Details for: COL4A3
Associated with
Cells (max top 100)
(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: anterior lens cell (CL0002223)
Fold Change: 4.46
Marker Score: 5,999 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 3.59
Marker Score: 4,344 - Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 3.17
Marker Score: 1,846 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 2.81
Marker Score: 1,644 - Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 2.67
Marker Score: 5,134 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 2.55
Marker Score: 5,596 - Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 2.53
Marker Score: 2,562 - Cell Name: rod bipolar cell (CL0000751)
Fold Change: 2.36
Marker Score: 1,235 - Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 2.35
Marker Score: 1,239 - Cell Name: type I pneumocyte (CL0002062)
Fold Change: 2.28
Marker Score: 2,743 - Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 2.12
Marker Score: 5,677 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 2.1
Marker Score: 8,787 - Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 2.06
Marker Score: 861 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 1.87
Marker Score: 546 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 1.63
Marker Score: 4,093 - Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 1.61
Marker Score: 439 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.6
Marker Score: 1,166 - Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 1.56
Marker Score: 1,800 - Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 1.54
Marker Score: 1,901 - Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 1.53
Marker Score: 1,619 - Cell Name: mural cell (CL0008034)
Fold Change: 1.47
Marker Score: 168,274 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.44
Marker Score: 1,439 - Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 1.44
Marker Score: 522 - Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.37
Marker Score: 868 - Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 1.34
Marker Score: 651 - Cell Name: lactocyte (CL0002325)
Fold Change: 1.28
Marker Score: 20,621 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.26
Marker Score: 853 - Cell Name: podocyte (CL0000653)
Fold Change: 1.24
Marker Score: 458 - Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 1.21
Marker Score: 2,851 - Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 1.18
Marker Score: 1,275 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 1.17
Marker Score: 486 - Cell Name: epithelial cell of alveolus of lung (CL0010003)
Fold Change: 1.16
Marker Score: 521 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.15
Marker Score: 4,806 - Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 1.14
Marker Score: 4,061 - Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 1.13
Marker Score: 359 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 1.09
Marker Score: 502 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 1.07
Marker Score: 1,185 - Cell Name: renal principal cell (CL0005009)
Fold Change: 1.06
Marker Score: 813 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71,810 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48,034 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.99
Marker Score: 508 - Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,407 - Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.98
Marker Score: 461 - Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 0.96
Marker Score: 913 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2,411 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.93
Marker Score: 374 - Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.92
Marker Score: 5,278 - Cell Name: interneuron (CL0000099)
Fold Change: 0.91
Marker Score: 418 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2,736 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.91
Marker Score: 326 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 0.89
Marker Score: 281 - Cell Name: fat cell (CL0000136)
Fold Change: 0.88
Marker Score: 494 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5,282 - Cell Name: skin fibroblast (CL0002620)
Fold Change: 0.86
Marker Score: 223 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.85
Marker Score: 652 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.85
Marker Score: 13,285 - Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 0.8
Marker Score: 421 - Cell Name: papillary tips cell (CL1000597)
Fold Change: 0.8
Marker Score: 161 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.78
Marker Score: 8,086 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1,266 - Cell Name: brush cell (CL0002204)
Fold Change: 0.77
Marker Score: 707 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 0.77
Marker Score: 11,582 - Cell Name: lens fiber cell (CL0011004)
Fold Change: 0.77
Marker Score: 245 - Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.77
Marker Score: 397 - Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 0.77
Marker Score: 195 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.76
Marker Score: 4,586 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: 0.76
Marker Score: 10,138 - Cell Name: cardiac neuron (CL0010022)
Fold Change: 0.76
Marker Score: 943 - Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 0.76
Marker Score: 1,071 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.75
Marker Score: 256 - Cell Name: melanocyte (CL0000148)
Fold Change: 0.75
Marker Score: 304 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.72
Marker Score: 461 - Cell Name: neuron (CL0000540)
Fold Change: 0.71
Marker Score: 2,874 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.7
Marker Score: 179 - Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.68
Marker Score: 177 - Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: 0.64
Marker Score: 2,651 - Cell Name: follicular B cell (CL0000843)
Fold Change: 0.6
Marker Score: 651 - Cell Name: ionocyte (CL0005006)
Fold Change: 0.59
Marker Score: 179 - Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 0.58
Marker Score: 969 - Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.57
Marker Score: 1,163 - Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.56
Marker Score: 149 - Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.56
Marker Score: 448 - Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.56
Marker Score: 337 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.55
Marker Score: 18,655 - Cell Name: Schwann cell (CL0002573)
Fold Change: 0.55
Marker Score: 191 - Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.55
Marker Score: 230 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.55
Marker Score: 174 - Cell Name: monocyte (CL0000576)
Fold Change: 0.54
Marker Score: 706 - Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.53
Marker Score: 170 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 0.53
Marker Score: 4,032 - Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.52
Marker Score: 164 - Cell Name: lymphocyte (CL0000542)
Fold Change: 0.49
Marker Score: 247 - Cell Name: Mueller cell (CL0000636)
Fold Change: 0.49
Marker Score: 673 - Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 0.47
Marker Score: 192 - Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: 0.46
Marker Score: 1,641 - Cell Name: nephron tubule epithelial cell (CL1000494)
Fold Change: 0.46
Marker Score: 107 - Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 0.45
Marker Score: 417 - Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.44
Marker Score: 248 - Cell Name: retinal pigment epithelial cell (CL0002586)
Fold Change: 0.43
Marker Score: 126 - Cell Name: type II pneumocyte (CL0002063)
Fold Change: 0.43
Marker Score: 2,789
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 4167604688
Symbol: CO4A3_HUMAN
Name: Collagen alpha-3(IV) chain
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8083201
Title: Complete primary structure of the human alpha 3(IV) collagen chain. Coexpression of the alpha 3(IV) and alpha 4(IV) collagen chains in human tissues.
PubMed ID: 8083201
PubMed ID: 11134255
Title: Structure of the human type IV collagen gene COL4A3 and mutations in autosomal Alport syndrome.
PubMed ID: 11134255
DOI: 10.1681/asn.v12197
PubMed ID: 15815621
Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
PubMed ID: 15815621
DOI: 10.1038/nature03466
PubMed ID: 9537506
Title: Two genes, COL4A3 and COL4A4 coding for the human alpha3(IV) and alpha4(IV) collagen chains are arranged head-to-head on chromosome 2q36.
PubMed ID: 9537506
PubMed ID: 1737849
Title: Molecular cloning of the human Goodpasture antigen demonstrates it to be the alpha 3 chain of type IV collagen.
PubMed ID: 1737849
DOI: 10.1172/jci115625
PubMed ID: 1400291
Title: Exon/intron structure of the human alpha 3(IV) gene encompassing the Goodpasture antigen (alpha 3(IV)NC1). Identification of a potentially antigenic region at the triple helix/NC1 domain junction.
PubMed ID: 1400291
PubMed ID: 8006044
PubMed ID: 7758473
Title: Characterization and expression of multiple alternatively spliced transcripts of the Goodpasture antigen gene region. Goodpasture antibodies recognize recombinant proteins representing the autoantigen and one of its alternative forms.
PubMed ID: 7758473
PubMed ID: 10766752
Title: Distinct antitumor properties of a type IV collagen domain derived from basement membrane.
PubMed ID: 10766752
PubMed ID: 8294492
Title: Alternative splicing of the NC1 domain of the human alpha 3(IV) collagen gene. Differential expression of mRNA transcripts that predict three protein variants with distinct carboxyl regions.
PubMed ID: 8294492
PubMed ID: 1882840
Title: Sequence and localization of a partial cDNA encoding the human alpha 3 chain of type IV collagen.
PubMed ID: 1882840
PubMed ID: 8505332
Title: The human mRNA encoding the Goodpasture antigen is alternatively spliced.
PubMed ID: 8505332
PubMed ID: 7523402
Title: Complete primary structure of the human type IV collagen alpha 4(IV) chain. Comparison with structure and expression of the other alpha (IV) chains.
PubMed ID: 7523402
PubMed ID: 10212244
Title: Characterization of a novel type of serine/threonine kinase that specifically phosphorylates the human goodpasture antigen.
PubMed ID: 10212244
PubMed ID: 10837460
Title: Two RGD-independent alpha vbeta 3 integrin binding sites on tumstatin regulate distinct anti-tumor properties.
PubMed ID: 10837460
PubMed ID: 11044206
Title: Autosomal dominant Alport syndrome caused by a COL4A3 splice site mutation.
PubMed ID: 11044206
PubMed ID: 12193605
Title: Quaternary organization of the goodpasture autoantigen, the alpha 3(IV) collagen chain. Sequestration of two cryptic autoepitopes by intrapromoter interactions with the alpha4 and alpha5 NC1 domains.
PubMed ID: 12193605
PubMed ID: 12682293
Title: Human tumstatin and human endostatin exhibit distinct antiangiogenic activities mediated by alpha v beta 3 and alpha 5 beta 1 integrins.
PubMed ID: 12682293
PubMed ID: 15492988
Title: Implication of tumstatin in tumor progression of human bronchopulmonary carcinomas.
PubMed ID: 15492988
PubMed ID: 7987301
Title: Mutations in the type IV collagen alpha 3 (COL4A3) gene in autosomal recessive Alport syndrome.
PubMed ID: 7987301
DOI: 10.1093/hmg/3.8.1269
PubMed ID: 11961012
Title: Mutations in the COL4A4 and COL4A3 genes cause familial benign hematuria.
PubMed ID: 11961012
DOI: 10.1681/asn.v1351248
PubMed ID: 15954103
Title: Novel COL4A5, COL4A4, and COL4A3 mutations in Alport syndrome.
PubMed ID: 15954103
DOI: 10.1002/humu.9349
PubMed ID: 29946535
Title: Heterozygous COL4A3 variants in histologically diagnosed focal segmental glomerulosclerosis.
PubMed ID: 29946535
Sequence Information:
- Length: 1670
- Mass: 161813
- Checksum: AA65D50903D82B99
- Sequence:
MSARTAPRPQ VLLLPLLLVL LAAAPAASKG CVCKDKGQCF CDGAKGEKGE KGFPGPPGSP GQKGFTGPEG LPGPQGPKGF PGLPGLTGSK GVRGISGLPG FSGSPGLPGT PGNTGPYGLV GVPGCSGSKG EQGFPGLPGT LGYPGIPGAA GLKGQKGAPA KEEDIELDAK GDPGLPGAPG PQGLPGPPGF PGPVGPPGPP GFFGFPGAMG PRGPKGHMGE RVIGHKGERG VKGLTGPPGP PGTVIVTLTG PDNRTDLKGE KGDKGAMGEP GPPGPSGLPG ESYGSEKGAP GDPGLQGKPG KDGVPGFPGS EGVKGNRGFP GLMGEDGIKG QKGDIGPPGF RGPTEYYDTY QEKGDEGTPG PPGPRGARGP QGPSGPPGVP GSPGSSRPGL RGAPGWPGLK GSKGERGRPG KDAMGTPGSP GCAGSPGLPG SPGPPGPPGD IVFRKGPPGD HGLPGYLGSP GIPGVDGPKG EPGLLCTQCP YIPGPPGLPG LPGLHGVKGI PGRQGAAGLK GSPGSPGNTG LPGFPGFPGA QGDPGLKGEK GETLQPEGQV GVPGDPGLRG QPGRKGLDGI PGTPGVKGLP GPKGELALSG EKGDQGPPGD PGSPGSPGPA GPAGPPGYGP QGEPGLQGTQ GVPGAPGPPG EAGPRGELSV STPVPGPPGP PGPPGHPGPQ GPPGIPGSLG KCGDPGLPGP DGEPGIPGIG FPGPPGPKGD QGFPGTKGSL GCPGKMGEPG LPGKPGLPGA KGEPAVAMPG GPGTPGFPGE RGNSGEHGEI GLPGLPGLPG TPGNEGLDGP RGDPGQPGPP GEQGPPGRCI EGPRGAQGLP GLNGLKGQQG RRGKTGPKGD PGIPGLDRSG FPGETGSPGI PGHQGEMGPL GQRGYPGNPG ILGPPGEDGV IGMMGFPGAI GPPGPPGNPG TPGQRGSPGI PGVKGQRGTP GAKGEQGDKG NPGPSEISHV IGDKGEPGLK GFAGNPGEKG NRGVPGMPGL KGLKGLPGPA GPPGPRGDLG STGNPGEPGL RGIPGSMGNM GMPGSKGKRG TLGFPGRAGR PGLPGIHGLQ GDKGEPGYSE GTRPGPPGPT GDPGLPGDMG KKGEMGQPGP PGHLGPAGPE GAPGSPGSPG LPGKPGPHGD LGFKGIKGLL GPPGIRGPPG LPGFPGSPGP MGIRGDQGRD GIPGPAGEKG ETGLLRAPPG PRGNPGAQGA KGDRGAPGFP GLPGRKGAMG DAGPRGPTGI EGFPGPPGLP GAIIPGQTGN RGPPGSRGSP GAPGPPGPPG SHVIGIKGDK GSMGHPGPKG PPGTAGDMGP PGRLGAPGTP GLPGPRGDPG FQGFPGVKGE KGNPGFLGSI GPPGPIGPKG PPGVRGDPGT LKIISLPGSP GPPGTPGEPG MQGEPGPPGP PGNLGPCGPR GKPGKDGKPG TPGPAGEKGN KGSKGEPGPA GSDGLPGLKG KRGDSGSPAT WTTRGFVFTR HSQTTAIPSC PEGTVPLYSG FSFLFVQGNQ RAHGQDLGTL GSCLQRFTTM PFLFCNVNDV CNFASRNDYS YWLSTPALMP MNMAPITGRA LEPYISRCTV CEGPAIAIAV HSQTTDIPPC PHGWISLWKG FSFIMFTSAG SEGTGQALAS PGSCLEEFRA SPFLECHGRG TCNYYSNSYS FWLASLNPER MFRKPIPSTV KAGELEKIIS RCQVCMKKRH
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.