Genular: Defining Cellular Identity and Function

Details for: Cops2

Gene ID: 12848

Symbol: Cops2

Ensembl ID: ENSMUSG00000027206

Description: COP9 signalosome subunit 2

Associated with

Cargo recognition for clathrin-mediated endocytosis
(R-MMU-8856825)
Clathrin-mediated endocytosis
(R-MMU-8856828)
Dna damage recognition in gg-ner
(R-MMU-5696394)
Dna repair
(R-MMU-73894)
Formation of tc-ner pre-incision complex
(R-MMU-6781823)
Global genome nucleotide excision repair (gg-ner)
(R-MMU-5696399)
Membrane trafficking
(R-MMU-199991)
Metabolism of proteins
(R-MMU-392499)
Neddylation
(R-MMU-8951664)
Nucleotide excision repair
(R-MMU-5696398)
Post-translational protein modification
(R-MMU-597592)
Rhobtb1 gtpase cycle
(R-MMU-9013422)
Rhobtb gtpase cycle
(R-MMU-9706574)
Rho gtpase cycle
(R-MMU-9012999)
Signaling by rho gtpases
(R-MMU-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-MMU-9716542)
Signal transduction
(R-MMU-162582)
Transcription-coupled nucleotide excision repair (tc-ner)
(R-MMU-6781827)
Vesicle-mediated transport
(R-MMU-5653656)
Cop9 signalosome
(GO:0008180)
Cytoplasm
(GO:0005737)
Inner cell mass cell proliferation
(GO:0001833)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Neuron differentiation
(GO:0030182)
Nucleus
(GO:0005634)
Protein binding
(GO:0005515)
Protein deneddylation
(GO:0000338)
Protein phosphorylation
(GO:0006468)
Skeletal muscle cell differentiation
(GO:0035914)
Transcription corepressor activity
(GO:0003714)
Trophectodermal cell proliferation
(GO:0001834)

Other Information

Proteins

COP9 signalosome complex subunit 2
Q3V3N6_MOUSE

Genular Protein ID: 1757571649

Symbol: CSN2_MOUSE

Name: COP9 signalosome complex subunit 2

UniProtKB Accession Codes:

P61202 O88950 Q15647 Q3V1W6 Q8R5B0 Q9CWU1 Q9R249 Q9UNQ5

Database IDs:

Citations:

PubMed ID: 10087198

Title: Coding sequence, genomic organization, chromosomal localization, and expression pattern of the signalosome component Cops2: the mouse homologue of Drosophila alien.

PubMed ID: 10087198

DOI: 10.1006/geno.1998.5728

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9707402

Title: The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex.

PubMed ID: 9707402

DOI: 10.1016/s0960-9822(07)00372-7

PubMed ID: 11967155

Title: The COP9 signalosome inhibits p27(kip1) degradation and impedes G1-S phase progression via deneddylation of SCF Cul1.

PubMed ID: 11967155

DOI: 10.1016/s0960-9822(02)00791-1

PubMed ID: 12522100

Title: The role of transcriptional corepressor Nif3l1 in early stage of neural differentiation via cooperation with Trip15/CSN2.

PubMed ID: 12522100

DOI: 10.1074/jbc.m209856200

PubMed ID: 12972599

Title: Disruption of the COP9 signalosome Csn2 subunit in mice causes deficient cell proliferation, accumulation of p53 and cyclin E, and early embryonic death.

PubMed ID: 12972599

DOI: 10.1128/mcb.23.19.6790-6797.2003

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 443
Mass: 51597
Checksum: 1DB6FA774C13BC59
Sequence:

MSDMEDDFMC DDEEDYDLEY SEDSNSEPNV DLENQYYNSK ALKEDDPKAA LSSFQKVLEL 
EGEKGEWGFK ALKQMIKINF KLTNFPEMMN RYKQLLTYIR SAVTRNYSEK SINSILDYIS 
TSKQMDLLQE FYETTLEALK DAKNDRLWFK TNTKLGKLYL EREEYGKLQK ILRQLHQSCQ 
TDDGEDDLKK GTQLLEIYAL EIQMYTAQKN NKKLKALYEQ SLHIKSAIPH PLIMGVIREC 
GGKMHLREGE FEKAHTDFFE AFKNYDESGS PRRTTCLKYL VLANMLMKSG INPFDSQEAK 
PYKNDPEILA MTNLVSAYQN NDITEFEKIL KTNHSNIMDD PFIREHIEEL LRNIRTQVLI 
KLIKPYTRIH IPFISKELNI DVADVESLLV QCILDNTIHG RIDQVNQLLE LDHQKRGGAR 
YTALDKWTNQ LNSLNQAVVS KLA

Genular Protein ID: 1518845155

Symbol: Q3V3N6_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3V3N6

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

Length: 450
Mass: 52405
Checksum: 581DE764677E90C0
Sequence:

MSDMEDDFMC DDEEDYDLEY SEDSNSEPNV DLENQYYNSK ALKEDDPKAA LSSFQKVLEL 
EGEKGEWGFK ALKQMIKINF KLTNFPEMMN RYKQLLTYIR SAVTRNYSEK SINSILDYIS 
TSKQNSDFLC QMDLLQEFYE TTLEALKDAK NDRLWFKTNT KLGKLYLERE EYGKLQKILR 
QLHQSCQTDD GEDDLKKGTQ LLEIYALEIQ MYTAQKNNKK LKALYEQSLH IKSAIPHPLI 
MGVIRECGGK MHLREGEFEK AHTDFFEAFK NYDESGSPRR TTCLKYLVLA NMLMKSGINP 
FDSQEAKPYK NDPEILAMTN LVSAYQNNDI TEFEKILKTN HSNIMDDPFI REHIEELLRN 
IRTQVLIKLI KPYTRIHIPF ISKELNIDVA DVESLLVQCI LDNTIHGRID QVNQLLELDH 
QKRGGARYTA LDKWTNQLNS LNQAVVSKLA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Cops2

Associated with

Other Information

Coding sequence, genomic organization, chromosomal localization, and expression pattern of the signalosome component Cops2: the mouse homologue of Drosophila alien. PubMed ID: 10087198

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex. PubMed ID: 9707402

The COP9 signalosome inhibits p27(kip1) degradation and impedes G1-S phase progression via deneddylation of SCF Cul1. PubMed ID: 11967155

The role of transcriptional corepressor Nif3l1 in early stage of neural differentiation via cooperation with Trip15/CSN2. PubMed ID: 12522100

Disruption of the COP9 signalosome Csn2 subunit in mice causes deficient cell proliferation, accumulation of p53 and cyclin E, and early embryonic death. PubMed ID: 12972599

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073