed ID: 32686688

Author Correction: Mutations in COMP cause familial carpal tunnel syndrome. PubMed ID: 32747625

Storage function of cartilage oligomeric matrix protein: the crystal structure of the coiled-coil domain in complex with vitamin D(3). PubMed ID: 12426368