Genular: Defining Cellular Identity and Function

Details for: Comt

Gene ID: 12846

Symbol: Comt

Ensembl ID: ENSMUSG00000000326

Description: catechol-O-methyltransferase

Associated with

Biological oxidations
(R-MMU-211859)
Dopamine clearance from the synaptic cleft
(R-MMU-379401)
Enzymatic degradation of dopamine by comt
(R-MMU-379397)
Enzymatic degradation of dopamine by monoamine oxidase
(R-MMU-379398)
Metabolism
(R-MMU-1430728)
Neuronal system
(R-MMU-112316)
Neurotransmitter clearance
(R-MMU-112311)
Phase ii - conjugation of compounds
(R-MMU-156580)
Transmission across chemical synapses
(R-MMU-112315)
Artery development
(GO:0060840)
Behavior
(GO:0007610)
Behavioral fear response
(GO:0001662)
Catecholamine catabolic process
(GO:0042424)
Catecholamine metabolic process
(GO:0006584)
Catechol o-methyltransferase activity
(GO:0016206)
Cellular response to cocaine
(GO:0071314)
Cellular response to phosphate starvation
(GO:0016036)
Cerebellar cortex morphogenesis
(GO:0021696)
Cholesterol efflux
(GO:0033344)
Cognition
(GO:0050890)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Detection of temperature stimulus involved in sensory perception of pain
(GO:0050965)
Developmental process
(GO:0032502)
Dopamine catabolic process
(GO:0042420)
Dopamine metabolic process
(GO:0042417)
Dopamine secretion
(GO:0014046)
Estrogen metabolic process
(GO:0008210)
Exploration behavior
(GO:0035640)
Fear response
(GO:0042596)
Female pregnancy
(GO:0007565)
Gene expression
(GO:0010467)
Glomerulus development
(GO:0032835)
Glycogen metabolic process
(GO:0005977)
Habituation
(GO:0046959)
Kidney development
(GO:0001822)
L-dopa o-methyltransferase activity
(GO:0102084)
Learning
(GO:0007612)
Learning or memory
(GO:0007611)
Lipid metabolic process
(GO:0006629)
Magnesium ion binding
(GO:0000287)
Mastication
(GO:0071626)
Memory
(GO:0007613)
Metal ion binding
(GO:0046872)
Methylation
(GO:0032259)
Methyltransferase activity
(GO:0008168)
Mitochondrion
(GO:0005739)
Multicellular organismal reproductive process
(GO:0048609)
Multicellular organismal response to stress
(GO:0033555)
Multicellular organism growth
(GO:0035264)
Negative regulation of dopamine metabolic process
(GO:0045963)
Negative regulation of smooth muscle cell proliferation
(GO:0048662)
Norepinephrine metabolic process
(GO:0042415)
Norepinephrine secretion
(GO:0048243)
O-methyltransferase activity
(GO:0008171)
Orcinol o-methyltransferase activity
(GO:0102938)
Positive regulation of homocysteine metabolic process
(GO:0050668)
Prostaglandin metabolic process
(GO:0006693)
Protein methylation
(GO:0006479)
Protein phosphorylation
(GO:0006468)
Regulation of blood pressure
(GO:0008217)
Renal albumin absorption
(GO:0097018)
Renal filtration
(GO:0097205)
Renal sodium excretion
(GO:0035812)
Renin secretion into blood stream
(GO:0002001)
Response to amphetamine
(GO:0001975)
Response to angiotensin
(GO:1990776)
Response to corticosterone
(GO:0051412)
Response to cytokine
(GO:0034097)
Response to dopamine
(GO:1903350)
Response to external stimulus
(GO:0009605)
Response to food
(GO:0032094)
Response to hypoxia
(GO:0001666)
Response to inorganic substance
(GO:0010035)
Response to methylphenidate
(GO:0036271)
Response to organic substance
(GO:0010033)
Response to oxidative stress
(GO:0006979)
Response to pain
(GO:0048265)
Response to salt
(GO:1902074)
Response to stress
(GO:0006950)
Response to temperature stimulus
(GO:0009266)
Response to toxic substance
(GO:0009636)
Response to wounding
(GO:0009611)
Response to xenobiotic stimulus
(GO:0009410)
S-adenosylmethionine-dependent methyltransferase activity
(GO:0008757)
Short-term memory
(GO:0007614)
Startle response
(GO:0001964)
Synaptic transmission, dopaminergic
(GO:0001963)
Transferase activity
(GO:0016740)
Visual learning
(GO:0008542)

Other Information

Proteins

COMT_MOUSE

Genular Protein ID: 4020998717

Symbol: COMT_MOUSE

Name: N/A

UniProtKB Accession Codes:

O88587 Q91XH4

Database IDs:

Citations:

PubMed ID: 9707588

Title: Catechol-O-methyltransferase-deficient mice exhibit sexually dimorphic changes in catecholamine levels and behavior.

PubMed ID: 9707588

DOI: 10.1073/pnas.95.17.9991

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 18794526

Title: A catechol-O-methyltransferase that is essential for auditory function in mice and humans.

PubMed ID: 18794526

DOI: 10.1073/pnas.0807219105

PubMed ID: 19144319

Title: The phagosomal proteome in interferon-gamma-activated macrophages.

PubMed ID: 19144319

DOI: 10.1016/j.immuni.2008.11.006

PubMed ID: 19131326

Title: Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry.

PubMed ID: 19131326

DOI: 10.1074/mcp.m800451-mcp200

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 265
Mass: 29486
Checksum: E82E9307F6D8A6CF
Sequence:

MLLAAVSLGL LLLAFLLLLR HLGWGLVAIG WFEFVQQPVH NLLMGGTKEQ RILRHVQQHA 
KPGDPQSVLE AIDTYCSEKE WAMNVGDAKG QIMDAVIREY RPSLVLELGA YCGYSAVRMA 
RLLPPGARLL TMEINPDYAA ITQQMLDFAG LQDKVSILIG ASQDLIPQLK KKYDVDTLDM 
VFLDHWKDRY LPDTLLLEEC GLLRKGTVLL ADNVIVPGTP DFLAYVRGSS SFECTHYSSY 
LEYMKVVDGL EKAVYQGPGS SPVKS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Comt

Associated with

Other Information

Catechol-O-methyltransferase-deficient mice exhibit sexually dimorphic changes in catecholamine levels and behavior. PubMed ID: 9707588

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Large-scale phosphorylation analysis of mouse liver. PubMed ID: 17242355

A catechol-O-methyltransferase that is essential for auditory function in mice and humans. PubMed ID: 18794526

The phagosomal proteome in interferon-gamma-activated macrophages. PubMed ID: 19144319

Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry. PubMed ID: 19131326

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079